phytic acid

Summary

Summary: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.

Top Publications

  1. Puhl A, Greiner R, Selinger L. Stereospecificity of myo-inositol hexakisphosphate hydrolysis by a protein tyrosine phosphatase-like inositol polyphosphatase from Megasphaera elsdenii. Appl Microbiol Biotechnol. 2009;82:95-103 pubmed publisher
  2. Wawszczyk J, Kapral M, Hollek A, Węglarz L. The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells. Acta Pol Pharm. 2012;69:1313-9 pubmed
    ..The expression of both interleukins is regulated by nuclear factor KB (NF-kappaB). Phytic acid (IP6) is an essential component of high fiber diet...
  3. Anekonda T, Wadsworth T, Sabin R, Frahler K, Harris C, Petriko B, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23:21-35 pubmed publisher
    ..We propose a novel protective treatment for AD pathology with phytic acid (inositol hexakisphosphate), a phytochemical found in food grains and a key signaling molecule in mammalian ..
  4. López González A, Grases F, Roca P, Mari B, Vicente Herrero M, Costa Bauza A. Phytate (myo-inositol hexaphosphate) and risk factors for osteoporosis. J Med Food. 2008;11:747-52 pubmed publisher
    ..Phytate consumption had a protective effect against osteoporosis, suggesting that low phytate consumption should be considered an osteoporosis risk factor...
  5. Dai F, Qiu L, Xu Y, Cai S, Qiu B, Zhang G. Differences in phytase activity and phytic acid content between cultivated and Tibetan annual wild barleys. J Agric Food Chem. 2010;58:11821-4 pubmed publisher
    ..At present, little is known about the phytase activity (Phy) or phytic acid content (PA) in grains of Tibetan annual wild barley...
  6. Hellström A, Almgren A, Carlsson N, Svanberg U, Andlid T. Degradation of phytate by Pichia kudriavzevii TY13 and Hanseniaspora guilliermondii TY14 in Tanzanian togwa. Int J Food Microbiol. 2012;153:73-7 pubmed publisher
    ..kudriavzevii TY13 and H. guilliermondii TY14 seem particularly well adapted to phytate degradation in togwa, and is our choice for further studies and strain improvement...
  7. Frontela C, Scarino M, Ferruzza S, Ros G, Martinez C. Effect of dephytinization on bioavailability of iron, calcium and zinc from infant cereals assessed in the Caco-2 cell model. World J Gastroenterol. 2009;15:1977-84 pubmed
    ..To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells...
  8. Hambidge K, Miller L, Westcott J, Sheng X, Krebs N. Zinc bioavailability and homeostasis. Am J Clin Nutr. 2010;91:1478S-1483S pubmed publisher
    ..The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc...
  9. Brown K, Hambidge K, Ranum P. Zinc fortification of cereal flours: current recommendations and research needs. Food Nutr Bull. 2010;31:S62-74 pubmed
    ..Zinc fortification is recommended as an appropriate strategy to enhance population zinc status, but guidelines are needed on the appropriate types and levels of zinc fortification of cereal flours for mass fortification programs...

Scientific Experts

More Information

Publications62

  1. Wang Y, Zeng T, Wang S, Wang W, Wang Q, Yu H. Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice. Nutrition. 2010;26:305-11 pubmed publisher
    We explored the effects of fructo-oligosaccharides (FOS) and phytic acid (PA) on the absorption of minerals and their interaction.
  2. Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, et al. Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation. Biochem J. 2013;450:115-25 pubmed publisher
    ..The results of the present study indicate that tumour cells employ this enzyme to utilize the micronutrients myo-inositol and metal-phosphate when encountering extracellular InsP6 and thus to enhance their growth potential...
  3. Aluru M, Rodermel S, Reddy M. Genetic modification of low phytic acid 1-1 maize to enhance iron content and bioavailability. J Agric Food Chem. 2011;59:12954-62 pubmed publisher
    ..We have exploited the low phytic acid 1-1 (lpa1-1) mutant of maize to generate transgenic plants with up-to 70 ?g/g seed iron through the endosperm-..
  4. Hunt J. Algorithms for iron and zinc bioavailability: are they accurate?. Int J Vitam Nutr Res. 2010;80:257-62 pubmed publisher
    ..absorption is substantially influenced by the amount of zinc consumed, and this factor, together with ingested phytic acid, account for a considerable degree of the variance...
