bisoprolol

Summary

Summary: A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.

Top Publications

  1. Horikiri Y, Suzuki T, Mizobe M. Pharmacokinetics and metabolism of bisoprolol enantiomers in humans. J Pharm Sci. 1998;87:289-94 pubmed
    The plasma concentrations and urinary excretions of bisoprolol enantiomers in four Japanese male healthy volunteers after a single oral administration of 20 mg of racemic bisoprolol were evaluated...
  2. de Groote P, Delour P, Lamblin N, Dagorn J, Verkindère C, Tison E, et al. Effects of bisoprolol in patients with stable congestive heart failure. Ann Cardiol Angeiol (Paris). 2004;53:167-70 pubmed
    To analyze the effect of bisoprolol in patients with stable congestive heart failure and who tolerated beta-blockers.
  3. Lawson G, Cocks E, Tanna S. Bisoprolol, ramipril and simvastatin determination in dried blood spot samples using LC-HRMS for assessing medication adherence. J Pharm Biomed Anal. 2013;81-82:99-107 pubmed publisher
    ..resolution mass spectrometry (LC-HRMS) method was developed and validated for the determination of bisoprolol, ramipril and simvastatin...
  4. Joshi S, Karbhari P, Bhoir S, Bindu K, Das C. RP-HPLC method for simultaneous estimation of bisoprolol fumarate and hydrochlorothiazide in tablet formulation. J Pharm Biomed Anal. 2010;52:362-71 pubmed publisher
    ..precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of bisoprolol fumarate and hydrochlorothiazide in pharmaceutical dosage form...
  5. Tahara K, Kagawa Y, Takaai M, Taguchi M, Hashimoto Y. Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 Cells. Drug Metab Pharmacokinet. 2008;23:340-6 pubmed
    To evaluate the mechanism responsible for the tubular secretion of bisoprolol, we compared transcellular transport of bisoprolol with that of tetraethylammonium (TEA), cimetidine, and quinidine across LLC-PK1 cell monolayers grown on ..
  6. Agostoni P, Contini M, Cattadori G, Apostolo A, Sciomer S, Bussotti M, et al. Lung function with carvedilol and bisoprolol in chronic heart failure: is beta selectivity relevant?. Eur J Heart Fail. 2007;9:827-33 pubmed
    Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence...
  7. Ding L, Zhou X, Guo X, Song Q, He J, Xu G. LC-ESI-MS method for the determination of bisoprolol in human plasma. J Pharm Biomed Anal. 2007;44:520-5 pubmed
    ..ionization-mass spectrometry (LC-ESI-MS) method has been developed and validated for the determination of bisoprolol in human plasma, using metoprolol as internal standard (I.S.)...
  8. Nozawa T, Taguchi M, Tahara K, Hashimoto Y, Igarashi N, Nonomura M, et al. Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol. J Cardiovasc Pharmacol. 2005;46:713-20 pubmed
    ..rate to isoproterenol (IP) were studied at its peak and trough concentrations and were compared with those of bisoprolol. In 72 patients treated with metoprolol or bisoprolol, CYP2D6 genotype (ie, CYP2D6*1, *2, *4, *5, *10, and *14) ..
  9. de Man F, Handoko M, van Ballegoij J, Schalij I, Bogaards S, Postmus P, et al. Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail. 2012;5:97-105 pubmed publisher
    ..We therefore investigated whether chronic low-dose treatment with bisoprolol (a cardioselective ?-blocker) has beneficial effects on cardiac function in experimental PH.

More Information

Publications62

  1. Bundkirchen A, Brixius K, Bölck B, Nguyen Q, Schwinger R. Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies. Eur J Pharmacol. 2003;460:19-26 pubmed
    ..The present study compared the beta(1)-adrenoceptor selectivity of nebivolol and bisoprolol with that of carvedilol in the human myocardium, using a binding assay in conjunction with either the ..
  2. Erdmann E, Lechat P, Verkenne P, Wiemann H. Results from post-hoc analyses of the CIBIS II trial: effect of bisoprolol in high-risk patient groups with chronic heart failure. Eur J Heart Fail. 2001;3:469-79 pubmed
    The beneficial effects of the beta-blocker bisoprolol on mortality and rate of hospitalisation as well as its safety in patients with chronic heart failure has been proven...
  3. Taniguchi T, Ohtani T, Mizote I, Kanzaki M, Ichibori Y, Minamiguchi H, et al. Switching from carvedilol to bisoprolol ameliorates adverse effects in heart failure patients with dizziness or hypotension. J Cardiol. 2013;61:417-22 pubmed publisher
    ..The aim of this study was to examine whether switching to bisoprolol from carvedilol would help to avoid adverse symptoms and signs related to carvedilol administration.
