tromethamine

Summary

Summary: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)

Top Publications

  1. Levine L, Kranc D. Evaluation of carboprost tromethamine in the treatment of cyclophosphamide-induced hemorrhagic cystitis. Cancer. 1990;66:242-5 pubmed
    ..Each patient had failed to respond to conservative management. Carboprost tromethamine (Hemabate) was instilled into the bladder, with dwell times ranging from 45 to 60 minutes, three to four times ..
  2. Kaneko T, Whittingham D, Yanagimachi R. Effect of pH value of freeze-drying solution on the chromosome integrity and developmental ability of mouse spermatozoa. Biol Reprod. 2003;68:136-9 pubmed
    ..0) rather than near neutral or acidic (pH 7.4-6.0). The data indicated that the chromosome integrity and developmental ability of mouse spermatozoa are affected by the pH value of freeze-drying solution...
  3. Rodríguez M, Arbós R, Amaro S. Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller. Expert Rev Neurother. 2008;8:1625-40 pubmed publisher
  4. Api O, Ergen B, Api M, Ugurel V, Emeksiz M, Unal O. Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2010;203:28.e1-7 pubmed publisher
    ..We sought to investigate the analgesic efficacy of oral dexketoprofen trometamol and intrauterine lidocaine in patients undergoing fractional curettage...
  5. Geisslinger G, Peskar B, Pallapies D, Sittl R, Levy M, Brune K. The effects on platelet aggregation and prostanoid biosynthesis of two parenteral analgesics: ketorolac tromethamine and dipyrone. Thromb Haemost. 1996;76:592-7 pubmed
    The pharmacokinetics and effects on platelet function of dipyrone (1.0 g; 2.5 g; i.v.) and ketorolac tromethamine (30 mg; i.m.) were studied in a three-way crossover study in twelve healthy subjects...
  6. Nau R, Desel H, Lassek C, Kolenda H, Prange H. Entry of tromethamine into the cerebrospinal fluid of humans after cerebrovascular events. Clin Pharmacol Ther. 1999;66:25-32 pubmed
    The intravenous administration of tromethamine (INN, trometamol) lowers the intracranial pressure in patients with brain edema. One postulated mechanism of action is the increase of the pH of the cerebrospinal fluid.
  7. Kallet R, Jasmer R, Luce J, Lin L, Marks J. The treatment of acidosis in acute lung injury with tris-hydroxymethyl aminomethane (THAM). Am J Respir Crit Care Med. 2000;161:1149-53 pubmed
    ..Although further studies are needed to confirm these observations, THAM appears to be an effective alternative to sodium bicarbonate for treating acidosis during ALI...
  8. Kranc D, Kim J, Straus F, Levine L. Prophylactic and therapeutic carboprost tromethamine bladder irrigation in rats with cyclophosphamide-induced hemorrhagic cystitis. J Urol. 1992;148:1326-30 pubmed
    ..Among the prostaglandins studied is carboprost tromethamine, a PGF2a analog...
  9. Yee R. Analgesic efficacy and safety of nonpreserved ketorolac tromethamine ophthalmic solution following radial keratotomy. Ketorolac Radial Keratotomy Study Group. Am J Ophthalmol. 1998;125:472-80 pubmed
    To compare the analgesic efficacy and safety of nonpreserved ketorolac tromethamine 0.5% with those of its vehicle in the treatment of postsurgical ocular pain following radial keratotomy.

More Information

Publications62

  1. Brunzelle J, Jordan D, McCaslin D, Olczak A, Wawrzak Z. Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane. Arch Biochem Biophys. 2008;474:157-66 pubmed publisher
    ..Similar k(cat) and k(cat)/K(m) values were determined when the tetramer/dimer ratio changes from 0.0028 to 26 suggesting that dimers and tetramers are equally active forms...
  2. Baldoli C, Rigamonti C, Maiorana S, Licandro E, Falciola L, Mussini P. A new triferrocenyl-tris(hydroxymethyl)aminomethane derivative as a highly sensitive electrochemical marker of biomolecules: application to the labelling of PNA monomers and their electrochemical characterization. Chemistry. 2006;12:4091-100 pubmed
    ..These results are a good premise for the use of the trisferrocene unit as an effective electrochemical probe for biomolecules...
  3. Gokulan K, Khare S, Ronning D, Linthicum S, Sacchettini J, Rupp B. Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners. Biochemistry. 2005;44:9889-98 pubmed
    ..Overall similarities and partial conservation of interactions indicate that the NC6.8 Fab surrogate is representing crucial features of the T1R2 taste receptor VFTM binding site...