  5. Hattori Y, Shi L, Ding W, Koga K, Kawano K, Hakoshima M, et al. Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors. J Control Release. 2009;136:30-7 pubmed publisher
    b>Phytic acid (IP-6) is a polyphosphorylated carbohydrate with antitumor activity for many kinds of tumors...
  6. Bretti C, Cigala R, Lando G, Milea D, Sammartano S. Sequestering ability of phytate toward biologically and environmentally relevant trivalent metal cations. J Agric Food Chem. 2012;60:8075-82 pubmed publisher
    ..87, and 8.34 (Al(3+) < Fe(3+) < Cr(3+)). All of the pL(0.5) values, and therefore the sequestering ability, regularly increase with increasing pH, and the dependence of pL(0.5) on pH was modeled using some empirical equations...
  7. Georges F, Das S, Ray H, Bock C, Nokhrina K, Kolla V, et al. Over-expression of Brassica napus phosphatidylinositol-phospholipase C2 in canola induces significant changes in gene expression and phytohormone distribution patterns, enhances drought tolerance and promotes early flowering and maturation. Plant Cell Environ. 2009;32:1664-81 pubmed publisher
    ..Other changes included increased phytic acid levels and phytohormone organization patterns...
  8. Abizari A, Moretti D, Zimmermann M, Armar Klemesu M, Brouwer I. Whole cowpea meal fortified with NaFeEDTA reduces iron deficiency among Ghanaian school children in a malaria endemic area. J Nutr. 2012;142:1836-42 pubmed
    Cowpeas, like other legumes, contain high amounts of native iron but are rich in phytic acid (PA) and polyphenols (PP) that inhibit iron absorption. NaFeEDTA may overcome the combined inhibitory effect of PA and PP...
  9. Sanz Penella J, Tamayo Ramos J, Sanz Y, Haros M. Phytate reduction in bran-enriched bread by phytase-producing bifidobacteria. J Agric Food Chem. 2009;57:10239-44 pubmed publisher
  10. Liang J, Han B, Nout M, Hamer R. In vitro solubility of calcium, iron and zinc in relation to phytic acid levels in rice-based consumer products in China. Int J Food Sci Nutr. 2010;61:40-51 pubmed publisher
    In vitro solubility of calcium, iron and zinc in relation to phytic acid (PA) levels in 30 commercial rice-based foods from China was studied. Solubility of minerals and molar ratios of PA to minerals varied with degrees of processing...
  11. Braconi D, Laschi M, Amato L, Bernardini G, Millucci L, Marcolongo R, et al. Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. Rheumatology (Oxford). 2010;49:1975-83 pubmed publisher
  12. Panzeri D, Cassani E, Doria E, Tagliabue G, Forti L, Campion B, et al. A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity. New Phytol. 2011;191:70-83 pubmed publisher
    We previously identified the lpa1 (low phytic acid) 280-10 line that carries a mutation conferring a 90% reduction in phytic acid (InsP(6) ) content...
  13. Sala M, Makuc D, Kolar J, Plavec J, Pihlar B. Potentiometric and ³¹P NMR studies on inositol phosphates and their interaction with iron(III) ions. Carbohydr Res. 2011;346:488-94 pubmed publisher
    ..and ³¹P NMR titrations have been applied to study interactions between myo-inositol hexakisphosphate (phytic acid), (±)-myo-inositol 1,2,3,5-tetrakisphosphate and (±)-myo-inositol 1,2,3-trisphosphate with iron(III) ions...
  14. Bertinato J, Sherrard L, Plouffe L. EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet. J Trace Elem Med Biol. 2012;26:227-33 pubmed publisher
    ..compounds have unique properties that may influence the amount of Zn absorbed particularly in the presence of phytic acid (PA), a common food component that binds Zn and decreases its bioavailability...
  15. Iwai T, Takahashi M, Oda K, Terada Y, Yoshida K. Dynamic changes in the distribution of minerals in relation to phytic acid accumulation during rice seed development. Plant Physiol. 2012;160:2007-14 pubmed publisher
    b>Phytic acid (inositol hexakisphosphate [InsP(6)]) is the storage compound of phosphorus in seeds. As phytic acid binds strongly to metallic cations, it also acts as a storage compound of metals...
  16. Egerer M, Satchell K. Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins. PLoS Pathog. 2010;6:e1000942 pubmed publisher
  17. Amirabdollahian F, Ash R. An estimate of phytate intake and molar ratio of phytate to zinc in the diet of the people in the United Kingdom. Public Health Nutr. 2010;13:1380-8 pubmed publisher
    ..To estimate the phytate intake and molar ratio of phytate to zinc in the diet of the people in the United Kingdom...
