inositol

Summary

Summary: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.

Top Publications

  1. Zhang H, Anderson A, Trowell S, Luo A, Xiang Z, Xia Q. Topological and functional characterization of an insect gustatory receptor. PLoS ONE. 2011;6:e24111 pubmed publisher
    ..functions independently in Sf9 cells and responds in a concentration-dependent manner to the polyalcohols myo-inositol and epi-inositol but not to a range of mono- and di-saccharides...
  2. Vesala L, Salminen T, Kostál V, Zahradnícková H, Hoikkala A. Myo-inositol as a main metabolite in overwintering flies: seasonal metabolomic profiles and cold stress tolerance in a northern drosophilid fly. J Exp Biol. 2012;215:2891-7 pubmed publisher
    ..moderately accumulated glucose, trehalose and proline in autumn, but the single largest change occurred in myo-inositol concentrations...
  3. Walecki J, Barcikowska M, Cwikła J, Gabryelewicz T. N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI). Med Sci Monit. 2011;17:MT105-11 pubmed
    ..Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up...
  4. Godage H, Riley A, Woodman T, Thomas M, Mahon M, Potter B. Regioselective opening of myo-inositol orthoesters: mechanism and synthetic utility. J Org Chem. 2013;78:2275-88 pubmed publisher
    Acid hydrolysis of myo-inositol 1,3,5-orthoesters, apart from orthoformates, exclusively affords the corresponding 2-O-acyl myo-inositol products via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observed by NMR ..
  5. Panzeri D, Cassani E, Doria E, Tagliabue G, Forti L, Campion B, et al. A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity. New Phytol. 2011;191:70-83 pubmed publisher
    ..expression level of several genes of the InsP(6) pathway are reduced in the lpa1(280-10) mutant as well as the inositol and raffinosaccharide content. PvMrp2, a very similar paralogue of PvMrp1 was also mapped and sequenced...
  6. Wang Y, Liu T, Delmas G, Park S, Perlin D, Xue C. Two major inositol transporters and their role in cryptococcal virulence. Eukaryot Cell. 2011;10:618-28 pubmed publisher
    ..The existence of high inositol concentrations in brain and our earlier discovery of a large inositol transporter (ITR) gene family in C...
  7. Lentz M, Kim W, Kim H, Soulas C, Lee V, Venna N, et al. Alterations in brain metabolism during the first year of HIV infection. J Neurovirol. 2011;17:220-9 pubmed publisher
    ..These results suggest that HIV infection induces metabolic changes in the brain early during infection and that these changes may be related to monocyte dynamics in the periphery...
  8. Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato M, Vieste G, et al. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. 2012;15:490-5 pubmed publisher
    To evaluate the 12-month effect of myo-inositol treatment on some biochemical parameters of women affected by metabolic syndrome.
  9. Liu T, Kim J, Wang Y, Toffaletti D, Eugenin E, Perfect J, et al. Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. PLoS Pathog. 2013;9:e1003247 pubmed publisher
    ..The facts that human and animal brains contain abundant inositol and that Cryptococcus has a sophisticated system for the acquisition of inositol from the environment suggests ..

