2 propanol

Summary

Summary: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Top Publications

  1. Hess M, Antranikian G. Archaeal alcohol dehydrogenase active at increased temperatures and in the presence of organic solvents. Appl Microbiol Biotechnol. 2008;77:1003-13 pubmed
  2. Adams D, Quayum M, Worthington T, Lambert P, Elliott T. Evaluation of a 2% chlorhexidine gluconate in 70% isopropyl alcohol skin disinfectant. J Hosp Infect. 2005;61:287-90 pubmed
    ..5% (w/v) aqueous CHG, 2% (w/v) aqueous CHG and 0.5% (w/v) CHG in 70% (v/v) IPA]...
  3. Kramer A, Rudolph P, Kampf G, Pittet D. Limited efficacy of alcohol-based hand gels. Lancet. 2002;359:1489-90 pubmed
  4. Hibbard J, Mulberry G, Brady A. A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine. J Infus Nurs. 2002;25:244-9 pubmed
    ..0001). CHG + IPA provided significantly more persistent antimicrobial activity on abdominal sites than IPA (P =.003) or CHG (P =.028) at 24 hours. No skin irritations were reported for any of the three antiseptics...
  5. Nishikori S, Shiraki K, Okanojo M, Imanaka T, Takagi M. Equilibrium and kinetic stability of a hyperthermophilic protein, O6-methylguanine-DNA methyltransferase under various extreme conditions. J Biochem. 2004;136:503-8 pubmed
    ..This slow rate of unfolding under extreme conditions is a significant property that distinguishes Tk-MGMT from mesophilic proteins...
  6. Gotmar G, Samuelsson J, Karlsson A, Fornstedt T. Thermodynamic characterization of the adsorption of selected chiral compounds on immobilized amyloglucosidase in liquid chromatography. J Chromatogr A. 2007;1156:3-13 pubmed
    ..Thus, at high temperatures the retention decreases with increasing modifier content, whereas the opposite (unusual) trend is the case at low temperatures...
  7. Leech D, Snyder M, Wetzel R. Natural organic matter and sunlight accelerate the degradation of 17ss-estradiol in water. Sci Total Environ. 2009;407:2087-92 pubmed publisher
    ..Although photodegradation was greatest in full sunlight containing UV-B (290-320 nm), degradation was also detected with UV-A (320-400 nm) and visible light (400-720 nm) alone...
  8. Hirschberg A, Edlund M, Svane G, Azavedo E, Skoog L, von Schoultz B. An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women. Menopause. 2007;14:89-96 pubmed
  9. Kantarci G, Ozguney I, Karasulu H, Arzik S, Guneri T. Comparison of different water/oil microemulsions containing diclofenac sodium: preparation, characterization, release rate, and skin irritation studies. AAPS PharmSciTech. 2007;8:E91 pubmed publisher
    ..In conclusion, M prepared with P may be a more appropriate formulation than the other 2 formulations studied as drug carrier for topical application...

More Information

Publications62

  1. Iavicoli I, Fontana L, Iavicoli S. [Modifications of hepatic transaminases in workers exposed to low doses of isopropanol]. G Ital Med Lav Ergon. 2007;29:271-2 pubmed
    ..In conclusion, the results of this study show that the removal of IPA from the industry had a positive health effect improving the hepatic function of the workers...
  2. Uppu R. Synthesis of peroxynitrite using isoamyl nitrite and hydrogen peroxide in a homogeneous solvent system. Anal Biochem. 2006;354:165-8 pubmed
    ..The method as reported is amenable for large scale synthesis as it involves sequential mixing of solvents (water and IPA) to alkali followed by the addition of H2O2 and alkyl nitrite...
  3. Groszek G, Bednarski M, Dybała M, Filipek B. Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1. Eur J Med Chem. 2009;44:809-17 pubmed publisher
    ..The results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic but not spasmolytic properties...
  4. Liao F, Zhao L, Zhao Y, Tao J, Zuo Y. Integrated rate equation considering product inhibition and its application to kinetic assay of serum ethanol. Anal Sci. 2007;23:439-44 pubmed
    ..The upper limit of linear response for A(mk) was about 40 times of the lower limit. These results indicated that this kinetic method was reliable for serum ethanol assays with obvious advantages...
  5. Wolfart M, Lehmann F, Wolfart S, Kern M. Durability of the resin bond strength to zirconia ceramic after using different surface conditioning methods. Dent Mater. 2007;23:45-50 pubmed
    ..The purpose of this in vitro study was the evaluation of the bond strength and its durability of two composite resins to zirconia ceramic after using different surface conditioning methods...