  18. Grases F, Prieto R, Sanchis P, Saus C, de Francisco T. Role of phytate and osteopontin in the mechanism of soft tissue calcification. J Nephrol. 2008;21:768-75 pubmed
    ..The present study examined the role of phytate and osteopontin during the development of soft tissue calcification in an animal model...
  19. Egerer M, Giesemann T, Herrmann C, Aktories K. Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate. J Biol Chem. 2009;284:3389-95 pubmed publisher
    ..4 microm for binding of InsP6 to toxin fragment 544-955 with a stoichiometry factor of 0.86. Lysine 600 of toxin B was identified as essential amino acid for InsP6 binding and for InsP6-dependent activation of the protease activity...
  20. Campion B, Sparvoli F, Doria E, Tagliabue G, Galasso I, Fileppi M, et al. Isolation and characterisation of an lpa (low phytic acid) mutant in common bean (Phaseolus vulgaris L.). Theor Appl Genet. 2009;118:1211-21 pubmed publisher
    b>Phytic acid is considered as one of the major antinutritional compounds in cereal and legume seeds...
  21. Landoni M, Cerino Badone F, Haman N, Schiraldi A, Fessas D, Cesari V, et al. Low phytic acid 1 mutation in maize modifies density, starch properties, cations, and fiber contents in the seed. J Agric Food Chem. 2013;61:4622-30 pubmed publisher
    Monogastric animals are unable to digest phytic acid, so it represents an antinutritional factor and also an environmental problem...
  22. Kuwano M, Mimura T, Takaiwa F, Yoshida K. Generation of stable 'low phytic acid' transgenic rice through antisense repression of the 1D-myo-inositol 3-phosphate synthase gene (RINO1) using the 18-kDa oleosin promoter. Plant Biotechnol J. 2009;7:96-105 pubmed publisher
    b>Phytic acid acts as the major storage form of phosphorus in plant seeds and is poorly digested by monogastric animals. The degradation of phytic acid in animal diets is necessary to overcome both environmental and nutritional issues...
  23. Sanz Penella J, Laparra J, Sanz Y, Haros M. Assessment of iron bioavailability in whole wheat bread by addition of phytase-producing bifidobacteria. J Agric Food Chem. 2012;60:3190-5 pubmed publisher
    ..Further refinement of the use of phytase-producing bifidobacterial strains and/or breadmaking technological processes is deserved for improving Fe uptake...
  24. Pruitt R, Chagot B, Cover M, Chazin W, Spiller B, Lacy D. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. J Biol Chem. 2009;284:21934-40 pubmed publisher
  25. Tran T, Hatti Kaul R, Dalsgaard S, Yu S. A simple and fast kinetic assay for phytases using phytic acid-protein complex as substrate. Anal Biochem. 2011;410:177-84 pubmed publisher
    ..The influences of temperature, pH, phosphate, and other salts on the kinetic assay were examined. All salts, including NaCl, CaCl(2), and phosphate, showed a concentration-dependent interference...
  26. Hambidge K. Micronutrient bioavailability: Dietary Reference Intakes and a future perspective. Am J Clin Nutr. 2010;91:1430S-1432S pubmed publisher
    ..These factors, it is argued, are best considered separately from even a broad definition of bioavailability and have the potential to provide new insights into some micronutrient requirements...
  27. Regvar M, Eichert D, Kaulich B, Gianoncelli A, Pongrac P, Vogel Mikus K, et al. New insights into globoids of protein storage vacuoles in wheat aleurone using synchrotron soft X-ray microscopy. J Exp Bot. 2011;62:3929-39 pubmed publisher
    ..the accumulation patterns between the apoplast and symplast, and highlight the importance of globoids with phytic acid mineral salts and walls as preferential storage structures...
  28. Abizari A, Moretti D, Schuth S, Zimmermann M, Armar Klemesu M, Brouwer I. Phytic acid-to-iron molar ratio rather than polyphenol concentration determines iron bioavailability in whole-cowpea meal among young women. J Nutr. 2012;142:1950-5 pubmed publisher
    ..and between red and white varieties of cowpea with different concentrations of polyphenols (PP) but similar phytic acid (PA)-to-iron molar ratios. We performed a paired crossover study in young women (n = 16)...