More Information

Publications62

  1. Newton G, Buchmeier N, La Clair J, Fahey R. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011;19:3956-64 pubmed publisher
    ..We also determined that NTF1836 kills non-replicating M. tuberculosis in the carbon starvation model of latency...
  2. Sinha S, Du Z, Maiti P, Klärner F, Schrader T, Wang C, et al. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci. 2012;3:451-8 pubmed publisher
    ..Two such compounds, the natural inositol derivative scyllo-inositol and the green-tea-derived flavonoid epigallocatechin gallate (EGCG), currently are in ..
  3. Asamizu S, Yang J, Almabruk K, Mahmud T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc. 2011;133:12124-35 pubmed publisher
    ..The enzyme operates in sequence with a phosphatase, which dephosphorylates validoxylamine A 7'-phosphate to validoxylamine A...
  4. González Salgado A, Steinmann M, Greganova E, Rauch M, M ser P, Sigel E, et al. myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. J Biol Chem. 2012;287:13313-23 pubmed publisher
    myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes...
  5. Promlek T, Ishiwata Kimata Y, Shido M, Sakuramoto M, Kohno K, Kimata Y. Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol Biol Cell. 2011;22:3520-32 pubmed publisher
    ..In contrast, this mutant was activated like wild-type Ire1 by depletion of the membrane lipid component inositol or by deletion of genes involved in lipid homeostasis...
  6. McLarty K, Moran M, Scollard D, Chan C, Sabha N, Mukherjee J, et al. Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. Nucl Med Biol. 2011;38:953-9 pubmed publisher
    The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice...
  7. Candiota A, Majos C, Julià Sapé M, Cabanas M, Acebes J, Moreno Torres A, et al. Non-invasive grading of astrocytic tumours from the relative contents of myo-inositol and glycine measured by in vivo MRS. JBR-BTR. 2011;94:319-29 pubmed
    ..The discrepancy between in vivo and in vitro data suggests that the NMR visibility of glycine in glial brain tumours is restricted in vivo...
  8. Croze M, Soulage C. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013;95:1811-27 pubmed publisher
    Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose...
  9. Carlomagno G, Unfer V. Inositol safety: clinical evidences. Eur Rev Med Pharmacol Sci. 2011;15:931-6 pubmed
    Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups...
  10. Wood P, Smith T, Pelzer L, Goodenowe D. Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction. Lipids Health Dis. 2011;10:102 pubmed publisher
    ..Further targeted metabolomics analyses were conducted to obtain a preliminary evaluation of the metabolic consequences of lipid changes and gene mutations in these cell models...
  11. Chumnanpuen P, Zhang J, Nookaew I, Nielsen J. Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast. Mol Genet Genomics. 2012;287:541-54 pubmed publisher
    ..In the yeast Saccharomyces cerevisiae many genes involved in lipid biosynthesis are transcriptionally controlled by inositol-choline and the protein kinase Snf1...
  12. Sacchi R, Li J, Villarreal F, Gardell A, K ltz D. Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium. J Exp Biol. 2013;216:4626-38 pubmed publisher
    The myo-inositol biosynthesis (MIB) pathway converts glucose-6-phosphate to the compatible osmolyte myo-inositol that protects cells from osmotic stress...
  13. Bleiholder C, Do T, Wu C, Economou N, Bernstein S, Buratto S, et al. Ion mobility spectrometry reveals the mechanism of amyloid formation of A?(25-35) and its modulation by inhibitors at the molecular level: epigallocatechin gallate and scyllo-inositol. J Am Chem Soc. 2013;135:16926-37 pubmed publisher
    ..in the amyloid-? protein fragment A?(25-35) by two amyloid inhibitors (epigallocatechin gallate and scyllo-inositol) that are currently in clinical trials for Alzheimer's Disease...
  14. Gonzales M, Tarumi T, Eagan D, Tanaka H, Vaghasia M, Haley A. Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations. Psychosom Med. 2012;74:691-8 pubmed publisher
    ..The goal of the current study was to assess mechanisms of early brain vulnerability by examining if higher BMI at midlife affects current cognitive performance through alterations in cerebral neurochemistry...
  15. Hamby S, Joseph S, Forsythe S, Chuzhanova N. In Silico identification of pathogenic strains of Cronobacter from Biochemical data reveals association of inositol fermentation with pathogenicity. BMC Microbiol. 2011;11:204 pubmed publisher
    ..Therefore to be able to differentiate between the pathogenic and non-pathogenic strains is of interest to the food industry and regulators...
  16. Dailey M, Kim S. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun. 2012;421:1-3 pubmed publisher
    ..Recent evidence shows that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid inositol kinase ..
  17. D Anna R, Scilipoti A, Giordano D, Caruso C, Cannata M, Interdonato M, et al. myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study. Diabetes Care. 2013;36:854-7 pubmed publisher
    To check the hypothesis that myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) onset in pregnant women with a family history of type 2 diabetes.
  18. Unfer V, Carlomagno G, Dante G, Facchinetti F. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol Endocrinol. 2012;28:509-15 pubmed publisher
