erythritol

Summary

Summary: A four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator.

Top Publications

  1. Arrigoni E, Brouns F, Amado R. Human gut microbiota does not ferment erythritol. Br J Nutr. 2005;94:643-6 pubmed
    b>Erythritol, a naturally occurring polyol, is gaining attention as a bulk sweetener for human nutrition. Industrially, it is produced from glucose by fermentation. From various studies it is known to be non-cariogenic...
  2. Takahashi S, Kuzuyama T, Watanabe H, Seto H. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A. 1998;95:9879-84 pubmed
    ..In the alternative pathway, 2-C-methyl-D-erythritol or its 4-phosphate, which is proposed to be formed from 1-deoxy-D-xylulose 5-phosphate via intramolecular ..
  3. Yost C, Rath A, Noel T, Hynes M. Characterization of genes involved in erythritol catabolism in Rhizobium leguminosarum bv. viciae. Microbiology. 2006;152:2061-74 pubmed
    A genetic locus encoding erythritol uptake and catabolism genes was identified in Rhizobium leguminosarum bv. viciae, and shown to be plasmid encoded in a wide range of R. leguminosarum strains...
  4. Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia Estrabot A, et al. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. FEBS Lett. 2003;541:115-20 pubmed
    ..Enzymatic activity required the presence of a reducing system such as flavodoxin/flavodoxin reductase/reduced nicotinamide adenine dinucleotide phosphate or the photoreduced deazaflavin radical...
  5. Kitajima J, Ishikawa T, Fujimatu E, Kondho K, Takayanagi T. Glycosides of 2-C-methyl-D-erythritol from the fruits of anise, coriander and cumin. Phytochemistry. 2003;62:115-20 pubmed
    Eight glycosides of 2-C-methyl-D-erythritol (1) were isolated from the fruit of anise, and their structures were clarified as 1-O-beta-D-glucopyranoside, 3-O-beta-D-glucopyranoside, 4-O-beta-D-glucopyranoside, 1-O-beta-D-fructofuranoside, ..
  6. Makinen K, Isotupa K, Kivilompolo T, Makinen P, Toivanen J, Soderling E. Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci. Caries Res. 2001;35:129-35 pubmed
    The effect of 2-month usage of saliva-stimulating pastils containing either erythritol or xylitol was studied in a cohort of 30 subjects assigned to the respective polyol groups (n = 15). The daily consumption level of both polyols was 5...
  7. Lee J, Koo B, Kim S. Fumarate-mediated inhibition of erythrose reductase, a key enzyme for erythritol production by Torula corallina. Appl Environ Microbiol. 2002;68:4534-8 pubmed
    Torula corallina, a strain presently being used for the industrial production of erythritol, has the highest erythritol yield ever reported for an erythritol-producing microorganism...
  8. Ookura T, Azuma K, Isshiki K, Taniguchi H, Kasumi T, Kawamura Y. Primary structure analysis and functional expression of erythrose reductases from erythritol-producing fungi (Trichosporonoides megachiliensis SNG-42). Biosci Biotechnol Biochem. 2005;69:944-51 pubmed
    NADPH-dependent erythrose reductases (ERs) in erythritol-producing fungi, Trichosporonoides megachiliensis SNG-42, catalyze the reduction of D-erythrose...
  9. Bellaire B, Elzer P, Baldwin C, Roop R. Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low-iron conditions in vitro. Infect Immun. 2003;71:2927-832 pubmed
    ..abortus 2308, when cultured in the presence of erythritol under low-iron conditions...

More Information

Publications62

  1. Altincicek B, Duin E, Reichenberg A, Hedderich R, Kollas A, Hintz M, et al. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. FEBS Lett. 2002;532:437-40 pubmed
    ..The maximal specific activity of 6.6+/-0.3 micromol x min(-1) x mg(-1) protein was determined at pH 7.5 and 60 degrees C. The k(cat) value of the LytB protein was 3.7+/-0.2 s(-1) and the K(m) value for HMBPP was 590+/-60 microM...
  2. Poysti N, Oresnik I. Characterization of Sinorhizobium meliloti triose phosphate isomerase genes. J Bacteriol. 2007;189:3445-51 pubmed
    ..tpiB has been shown to be required for growth with erythritol. TpiB activity is induced by growth with erythritol; however, basal levels of TpiB activity present in tpiA ..
