sorbitol

Summary

Summary: A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Top Publications

  1. Trottier V, Drolet S, Morcos M. Ileocolic perforation secondary to sodium polystyrene sulfonate in sorbitol use: a case report. Can J Gastroenterol. 2009;23:689-90 pubmed
    ..It can lead to various complications including cardiac arrhythmias. Sodium polystyrene sulfonate (SPS) in sorbitol is an ion-exchange resin that can be used to treat hyperkalemia. It can be used in enema or in oral form...
  2. Fernández Bañares F, Esteve M, Viver J. Fructose-sorbitol malabsorption. Curr Gastroenterol Rep. 2009;11:368-74 pubmed
    Important dietary carbohydrates such as fructose and sorbitol are incompletely absorbed in the normal small intestine...
  3. Jakubczak A, Szych J, Januszkiewicz K. [Characterization of first sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H- strain isolated in Poland]. Med Dosw Mikrobiol. 2008;60:173-81 pubmed
    b>Sorbitol-fermenting shiga toxin-producing E. coli O157:H- strains have emerged as a cause of human disease in many European and non-European countries...
  4. Gerlach J, Brayfield C, Puhl G, Borneman R, Muller C, Schmelzer E, et al. Lidocaine/monoethylglycinexylidide test, galactose elimination test, and sorbitol elimination test for metabolic assessment of liver cell bioreactors. Artif Organs. 2010;34:462-72 pubmed publisher
    ..Measurements of monoethylglycinexylidide synthesis and elimination of lidocaine, galactose elimination, and sorbitol elimination proved to be useful for routine QA of primary liver cell cultures...
  5. Diaz S, Vidal D, Herrera Leon S, Sanchez S. Sorbitol-fermenting, ?-glucuronidase-positive, Shiga toxin-negative Escherichia coli O157:H7 in free-ranging red deer in South-Central Spain. Foodborne Pathog Dis. 2011;8:1313-5 pubmed publisher
    ..coli O157:H7 in free-ranging red deer in south-central Spain, to assess their potential as reservoir hosts of sorbitol-fermenting (SF) E. coli O157:H7 strains, which are emerging causes of hemolytic uremic syndrome in Europe...
  6. Celik E, Calik P, Oliver S. Fed-batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co-substrate sorbitol. Yeast. 2009;26:473-84 pubmed publisher
    Batch-wise sorbitol addition as a co-substrate at the induction phase of methanol fed-batch fermentation by Pichia pastoris (Mut(+)) was proposed as a beneficial recombinant protein production strategy and the metabolic responses to ..
  7. Lanaspa M, Andres Hernando A, Rivard C, Dai Y, Li N, Berl T. ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. J Biol Chem. 2009;284:19974-81 pubmed publisher
    ..Because ZAC1 has been described to be a potential negative regulator of sorbitol dehydrogenase (SDH) in hippocampal cells, we examined whether this relationship also occurs in kidney cells under ..
  8. Withanage K, Nakagawa K, Ikeda M, Kurihara H, Kudo T, Yang Z, et al. Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells. J Biochem. 2012;152:111-9 pubmed publisher
    ..We demonstrated that RASSF6 as well as the Hippo pathway are involved in the sorbitol-induced apoptosis in immortalized human proximal renal tubular epithelial HK-2 cells.
  9. Kaplan F, Lewis L, Wastian J, Holzinger A. Plasmolysis effects and osmotic potential of two phylogenetically distinct alpine strains of Klebsormidium (Streptophyta). Protoplasma. 2012;249:789-804 pubmed publisher
    ..investigated in two different Klebsormidium strains from alpine habitats by incubation in 300-2,000 (3,000) mM sorbitol. Several members of this genus were previously found to tolerate desiccation in the vegetative state yet ..

Scientific Experts

More Information

Publications62

  1. Rosser T, Dransfield T, Allison L, Hanson M, Holden N, Evans J, et al. Pathogenic potential of emergent sorbitol-fermenting Escherichia coli O157:NM. Infect Immun. 2008;76:5598-607 pubmed publisher
    Non-sorbitol-fermenting (NSF) Escherichia coli O157:H7 is the primary Shiga toxin-producing E. coli (STEC) serotype associated with human infection...
