polysorbates

Summary

Summary: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Top Publications

  1. Fukase H, Furuie H, Yasuda Y, Komatsu R, Matsushita K, Minami T, et al. Assessment of the immunogenicity and safety of varying doses of an MF59®-adjuvanted cell culture-derived A/H1N1 pandemic influenza vaccine in Japanese paediatric, adult and elderly subjects. Vaccine. 2012;30:5030-7 pubmed publisher
  2. Ménard N, Tsapis N, Poirier C, Arnauld T, Moine L, Lefoulon F, et al. Drug solubilization and in vitro toxicity evaluation of lipoamino acid surfactants. Int J Pharm. 2012;423:312-20 pubmed publisher
    ..Although these solubilizers are promising, a compromise between drug solubilization and toxicity remains to be found...
  3. Heikkinen T, Young J, Van Beek E, Franke H, Verstraeten T, Weil J, et al. Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. Am J Obstet Gynecol. 2012;207:177.e1-8 pubmed publisher
    ..The 2009-2010 A/H1N1 pandemic provided a unique setting to study the safety of MF59-adjuvanted vaccination in pregnancy...
  4. Galli G, Hancock K, Hoschler K, DeVos J, Praus M, Bardelli M, et al. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc Natl Acad Sci U S A. 2009;106:7962-7 pubmed publisher
    ..These results suggest that pre-pandemic vaccination strategies should be considered...
  5. Kerwin B. Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways. J Pharm Sci. 2008;97:2924-35 pubmed
    b>Polysorbates 20 and 80 (Tween 20 and Tween 80) are used in the formulation of biotherapeutic products for both preventing surface adsorption and as stabilizers against protein aggregation...
  6. Thirumangalathu R, Krishnan S, Ricci M, Brems D, Randolph T, Carpenter J. Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. J Pharm Sci. 2009;98:3167-81 pubmed publisher
    ..A formulation strategy involving optimization of colloidal stability of the antibody as well as incorporation of surfactants such as polysorbate 20 is proposed to reduce silicone oil-induced aggregation of therapeutic protein products...
  7. Andrews N, Waight P, Yung C, Miller E. Age-specific effectiveness of an oil-in-water adjuvanted pandemic (H1N1) 2009 vaccine against confirmed infection in high risk groups in England. J Infect Dis. 2011;203:32-9 pubmed publisher
    ..The use of a squalene-containing (AS03) pandemic vaccine for high-risk groups in England allowed vaccine effectiveness (VE) of such novel oil-in-water adjuvanted vaccine to be evaluated...
  8. Wei J, Ho H, Chen C, Ke W, Chen E, Sheu M. Characterisation of fenofibrate dissolution delivered by a self-microemulsifying drug-delivery system. J Pharm Pharmacol. 2010;62:1685-96 pubmed publisher
    ..This study attempted to characterise the in-vitro release profiles of fenofibrate (FFB) from a self-microemulsifying drug-delivery system (SMEDDS) for optimising formulation factors and dissolution conditions for in-vivo absorption...
  9. Wang W, Wang Y, Wang D. Dual effects of Tween 80 on protein stability. Int J Pharm. 2008;347:31-8 pubmed
    ..Addition of 0.1% Tween 80 not only increased the rate of oxidation in general but also altered the temperature-dependency of IL-2 mutein oxidation...

More Information

Publications62

  1. Durando P, Icardi G, Ansaldi F. MF59-adjuvanted vaccine: a safe and useful tool to enhance and broaden protection against seasonal influenza viruses in subjects at risk. Expert Opin Biol Ther. 2010;10:639-51 pubmed publisher
    ..The protection offered by non-adjuvanted vaccines may be further reduced by periodic antigenic drifts...
  2. Ray R, Meyer K, Banerjee A, Basu A, Coates S, Abrignani S, et al. Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins. J Infect Dis. 2010;202:862-6 pubmed publisher
    ..Neutralizing serum samples had increased affinity levels and displayed >2-fold higher specific activity levels to well-characterized epitopes on E1/E2, especially to the hypervariable region 1 of E2...
  3. Madhun A, Akselsen P, Sjursen H, Pedersen G, Svindland S, Nøstbakken J, et al. An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. Vaccine. 2010;29:266-73 pubmed publisher
    ..A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic...