  4. Düngen H, Apostolovic S, Inkrot S, Tahirović E, Töpper A, Mehrhof F, et al. Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial. Eur J Heart Fail. 2011;13:670-80 pubmed publisher
    ..The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure...
  5. de Groote P, Ennezat P, Mouquet F. Bisoprolol in the treatment of chronic heart failure. Vasc Health Risk Manag. 2007;3:431-9 pubmed
    b>Bisoprolol fumarate is a highly selective beta-1 receptor blocker. Bisoprolol has been extensively studied in three large mortality trials in stable chronic heart failure (CHF) patients...
  6. Neal D, Brown M, Wilkinson I, Byrne C, Alexander G. Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation. Transplantation. 2004;77:748-50 pubmed
    ..Hypertension is common after liver transplantation. There are few published data on optimum treatment. Augmentation index (AIx) is a measure of arterial wave reflection determined by pulse wave analysis...
  7. Belenkov I, Skvortsov A, Mareev V, Nasonova S, Sychev A, Narusov O, et al. [Clinical, hemodynamic and neurohumoral effects of long-term therapy of patients with severe chronic heart failure with beta-adrenoblocker bisoprolol]. Kardiologiia. 2003;43:10-21 pubmed
    ..However basic mechanisms of these positive effects in severe heart failure remain to be elucidated...
  8. Poldermans D, Boersma E, Bax J, Thomson I, Paelinck B, van de Ven L, et al. Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery. Eur Heart J. 2001;22:1353-8 pubmed
    To assess the long-term cardioprotective effect of bisoprolol in a randomized high-risk population after successful major vascular surgery...
  9. Braza A, Modamio P, Lastra C, Mariño E. Development, validation and analytical error function of two chromatographic methods with fluorimetric detection for the determination of bisoprolol and metoprolol in human plasma. Biomed Chromatogr. 2002;16:517-22 pubmed
    This work describes two high-performance liquid chromatographic methods for the individual determination of bisoprolol and metoprolol in human plasma...
  10. Sezai A, Nakai T, Hata M, Yoshitake I, Shiono M, Kunimoto S, et al. Feasibility of landiolol and bisoprolol for prevention of atrial fibrillation after coronary artery bypass grafting: a pilot study. J Thorac Cardiovasc Surg. 2012;144:1241-8 pubmed publisher
    ..In the present study, we investigated the efficacy of increasing the dose and administration period of landiolol for prevention of postoperative AF, as well as the effect of oral bisoprolol in the early postoperative period.
  11. Funck Brentano C, Lancar R, Hansen S, Hohnloser S, Vanoli E. Predictors of medical events and of their competitive interactions in the Cardiac Insufficiency Bisoprolol Study 2 (CIBIS-2). Am Heart J. 2001;142:989-97 pubmed
    ..factors for medical events and interactions between events were not reported in the Cardiac Insufficiency Bisoprolol Study 2 (CIBIS-2)...
  12. Minami N, Yoshikawa T, Kataoka H, Mori N, Nagasaka M, Kurosawa H, et al. Effects of exercise and beta-blocker on blood pressure and baroreflexes in spontaneously hypertensive rats. Am J Hypertens. 2003;16:966-72 pubmed
    ..This study was undertaken to examine whether the effects of exercise training are additive to beta-blocker in spontaneously hypertensive rats (SHR)...
  13. Liu M, Zhang D, Sun Y, Wang Y, Liu Z, Gu J. Liquid chromatographic-electrospray tandem mass spectrometric determination of bisoprolol in human plasma. Biomed Chromatogr. 2007;21:508-13 pubmed
    An analytical method for the determination of bisoprolol in human plasma has been developed based on liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
  14. Sleilaty G, Madi Jebara S, Yazigi A, Haddad F, Hayeck G, El Rassi I, et al. Postoperative oral amiodarone versus oral bisoprolol as prophylaxis against atrial fibrillation after coronary artery bypass graft surgery: a prospective randomized trial. Int J Cardiol. 2009;137:116-22 pubmed publisher
    ..Amiodarone and beta blockers are effective as prophylaxis for AF after CABG. The purpose of this study was to compare oral amiodarone versus oral bisoprolol for prevention of AF after CABG.
