atenolol

Summary

Summary: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.

Top Publications

  1. Karaman R, Dajani K, Hallak H. Computer-assisted design for atenolol prodrugs for the use in aqueous formulations. J Mol Model. 2012;18:1523-40 pubmed publisher
    Based on stability studies on the drugs atenolol and propranolol and some of their derivatives it is believed that increasing the lipophilicity of the drug will lead to an increase in the stability of its aqueous solutions and will ..
  2. Filigheddu F, Argiolas G, Degortes S, Zaninello R, Frau F, Pitzoi S, et al. Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. Pharmacogenomics. 2010;11:319-25 pubmed publisher
    ..To analyze the association of haplotypes of the adrenergic system with essential hypertension and with the blood pressure response to beta-blockers...
  3. Kurnik D, Cunningham A, Sofowora G, Kohli U, Li C, Friedman E, et al. GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans. Pharmacogenomics. 2009;10:1581-7 pubmed publisher
    ..We hypothesized that the GRK5 Gln41Leu variant contributes to interindividual variability in response to beta-blockade and to the ethnic difference in sensitivity between black and Caucasian individuals...
  4. Beitelshees A, Gong Y, Bailey K, Turner S, Chapman A, Schwartz G, et al. Comparison of office, ambulatory, and home blood pressure antihypertensive response to atenolol and hydrochlorthiazide. J Clin Hypertens (Greenwich). 2010;12:14-21 pubmed publisher
    ..office BP (OBP), home BP (HBP), and ambulatory BP (ABP) for measuring responses to hydrochlorothiazide (HCTZ), atenolol, and their combination. After completing washout, eligible patients were randomized to atenolol 50 mg or HCTZ 12...
  5. Gupta A, Poulter N, Dobson J, Eldridge S, Cappuccio F, Caulfield M, et al. Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT Trial. Am J Hypertens. 2010;23:1023-30 pubmed publisher
    ..Some studies suggest that blood pressure (BP)-lowering effects of commonly used antihypertensive drugs differ among ethnic groups. However, differences in the response to second-line therapy have not been studied extensively...
  6. Bolbrinker J, Huber M, Scholze J, Kreutz R. Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjects. Fundam Clin Pharmacol. 2009;23:767-74 pubmed publisher
    The aim of this study was to investigate any influence on olmesartan plasma pharmacokinetics from amlodipine or atenolol. We analysed pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol ..
  7. Anroop B, Ghosh B, Parcha V, Khanam J. Transdermal delivery of atenolol: effect of prodrugs and iontophoresis. Curr Drug Deliv. 2009;6:280-90 pubmed
    ..the combined effect of two such techniques, iontophoresis and esterification, on the transdermal delivery of atenolol. A series of ester prodrugs of atenolol were synthesized, characterized and studied for physicochemical ..
  8. Johnson J, Gong Y, Bailey K, Cooper Dehoff R, Chapman A, Turner S, et al. Hydrochlorothiazide and atenolol combination antihypertensive therapy: effects of drug initiation order. Clin Pharmacol Ther. 2009;86:533-9 pubmed publisher
    ..Patients with uncomplicated hypertension were randomized to receive either hydrochlorothiazide (HCTZ) or atenolol monotherapy, followed by addition of the alternative drug...
  9. Forteza A, Evangelista A, Sanchez V, Teixidó G, Garcia D, Sanz P, et al. [Study of the efficacy and safety of losartan versus atenolol for aortic dilation in patients with Marfan syndrome]. Rev Esp Cardiol. 2011;64:492-8 pubmed publisher
    ..The aim of our clinical trial is to assess the efficacy and safety of losartan versus atenolol in the prevention of progressive dilation of the aorta in patients with Marfan syndrome.