  2. de Sousa S, Paniago M, Arruda P, Yunes J. Sugar levels modulate sorbitol dehydrogenase expression in maize. Plant Mol Biol. 2008;68:203-13 pubmed publisher
    ..This fructose can enter subsequent metabolism via hexokinase, or in maize kernels, by a sorbitol dehydrogenase that reversibly converts fructose + NADH to sorbitol + NAD...
  3. Haugum K, Lindstedt B, Løbersli I, Kapperud G, Brandal L. Identification of the anti-terminator qO111:H)- gene in Norwegian sorbitol-fermenting Escherichia coli O157:NM. FEMS Microbiol Lett. 2012;329:102-10 pubmed publisher
    b>Sorbitol-fermenting Escherichia coli O157:NM (SF O157) is an emerging pathogen suggested to be more virulent than nonsorbitol-fermenting Escherichia coli O157:H7 (NSF O157)...
  4. De Boeck R, Sarmiento Rubiano L, Nadal I, Monedero V, Perez Martinez G, Yebra M. Sorbitol production from lactose by engineered Lactobacillus casei deficient in sorbitol transport system and mannitol-1-phosphate dehydrogenase. Appl Microbiol Biotechnol. 2010;85:1915-22 pubmed publisher
    b>Sorbitol is a sugar alcohol largely used in the food industry as a low-calorie sweetener...
  5. Azizi A, Ranjbar B, Khajeh K, Ghodselahi T, Hoornam S, Mobasheri H, et al. Effects of trehalose and sorbitol on the activity and structure of Pseudomonas cepacia lipase: spectroscopic insight. Int J Biol Macromol. 2011;49:652-6 pubmed publisher
    ..In this study we have investigated the effects of sorbitol and trehalose on the structural stability and activity of Pseudomonas cepacia lipase (PCL), using UV-visible, ..
  6. Mavrogonatou E, Kletsas D. Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea. J Cell Physiol. 2012;227:1179-87 pubmed publisher
    ..the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea...
  7. Wang Z, Wang Y, Zhang D, Li J, Hua Z, Du G, et al. Enhancement of cell viability and alkaline polygalacturonate lyase production by sorbitol co-feeding with methanol in Pichia pastoris fermentation. Bioresour Technol. 2010;101:1318-23 pubmed publisher
    ..In order to enhance cell viability and volumetric recombinant protein productivity, sorbitol, which had been confirmed to be a non-repressive carbon source, was added together with methanol during the ..
  8. Chi M, Wu T, Chen H, Lo H, Lin L. Sorbitol counteracts temperature- and chemical-induced denaturation of a recombinant ?-amylase from alkaliphilic Bacillus sp. TS-23. J Ind Microbiol Biotechnol. 2012;39:1779-88 pubmed publisher
    ..In the presence of trimethylamine N-oxide (TMAO) and sorbitol, BAC?NC activity was retained significantly at elevated temperatures...
  9. Muthenna P, Suryanarayana P, Gunda S, Petrash J, Reddy G. Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance. FEBS Lett. 2009;583:3637-42 pubmed publisher
    Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes...
  10. Reddy P, Giridharan N, Balakrishna N, Validandi V, Pullakhandam R, Reddy G. Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB Life. 2013;65:472-8 pubmed publisher
    ..Previously we had demonstrated accumulation of sorbitol in the lens of obese rats (WNIN/Ob) and more so in a related strain with impaired glucose tolerance (WNIN/GR-Ob)...
  11. Cobbaut K, Houf K, Buvens G, Habib I, De Zutter L. Occurrence of non-sorbitol fermenting, verocytotoxin-lacking Escherichia coli O157 on cattle farms. Vet Microbiol. 2009;138:174-8 pubmed publisher
    ..8% (8/68) of the positive farms. From these eight farms, a total of 43 sorbitol-negative E. coli O157:H7 were collected...