  4. Ansaldi F, Canepa P, Parodi V, Bacilieri S, Orsi A, Compagnino F, et al. Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection. Vaccine. 2009;27:3345-8 pubmed publisher
    ..Promising results were obtained using a new generation of oil-in-water emulsion adjuvants, named AS, offering cross-protection against heterologous challenge in ferrets...
  5. Stoops J, Arora R, Armitage L, Wanger A, Song L, Blackburn M, et al. Certain surfactants show promise in the therapy of pulmonary tuberculosis. In Vivo. 2010;24:687-94 pubmed
    ..This protective barrier was removed by exposing the bacteria to certain surfactants...
  6. Mosca F, Tritto E, Muzzi A, Monaci E, Bagnoli F, Iavarone C, et al. Molecular and cellular signatures of human vaccine adjuvants. Proc Natl Acad Sci U S A. 2008;105:10501-6 pubmed publisher
    ..We propose that oil-in-water emulsions are the most efficient human vaccine adjuvants, because they induce an early and strong immunocompetent environment at the injection site by targeting muscle cells...
  7. Pass R, Zhang C, Evans A, Simpson T, Andrews W, Huang M, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med. 2009;360:1191-9 pubmed publisher
    ..Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns...
  8. Wilson B, Samanta M, Santhi K, Kumar K, Paramakrishnan N, Suresh B. Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease. Brain Res. 2008;1200:159-68 pubmed publisher
    ..82 fold by binding to poly(n-butylcyanoacrylate) nanoparticles coated with 1% nonionic surfactant polysorbate 80...
  9. O Hagan D, Wack A, Podda A. MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans: what did we learn during its development?. Clin Pharmacol Ther. 2007;82:740-4 pubmed
    ..The main lesson learned is that mouse models can be valuable, but one must ask the right questions and the models must be used appropriately...
  10. O Hagan D, Rappuoli R, De Gregorio E, Tsai T, Del Giudice G. MF59 adjuvant: the best insurance against influenza strain diversity. Expert Rev Vaccines. 2011;10:447-62 pubmed publisher
  11. O Hagan D. MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. Expert Rev Vaccines. 2007;6:699-710 pubmed
    ..MF59 has been shown to be more potent for both antibody and T-cell responses than aluminum-based adjuvants. MF59 has broad potential to be used as a safe and effective vaccine adjuvant for a wide range of vaccine types...
  12. Clark T, Pareek M, Hoschler K, Dillon H, Nicholson K, Groth N, et al. Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine. N Engl J Med. 2009;361:2424-35 pubmed publisher
    ..The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first pandemic of the 21st century. Development of effective vaccines is a public health priority...
  13. El Sahly H. MF59™ as a vaccine adjuvant: a review of safety and immunogenicity. Expert Rev Vaccines. 2010;9:1135-41 pubmed publisher
    ..Currently, MF59 is under evaluation as an adjuvant with other antigens such as pandemic influenza antigens and cytomegalovirus antigens...
  14. Atmar R, Keitel W, Patel S, Katz J, She D, El Sahly H, et al. Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations. Clin Infect Dis. 2006;43:1135-42 pubmed
    ..Influenza A/H9N2 viruses can infect humans and are considered to be a pandemic threat. Effective vaccines are needed for these and other avian influenza viruses...
  15. Zhang H, Cui Y, Zhu S, Feng F, Zheng X. Characterization and antimicrobial activity of a pharmaceutical microemulsion. Int J Pharm. 2010;395:154-60 pubmed publisher
  16. Gasparini R, Schioppa F, Lattanzi M, Barone M, Casula D, Pellegrini M, et al. Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvanted H1N1v vaccine (Focetria) in adult and elderly subjects. Int J Clin Pract. 2010;64:432-8 pubmed publisher
    ..We investigated prior seasonal vaccination in adult and elderly subjects, and concomitant vaccination with seasonal vaccine in adults, on the tolerability and immunogenicity of the Novartis MF59-adjuvanted H1N1v vaccine, Focetria...
  17. Tsai T, Kyaw M, Novicki D, Nacci P, Rai S, Clemens R. Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. Vaccine. 2010;28:1877-80 pubmed publisher
    ..Further data will be forthcoming from planned post-licensure studies of adjuvanted H1N1 vaccines as they are distributed in the pandemic response...