  4. Buchmueller K, Weeks K. Tris-borate is a poor counterion for RNA: a cautionary tale for RNA folding studies. Nucleic Acids Res. 2004;32:e184 pubmed
    ..Under some conditions, Tris-borate is a poor counterion for RNA and its use merits careful evaluation in RNA folding studies...
  5. Russ M, Deja M, Ott S, Bedarf J, Keckel T, Hiebl B, et al. Experimental high-volume hemofiltration with predilutional tris-hydroxymethylaminomethane for correction of low tidal volume ventilation-induced acidosis. Artif Organs. 2011;35:E108-18 pubmed publisher
    ..In conclusion, predilutional THAM-application and HVHF corrected the acid-base disorder and improved pulmonary hemodynamics. Further studies are necessary to optimize the protocol including the dosage...
  6. Cerruti M, Greenspan D, Powers K. An analytical model for the dissolution of different particle size samples of Bioglass in TRIS-buffered solution. Biomaterials. 2005;26:4903-11 pubmed
    ..It is suggested that variation of surface area has a significant impact on the course of the dissolution...
  7. Harinarayan C, Skidmore K, Kao Y, Zydney A, van Reis R. Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions:Study of citrate binding to a Fab. Biotechnol Bioeng. 2009;102:1718-22 pubmed publisher
    ..The study presents process solutions and utilizes a simple model to characterize clearance of small molecules which exhibit interactions with product protein...
  8. Ye X, Mori S, Yamada M, Inoue J, Xu Z, Hirokawa T. Electrokinetic supercharging preconcentration prior to CGE analysis of DNA: sensitivity depends on buffer viscosity and electrode configuration. Electrophoresis. 2013;34:583-9 pubmed publisher
    ..The obtained LOD of the weakest peak of 72 bp fragment was around 7.7 pg/mL, apparently improved more than 10,000-fold in comparison with conventional CGE with UV detection...
  9. Triana J, Yanagihashi M, Larson D. Mathematical modeling of buffers used in myocardial preservation. Perfusion. 2007;22:353-62 pubmed
    ..Our hypothesis is that mathematical modeling of three clinically used buffers will define their individual buffering capacities under simulated clinical conditions...
  10. Miranda H, Romero M, Puig M. Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. Fundam Clin Pharmacol. 2012;26:373-82 pubmed publisher
  11. Degim I, Kadioglu D. Cheap, suitable, predictable and manageable nanoparticles for drug delivery: quantum dots. Curr Drug Deliv. 2013;10:32-8 pubmed
    ..Drug coated ZnO quantum dots were found to increase transdermal penetration of ketoprofen and dexketoprofen through rat skin...
  12. Hacivelioglu S, Gencer M, Cakir Gungor A, Kosar S, Koc E, Cosar E. Can the addition of a paracervical block to systemic or local analgesics improve the pain perceived by the patient during hysterosalpingography?. J Obstet Gynaecol. 2014;34:48-53 pubmed publisher
    ..The combination of intramuscular dexketoprofen and a paracervical block with plain lidocaine produced the best pain relief during the three specified steps and at up to 30 min after the HSG procedure. ..
  13. Kang S, Lee S, Yeung E. Atypical mobilities of single native DNA molecules in microchip electrophoresis revealed by differential interference contrast microscopy. Electrophoresis. 2006;27:4149-57 pubmed
    ..The atypical migration order correlated well with the results in CE. The alignment of the deformable molecules due to viscous drag is likely responsible for these observations...
  14. Cho J, Cho M, Hwang H, Bhoo S, Hahn T. Improvement of plant protein solubilization and 2-DE gel resolution through optimization of the concentration of Tris in the solubilization buffer. Mol Cells. 2010;29:611-6 pubmed publisher
    ..The Ly200T buffer also improved the resolution of abundant and basic proteins. Thus, the Ly200T buffer can be used to achieve greater resolution of protein spots in plant proteomics research...
  15. Dumont A, Zheng Y, Hunting D, Sanche L. Protection by organic ions against DNA damage induced by low energy electrons. J Chem Phys. 2010;132:045102 pubmed publisher
    ..Moreover, it is proposed that the tris molecules may participate in the repair of DNA anions [such as G(-H)(-)] induced by DEA on DNA bases...
  16. Axnér E, Lagerson E. Cryopreservation of Dog Semen in a Tris Extender with 1% or 2% Soya Bean Lecithin as a Replacement of Egg Yolk. Reprod Domest Anim. 2016;51:262-8 pubmed publisher
    ..In conclusion, egg yolk was superior to lecithin in our study. The extender with 1% lecithin preserved sperm motility better than the extender with 2% lecithin. ..