  6. Kiyoyama T, Tokuda Y, Shiiki S, Hachiman T, Shimasaki T, Endo K. Isopropyl alcohol compared with isopropyl alcohol plus povidone-iodine as skin preparation for prevention of blood culture contamination. J Clin Microbiol. 2009;47:54-8 pubmed publisher
    ..The extremely low contamination rates in both groups suggest that the type of antiseptic used may not be as important as the use of proper technique...
  7. Athawale A, Katre P, Majumdar M. Nonaqueous phase synthesis of copper nanoparticles. J Nanosci Nanotechnol. 2005;5:991-3 pubmed
    ..e., Cu2+: cetyltrimethylammonium bromide = 1:30), formation of finer sized particles with a lower degree of size variation, approximately 2-10 nm, can be observed...
  8. Lecat P, Cropp E, McCord G, Haller N. Ethanol-based cleanser versus isopropyl alcohol to decontaminate stethoscopes. Am J Infect Control. 2009;37:241-3 pubmed publisher
    ..As an extension of the hand, a stethoscope should be cleaned with the same frequency as the hands. The simultaneous cleaning of hands and stethoscope may further increase compliance with current standards...
  9. Désy O, Carignan D, Caruso M, de Campos Lima P. Immunosuppressive effect of isopropanol: down-regulation of cytokine production results from the alteration of discrete transcriptional pathways in activated lymphocytes. J Immunol. 2008;181:2348-55 pubmed
    ..Our results suggest that IPA is potentially immunosuppressive to the adaptive and innate immune system and have broad significance given the exposure of the general population to this ubiquitous chemical...
  10. Sletmoen M, Stokke B, Geissler E. Small angle x-ray scattering study of local structure and collapse transition of (1,3)-beta-D-glucan-chitosan gels. J Chem Phys. 2006;125:054908 pubmed
    ..The triple helical structure of the molecule appears not to be conserved in the majority phase in this solvent, but it is conserved in the liquid crystalline domains...
  11. Katsoyiannis I, Ruettimann T, Hug S. pH dependence of Fenton reagent generation and As(III) oxidation and removal by corrosion of zero valent iron in aerated water. Environ Sci Technol. 2008;42:7424-30 pubmed
    ..OH-radials are the main oxidant for As(III) at low pH, whereas a more selective oxidant oxidizes As(III) at circumneutral pH...
  12. Wang R, Wang S, Liang S, Xu G, Weng Q. [Separation and determination of oleanolic acid and ursolic acid from Cornus officinalis by capillary electrophoresis]. Zhong Yao Cai. 2007;30:946-50 pubmed
    ..9996 and 0.9995, respectively. The effects of SDS, 2-propanol, dimethyl-beta-cyclodextrin, beta-cyclodextrin, NaH2PO4, Na2B4O7 and pH on separation were investigated...
  13. Avella J, Wetli C, Wilson J, Katz M, Hahn T. Fatal olanzapine-induced hyperglycemic ketoacidosis. Am J Forensic Med Pathol. 2004;25:172-5 pubmed
    ..Warnings concerning this potentially fatal complication of olanzapine therapy should be included in standard pharmaceutical and prescription references...
  14. Ramirez Arcos S, Goldman M. Skin disinfection methods: prospective evaluation and postimplementation results. Transfusion. 2010;50:59-64 pubmed publisher
    ..Optimal skin disinfection ensures blood safety. In this study, efficacies of the two-step skin disinfection methods used at Canadian Blood Services (CBS) and two one-step methods produced by different manufacturers were compared...
  15. Sabatini C, Pereira R, Gehlen M. Fluorescence modulation of acridine and coumarin dyes by silver nanoparticles. J Fluoresc. 2007;17:377-82 pubmed
    ..Amino coumarin fluorescence is only quenched by the silver nanoparticles in solution...
  16. Poza J, Fernandez R, Reyes F, Rodriguez J, Jimenez C. Isolation, biological significance, synthesis, and cytotoxic evaluation of new natural parathiosteroids A-C and analogues from the soft coral Paragorgia sp. J Org Chem. 2008;73:7978-84 pubmed publisher
    ..These natural products could be biosynthetic intermediates in the steroid side chain degradation pathway involving activation with CoA and beta-oxidations...
  17. Vujasinovic M, Kocar M, Kramer K, Bunc M, Brvar M. Poisoning with 1-propanol and 2-propanol. Hum Exp Toxicol. 2007;26:975-8 pubmed publisher
    ..In conclusion, 1-propanol and 2-propanol poisoning presents early with mixed acidosis and elevated anion gap and only later with ketonuria...