  15. Dunkelgrun M, Boersma E, Schouten O, Koopman van Gemert A, van Poorten F, Bax J, et al. Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV). Ann Surg. 2009;249:921-6 pubmed publisher
    ..This study evaluated the effectiveness and safety of beta-blockers and statins for the prevention of perioperative cardiovascular events in intermediate-risk patients undergoing noncardiovascular surgery...
  16. Schuchert A. Effects of bisoprolol treatment for chronic heart failure initiated and followed up by primary care physicians. Eur J Heart Fail. 2005;7:604-11 pubmed
    ..The aims of the study were to assess the effects of beta-blocker treatment in out-clinic patients with regard to NYHA class and frequency of adverse events. Beta-blocker treatment was initiated and followed up by primary care physicians...
  17. Gui H, Guo Y, Liu X, Zhang J, Yang Y, Huang G, et al. Effects of combination therapy with levamlodipine and bisoprolol on stroke in rats. CNS Neurosci Ther. 2013;19:178-82 pubmed publisher
    To examine the effects of combination with levamlodipine and bisoprolol on stroke in rats.
  18. Issa V, Guimarães G, Rezende M, Cruz F, Ferreira S, Bacal F, et al. Effects of bisoprolol on cardiac function and exercise in patients with heart failure. Arq Bras Cardiol. 2007;88:340-5 pubmed
    To assess the effects of bisoprolol on exercise capacity and ventricular function in patients with heart failure.
  19. McGavin J, Keating G. Bisoprolol: a review of its use in chronic heart failure. Drugs. 2002;62:2677-96 pubmed
    b>Bisoprolol is a highly selective beta(1)-adrenoceptor antagonist...
  20. Bristow M. beta-adrenergic receptor blockade in chronic heart failure. Circulation. 2000;101:558-69 pubmed
  21. Yu W, Lou M, Deng B, Song H, Wang H. [Beta1-adrenergic receptor (Arg389Gly) polymorphism and response to bisoprolol in patients with chronic heart failure]. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34:776-80 pubmed
    ..the relation between the Arg389Gly polymorphism of the beta(1)-AR gene and chronic heart failure (CHF) and to evaluate the effect of this polymorphism on clinical response to beta-adrenoceptor blockade (bisoprolol) in patients with CHF.
  22. Ignjatovic V, Petrovic N, Miloradovic V, Ignjatovic S, Cokanovic V, Grdinic A, et al. The influence of bisoprolol dose on ADP-induced platelet aggregability in patients on dual antiplatelet therapy. Coron Artery Dis. 2010;21:472-6 pubmed publisher
    ..b>Bisoprolol is a highly selective adrenoceptor-blocker, which is often used in the settings of percutaneous coronary ..
  23. Leizorovicz A, Lechat P, Cucherat M, Bugnard F. Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies--CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study. Am Heart J. 2002;143:301-7 pubmed
    ..This meta-analysis aims at providing a precise and quantitative estimate of the benefit and risks of long-term bisoprolol on major clinical events in patients with CHF, both overall and in selected subgroups...
  24. Düngen H, Apostolovic S, Inkrot S, Tahirović E, Krackhardt F, Pavlovic M, et al. Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial. Clin Res Cardiol. 2008;97:578-86 pubmed publisher
    ..Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce...
  25. Freitas J, Santos R, Azevedo E, Costa O, Carvalho M, de Freitas A. Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone. Clin Auton Res. 2000;10:293-9 pubmed
    ..The authors investigated the autonomic and hemodynamic profile of patients with POTS and the effectiveness of bisoprolol and fludrocortisone...
  26. Baxter A, Spensley A, Hildreth A, Karimova G, O Connell J, Gray C. Beta blockers in older persons with heart failure: tolerability and impact on quality of life. Heart. 2002;88:611-4 pubmed
    To determine tolerability and symptom changes associated with the introduction of bisoprolol treatment in older patients with heart failure.
  27. Dinicolantonio J, Lavie C, Fares H, Menezes A, O Keefe J. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013;111:765-9 pubmed publisher
    ..was performed of randomized, controlled, direct-comparison trials that included adults receiving atenolol, bisoprolol, metoprolol, nebivolol, or carvedilol to evaluate the effects of carvedilol compared to other BBs on mortality, ..
  28. Marazzi G, Iellamo F, Volterrani M, Caminiti G, Madonna M, Arisi G, et al. Comparison of effectiveness of carvedilol versus bisoprolol for prevention of postdischarge atrial fibrillation after coronary artery bypass grafting in patients with heart failure. Am J Cardiol. 2011;107:215-9 pubmed publisher
    ..In this prospective study, we investigated the effectiveness of the highly selective ?1 receptor antagonist bisoprolol compared to the less selective ? blocker carvedilol in preventing postdischarge AF after CABG in patients with ..