  17. Shah R, D mello A. Stabilization of phenylalanine ammonia lyase against organic solvent mediated deactivation. Int J Pharm. 2007;331:107-15 pubmed
    ..Emulsification of PAL solution with E:E resulted in a 50% decrease in its activity. Among the additives, hydroxypropyl-gamma-cyclodextrin and hydroxy propyl-beta-cyclodextrin protected PAL against emulsion mediated loss in activity...
  18. Jensen J, Walker J, Milki A, Westphal L, Behr B. The effect of a two-hour, room temperature incubation of human spermatozoa in TEST-yolk buffer on the rate of fertilization in vitro. J Assist Reprod Genet. 2004;21:169-73 pubmed
  19. Marinov B, Milanova K. [Some possibilities for application of "Pfizer" medicines--Prostin 15m, Prostin E2, Prepidil gel, Dostinex, Synarel--in the obstetrician practice]. Akush Ginekol (Sofiia). 2007;46 Suppl 2:57-60 pubmed
    ..Some of these medicines have no analogue in Bulgaria--i.e. Prostin 15M. The authors outline the advantages of the Pfiser medicines in comparison with other medicines with similar action...
  20. Rudenko S. Characterization of morphological response of red cells in a sucrose solution. Blood Cells Mol Dis. 2009;42:252-61 pubmed publisher
    ..It is suggested that MR represents a type of general cell reaction that occurs upon exposure to low ionic strength...
  21. Gungor F, Akyol K, Kesapli M, Celik A, Karaca A, Bozdemir M, et al. Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial. Cephalalgia. 2016;36:179-84 pubmed publisher
    ..Intravenous dexketoprofen is superior to placebo in relieving migraine headaches in the ED. It may be a suitable therapy with minimum side effects in patients presenting with a migraine headache to the ED. ..
  22. Mukherjee K, Bhattacharyya J, Sen J, Sistla R, Chaudhuri A. Covalent grafting of common trihydroxymethylaminomethane in the headgroup region imparts high serum compatibility and mouse lung transfection property to cationic amphiphile. J Med Chem. 2008;51:1967-71 pubmed publisher
  23. Riesová M, Hruska V, Gas B. A nonlinear electrophoretic model for PeakMaster: II. experimental verification. Electrophoresis. 2012;33:931-7 pubmed publisher
    ..We demonstrate that the results obtained in real experiments agree well with those calculated by PeakMaster 5.3...
  24. Le Gac S, Marrot J, Reinaud O, Jabin I. Allosterically coupled double induced fit for 1+1+1+1 self-assembly of a calix[6]trisamine, a calix[6]trisacid, and their guests. Angew Chem Int Ed Engl. 2006;45:3123-6 pubmed
  25. Isaka M, Imamura M, Sakuma I, Shiiya N, Fukushima S, Nakai K, et al. Cardioprotective effect of perfluorochemical emulsion for cardiac preservation after six-hour cold storage. ASAIO J. 2005;51:434-9 pubmed
    ..01). This study suggests that PFOB emulsion is beneficial for the cardioprotection of donor hearts, allowing a prolonged cardiac storage time...
  26. Chen Y, Lu X, Han Z, Qi L, Wang M, Yu X, et al. Chiral ion-exchange capillary electrochromatography of arylglycine amides with dextran sulfate as a pseudostationary phase. Electrophoresis. 2005;26:833-40 pubmed
    ..The amido group was shown irreplaceable to have chiral resolution with DS alone as an ionic and chiral pseudostationary phase...
  27. Chen Y, Zhang J, Zhang L, Chen G. Separation of dipeptides with two chiral centers using 2-hydroxypropyl-beta-CD-modified MEKC. Electrophoresis. 2010;31:1493-7 pubmed publisher
    ..Good separation of all enantiomers was obtained within 14 min. The proposed method was applied to chiral separation of dipeptide enantiomers in spiked human serum samples...
  28. Wathier M, Polidori A, Ruiz K, Fabiano A, Pucci B. Stabilization of polymerized vesicular systems: an application of the dynamic molecular shape concept. Chem Phys Lipids. 2002;115:17-37 pubmed
    ..The drug encapsulation ability of these systems was investigated by measurement of the release kinetics of a fluorescent dye, carboxyfluorescein (CF), before and after polymerization...