    ..With the present review, we aim to provide an overview on the clinical outcomes of the MYO use as a treatment to improve ovarian function and metabolic and hormonal parameters in women with PCOS...
  19. Hernick M. Mycothiol: a target for potentiation of rifampin and other antibiotics against Mycobacterium tuberculosis. Expert Rev Anti Infect Ther. 2013;11:49-67 pubmed publisher
  20. Zeng Y, Ko T, Lai H, Cheng Y, Wu T, Ma Y, et al. Crystal structures of Bacillus alkaline phytase in complex with divalent metal ions and inositol hexasulfate. J Mol Biol. 2011;409:214-24 pubmed publisher
    ..In this study, the interactions between a phytate analog (myo-inositol hexasulfate) and divalent metal ions in Bacillus subtilis phytase were revealed by the crystal structure at 1...
  21. Morita Y, Fukuda T, Sena C, Yamaryo Botte Y, McConville M, Kinoshita T. Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms. Biochim Biophys Acta. 2011;1810:630-41 pubmed publisher
    ..The cell walls of these bacteria have many unique features, including the abundance of various inositol lipids, such as phosphatidylinositol mannosides (PIMs), lipomannan (LM), and lipoarabinomannan (LAM)...
  22. Felberbaum R, Wilson N, Cheng D, Peng J, Hochstrasser M. Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol. 2012;32:64-75 pubmed publisher
    ..of either cellular sumoylation or cellular desumoylation mechanisms inhibits cell growth in the absence of inositol and exacerbates the inositol auxotrophy caused by deletion of SCS2...
  23. Zhou X, Wu H, Li Z, Zhou X, Bai L, Deng Z. Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008. Metab Eng. 2011;13:768-76 pubmed publisher
    ..15 in TL01 to 5.75. These data prove that validamycin A biosynthesis is limited by the supply of UDP-glucose, which can be relieved by Ugp over-expression...
  24. Yap T, Gruschus J, Velayati A, Westbroek W, Goldin E, Moaven N, et al. Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases. J Biol Chem. 2011;286:28080-8 pubmed publisher
  25. Chang P, Orabi B, Deranieh R, Dham M, Hoeller O, Shimshoni J, et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech. 2012;5:115-24 pubmed publisher
    ..and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis...
  26. Li G, Pomès R. Binding mechanism of inositol stereoisomers to monomers and aggregates of A?(16-22). J Phys Chem B. 2013;117:6603-13 pubmed publisher
    ..basis for stereochemistry-dependent inhibition of the formation of A? fibrils in vitro by a polyol, scyllo-inositol. We present molecular dynamics simulations of the monomeric, disordered aggregate, and protofibrillar states of A?..
  27. Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. 2011;15:509-14 pubmed
    ..The administration of myo-inositol, a B complex vitamin, was associated with a decreased of serum testosterone and simultaneously, due to its ..
  28. Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, et al. Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis. PLoS ONE. 2012;7:e32033 pubmed publisher
    ..Furthermore, the modeling of V7P in the active site of ValL suggests that ValL might have a similar SNi-like mechanism as OtsA...
  29. Kim Y, Hernandez M, Balla T. Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol. 2013;23:270-8 pubmed publisher
  30. Corrado F, D Anna R, Di Vieste G, Giordano D, Pintaudi B, Santamaria A, et al. The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Diabet Med. 2011;28:972-5 pubmed publisher
  31. Li G, Rauscher S, Baud S, Pomès R. Binding of inositol stereoisomers to model amyloidogenic peptides. J Phys Chem B. 2012;116:1111-9 pubmed publisher
    ..scyllo-Inositol is a stereochemistry-dependent in vitro inhibitor of amyloid formation...
  32. Baumgart M, Luder K, Grover S, Gätgens C, Besra G, Frunzke J. IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria. BMC Biol. 2013;11:122 pubmed publisher
    ..The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well understood, but the underlying regulatory mechanisms are largely unknown...
  33. Ayaori M, Iwakami N, Uto Kondo H, Sato H, Sasaki M, Komatsu T, et al. Dipeptidyl peptidase-4 inhibitors attenuate endothelial function as evaluated by flow-mediated vasodilatation in type 2 diabetic patients. J Am Heart Assoc. 2013;2:e003277 pubmed publisher
  34. Endres S, Tenhaken R. Down-regulation of the myo-inositol oxygenase gene family has no effect on cell wall composition in Arabidopsis. Planta. 2011;234:157-69 pubmed publisher
    The enzyme myo-inositol oxygenase (MIOX; E.C. 1.13.99...
  35. Ma K, Thomason L, McLaurin J. scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease. Adv Pharmacol. 2012;64:177-212 pubmed publisher
    Preclinical development of scyllo-inositol for the treatment of Alzheimer's disease (AD) has been investigated in both in vitro and in vivo models with positive results...
  36. Ali N, Paul S, Gayen D, Sarkar S, Datta K, Datta S. Development of low phytate rice by RNAi mediated seed-specific silencing of inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene (IPK1). PLoS ONE. 2013;8:e68161 pubmed publisher
    Phytic acid (InsP(6)) is considered to be the major source of phosphorus and inositol phosphates in most cereal grains. However, InsP(6) is not utilized efficiently by monogastric animals due to lack of phytase enzyme...
  37. D Anna R, Di Benedetto V, Rizzo P, Raffone E, Interdonato M, Corrado F, et al. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol. 2012;28:440-2 pubmed publisher