  18. Lages S, Ramakrishnan M, Goyal S. In-vivo efficacy of hand sanitisers against feline calicivirus: a surrogate for norovirus. J Hosp Infect. 2008;68:159-63 pubmed publisher
    ..Further research on alternative hand sanitisers should continue for effective control of norovirus infections...
  19. Miller M, Rosin A, Levsky M, Gregory T, Crystal C. Isopropyl alcohol pad use for blood ethanol sampling does not cause false-positive results. J Emerg Med. 2007;33:9-10 pubmed
    ..This study demonstrates that the use of isopropyl skin prep pads is unlikely to cause significant false-positive blood ethanol levels...
  20. Traore O, Hugonnet S, Lubbe J, Griffiths W, Pittet D. Liquid versus gel handrub formulation: a prospective intervention study. Crit Care. 2007;11:R52 pubmed
    ..Alcohol-based handrub is the new standard for hand hygiene action worldwide and usually requires a system change for its successful introduction in routine care. Product acceptability by HCWs is a crucial step in this process...
  21. Chung N, Wu Y, Tabata M. Spectrophotometric titration of cobalt(II) with CaCl2 in mixed solvents of 2-propanol and water for the analysis of the extraction mechanism of cobalt(II) by salting-out in the presence of CaCl2. Anal Sci. 2005;21:1287-90 pubmed
    ..The distribution constant, KD (= [CoCl4(2-)]org/[CoCl4(2-)]aq), however, decreased and became constant with [CaCl2]. The detailed extraction mechanism of Co(II) is discussed...
  22. Hatano B, Kubo D, Tagaya H. Study on the reactivity of diarylmethane derivatives in supercritical alcohols media: reduction of diarylmethanols and diaryl ketones to diarylmethanes using supercritical 2-propanol. Chem Pharm Bull (Tokyo). 2006;54:1304-7 pubmed
    ..Furthermore, we determined the specific reaction of fluorene using supercritical methanol at high temperature...
  23. Rotter M, Kampf G, Suchomel M, Kundi M. Population kinetics of the skin flora on gloved hands following surgical hand disinfection with 3 propanol-based hand rubs: a prospective, randomized, double-blind trial. Infect Control Hosp Epidemiol. 2007;28:346-50 pubmed
    ..To study the bacterial population kinetics on gloved hands following hand treatment with 3 optically indistinguishable, alcohol-based surgical hand rubs, with and without supplements to delay bacterial regrowth...
  24. Gapan R, Evyapan M, Namli H, Turhan O, Stanciu G. Characterization of a novel 1,3-bis(p-iminobenzoic acid)indane Langmuir-Blodgett film for organic vapor sensing. J Nanosci Nanotechnol. 2005;5:1108-12 pubmed
    ..This newly synthesized IBI is a suitable molecule for the fabrication of an LB film and can be regarded as a promising sensing material in the development of a room temperature gas sensor for benzene vapor applications...
  25. Radtke C, Polydore C, Cox S, Cobb G. Vapor-phase analysis of isobutyl acetate, isopropyl acetate, n-propyl acetate and their respective alcohols using solid-phase microextraction-gas chromatography with a mass selective detector. J Chromatogr A. 2005;1066:225-30 pubmed
    ..1 +/- 6.1% at 1 ppmv, becoming most precise at 50 ppmv at 1.01 +/- 0.45%, then increasing at 100 ppmv to 4.12 +/- 1.88%. The contributors to error trended as: concentration > daily effects > operator...
  26. Lv G, Wang L, Liu J, Li S. Method for determination of fatty acid amides in polyethylene packaging materials--gas chromatography/mass spectrometry. J Chromatogr A. 2009;1216:8545-8 pubmed publisher
    ..0 ng g(-1), 74.0 ng g(-1), 103.0 ng g(-1), and 105.0 ng g(-1), respectively, and the linearity were good. The proposed method was applied satisfactorily to determine these chemicals in different types of polyethylene samples...
  27. Shin Y, Shen Y. Preparation of coal slurry with 2-propanol. J Hazard Mater. 2006;137:152-6 pubmed
    ..Finally, coal-2-propanol slurries formed bulky sediment with loose structure even coal particles suspended in 2-propanol were more stable than coal particles in CWSs...