  29. De Luna Bertos E, Ramos Torrecillas J, Garcia Martinez O, Guildford A, Santin M, Ruiz C. Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential. ScientificWorldJournal. 2013;2013:809891 pubmed publisher
    ..The results of this paper provide evidences that NSAIDs inhibit the osteoblast differentiation process thus reducing their ability to produce new bone mineralized extracellular matrix...
  30. Zhang J, Xu X, Yang X. Role of Tris on the colorimetric recognition of anions with melamine-modified gold nanoparticle probe and the visual detection of sulfite and hypochlorite. Analyst. 2012;137:3437-40 pubmed publisher
    ..Colorimetric recognition and sensing of sulfite by melamine-modified gold nanoparticle is reported, using Tris-HCl as the operating buffer. Furthermore, indirect determination of hypochlorite is accomplished by its oxidation of sulfite...
  31. Ma J, Chen C, Wang D, Jiao Y, Shi J. Effect of magnesia on the degradability and bioactivity of sol-gel derived SiO2-CaO-MgO-P2O5 system glasses. Colloids Surf B Biointerfaces. 2010;81:87-95 pubmed publisher
    ..The influences of the composition upon glass properties are explained in terms of their internal structures...
  32. Bedrov I, Dvoretskii D, Cherniavskaia G. [Responses of isolated arterial segment to a slow changing of perfusion pressure in it]. Ross Fiziol Zh Im I M Sechenova. 2004;90:1145-50 pubmed
    ..The data obtained prompt a further deciphering of mechanisms of the mechanogenic regulation of the blood vessels...
  33. Heiner Z, Osvay K. Refractive index of dark-adapted bacteriorhodopsin and tris(hydroxymethyl)aminomethane buffer between 390 and 880 nm. Appl Opt. 2009;48:4610-5 pubmed
    ..The refractive indices of pure bR(WT) as well as of TRIS buffer have been determined from the concentration dependent refraction values. Sellmeier-type dispersion equations have been fitted for both the TRIS buffer and pure bR(WT)...
  34. Nighswander Rempel S, Kupriyanov V, Shaw R. Assessment of optical path length in tissue using neodymium and water absorptions for application to near-infrared spectroscopy. J Biomed Opt. 2005;10:024023 pubmed
    ..8+/-0.6 mm, based on the intensity of the water absorptions and the known tissue water concentration. These results are strictly valid only for the experimental geometry applied here...
  35. Harsha S, Grischkowsky D. Terahertz (far-infrared) characterization of tris(hydroxymethyl)aminomethane using high-resolution waveguide THz-TDS. J Phys Chem A. 2010;114:3489-94 pubmed publisher
    ..6 K is tracked by measuring the temperature dependence of the transmission spectrum. Resonances with fwhm linewidths as narrow as 12 GHz are obtained. These results provide strong constraints on theoretical modeling...
  36. Chłopecka M, Dziekan N, Mendel M, Bakała A, Małdyk J, Wiechetek M. Evaluation of the time-stability of an alternative research model based on isolated rat gastrointestinal strips. J Physiol Pharmacol. 2007;58 Suppl 3:73-86 pubmed
    ..Thus, the isolated stomach strips can be described as an alternative experimental model of high time-stability during long-term experiments...
  37. Rohanová D, Boccaccini A, Yunos D, Horkavcová D, Březovská I, Helebrant A. TRIS buffer in simulated body fluid distorts the assessment of glass-ceramic scaffold bioactivity. Acta Biomater. 2011;7:2623-30 pubmed publisher
  38. Brody J, Kern S. History and principles of conductive media for standard DNA electrophoresis. Anal Biochem. 2004;333:1-13 pubmed
    ..Such media allow for application of a higher electric field. Applications of DNA electrophoresis can now be reengineered for lower ionic strength, higher field strengths, and lower requirements for heat dissipation...
  39. Thanasarakhan W, Kruanetr S, Deming R, Liawruangrath B, Wangkarn S, Liawruangrath S. Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant. Talanta. 2011;84:1401-9 pubmed publisher
    ..The accuracy was found to be high as the Student's t-values were found to be less than the theoretical ones. The results were compared favorably with those obtained by the conventional spectrophotometric method...
  40. Rejsek K, Formanek P, Pavelka M. Estimation of protease activity in soils at low temperatures by casein amendment and with substitution of buffer by demineralized water. Amino Acids. 2008;35:411-7 pubmed
  41. Gehlbach B, Schmidt G. Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers. Crit Care. 2004;8:259-65 pubmed
    ..The evidence supporting and refuting attempts to correct arterial pH through the administration of currently available buffers is presented...