  12. Splieth C, Alkilzy M, Schmitt J, Berndt C, Welk A. Effect of xylitol and sorbitol on plaque acidogenesis. Quintessence Int. 2009;40:279-85 pubmed
    To evaluate the in vivo potential of xylitol to reduce plaque acidogenicity in comparison to sorbitol.
  13. McGowan C, Saha S, Chu G, Resnick M, Moss S. Intestinal necrosis due to sodium polystyrene sulfonate (Kayexalate) in sorbitol. South Med J. 2009;102:493-7 pubmed publisher
    Sodium polystyrene sulfonate (SPS, Kayexalate) has been implicated in the development of intestinal necrosis. Sorbitol, added as a cathartic agent, may be primarily responsible...
  14. Valeur J, Øines E, Morken M, Holst J, Berstad A. Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption. Scand J Gastroenterol. 2008;43:1212-8 pubmed publisher
    ..The purpose of this study was to investigate whether this could be explained by differences in ileal brake hormone secretion...
  15. Landau Z, Novotny M, Preston G, Wright K, Freeman T, Dai H, et al. Pharmacokinetics, pharmacodynamics, tolerability, and safety of a novel sorbitol dehydrogenase inhibitor in healthy participants. J Clin Pharmacol. 2010;50:521-30 pubmed publisher
    ..of flux through this pathway can be blocked through inhibition of either of 2 enzymes, aldose reductase (AR) or sorbitol dehydrogenase (SDH)...
  16. Lim C, Tung C, Rosli R, Chong P. An alternative Candida spp. cell wall disruption method using a basic sorbitol lysis buffer and glass beads. J Microbiol Methods. 2008;75:576-8 pubmed publisher
    ..which employs the use of glass beads in a simple sorbitol lysis buffer...
  17. Chou Y, Wang H, Hsieh M. Colonic necrosis in a young patient receiving oral kayexalate in sorbitol: case report and literature review. Kaohsiung J Med Sci. 2011;27:155-8 pubmed publisher
    ..Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal...
  18. Reddy P, Giridharan N, Reddy G. Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. Mol Vis. 2012;18:495-503 pubmed
  19. Watson M, Baker T, Nguyen A, Sebastianelli M, Stewart H, Oliver D, et al. Association of prescription of oral sodium polystyrene sulfonate with sorbitol in an inpatient setting with colonic necrosis: a retrospective cohort study. Am J Kidney Dis. 2012;60:409-16 pubmed publisher
    Colonic necrosis has been reported after sodium polystyrene sulfonate (SPS)/sorbitol use, but the incidence and relative risk (RR) are not established.
  20. Dewey C, Cenik B, Sephton C, Dries D, Mayer P, Good S, et al. TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor. Mol Cell Biol. 2011;31:1098-108 pubmed publisher
    ..In this study, we establish sorbitol as a novel physiological stressor that directs TDP-43 to stress granules in Hek293T cells and primary cultured ..
  21. Ido Y, Nyengaard J, Chang K, Tilton R, Kilo C, Mylari B, et al. Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation. Antioxid Redox Signal. 2010;12:39-51 pubmed publisher
    These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats...
  22. Verstraete K, Robyn J, Del Favero J, De Rijk P, Joris M, Herman L, et al. Evaluation of a multiplex-PCR detection in combination with an isolation method for STEC O26, O103, O111, O145 and sorbitol fermenting O157 in food. Food Microbiol. 2012;29:49-55 pubmed publisher
    ..non-stressed, cold-stressed or freeze-stressed clinical STEC strains, including serogroups O26, O103, O111, O145, sorbitol fermenting (SF) O157 and non-sorbitol fermenting (NSF) O157...
  23. Song J, Almasalmeh A, Krenc D, Beitz E. Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules. Biochim Biophys Acta. 2012;1818:1218-24 pubmed publisher
    ..e. sucrose, sorbitol, PEG300, and glycerol...