  3. Besser K, Harper A, Welsby N, Schauvinhold I, Slocombe S, Li Y, et al. Divergent regulation of terpenoid metabolism in the trichomes of wild and cultivated tomato species. Plant Physiol. 2009;149:499-514 pubmed publisher
    ..feeding all show that sesquiterpene biosynthesis relies mainly on products from the plastidic 2-C-methyl-d-erythritol-4-phosphate pathway in LA1777 but less so in the cultivated species...
  4. Sando T, Takeno S, Watanabe N, Okumoto H, Kuzuyama T, Yamashita A, et al. Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis. Biosci Biotechnol Biochem. 2008;72:2903-17 pubmed publisher
    ..natural rubber is biosynthesized through the mevalonate pathway, the involvement of an alternative 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is uncertain...
  5. Ostrovsky D, Diomina G, Lysak E, Matveeva E, Ogrel O, Trutko S. Effect of oxidative stress on the biosynthesis of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and isoprenoids by several bacterial strains. Arch Microbiol. 1998;171:69-72 pubmed
    ..and Pseudomonas putida, facultative parasites of plants and animals, were shown to accumulate 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate (MEC) in response to benzyl-viologen-induced oxidative stress...
  6. Altincicek B, Moll J, Campos N, Foerster G, Beck E, Hoeffler J, et al. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. J Immunol. 2001;166:3655-8 pubmed
    ..We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T ..
  7. Tomaszewska L, Rywińska A, Gładkowski W. Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol. J Ind Microbiol Biotechnol. 2012;39:1333-43 pubmed publisher
    ..This study presents an alternative means of crude glycerol valorization through the production of erythritol and mannitol...
  8. Rohdich F, Wungsintaweekul J, Luttgen H, Fischer M, Eisenreich W, Schuhr C, et al. Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato. Proc Natl Acad Sci U S A. 2000;97:8251-6 pubmed
    ..domain (residues 81-401) of a predicted tomato protein with similarity to 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase of Escherichia coli was expressed in a recombinant E. coli strain...
  9. Skorupinska Tudek K, Poznanski J, Wojcik J, Bienkowski T, Szostkiewicz I, Zelman Femiak M, et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. J Biol Chem. 2008;283:21024-35 pubmed publisher
    ..This study also illustrates an innovative application of mass spectrometry for qualitative and quantitative evaluation of the contribution of individual metabolic pathways to the biosynthesis of natural products...
  10. Rodríguez Concepción M. The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs. Curr Pharm Des. 2004;10:2391-400 pubmed
    ..Current efforts should eventually contribute to an effective drug designed to fight against microbial pathogens that show resistance to currently available agents...
  11. Eoh H, Brown A, Buetow L, Hunter W, Parish T, Kaur D, et al. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol. 2007;189:8922-7 pubmed
    ..In the MEP pathway, 4-diphosphocytidyl-2-C-methyl-D-erythritol is formed from 2-C-methyl-D-erythritol 4-phosphate (MEP) and CTP in a reaction catalyzed by a 4-diphosphocytidyl-..
  12. Kasahara H, Hanada A, Kuzuyama T, Takagi M, Kamiya Y, Yamaguchi S. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. J Biol Chem. 2002;277:45188-94 pubmed
    ..We also provide evidence to suggest that the MVA pathway still contributes to GA biosynthesis when this pathway is limiting...
  13. Söderling E, Hietala Lenkkeri A. Xylitol and erythritol decrease adherence of polysaccharide-producing oral streptococci. Curr Microbiol. 2010;60:25-9 pubmed publisher
    ..13 mol/l) and 4% (0.26 mol/l) xylitol. The effect of xylitol was compared to a novel polyol sweetener, erythritol. Except for Streptococcus mutans 10449 and S...
  14. Jain N, Rodriguez A, Kimsawatde G, Seleem M, Boyle S, Sriranganathan N. Effect of entF deletion on iron acquisition and erythritol metabolism by Brucella abortus 2308. FEMS Microbiol Lett. 2011;316:1-6 pubmed publisher
    ..Previous studies on Brucella have shown that 2,3-DHBA is associated with erythritol utilization and virulence in pregnant ruminants...