  29. Funck Brentano C, Lancar R, Le Heuzey J, Lardoux H, Soubrie C, Lechat P. Predictors of medical events in patients enrolled in the cardiac insufficiency bisoprolol study (CIBIS): a study of the interactions between beta-blocker therapy and occurrence of critical events using analysis of competitive risks. Am Heart J. 2000;139:262-71 pubmed
    ..of this study was to examine the relations between baseline variables, the interactions between treatment, bisoprolol, or placebo, and the occurrence of critical events during the CIBIS trial, a mortality and morbidity trial of ..
  30. Ichihara S, Yamada Y, Ichihara G, Kanazawa H, Hashimoto K, Kato Y, et al. Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy. Biochem Biophys Res Commun. 2006;350:105-13 pubmed
    ..We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a ..
  31. Galatius S, Gustafsson F, Atar D, Hildebrandt P. Tolerability of beta-blocker initiation and titration with bisoprolol and carvedilol in congestive heart failure -- a randomized comparison. Cardiology. 2004;102:160-5 pubmed
    ..1 +/- 10.6 years, 24% females, LVEF 0.28 +/- 0.10, NYHA III-IV 29%) to treatment with either bisoprolol or carvedilol, in order to assess and compare the maximally achievable number of patients on treatment with ..
  32. Rau T, Düngen H, Edelmann F, Waagstein F, Lainscak M, Dimkovic S, et al. Impact of the ?1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients. Clin Pharmacol Ther. 2012;92:21-8 pubmed publisher
    ..CIBIS-ELD trial determined the impact of the ?1-adrenoceptor Arg189Gly polymorphism on heart-rate responses to bisoprolol or carvedilol in elderly patients with heart failure (421 with sinus rhythm, 107 with atrial fibrillation)...
  33. Kahonen M, Ylitalo R, Koobi T, Turjanmaa V, Ylitalo P. Influences of nonselective, beta(1)-selective and vasodilatory beta(1)-selective beta-blockers on arterial pulse wave velocity in normotensive subjects. Gen Pharmacol. 2000;35:219-24 pubmed
    ..Therefore, influences of single medium doses of bisoprolol, propranolol and celiprolol on PWV were compared in healthy subjects...
  34. Lechat P, Hulot J, Escolano S, Mallet A, Leizorovicz A, Werhlen Grandjean M, et al. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation. 2001;103:1428-33 pubmed
    ..beta-Blockade-induced benefit in heart failure (HF) could be related to baseline heart rate and treatment-induced heart rate reduction, but no such relationships have been demonstrated...
  35. Stoschitzky K, Stoschitzky G, Brussee H, Bonelli C, Dobnig H. Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol. Cardiology. 2006;106:199-206 pubmed
    b>Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly.
  36. Zhang S, He B, Goldstein S, Ge J, Wang Z, Ruiz G. Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention. Can J Physiol Pharmacol. 2011;89:109-15 pubmed publisher
    ..explore the changes in expression of myocardial adiponectin (APN), changes in serum APN, and the significance of bisoprolol intervention in acute myocardial infarction (AMI) rats...
  37. Funck Brentano C, van Veldhuisen D, van de Ven L, Follath F, Goulder M, Willenheimer R. Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial. Eur J Heart Fail. 2011;13:765-72 pubmed publisher
    ..We also assessed the relations between dose levels and baseline variables or adverse events...
  38. Yang Y, Yu L, Wu Z, Yu J, Zhang J, Chen Q, et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012;18:471-4 pubmed publisher
    ..The objective of this work was to study the synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats (SHR).
  39. Papadopoulos D, Papademetriou V. Low-dose fixed combination of bisoprolol/hydrochlorothiazide as first line for hypertension: a review of the rationale and clinical evidence. Angiology. 2009;60:601-7 pubmed publisher
    ..This review summarizes the beneficial effect of low-dose bisoprolol/ hydrochlorothiazide combination in the treatment of patients with stage I and II hypertension.
  40. Nishio M, Sakata Y, Mano T, Ohtani T, Takeda Y, Miwa T, et al. Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats. Eur J Heart Fail. 2008;10:446-53 pubmed publisher
    ..beta-blocker therapy is an established therapeutic strategy for systolic heart failure. However, its benefits in diastolic heart failure (DHF) are controversial...