  24. Sibik J, Shalaev E, Zeitler J. Glassy dynamics of sorbitol solutions at terahertz frequencies. Phys Chem Chem Phys. 2013;15:11931-42 pubmed publisher
    The absorption spectra of D-sorbitol and a range of its concentrated aqueous solutions were studied by terahertz spectroscopy over the temperature interval of 80 K < T < 310 K...
  25. Orth D, Grif K, Zimmerhackl L, Wurzner R. Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157 in Austria. Wien Klin Wochenschr. 2009;121:108-12 pubmed publisher
    ..Shiga toxins are considered to be the most important virulence factor of EHEC strains. Non-sorbitol-fermenting EHEC O157:H7 is still the most prevalent serotype isolated worldwide; however, sorbitol-fermenting (SF)..
  26. Cao W, Aghajanian H, Haig Ladewig L, Gerton G. Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase. Biol Reprod. 2009;80:124-33 pubmed publisher
    ..Two major monosaccharides, sorbitol and fructose, are present in semen...
  27. Koivistoinen O, Richard P, Penttila M, Ruohonen L, Mojzita D. Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive D-galactose pathway and essential for D-sorbitol catabolism. FEBS Lett. 2012;586:378-83 pubmed publisher
    ..pathway D-galactose is converted to d-fructose in a series of steps where the last step is the oxidation of d-sorbitol by an NAD-dependent dehydrogenase...
  28. Rutten L, Ribot C, Trejo Aguilar B, Wosten H, de Vries R. A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol. BMC Microbiol. 2009;9:166 pubmed publisher
    ..only differ in the activity on their biological substrate, but also that only XDH has significant activity on D-sorbitol and may therefore be more closely related to D-sorbitol dehydrogenases (SDH)...
  29. Alcántara C, Sarmiento Rubiano L, Monedero V, Deutscher J, Perez Martinez G, Yebra M. Regulation of Lactobacillus casei sorbitol utilization genes requires DNA-binding transcriptional activator GutR and the conserved protein GutM. Appl Environ Microbiol. 2008;74:5731-40 pubmed publisher
    Sequence analysis of the five genes (gutRMCBA) downstream from the previously described sorbitol-6-phosphate dehydrogenase-encoding Lactobacillus casei gutF gene revealed that they constitute a sorbitol (glucitol) utilization operon...
  30. Alpers K, Werber D, Frank C, Koch J, Friedrich A, Karch H, et al. Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiol Infect. 2009;137:389-95 pubmed publisher
    An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002...
  31. Matsumura S, Yoneda T, Aki S, Eguchi A, Manabe Y, Tsuzuki S, et al. Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice. Physiol Behav. 2010;99:509-14 pubmed publisher
    ..Although mice showed high affinity for a low-energy fat substitute--sorbitol fatty acid esters and low-concentration linoleic acid solution--they did not exhibit a place preference toward a ..
  32. van der Hoven B, Van Pelt H, Swart E, Bonthuis F, Tilanus H, Bakker J, et al. Noninvasive functional liver blood flow measurement: comparison between bolus dose and steady-state clearance of sorbitol in a small-rodent model. Am J Physiol Gastrointest Liver Physiol. 2010;298:G177-81 pubmed publisher
    Plasma clearance of D-sorbitol, a nontoxic polyol, occurs predominantly in the liver and has been used to measure functional liver blood flow after bolus and steady- state intravenous administration...
  33. Wu L, Ma Z, Fan X, Zhao T, Liu Z, Huang X, et al. The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells. Cell Stress Chaperones. 2010;15:387-94 pubmed publisher
    ..In addition, sorbitol synthesized from glucose catalyzed by AR is directly related to cell volume regulation...
  34. Saraswat M, Muthenna P, Suryanarayana P, Petrash J, Reddy G. Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications. Asia Pac J Clin Nutr. 2008;17:558-65 pubmed
    ..in high glucose containing medium was used to underscore the significance in terms of prevention of intracellular sorbitol accumulation...