  29. Kunyanga C, Imungi J, Okoth M, Biesalski H, Vadivel V. Antioxidant and type 2 diabetes related functional properties of phytic acid extract from Kenyan local food ingredients: effects of traditional processing methods. Ecol Food Nutr. 2011;50:452-71 pubmed publisher
    Emerging scientific evidences reveal that phytic acid has several positive effects on human health...
  30. Kim S, Tai T. Identification of genes necessary for wild-type levels of seed phytic acid in Arabidopsis thaliana using a reverse genetics approach. Mol Genet Genomics. 2011;286:119-33 pubmed publisher
    The majority of phosphorus (P) in seeds is found in phytic acid (InsP(6)) which accumulates as the mixed salt phytate...
  31. Grases F, Perello J, Sanchis P, Isern B, Prieto R, Costa Bauza A, et al. Anticalculus effect of a triclosan mouthwash containing phytate: a double-blind, randomized, three-period crossover trial. J Periodontal Res. 2009;44:616-21 pubmed publisher
    ..The aim of the present study was to examine the effects of phytate and zinc, administered in a mouthwash solution, to prevent the formation of dental calculus...
  32. Parfiniewicz B, Pendzich J, Gruchlik A, Hollek A, Węglarz L. Impact of celecoxib on soluble intercellular adhesion molecule-1 and soluble e-cadherin concentrations in human colon cancer cell line cultures exposed to phytic acid and TNF-alpha. Acta Pol Pharm. 2012;69:1283-90 pubmed
    ..The latest studies demonstrate, that phytic acid (IP6), a myo-inositol derivative, abundantly present in high-fiber diets could substantially reduce colon ..
  33. Schlemmer U, Frølich W, Prieto R, Grases F. Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009;53 Suppl 2:S330-75 pubmed publisher
    The article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables...
  34. Schroterova L, Haskova P, Rudolf E, Cervinka M. Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma. Oncol Rep. 2010;23:787-93 pubmed
    We characterized the effect of phytic acid (inositol hexaphosphate, IP6) as a potential adjuvant in treatment of colorectal carcinoma and evaluated the optimal concentration and treatment time to produe the maximal therapeutic effect...
  35. Ravichandran R, Seitz V, Reddy Venugopal J, Sridhar R, Sundarrajan S, Mukherjee S, et al. Mimicking native extracellular matrix with phytic acid-crosslinked protein nanofibers for cardiac tissue engineering. Macromol Biosci. 2013;13:366-75 pubmed publisher
    ..of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction.
  36. Jørgensen C, Jensen H, Andersen F, Egemose S, Reitzel K. Occurrence of orthophosphate monoesters in lake sediments: significance of myo- and scyllo-inositol hexakisphosphate. J Environ Monit. 2011;13:2328-34 pubmed publisher
  37. Prochazkova K, Shuvalova L, Minasov G, Voburka Z, Anderson W, Satchell K. Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites. J Biol Chem. 2009;284:26557-68 pubmed publisher
    ..Processed CPD also cleaved other proteins in trans, including the leucine-rich protein YopM, demonstrating that it is a promiscuous leucine-specific protease...
  38. Lupardus P, Shen A, Bogyo M, Garcia K. Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science. 2008;322:265-8 pubmed publisher
    ..Biochemical and kinetic analyses of CPD mutants indicate that InsP6 binding induces an allosteric switch that leads to the autoprocessing and intracellular release of toxin-effector domains...
  39. Norhaizan M, Ng S, Norashareena M, Abdah M. Antioxidant and cytotoxicity effect of rice bran phytic acid as an anticancer agent on ovarian, breast and liver cancer cell lines. Malays J Nutr. 2011;17:367-75 pubmed
    b>Phytic acid (PA) has been shown to have positive nutritional benefits. There are also claims that it is able to prevent cancer through its antioxidant capability...
  40. Prosser N, Heath A, Williams S, Gibson R. Influence of an iron intervention on the zinc status of young adult New Zealand women with mild iron deficiency. Br J Nutr. 2010;104:742-50 pubmed publisher
    ..In conclusion, Zn status was not improved compared with placebo by an Fe-based dietary intervention. However, a daily moderate-dose Fe supplement with meals appeared to lower Zn status in these young adult women...
  41. Petry N, Egli I, Zeder C, Walczyk T, Hurrell R. Polyphenols and phytic acid contribute to the low iron bioavailability from common beans in young women. J Nutr. 2010;140:1977-82 pubmed publisher
    ..High levels of phytic acid (PA) and polyphenols (PP) inhibit iron absorption; however, the effect of bean PP on iron absorption in humans ..