  18. Zhang H, Shen Y, Weng P, Zhao G, Feng F, Zheng X. Antimicrobial activity of a food-grade fully dilutable microemulsion against Escherichia coli and Staphylococcus aureus. Int J Food Microbiol. 2009;135:211-5 pubmed publisher
    ..This work suggests the potential use of food-grade fully dilutable microemulsions for antimicrobial purposes in beverages or seafood products...
  19. Galli G, Medini D, Borgogni E, Zedda L, Bardelli M, Malzone C, et al. Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. Proc Natl Acad Sci U S A. 2009;106:3877-82 pubmed publisher
    ..We suggest that CD4(+) T cell priming might be used as an early predictor of the immunogenicity of prepandemic vaccines...
  20. Ema M, Hara H, Matsumoto M, Hirata Koizumi M, Hirose A, Kamata E. Evaluation of developmental neurotoxicity of polysorbate 80 in rats. Reprod Toxicol. 2008;25:89-99 pubmed
    ..Histopathological examinations of the brain revealed no toxicological changes. Lowered body weight was observed in male and female offspring at 7.5%. The NOAEL in this study was considered to be 1.0% (1.864ml/mg/kgbw/day)...
  21. Ansaldi F, Bacilieri S, Durando P, Sticchi L, Valle L, Montomoli E, et al. Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. Vaccine. 2008;26:1525-9 pubmed publisher
    ..Thus, MF59-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations...
  22. Seubert A, Monaci E, Pizza M, O Hagan D, Wack A. The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. J Immunol. 2008;180:5402-12 pubmed
  23. Wilson B, Samanta M, Santhi K, Kumar K, Paramakrishnan N, Suresh B. Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles. Eur J Pharm Biopharm. 2008;70:75-84 pubmed publisher
    ..In conclusion, the present study demonstrates that the brain concentration of intravenously injected tacrine can be enhanced by binding to poly(n-butylcyanoacrylate) nanoparticles, coated with 1% the nonionic surfactant polysorbate 80...
  24. Hickey S, Hagan S, Kudryashov E, Buckin V. Analysis of phase diagram and microstructural transitions in an ethyl oleate/water/Tween 80/Span 20 microemulsion system using high-resolution ultrasonic spectroscopy. Int J Pharm. 2010;388:213-22 pubmed publisher
  25. Gonzalez Mira E, Egea M, Garcia M, Souto E. Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. Colloids Surf B Biointerfaces. 2010;81:412-21 pubmed publisher
    ..The developed systems were shown physico-chemically stable with high tolerance for eye instillation...
  26. Wang C, Huang L, Hou L, Jiang L, Yan Z, Wang Y, et al. Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model. Brain Res. 2009;1261:91-9 pubmed publisher
    ..05). Taken together, 1% polysorbate-80 coated GCTB-PBCA-NPs can effectively inhibit the growth of C6 glioma cells in vitro and enhance antitumor activity on brain tumor in vivo...
  27. Banzhoff A, Gasparini R, Laghi Pasini F, Staniscia T, Durando P, Montomoli E, et al. MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. PLoS ONE. 2009;4:e4384 pubmed publisher
    ..Pathogenic avian influenza virus (H5N1) has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic memory and broad heterotypic response are needed...
  28. Frey S, Houghton M, Coates S, Abrignani S, Chien D, Rosa D, et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. Vaccine. 2010;28:6367-73 pubmed publisher
    ..We describe the first in humans clinical trial of this prophylactic HCV vaccine...
  29. Pellegrini M, Nicolay U, Lindert K, Groth N, Della Cioppa G. MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database. Vaccine. 2009;27:6959-65 pubmed publisher
    ..Adding adjuvants such as MF59((R)) to influenza vaccines can enhance the immune response. This analysis evaluated the safety profile of MF59-adjuvanted [(+)MF59] compared with non-adjuvanted [(-)MF59] vaccines in a large clinical database...
  30. Cheong H, Song J, Heo J, Noh J, Choi W, Park D, et al. Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine. Clin Vaccine Immunol. 2011;18:1358-64 pubmed publisher
    ..75-?g, MF59 adjuvanted vaccine priming schedule. Following a two-dose priming schedule, the increase in hemagglutinin inhibition titers was higher with MF59 adjuvanted vaccine than with nonadjuvanted vaccine...