  35. Chiong M, Parra V, Eisner V, Ibarra C, Maldonado C, Criollo A, et al. Parallel activation of Ca(2+)-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress. Apoptosis. 2010;15:887-903 pubmed publisher
    ..Here, we investigated if Ca(2+) signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] elicited large and oscillatory intracellular Ca(2+) concentration increases...
  36. de Sanctis D, McVey C, Enguita F, Carrondo M. Crystal structure of the full-length sorbitol operon regulator SorC from Klebsiella pneumoniae: structural evidence for a novel transcriptional regulation mechanism. J Mol Biol. 2009;387:759-70 pubmed publisher
    ..Here we report the first crystal structure of a full-length SorC, the sorbitol operon regulator SorC from Klebsiella pneumoniae, the prototype of its family...
  37. Nielsen S, Frank C, Fruth A, Spode A, Prager R, Graff A, et al. Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009. Zoonoses Public Health. 2011;58:567-72 pubmed publisher
    Infection with sorbitol-fermenting Shiga toxin-producing Escherichia coli O157:H- (sf STEC O157:H-) is rare, but emerging in Europe...
  38. Chanapiwat P, Kaeoket K, Tummaruk P. Cryopreservation of boar semen by egg yolk-based extenders containing lactose or fructose is better than sorbitol. J Vet Med Sci. 2012;74:351-4 pubmed
    The present study determined the effect of different types of sugars (lactose, fructose, glucose and sorbitol) used in egg yolk-based extender on the post-thawed boar semen quality...
  39. Amano S, Yamagishi S, Koda Y, Tsuneoka M, Soejima M, Okamoto T, et al. Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy. Med Hypotheses. 2003;60:550-1 pubmed
    The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, ..
  40. Bielaszewska M, Prager R, Zhang W, Friedrich A, Mellmann A, Tsch pe H, et al. Chromosomal dynamism in progeny of outbreak-related sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM. Appl Environ Microbiol. 2006;72:1900-9 pubmed publisher
    b>Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:NM (nonmotile) is a unique clone that causes outbreaks of hemorrhagic colitis and hemolytic-uremic syndrome...
  41. Zhou R, Cheng L, Dandekar A. Down-regulation of sorbitol dehydrogenase and up-regulation of sucrose synthase in shoot tips of the transgenic apple trees with decreased sorbitol synthesis. J Exp Bot. 2006;57:3647-57 pubmed
    Both sorbitol and sucrose are translocated to, and utilized in, sink tissues of apple (Malus domestica)...
  42. Liu T, Juang S, Cheng J, Tong Y. The role of sorbitol pathway and treatment effect of aldose reductase inhibitor ONO2235 in the up-regulation of cardiac M2-muscarinic receptors in streptozotocin-induced diabetic rats. Neurosci Lett. 2005;383:131-5 pubmed
    This study investigated the role of the sorbitol pathway on the genetic up-regulation of the cardiac M(2) muscarinic receptor (M(2)-mAChR) in streptozotocin (STZ)-induced diabetic rats...
  43. Fujiwara Y, Tanaka Y, Iwata K, Rubio R, Yaginuma T, Yamashita O, et al. ERK/MAPK regulates ecdysteroid and sorbitol metabolism for embryonic diapause termination in the silkworm, Bombyx mori. J Insect Physiol. 2006;52:569-75 pubmed publisher
    ..Diapause termination requires a decrease in the sorbitol concentration, which arrests embryonic development, and the secretion factors from yolk cells that promote ..
  44. Tursi A, Brandimarte G, Giorgetti G, Inchingolo C. Effectiveness of the sorbitol H2 breath test in detecting histological damage among relatives of coeliacs. Scand J Gastroenterol. 2003;38:727-31 pubmed
    ..The aim of this study was to compare the effectiveness of the sorbitol H2 breath test (H2-BT) and serological tests (antigliadin (AGA), antiendomysium (EMA) and anti-tissue ..