  42. Oomah B, Blanchard C, Balasubramanian P. Phytic acid, phytase, minerals, and antioxidant activity in Canadian dry bean ( Phaseolus vulgaris L.) cultivars. J Agric Food Chem. 2008;56:11312-9 pubmed publisher
    ..b>Phytic acid content and phytase activity varied significantly among cultivars and market classes, ranging from 16.7 to 25...
  43. Lopez Gonzalez A, Grases F, Perello J, Tur F, Costa Bauza A, Monroy N, et al. Phytate levels and bone parameters: a retrospective pilot clinical trial. Front Biosci (Elite Ed). 2010;2:1093-8 pubmed
    ..This finding demonstrates the potential use of phytate in the treatment of bone related diseases, as it uses a mechanism of action similar to some bisphosphonates...
  44. Kapral M, Parfiniewicz B, Strzałka Mrozik B, Zachacz A, Węglarz L. Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells. Acta Pol Pharm. 2008;65:697-702 pubmed
    Over the last years phytic acid, a hexaphosphorylated inositol (IP6) has attracted particular attention due to its anti-cancer activity, however, the molecular mechanisms of its action have not been elucidated, as yet...
  45. Lonnerdal B, Mendoza C, Brown K, Rutger J, Raboy V. Zinc absorption from low phytic acid genotypes of maize (Zea mays L.), Barley (Hordeum vulgare L.), and Rice (Oryza sativa L.) assessed in a suckling rat pup model. J Agric Food Chem. 2011;59:4755-62 pubmed publisher
    Dietary phytic acid is a major causative factor for low Zn bioavailability in many cereal- and legume-based diets. The bioavailability of Zn in seed of low phytic acid (lpa) variants of maize ( Zea mays L.), rice ( Oryza sativa L...
  46. Norazalina S, Norhaizan M, Hairuszah I, Norashareena M. Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp Toxicol Pathol. 2010;62:259-68 pubmed publisher
    This study is carried out to determine the potential of phytic acid extracted from rice bran in the suppression of colon carcinogenesis induced by azoxymethane (AOM) in rats...
  47. Jorquera M, Crowley D, Marschner P, Greiner R, Fernández M, Romero D, et al. Identification of ?-propeller phytase-encoding genes in culturable Paenibacillus and Bacillus spp. from the rhizosphere of pasture plants on volcanic soils. FEMS Microbiol Ecol. 2011;75:163-72 pubmed publisher
    ..The phytase-encoding genes described here may prove valuable as molecular markers to evaluate the role of EFB in organic P mobilization in the rhizosphere...
  48. Ogawa S, Kobayashi H, Amada S, Yahata H, Sonoda K, Abe K, et al. Sentinel node detection with (99m)Tc phytate alone is satisfactory for cervical cancer patients undergoing radical hysterectomy and pelvic lymphadenectomy. Int J Clin Oncol. 2010;15:52-8 pubmed publisher
    ..We assessed feasibility and accuracy of SLN detection using (99m)Tc phytate in patients with cervical cancer...
  49. Woyengo T, Cowieson A, Adeola O, Nyachoti C. Ileal digestibility and endogenous flow of minerals and amino acids: responses to dietary phytic acid in piglets. Br J Nutr. 2009;102:428-33 pubmed publisher
    Effects of phytic acid (PA) on ileal mineral and amino acid (AA) digestibilities and ileal endogenous AA flow in piglets were investigated...
  50. Mittal R, Peak Chew S, Sade R, Vallis Y, McMahon H. The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate. J Biol Chem. 2010;285:19927-34 pubmed publisher
  51. Doria E, Galleschi L, Calucci L, Pinzino C, Pilu R, Cassani E, et al. Phytic acid prevents oxidative stress in seeds: evidence from a maize (Zea mays L.) low phytic acid mutant. J Exp Bot. 2009;60:967-78 pubmed publisher
    A maize mutant defective in the synthesis of phytic acid during seed maturation was used as a tool to study the consequences of the lack of this important reserve substance on seed survival...
  52. Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr. 2010;91:1461S-1467S pubmed publisher
    ..It would therefore be timely to develop a range of iron bioavailability factors based not only on diet composition but also on subject characteristics, such as iron status and prevalence of obesity...
  53. Gibson R, Bailey K, Gibbs M, Ferguson E. A review of phytate, iron, zinc, and calcium concentrations in plant-based complementary foods used in low-income countries and implications for bioavailability. Food Nutr Bull. 2010;31:S134-46 pubmed