  28. Schroer K, Zelic B, Oldiges M, Lutz S. Metabolomics for biotransformations: Intracellular redox cofactor analysis and enzyme kinetics offer insight into whole cell processes. Biotechnol Bioeng. 2009;104:251-60 pubmed publisher
  29. Chae S, Lee C, Lee S, Kim T, Kang J. Oil droplet generation in PDMS microchannel using an amphiphilic continuous phase. Lab Chip. 2009;9:1957-61 pubmed publisher
    ..With this new continuous phase solution, IPA, we could successfully generate not only oil droplets but also double emulsions in the PDMS microfluidic chips...
  30. Lu R, Gan W, Wu B, Zhang Z, Guo Y, Wang H. C-H stretching vibrations of methyl, methylene and methine groups at the vapor/alcohol (N = 1-8) interfaces. J Phys Chem B. 2005;109:14118-29 pubmed
    ..Therefore, the advancement on vibrational spectra assignment may find broad applications in the related fields using IR and Raman as vibrational spectroscopic tools...
  31. Höllrigl V, Hollmann F, Kleeb A, Buehler K, Schmid A. TADH, the thermostable alcohol dehydrogenase from Thermus sp. ATN1: a versatile new biocatalyst for organic synthesis. Appl Microbiol Biotechnol. 2008;81:263-73 pubmed publisher
    ..When applying cofactor regeneration at high pH, however, the ratio of acid to alcohol could be changed, and full conversion to the carboxylic acid was achieved...
  32. Zhilina T, Zavarzina D, Kolganova T, Turova T, Zavarzin G. ["Candidatus contubernalis alkalaceticum," an obligately syntrophic alkaliphilic bacterium capable of anaerobic acetate oxidation in a coculture with Desulfonatronum cooperativum]. Mikrobiologiia. 2005;74:800-9 pubmed
    ..Based on its phylogenetic position, the new acetate-oxidizing syntrophic bacterium is proposed to be assigned, in a Candidate status, to a new genus and species: "Candidatus Contubernalis alkalaceticum."..
  33. Samaratunga S, Nishimoto J, Tabata M. Extraction of chromium(VI) by salting-out with a homogeneous, mixed solvent of water and 2-propanol: a laboratory study. Environ Sci Pollut Res Int. 2008;15:27-30 pubmed
    ..Therefore, the aim of this laboratory research was to develop a rapid, simple and adaptable solvent extraction system to quantitatively remove Cr(VI) from polluted waters...
  34. Takigami H, Etoh T, Nishio T, Sakai S. Chemical and bioassay monitoring of PCB-contaminated soil remediation using solvent extraction technology. J Environ Monit. 2008;10:198-205 pubmed publisher
    ..After full-scale treatment, the amount of PCBs recovered from the solvent purification system approximated the estimated amount of PCBs spilled...
  35. Balaxi M, Nikolakakis I, Malamataris S. Preparation of porous microcrystalline cellulose pellets by freeze-drying: effects of wetting liquid and initial freezing conditions. J Pharm Sci. 2010;99:2104-13 pubmed publisher
  36. Freitas S, Azzoni A, Santos J, Monteiro G, Prazeres D. On the stability of plasmid DNA vectors during cell culture and purification. Mol Biotechnol. 2007;36:151-8 pubmed
  37. Shin Y, Shen Y. Preparation of coal slurry with organic solvents. Chemosphere. 2007;68:389-93 pubmed
    ..Thus, more surface area is available for combustion and the combustion rate of coal slurries was increased...
  38. Pimentel M, Leāo A, Melo E, Ledingham W, Filho J, Sivewright M, et al. Immobilization of Candida rugosa lipase on magnetized Dacron: kinetic study. Artif Cells Blood Substit Immobil Biotechnol. 2007;35:221-35 pubmed
    ..The ferromagnetic Dacron-lipase derivative was able to catalyze the synthesis of triolein from glycerol and oleic acid with 50% of conversion after 72 h at 40 degrees C...
  39. Karasulu H, Karabulut B, Goker E, Guneri T, Gabor F. Controlled release of methotrexate from w/o microemulsion and its in vitro antitumor activity. Drug Deliv. 2007;14:225-33 pubmed
    ..These results indicate that M-MTX may exert a low cytotoxic effect on normal cells and may be effective as an antitumor agent that induces apoptosis...
  40. Asada N, Namba M, Kodama T, Kyogoku Y. Circular dichroism of prophenol oxidase in relation to the structural stability in Drosophila melanogaster. Arch Insect Biochem Physiol. 2004;56:1-6 pubmed
    ..However, it showed reversible recovery by renaturation after returning to low temperature at 30 degrees C. The conformational changes and reversible denaturation-renaturation interaction of the prophenol oxidase protein are discussed...