  31. Weyenberg W, Filev P, Van den Plas D, Vandervoort J, De Smet K, Sollie P, et al. Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. Int J Pharm. 2007;337:291-8 pubmed
    ..Survival of macrophages was highly affected by stearic acid and stearylamine. In general a viability of more than 90% was observed when semi-synthetic glycerides or hard fat was employed to formulate nanoparticles...
  32. Attama A, Muller Goymann C. Investigation of surface-modified solid lipid nanocontainers formulated with a heterolipid-templated homolipid. Int J Pharm. 2007;334:179-89 pubmed
    ..The result of this study also shows a method of improving natural lipids for use in particulate drug delivery systems...
  33. Black S, Della Cioppa G, Malfroot A, Nacci P, Nicolay U, Pellegrini M, et al. Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis. Vaccine. 2010;28:7331-6 pubmed publisher
    ..These data support the safety of MF59-adjuvanted influenza vaccines in the pediatric population...
  34. Calabro S, Tortoli M, Baudner B, Pacitto A, Cortese M, O Hagan D, et al. Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine. 2011;29:1812-23 pubmed publisher
    ..Further studies will reveal whether other single cell types are crucial or whether the different recruited cell populations are redundant with overlapping functions...
  35. Song L, Zhang Y, Wang W, Ma L, Liu Y, Hao Y, et al. Microfluidic assay without blocking for rapid HIV screening and confirmation. Biomed Microdevices. 2012;14:631-40 pubmed publisher
    ..Methods like this one will find wide applications in clinical diagnosis and biochemical analysis based on the interactions between pairs of molecules...
  36. Pei G, Zhu Y, Cai X, Shi W, Li H. Surfactant flushing remediation of o-dichlorobenzene and p-dichlorobenzene contaminated soil. Chemosphere. 2017;185:1112-1121 pubmed publisher
    ..Thus, it was confirmed that the biosurfactants saponin and alkyl polyglycoside could be used for remediation of o-DCB and p-DCB contaminated soil. ..
  37. Natarajan S, Lakshmanan P. Effect of processing variables on characterization of ofloxacin loaded lipospheres prepared by melt dispersion technique. Curr Drug Deliv. 2013;10:517-26 pubmed
    ..The optimized liposphere batch was selected and formulated as tablets and evaluated the in vitro drug release profile. These studies showed that ofloxacin loaded lipospheres were able to control the drug release for a period of 16h. ..
  38. Ishak R, Awad G, Zaki N, El Shamy A, Mortada N. A comparative study of chitosan shielding effect on nano-carriers hydrophilicity and biodistribution. Carbohydr Polym. 2013;94:669-76 pubmed publisher
    ..The results proved that although a similarity in surface hydrophilicity, chitosan-stealth NPs showed different pharmacokinetic profile and biodistribution behavior compared to polysorbate-stealth NPs...
  39. Zhang L, Liu Z, Cheng X, Xia Z, Liu Y, Yu Y. Docetaxel-Loaded Lecithoid Nanoparticles with Enhanced Lung Targeting Efficiency and Reduced Systemic Toxicity: Developed by Solid Dispersion and Effervescent Techniques. Chem Pharm Bull (Tokyo). 2017;65:959-966 pubmed publisher
    ..Hence, this work would provide an insight for improving lung delivery efficacy of drugs with reduced systemic toxicity...
  40. Jäpelt K, Johnsen L, Christensen J. Removal of Polysorbate 80 by complexation prior to LC-MS analysis. Anal Bioanal Chem. 2016;408:2303-7 pubmed publisher
    ..The precipitation procedure was tested on a mixture of low molecular weight compounds (e.g. amino acids and non-amino organic acids) and it was shown that none of the tested compounds were precipitated. ..
  41. Izurieta P, Uy Aragon M, Drame M, Vaughn D. Assessment of Prime-boost Vaccination Using an AS03B-adjuvanted Influenza A (H5N1) Vaccine: A Randomized Trial in Children of Three to Less Than Eighteen Years of Age. Pediatr Infect Dis J. 2016;35:e35-47 pubmed publisher
    ..Persistence of immune response and safety of influenza A (H5N1) vaccine adjuvanted with adjuvant system containing ?-tocopherol and squalene in an oil-in-water emulsion (AS03B) were evaluated...