  15. Lherbet C, Pojer F, Richard S, Noel J, Poulter C. Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry. 2006;45:3548-53 pubmed publisher
    The conversion of 2-C-methyl-d-erythritol 4-phosphate (MEP) to 2-C-methyl-d-erythritol 2,4-cyclodiphosphate (cMEDP) in the MEP entry into the isoprenoid biosynthetic pathway occurs in three consecutive steps catalyzed by the IspD, IspE, ..
  16. Rodríguez Concepción M, Forés O, Martinez Garcia J, Gonzalez V, Phillips M, Ferrer A, et al. Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. Plant Cell. 2004;16:144-56 pubmed
  17. Herz S, Wungsintaweekul J, Schuhr C, Hecht S, Luttgen H, Sagner S, et al. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. Proc Natl Acad Sci U S A. 2000;97:2486-90 pubmed
    ..The recombinant protein was found to convert 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP...
  18. Xiao Y, Savchenko T, Baidoo E, Chehab W, Hayden D, Tolstikov V, et al. Retrograde signaling by the plastidial metabolite MEcPP regulates expression of nuclear stress-response genes. Cell. 2012;149:1525-35 pubmed publisher
  19. Storey D, Lee A, Bornet F, Brouns F. Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid. Eur J Clin Nutr. 2007;61:349-54 pubmed
    To determine and compare the gastrointestinal (GI) responses of young adults following consumption of 45 g sucrose, 20, 35 and 50 g xylitol or erythritol given as a single oral, bolus dose in a liquid.
  20. Oudin A, Mahroug S, Courdavault V, Hervouet N, Zelwer C, Rodríguez Concepción M, et al. Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus. Plant Mol Biol. 2007;65:13-30 pubmed
    ..Secologanin, the monoterpenoid moiety incorporated into MIAs, is derived from the plastidial methyl-D: -erythritol 4-phosphate (MEP) pathway...
  21. Gerber E, Hemmerlin A, Hartmann M, Heintz D, Hartmann M, Mutterer J, et al. The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells. Plant Cell. 2009;21:285-300 pubmed publisher
    ..Treatment with fosmidomycin (Fos) or oxoclomazone (OC), inhibitors of the plastidial 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway, caused mislocalization of the protein to the nucleus, whereas treatment with ..
  22. Begley M, Bron P, Heuston S, Casey P, Englert N, Wiesner J, et al. Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. Infect Immun. 2008;76:5392-401 pubmed publisher
    ..diphosphate (IPP): either the classical mevalonate pathway or the alternative non-mevalonate 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway...
  23. Guevara García A, San Román C, Arroyo A, Cortés M, de la Luz Gutiérrez Nava M, Leon P. Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-D-erythritol 4-phosphate pathway. Plant Cell. 2005;17:628-43 pubmed
    ..The mevalonic pathway operates in the cytoplasm, and the methyl-d-erythritol 4-phosphate (MEP) pathway operates in plastids...
  24. Schwender J, Gemünden C, Lichtenthaler H. Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. Planta. 2001;212:416-23 pubmed
  25. Testa C, Cornish R, Poulter C. The sorbitol phosphotransferase system is responsible for transport of 2-C-methyl-D-erythritol into Salmonella enterica serovar typhimurium. J Bacteriol. 2004;186:473-80 pubmed
    2-C-methyl-D-erythritol 4-phosphate is the first committed intermediate in the biosynthesis of the isoprenoid precursors isopentenyl diphosphate and dimethylallyl diphosphate...
  26. Kayingo G, Kilian S, Prior B. Conservation and release of osmolytes by yeasts during hypo-osmotic stress. Arch Microbiol. 2001;177:29-35 pubmed
    ..However, Z. rouxii also released arabitol, whereas P. sorbitophila released erythritol in addition to arabitol and glycerol...
  27. Dudareva N, Andersson S, Orlova I, Gatto N, Reichelt M, Rhodes D, et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. Proc Natl Acad Sci U S A. 2005;102:933-8 pubmed
    ..The trafficking of IPP occurs unidirectionally from the plastids to cytosol. The MEP pathway operates in a rhythmic manner controlled by the circadian clock, which determines the rhythmicity of terpenoid emission...
  28. Campos N, Rodríguez Concepción M, Sauret Güeto S, Gallego F, Lois L, Boronat A. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Biochem J. 2001;353:59-67 pubmed
    ..can be synthesized by two independent pathways: the mevalonate pathway and the recently discovered 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway...