  45. Hirasawa T, Ashitani K, Yoshikawa K, Nagahisa K, Furusawa C, Katakura Y, et al. Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray. J Biosci Bioeng. 2006;102:568-71 pubmed
    ..laboratory and brewing strains of Saccharomyces cerevisiae to osmotic stresses induced by adding either NaCl or sorbitol to their cultures were compared by clustering DNA microarray data...
  46. Penha Silva N, Arvelos L, Cunha C, Aversi Ferreira T, Gouvêa e Silva L, Garrote Filho M, et al. Effects of glycerol and sorbitol on the thermal dependence of the lysis of human erythrocytes by ethanol. Bioelectrochemistry. 2008;73:23-9 pubmed publisher
    In this work, the effects of 1 mol/L glycerol or sorbitol on the thermal dependence (27-47 degrees C) of the lysis of human erythrocytes by ethanol in saline solution (0.154 mol/L NaCl) have been evaluated...
  47. Pommerrenig B, Papini Terzi F, Sauer N. Differential regulation of sorbitol and sucrose loading into the phloem of Plantago major in response to salt stress. Plant Physiol. 2007;144:1029-38 pubmed
    ..results on the differential regulation of genes that encode transport proteins involved in phloem loading with sorbitol and Suc under salt stress...
  48. Shioya T, Yoshino M, Ogata M, Shibuya T, Tokunaga A, Matsumoto K, et al. Successful treatment of a colonic ulcer penetrating the urinary bladder caused by the administration of calcium polystyrene sulfonate and sorbitol. J Nippon Med Sch. 2007;74:359-63 pubmed
    ..After admission, she received oral calcium polystyrene sulfonate and sorbitol to treat hyperkalemia. Nine days later, severe abdominal pain developed...
  49. Soemphol W, Adachi O, Matsushita K, Toyama H. Distinct physiological roles of two membrane-bound dehydrogenases responsible for D-sorbitol oxidation in Gluconobacter frateurii. Biosci Biotechnol Biochem. 2008;72:842-50 pubmed
    Two different membrane-bound enzymes oxidizing D-sorbitol are found in Gluconobacter frateurii THD32: pyroloquinoline quinone-dependent glycerol dehydrogenase (PQQ-GLDH) and FAD-dependent D-sorbitol dehydrogenase (FAD-SLDH)...
  50. Bágel ová J, Fedunova D, Gazova Z, Fabian M, Antalik M. Influence of NaCl and sorbitol on the stability of conformations of cytochrome c. Biophys Chem. 2008;135:110-5 pubmed publisher
    Influence of ionic (NaCl) and non-ionic (sorbitol) additives on structural transitions of cytochrome c was investigated by circular dichroism, optical and EPR spectroscopy...
  51. Yang Z, Kovar J, Kim J, Nietfeldt J, Smith D, Moxley R, et al. Identification of common subpopulations of non-sorbitol-fermenting, beta-glucuronidase-negative Escherichia coli O157:H7 from bovine production environments and human clinical samples. Appl Environ Microbiol. 2004;70:6846-54 pubmed
    Non-sorbitol-fermenting, beta-glucuronidase-negative Escherichia coli O157:H7 strains are regarded as a clone complex, and populations from different geographical locations are believed to share a recent common ancestor...
  52. Huang P, Jiang Z, Teng S, Wong Y, Frohman M, Chung S, et al. Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. Exp Eye Res. 2006;83:939-48 pubmed
    ..Together, these data suggest that increased PLD2 activity in the lens under hyperglycemic condition might impair its osmoregulatory mechanism and reduce its ability to cope with the osmotic stress triggered by sorbitol accumulation.
  53. Toyama H, Soemphol W, Moonmangmee D, Adachi O, Matsushita K. Molecular properties of membrane-bound FAD-containing D-sorbitol dehydrogenase from thermotolerant Gluconobacter frateurii isolated from Thailand. Biosci Biotechnol Biochem. 2005;69:1120-9 pubmed
    There are two types of membrane-bound D-sorbitol dehydrogenase (SLDH) reported: PQQ-SLDH, having pyrroloquinoline quinone (PQQ), and FAD-SLDH, containing FAD and heme c as the prosthetic groups...