  41. Willenheimer R, van Veldhuisen D, Silke B, Erdmann E, Follath F, Krum H, et al. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation. 2005;112:2426-35 pubmed
    ..In patients with chronic heart failure (CHF), a beta-blocker is generally added to a regimen containing an angiotensin-converting-enzyme (ACE) inhibitor. It is unknown whether beta-blockade as initial therapy may be as useful...
  42. Taguchi M, Nozawa T, Igawa A, Inoue H, Takesono C, Tahara K, et al. Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients. Biol Pharm Bull. 2005;28:876-81 pubmed
    The nonlinear mixed effects model (NONMEM) was used to analyze the pharmacokinetics of routinely administered bisoprolol in middle-aged and elderly Japanese patients. The subjects consisted of 29 males and 11 females with a mean age of 63...
  43. Schouten O, Poldermans D, Visser L, Kertai M, Klein J, van Urk H, et al. Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study. Am Heart J. 2004;148:1047-52 pubmed
  44. Simon T, Mary Krause M, Funck Brentano C, Jaillon P. Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). Circulation. 2001;103:375-80 pubmed
    ..The Cardiac Insufficiency Bisoprolol Study (CIBIS) II showed that bisoprolol reduced all-cause mortality and morbidity rates in CHF patients treated ..
  45. Odili A, Richart T, Thijs L, Kingue S, Boombhi H, Lemogoum D, et al. Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial. Blood Press. 2011;20:256-66 pubmed publisher
  46. Simon T, Mary Krause M, Funck Brentano C, Lechat P, Jaillon P. Bisoprolol dose-response relationship in patients with congestive heart failure: a subgroup analysis in the cardiac insufficiency bisoprolol study(CIBIS II). Eur Heart J. 2003;24:552-9 pubmed
    ..Whether all patients with congestive heart failure (CHF) need to reach the target dose of beta-blocker to obtain a benefit in terms of survival remains uncertain...
  47. Lechat P, Escolano S, Golmard J, Lardoux H, Witchitz S, Henneman J, et al. Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency BIsoprolol Study (CIBIS). Circulation. 1997;96:2197-205 pubmed
    To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS).
  48. Lainscak M, Podbregar M, Kovacic D, Rozman J, von Haehling S. Differences between bisoprolol and carvedilol in patients with chronic heart failure and chronic obstructive pulmonary disease: a randomized trial. Respir Med. 2011;105 Suppl 1:S44-9 pubmed publisher
    ..This study compared effects of bisoprolol and carvedilol in patients with both conditions.
  49. Czuriga I, Riecansky I, Bodnar J, Fulop T, Kruzsicz V, Kristof E, et al. Comparison of the new cardioselective beta-blocker nebivolol with bisoprolol in hypertension: the Nebivolol, Bisoprolol Multicenter Study (NEBIS). Cardiovasc Drugs Ther. 2003;17:257-63 pubmed
    The aim of the present study was to evaluate the antihypertensive efficacy of the highly beta(1)-selective adrenergic antagonist nebivolol in comparison with bisoprolol in the treatment of mild to moderate essential hypertension.
  50. Vanhees L, Defoor J, Schepers D, Lijnen P, Peeters B, Lacante P, et al. Effect of bisoprolol and atenolol on endurance exercise capacity in healthy men. J Hypertens. 2000;18:35-43 pubmed
    To compare the effects of a highly beta1-selective adrenoceptor antagonist bisoprolol with those of atenolol and placebo on endurance exercise capacity in young, healthy male volunteers.
  51. Prisant L, Neutel J, Ferdinand K, Papademetriou V, DeQuattro V, Hall W, et al. Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks. J Natl Med Assoc. 1999;91:40-8 pubmed
    To assess the efficacy and safety of bisoprolol/6.25-mg hydrochlorothiazide (HCTZ), amlodipine, and enalapril in black and nonblack patients, data from two comparative studies were pooled and subgroup analyses performed...
  52. Konishi M, Haraguchi G, Kimura S, Inagaki H, Kawabata M, Hachiya H, et al. Comparative effects of carvedilol vs bisoprolol for severe congestive heart failure. Circ J. 2010;74:1127-34 pubmed
    Although carvedilol and bisoprolol are effective medicines for the treatment of patients with heart failure (HF), only a few reports have compared their effects...
  53. Dubach P, Myers J, Bonetti P, Schertler T, Froelicher V, Wagner D, et al. Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging. Am Heart J. 2002;143:676-83 pubmed
    ..We examined the effects of bisoprolol fumarate on exercise capacity and left ventricular volume with magnetic resonance imaging (MRI) and applied a ..