  42. Krumova S, Dijkema C, de Waard P, van As H, Garab G, van Amerongen H. Phase behavior of phosphatidylglycerol in spinach thylakoid membranes as revealed by 31P-NMR. Biochim Biophys Acta. 2008;1778:997-1003 pubmed publisher
    ..Thus, our data show that the location of the phospholipids is not restricted to the bilayer phase and that the lamellar phase co-exists with a non-bilayer isotropic phase...
  43. Liu C, Chen T, Misra T. A macrocyclic polyamine as an anion receptor in the capillary electrochromatographic separation of carbohydrates. J Chromatogr A. 2007;1154:407-15 pubmed
  44. Bonfiglio G, Mattina R, Lanzafame A, Cammarata E, Tempera G. Fosfomycin tromethamine in uncomplicated urinary tract infections: a clinical study. Chemotherapy. 2005;51:162-6 pubmed
    The aim of our study was to verify if the empiric therapy with a single dose of 3 g fosfomycin tromethamine in patients with uncomplicated urinary tract infections (UTIs) was able to clinically resolveand to microbiologically eradicate ..
  45. Davey R, Davey M, Cullen K, Wells X, Francis C, Williams H, et al. The use of Tris-lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1. Br J Pharmacol. 2002;137:1280-6 pubmed
    ..5. Tris-Lipidation may therefore provide a useful way of manipulating the pharmacokinetic properties of drugs...
  46. Berke G, Neubauer J, Berry D, Ye M, Chhetri D. Ex vivo perfused larynx model of phonation: preliminary study. Ann Otol Rhinol Laryngol. 2007;116:866-70 pubmed
    ..Our aim was to develop an ex vivo larynx model of phonation, and combine the benefits of the in vivo and excised laryngeal models to the ex vivo situation...
  47. Tuncer S, Tavlan A, Köstekçi H, Reisli R, Otelcioglu S. [Postoperatif a?rida deksketoprofen kullanimi]. Agri. 2006;18:30-5 pubmed
    ..05). We conclude that the preoperative and postoperative administration of dexketoprofen provided a significant analgesic benefit and decreased the opioid requirements in patients undergoing abdominal hysterectomy...
  48. Sun H, Wang H, Kwon W, Kim Y, In J, Yang D. A simple and rapid technique for the authentication of the ginseng cultivar, Yunpoong, using an SNP marker in a large sample of ginseng leaves. Gene. 2011;487:75-9 pubmed publisher
    ..Thus, this strategy provides a rapid and reliable method for the specific identification of Yunpoong in a large number of samples...
  49. Oliveira K, Miranda S, Leão D, Brito A, Santos R, Domingues S. Semen coagulum liquefaction, sperm activation and cryopreservation of capuchin monkey (Cebus apella) semen in coconut water solution (CWS) and TES-TRIS. Anim Reprod Sci. 2011;123:75-80 pubmed publisher
    ..For cryopreservation of semen from C. apella TES-TRIS (3.5% glycerol) was more appropriate than CWS (2.5% glycerol). CWS+caffeine potentially increase sperm motility and may be useful in artificial insemination of fresh diluted semen...
  50. Zhang Y, Wang J, Okamoto Y, Tokeshi M, Kaji N, Baba Y. Velocity gap theory developed for magnifying resolutions without changing separation mechanisms or separation lengths. Anal Chem. 2009;81:2745-50 pubmed publisher
    ..Our results indicate that VG effect could enlarge the distance between two moving objects and may potentially be utilized to ameliorate separation efficiency...
  51. Mold M, Shrive A, Exley C. Serum amyloid P component accelerates the formation and enhances the stability of amyloid fibrils in a physiologically significant under-saturated solution of amyloid-?42. J Alzheimers Dis. 2012;29:875-81 pubmed publisher
    ..Our observations support serum amyloid P component as a therapeutic target in Alzheimer's disease...
  52. Gil M, Abeydeera L, Day B, Vazquez J, Roca J, Martinez E. Effect of the volume of medium and number of oocytes during in vitro fertilization on embryo development in pigs. Theriogenology. 2003;60:767-76 pubmed
    ..These results indicate that when 2000 spermatozoa/oocyte were used, a low volume of IVF medium (0.1 ml) and the number of oocytes during IVF (30-50) can improve the in vitro embryo production in pigs...
  53. Das J. Photoincorporation of azialcohol to the C1B domain of PKCdelta is buffer dependent. J Photochem Photobiol B. 2009;95:185-8 pubmed publisher
    ..This observation will be useful in selecting buffer system for biochemical studies on PKC...