  42. Meng F, Liu C, Chen M, Lu X, Zhao S. [Simultaneous determination of three aminothiols in human plasma by high performance liquid chromatography with gold nanoparticle enrichment]. Se Pu. 2012;30:1056-61 pubmed
    ..The results showed that the levels of Hcys and GSH had significant differences between the patients and the controls, while that of Cys had no significant difference...
  43. Queruau Lamerie T, Nussbaumer S, Decaudin B, Fleury Souverain S, Goossens J, Bonnabry P, et al. Evaluation of decontamination efficacy of cleaning solutions on stainless steel and glass surfaces contaminated by 10 antineoplastic agents. Ann Occup Hyg. 2013;57:456-69 pubmed publisher
    ..This study was designed to assess the potential of several chemical solutions to decontaminate two types of work surfaces that were intentionally contaminated with antineoplastic drugs...
  44. Violante T, Haase E, Vickerman M. Collagen-binding streptococcal surface proteins influence the susceptibility of biofilm cells to endodontic antimicrobial solutions. J Endod. 2013;39:370-4 pubmed publisher
  45. Devenish S, Kaltenbach M, Fischlechner M, Hollfelder F. Droplets as reaction compartments for protein nanotechnology. Methods Mol Biol. 2013;996:269-86 pubmed publisher
  46. Sotthivirat S, McKelvey C, Moser J, Rege B, Xu W, Zhang D. Development of amorphous solid dispersion formulations of a poorly water-soluble drug, MK-0364. Int J Pharm. 2013;452:73-81 pubmed publisher
    ..The physical stability of both the solid dispersion formulations was also evaluated for 54 weeks under different conditions. The copovidone-based solid dispersion requires protection from moisture. ..
  47. Calabro S, Tritto E, Pezzotti A, Taccone M, Muzzi A, Bertholet S, et al. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. Vaccine. 2013;31:3363-9 pubmed publisher
    ..These observations may have important implications in the design of optimal emulsion-based vaccine adjuvants. ..
  48. Poder A, Simurka P, Li P, Roy Ghanta S, Vaughn D. An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. Vaccine. 2014;32:1121-9 pubmed publisher
  49. Chen W, Jackson L, Edwards K, Keitel W, Hill H, Noah D, et al. Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant. Clin Vaccine Immunol. 2016;23:73-7 pubmed publisher
    ..We previously reported the immunogenicity of an A/H5N1 vaccine extemporaneously mixed with the AS03 adjuvant for 42 days following vaccination. This report extends those findings to 1 year after vaccination. ..
  50. Khan W, Aldouby Y, Avramoff A, Domb A. Cyclosporin nanosphere formulation for ophthalmic administration. Int J Pharm. 2012;437:275-6 pubmed publisher
    ..Results obtained demonstrated that proposed CsA-NS formulation causes less irritation in rabbit eyes, with nearly same CsA penetration in the rabbit eyes in comparison to marketed emulsion formulation...
  51. Bhattacharya D, Samanta S, Mukherjee A, Santra C, Ghosh A, Niyogi S, et al. Antibacterial activities of polyethylene glycol, tween 80 and sodium dodecyl sulphate coated silver nanoparticles in normal and multi-drug resistant bacteria. J Nanosci Nanotechnol. 2012;12:2513-21 pubmed
    ..Thus our present investigation implicates the potential therapeutic use of silver nanoparticles as antibacterial agent particularly the polyethylene glycol coated one...
  52. Mnif I, Sahnoun R, Ellouze Chaabouni S, Ghribi D. Evaluation of B. subtilis SPB1 biosurfactants' potency for diesel-contaminated soil washing: optimization of oil desorption using Taguchi design. Environ Sci Pollut Res Int. 2014;21:851-61 pubmed publisher
    ..This study can be complemented with the investigation of potential role in improving the biodegradation of the diesel adsorbed to the soil...
  53. Serno T, Hartl E, Besheer A, Miller R, Winter G. The role of polysorbate 80 and HP?CD at the air-water interface of IgG solutions. Pharm Res. 2013;30:117-30 pubmed publisher
    To test the hypothesis of surface displacement as the underlying mechanism for IgG stabilization by polysorbates and HP?CD against surface-induced aggregation.