  29. Campos N, Rodríguez Concepción M, Seemann M, Rohmer M, Boronat A. Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 2001;488:170-3 pubmed
    The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in most eubacteria and plants and has remarkable biotechnological interest. However, only the first steps of this pathway have been determined...
  30. Rohmer M. From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway. Lipids. 2008;43:1095-107 pubmed publisher
    ..It is present in most bacteria and in the plastids of all organisms belonging to phototrophic phyla. The key steps of the discovery and elucidation of this metabolic route are presented in this review...
  31. Kardon T, Stroobant V, Veiga da Cunha M, Schaftingen E. Characterization of mammalian sedoheptulokinase and mechanism of formation of erythritol in sedoheptulokinase deficiency. FEBS Lett. 2008;582:3330-4 pubmed publisher
    Our aim was to identify the product formed by sedoheptulokinase and to understand the mechanism of formation of erythritol in patients with sedoheptulokinase deficiency...
  32. Xie Z, Kapteyn J, Gang D. A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes. Plant J. 2008;54:349-61 pubmed publisher
    ..Differential phosphorylation of enzymes in the 2-C-methyl-d-erythritol 4-phosphate (MEP)/terpenoid and shikimate/phenylpropanoid pathways appears to play an important role in ..
  33. Nagata N, Suzuki M, Yoshida S, Muranaka T. Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. Planta. 2002;216:345-50 pubmed
    ..pathways in higher plants: the mevalonate (MVA) pathway in the cytoplasm and the non-mevalonate 2-C-methyl- D-erythritol-4-phosphate (MEP) pathway in plastids...
  34. Puan K, Wang H, Dairi T, Kuzuyama T, Morita C. fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. FEBS Lett. 2005;579:3802-6 pubmed
    ..Thus, the essential role for flavodoxin I in E. coli is in the MEP pathway for isoprenoid biosynthesis...
  35. Kohl E, Leet T, Lee D, Kim H, Ryu Y, Seo J. Scale-up of erythritol production by an osmophilic mutant of Candida magnoliae. Biotechnol Lett. 2003;25:2103-5 pubmed
    b>Erythritol production by an osmophilic mutant of Candida magnoliae was performed in fermentations of up 50 l to develop an optimized commercial process. By simultaneous feeding glucose and yeast extract, erythritol productivity of 1...
  36. Rivasseau C, Seemann M, Boisson A, Streb P, Gout E, Douce R, et al. Accumulation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in illuminated plant leaves at supraoptimal temperatures reveals a bottleneck of the prokaryotic methylerythritol 4-phosphate pathway of isoprenoid biosynthesis. Plant Cell Environ. 2009;32:82-92 pubmed publisher
    ..magnetic resonance ((31)P-NMR) revealed that the leaves of different herbs and trees accumulate 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcDP), an intermediate of the methylerythritol 4-phosphate (MEP) pathway, during bright ..
  37. Luttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr C, et al. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proc Natl Acad Sci U S A. 2000;97:1062-7 pubmed
    ..recombinant protein was purified to homogeneity and was shown to phosphorylate 4-diphosphocytidyl-2C-methyl-D-erythritol in an ATP-dependent reaction...
  38. Estevez J, Cantero A, Romero C, Kawaide H, Jimenez L, Kuzuyama T, et al. Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D-erythritol-4-phosphate pathway in Arabidopsis. Plant Physiol. 2000;124:95-104 pubmed
    The discovery of the 2-C-methyl-D-erythritol-4-phosphate pathway for the biosynthesis of isoprenoids raises the important question of the nature and regulation of the enzymes involved in this pathway...
  39. Chow K, Mat Isa M, Bahari A, Ghazali A, Alias H, Mohd Zainuddin Z, et al. Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. J Exp Bot. 2012;63:1863-71 pubmed publisher
    ..However, the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway may be an alternative source of IPP since its more recent discovery in plants...
  40. Geddes B, Pickering B, Poysti N, Collins H, Yudistira H, Oresnik I. A locus necessary for the transport and catabolism of erythritol in Sinorhizobium meliloti. Microbiology. 2010;156:2970-81 pubmed publisher
    In this work we have genetically defined an erythritol utilization locus in Sinorhizobium meliloti. A cosmid containing the locus was isolated by complementation of a transposon mutant and was subsequently mutagenized using Tn5?:?:?B20...