    To evaluate retrospectively the prevalence of gestational diabetes (GD) in pregnancies obtained with myo-inositol administration in women with polycystic ovary syndrome...
  38. Lindner S, Seibold G, Henrich A, Kramer R, Wendisch V. Phosphotransferase system-independent glucose utilization in corynebacterium glutamicum by inositol permeases and glucokinases. Appl Environ Microbiol. 2011;77:3571-81 pubmed publisher
    ..PTS component HPr in glucose medium could be overcome by suppressor mutations leading to the high expression of inositol utilization genes or by the addition of inositol to the growth medium if a glucokinase is overproduced ..
  39. Gillaspy G. The cellular language of myo-inositol signaling. New Phytol. 2011;192:823-39 pubmed publisher
    The simple polyol, myo-inositol, is used as a building block of a cellular language that plays various roles in signal transduction...
  40. Tang T, Lord J, Norman R, Yasmin E, Balen A. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev. 2012;:CD003053 pubmed publisher
    ..Hyperinsulinaemia is associated with an increase in cardiovascular risk and the development of diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating the features of PCOS, including anovulation...
  41. Valluru R, Van den Ende W. Myo-inositol and beyond--emerging networks under stress. Plant Sci. 2011;181:387-400 pubmed publisher
    Myo-inositol is a versatile compound that generates diversified derivatives upon phosphorylation by lipid-dependent and -independent pathways...
  42. Unfer V, Raffone E, Rizzo P, Buffo S. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol Endocrinol. 2011;27:857-61 pubmed publisher
    ..Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin).
  43. Pascual F, Soto Cardalda A, Carman G. PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae. J Biol Chem. 2013;288:35781-92 pubmed publisher
    ..PAH1 expression was induced throughout growth and that the induction in the stationary phase was stimulated by inositol supplementation...
  44. Luo Y, Qin G, Zhang J, Liang Y, Song Y, Zhao M, et al. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. Plant Cell. 2011;23:1352-72 pubmed publisher
    In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction and membrane biogenesis...
  45. Klaffl S, Brocker M, Kalinowski J, Eikmanns B, Bott M. Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum. J Bacteriol. 2013;195:4283-96 pubmed publisher
    ..upstream and in a divergent orientation with respect to a iol gene cluster, encoding proteins involved in myo-inositol uptake and degradation...
  46. Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S. Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Eur Rev Med Pharmacol Sci. 2011;15:452-7 pubmed
    ..Myo-inositol and D-chiro-inositol are insulin sensitizing agents used in PCOS treatment...
  47. Fenili D, Weng Y, Aubert I, Nitz M, McLaurin J. Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology. PLoS ONE. 2011;6:e24032 pubmed publisher
    b>Inositol stereoisomers, myo- and scyllo-inositol, are known to enter the brain and are significantly elevated following oral administration...
  48. Jiang W, Wu P, Kuang S, Liu Y, Jiang J, Hu K, et al. Myo-inositol prevents copper-induced oxidative damage and changes in antioxidant capacity in various organs and the enterocytes of juvenile Jian carp (Cyprinus carpio var. Jian). Aquat Toxicol. 2011;105:543-51 pubmed publisher
    ..This study assessed the possible protective effects of myo-inositol (MI) against subsequent Cu exposure in juvenile Jian carp (Cyprinus carpio var...
  49. Seino Y, Fujita T, Hiroi S, Hirayama M, Kaku K. Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension. Curr Med Res Opin. 2011;27 Suppl 3:21-9 pubmed publisher
    ..To compare the efficacy and safety of alogliptin and placebo as add-on therapy in Japanese patients with type 2 diabetes who experienced inadequate glycemic control on voglibose plus diet/exercise therapy...
  50. Zhang G, Tian Y, Hu K, Zhu Y, Chater K, Feng C, et al. Importance and regulation of inositol biosynthesis during growth and differentiation of Streptomyces. Mol Microbiol. 2012;83:1178-94 pubmed publisher
    Unusually among bacteria, actinobacteria possess myo-inositol 1-phosphate synthase (mIPS). In the developmentally complex Streptomyces coelicolor, the mIPS-encoding gene (inoA) is cotranscribed with a putative regulatory gene (inoR)...
  51. Bathena S, Huang J, Epstein A, Gendelman H, Boska M, Alnouti Y. Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;893-894:15-20 pubmed publisher
    Amino acids and myo-inositol have long been proposed as putative biomarkers for neurodegenerative diseases. Accurate measures and stability have precluded their selective use...
  52. Yamaoka M, Osawa S, Morinaga T, Takenaka S, Yoshida K. A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease. Microb Cell Fact. 2011;10:69 pubmed publisher
    A stereoisomer of inositol, scyllo-inositol, is known as a promising therapeutic agent for Alzheimer's disease, since it prevents the accumulation of beta-amyloid deposits, a hallmark of the disease...
  53. Gardell A, Yang J, Sacchi R, Fangue N, Hammock B, Kültz D. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol. 2013;216:4615-25 pubmed publisher
    This study aimed to determine the regulation of the de novo myo-inositol biosynthetic (MIB) pathway in Mozambique tilapia (Oreochromis mossambicus) brain following acute (25 ppt) and chronic (30, 60 and 90 ppt) salinity acclimations...