  41. Hupka L, Nalaskowski J, Miller J. Interaction forces for symmetric hydrophilic and hydrophobic systems in aqueous isopropanol solutions. Langmuir. 2010;26:2200-8 pubmed publisher
    ..An increase in the isopropyl alcohol content of the solution diminishes both the repulsive forces in the case of the hydrophilic system and the attractive interactions in the case of the hydrophobic system...
  42. Rencurosi A, Lay L, Russo G, Caneva E, Poletti L. NMR evidence for the participation of triflated ionic liquids in glycosylation reaction mechanisms. Carbohydr Res. 2006;341:903-8 pubmed
    ..The influence of the triflate anion derived from [emim][OTf] on the stereochemistry of the glycosylation products was evaluated...
  43. Magnavita N, Bordignon P, Ciaffi G, Ferraro P, Vincenti F. [Dysphonia and cacosmia in a worker in sterilized rooms]. G Ital Med Lav Ergon. 2007;29:804-5 pubmed
    ..We rejected the hypothesis of association between complaint and job exposure, and advised him to work in a well defined working situation, such as in a clean room, where chemical contamination may be effectively controlled over time...
  44. Park J, Park Y, Kang H, Kim C. Solvent effects on physicochemical behavior of estradiols recrystallized for transdermal delivery. Arch Pharm Res. 2008;31:111-6 pubmed
  45. Ghorab M, Adeyeye M. High shear mixing granulation of ibuprofen and beta-cyclodextrin: effects of process variables on ibuprofen dissolution. AAPS PharmSciTech. 2007;8:E84 pubmed publisher
    ..However, a successful HSM granulation scale-up was not achieved due to the difference in the solvent mixture's effect from 1 scale to the other...
  46. Jena S, Jeanmeure L, Wichukorn S, Wright P. Carbon substrate utilisation profile of a high concentration effluent degrading microbial consortium. Environ Technol. 2006;27:863-73 pubmed
    ..Carbohydrates, amino acids and carboxylic acids were the most predominant groups of sole carbon substrates showing similar growth behaviour in the consortium...
  47. Kretzschmar G, Nisslein T, Zierau O, Vollmer G. No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment. J Steroid Biochem Mol Biol. 2005;97:271-7 pubmed
    ..Contrary to earlier suggestions C. racemosa does not seem to act as an estrogen agonist, but possibly as a weak antiestrogen...
  48. Pappa Louisi A, Nikitas P, Agrafiotou P. Column equilibration effects in gradient elution in reversed-phase liquid chromatography. J Chromatogr A. 2006;1127:97-107 pubmed
    ..The origin of the discrepancies between theory and experiment as well as their impact on the resolution is also discussed...
  49. Gurzadyan G, Reynisson J, Steenken S. Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity. Phys Chem Chem Phys. 2007;9:288-98 pubmed
    ..3-1 x 10(9) s(-1)) is almost independent of the solvent polarity in the range from cyclohexane to methanol. In highly polar solvents (ET(N) > 0.9) the rate increases to (0.5-5) x 10(10) s(-1)...
  50. Chrysanthakopoulos M, Giaginis C, Tsantili Kakoulidou A. Retention of structurally diverse drugs in human serum albumin chromatography and its potential to simulate plasma protein binding. J Chromatogr A. 2010;1217:5761-8 pubmed publisher
    ..The above results were further confirmed by linear solvation energy relationships (LSER)...
  51. Buncek M, Backovská V, Holasova S, Radilova H, Safarova M, Kunc F, et al. Unusual chromatographic behavior of oligonucleotide sequence isomers on two different anion exchange HPLC columns. Anal Biochem. 2006;348:300-6 pubmed
    ..This is the first report of such a "same composition different sequence" effect, described for the short peptides, for synthetic oligonucleotides...
  52. Arakawa T, Futatsumori Sugai M, Tsumoto K, Kita Y, Sato H, Ejima D. MEP HyperCel chromatography II: binding, washing and elution. Protein Expr Purif. 2010;71:168-73 pubmed publisher
  53. Yang B, Lange Jansen H, Scharnberg M, Wolfart S, Ludwig K, Adelung R, et al. Influence of saliva contamination on zirconia ceramic bonding. Dent Mater. 2008;24:508-13 pubmed
    ..The purpose of this study was to investigate the influence of saliva contamination and cleaning methods on adhesive bonding to dental zirconia ceramic with a phosphate-monomer-containing luting resin...