  41. Seemann M, Tse Sum Bui B, Wolff M, Miginiac Maslow M, Rohmer M. Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG. FEBS Lett. 2006;580:1547-52 pubmed
    ..phosphate pathway for isoprenoid biosynthesis, the GcpE/IspG enzyme catalyzes the conversion of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate into (E)-4-hydroxy-3-methylbut-2-enyl diphosphate...
  42. Oh D, Cho C, Lee J, Kim S. Increased erythritol production in fed-batch cultures of Torula sp. by controlling glucose concentration. J Ind Microbiol Biotechnol. 2001;26:248-52 pubmed
    The effect of glucose concentration on erythritol production by Torula sp. was investigated. The maximum volumetric productivity of erythritol was obtained at an initial glucose concentration of 300 g l(-1) in batch culture...
  43. Campbell T, Brown E. Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis. J Bacteriol. 2002;184:5609-18 pubmed
    The ispF gene product in Escherichia coli has been shown to catalyze the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis. In this work, the E...
  44. Rymowicz W, Rywińska A, Marcinkiewicz M. High-yield production of erythritol from raw glycerol in fed-batch cultures of Yarrowia lipolytica. Biotechnol Lett. 2009;31:377-80 pubmed publisher
    ..lipolytica Wratislavia K1 was selected that, when grown with 300 g raw glycerol l(-1) at pH 3, produced 170 g erythritol l(-1) after 7 days, corresponding to a 56% yield and a productivity of 1 g l(-1) h(-1)...
  45. Burlat V, Oudin A, Courtois M, Rideau M, St Pierre B. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-d. Plant J. 2004;38:131-41 pubmed
    In higher plants, isopentenyl diphosphate (IPP) is synthesised both from the plastidic 2-C-methyl-d-erythritol 4-phosphate (MEP) and from the cytosolic mevalonate (MVA) pathways...
  46. Moon H, Jeya M, Kim I, Lee J. Biotechnological production of erythritol and its applications. Appl Microbiol Biotechnol. 2010;86:1017-25 pubmed publisher
    b>Erythritol, a four-carbon polyol, is a biological sweetener with applications in food and pharmaceutical industries...
  47. Barta C, Loreto F. The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves. Plant Physiol. 2006;141:1676-83 pubmed
    It was investigated whether the methyl-erythritol phosphate (MEP) pathway that generates volatile isoprenoids and carotenoids also produces foliar abscisic acid (ABA) and controls stomatal opening...
  48. Hemmerlin A, Hoeffler J, Meyer O, Tritsch D, Kagan I, Grosdemange Billiard C, et al. Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. J Biol Chem. 2003;278:26666-76 pubmed
    ..1-Deoxy-d-xylulose (DX), the dephosphorylated first precursor of the plastidial 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway, complemented growth inhibition by mevinolin in the low millimolar concentration range...
  49. Kemp L, Bond C, Hunter W. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development. Proc Natl Acad Sci U S A. 2002;99:6591-6 pubmed publisher
    The crystal structure of the zinc enzyme Escherichia coli 2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase in complex with cytidine 5'-diphosphate and Mn(2+) has been determined to 1.8-A resolution. This enzyme is essential in E...
  50. Okada A, Shimizu T, Okada K, Kuzuyama T, Koga J, Shibuya N, et al. Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice. Plant Mol Biol. 2007;65:177-87 pubmed
    ..DXS), 1-deoxy-D: -xylulose 5-phosphate reductoisomerase (DXR), and 4-(cytidine 5'-diphospho)-2-C-methyl-D: -erythritol synthase (CMS), which catalyze the first three committed steps in the MEP pathway, were further shown to have ..
  51. Altincicek B, Kollas A, Eberl M, Wiesner J, Sanderbrand S, Hintz M, et al. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 2001;499:37-40 pubmed
    The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite...
  52. Xiao Y, Nyland R, Meyers C, Liu P. Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms. Chem Commun (Camb). 2010;46:7220-2 pubmed publisher
  53. Yokozawa T, Kim H, Cho E. Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats. J Agric Food Chem. 2002;50:5485-9 pubmed
    We investigated the effects of erythritol on rats with streptozotocin- (STZ-) induced diabetes mellitus...