More Information

Publications62

  1. Smith S, Gong Y, Turner S, Cooper Dehoff R, Beitelshees A, Chapman A, et al. Blood pressure responses and metabolic effects of hydrochlorothiazide and atenolol. Am J Hypertens. 2012;25:359-65 pubmed publisher
    ..We aimed to determine whether AMEs are correlated with BP response in uncomplicated hypertensives...
  2. Mikami M, Goubaeva F, Song J, Lee H, Yang J. beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. Eur J Pharmacol. 2008;589:14-21 pubmed publisher
    ..effects of three beta-adrenoceptor blockers propranolol (1-(isoproplyamino)-3-(naphthalene-1-yloxy)propan-2-ol), atenolol (2-[4-[2-hydroxy-3-(1-methylethylamino)propoxyl]phenyl]ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-..
  3. Lacro R, Guey L, Dietz H, Pearson G, Yetman A, Gelb B, et al. Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy. Am Heart J. 2013;165:828-835.e3 pubmed publisher
    ..root growth and other short-term cardiovascular outcomes in children and young adults with Marfan syndrome randomized to receive atenolol or losartan. We report here the characteristics of the screened population and enrolled subjects.
  4. Krymchantowski A, Jevoux C, Moreira P. An open pilot study assessing the benefits of quetiapine for the prevention of migraine refractory to the combination of atenolol, nortriptyline, and flunarizine. Pain Med. 2010;11:48-52 pubmed publisher
    ..Accordingly, the aim of this study was to evaluate the use of Quetiapine (QTP) in the preventive treatment of refractory migraine, defined as previous unresponsiveness to the combination of atenolol, nortriptyline, and flunarizine.
  5. Dietz R, Dechend R, Yu C, Bheda M, Ford J, Prescott M, et al. Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2008;9:163-75 pubmed publisher
    ..Aliskiren is the first in a new class of direct renin inhibitors to be approved for the treatment of hypertension...
  6. Salgado R, Pereira V, Carvalho G, Soeiro R, Gaffney V, Almeida C, et al. Photodegradation kinetics and transformation products of ketoprofen, diclofenac and atenolol in pure water and treated wastewater. J Hazard Mater. 2013;244-245:516-27 pubmed publisher
    Pharmaceutical compounds such as ketoprofen, diclofenac and atenolol are frequently detected at relatively high concentrations in secondary effluents from wastewater treatment plants...
  7. Bhushan R, Tanwar S. Different approaches of impregnation for resolution of enantiomers of atenolol, propranolol and salbutamol using Cu(II)-L-amino acid complexes for ligand exchange on commercial thin layer chromatographic plates. J Chromatogr A. 2010;1217:1395-8 pubmed publisher
    b>Atenolol and propranolol (the beta-blocking agents) and salbutamol (broncho- and vasodilator) were resolved into their enantiomers by adopting different modes of loading/impregnating the Cu(II) complexes of L-proline (L-Pro), L-..
  8. Johnson J, Boerwinkle E, Zineh I, Chapman A, Bailey K, Cooper Dehoff R, et al. Pharmacogenomics of antihypertensive drugs: rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study. Am Heart J. 2009;157:442-9 pubmed publisher
    ..Selection of antihypertensive therapy is often empiric, and use of genetic information to guide drug therapy selection holds future promise...
  9. Gullestad L, Pernow J, Bjurö T, Aaberge L, Skårdal R, Kjekshus E, et al. Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease. Scand Cardiovasc J. 2012;46:23-31 pubmed publisher
    To explore possible differential effects between metoprolol and atenolol in patients with coronary artery disease.
  10. Pareek A, Salkar H, Mulay P, Desai S, Chandurkar N, Redkar N. A randomized, comparative, multicentric evaluation of atenolol/amlodipine combination with atenolol alone in essential hypertensive patients. Am J Ther. 2010;17:46-52 pubmed publisher
    ..The primary objective was to demonstrate that atenolol/amlodipine combination therapy is superior to atenolol monotherapy with respect to mean fall in systolic blood ..
  11. Wikoff W, Frye R, Zhu H, Gong Y, Boyle S, Churchill E, et al. Pharmacometabolomics reveals racial differences in response to atenolol treatment. PLoS ONE. 2013;8:e57639 pubmed publisher
    ..a global biochemical approach to investigate biochemical changes induced by the beta-adrenergic receptor blocker atenolol in Caucasians and African Americans...
  12. Télez M, Ortiz Lastra E, Gonzalez A, Flores P, Huerta I, Ramírez J, et al. Assessment of the genotoxicity of atenolol in human peripheral blood lymphocytes: correlation between chromosomal fragility and content of micronuclei. Mutat Res. 2010;695:46-54 pubmed publisher
    The antihypertensive drug atenolol was found to induce chromosome loss, detected as micronuclei in the peripheral lymphocytes of treated patients...
  13. Reyes E, Stirrup J, Roughton M, D Souza S, Underwood S, Anagnostopoulos C. Attenuation of adenosine-induced myocardial perfusion heterogeneity by atenolol and other cardioselective beta-adrenoceptor blockers: a crossover myocardial perfusion imaging study. J Nucl Med. 2010;51:1036-43 pubmed publisher
    ..We sought to investigate the effect of oral beta-blockers on the presence, extent, and severity of myocardial perfusion abnormality induced by adenosine in patients with coronary artery disease...
  14. Navare H, Frye R, Cooper Dehoff R, Shuster J, Hall K, Schmidt S, et al. Atenolol exposure and risk for development of adverse metabolic effects: a pilot study. Pharmacotherapy. 2010;30:872-8 pubmed publisher
    To evaluate whether the level of systemic exposure to atenolol explains observed interindividual differences in adverse metabolic responses.
  15. Han P, Shen F, Xie H, Chen Y, Miao C, Mehta J, et al. The combination of atenolol and amlodipine is better than their monotherapy for preventing end-organ damage in different types of hypertension in rats. J Cell Mol Med. 2009;13:726-34 pubmed publisher
    ..animal models the necessity of adding the calcium channel blocker amlodipine to therapy with the ss-blocker atenolol to modulate end-organ damage...
  16. Shirotani M, Yokota R, Kouchi I, Hirai T, Uemori N, Haba K, et al. Influence of atenolol on coronary artery spasm after acute myocardial infarction in a Japanese population. Int J Cardiol. 2010;139:181-6 pubmed publisher
    ..This study sought to assess the effects of beta-adrenoceptor blockade on coronary vasospasm in Japanese patients with acute MI who had been treated with primary angioplasty...
  17. Kumar V, Malik S, Singh S. Polypill for the treatment of cardiovascular diseases part 2. LC-MS/TOF characterization of interaction/degradation products of atenolol/lisinopril and aspirin, and mechanisms of formation thereof. J Pharm Biomed Anal. 2008;48:619-28 pubmed publisher
    ..e., angiotensin-converting enzyme inhibitor (lisinopril), one among a beta-blocker (atenolol) or diuretic (hydrochlorothiazide), and a statin (simvastatin/atorvastatin/pravatsatin, etc.)...
  18. Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Abriel H, et al. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS ONE. 2009;4:e6610 pubmed publisher
    ..phenotyped either in response to chronic administration of a single dose of the beta-adrenergic receptor blocker atenolol or under a low and a high dose of the beta-agonist isoproterenol and compared to baseline condition...
  19. Marco Urrea E, Radjenovic J, Caminal G, Petrovic M, Vicent T, Barcelo D. Oxidation of atenolol, propranolol, carbamazepine and clofibric acid by a biological Fenton-like system mediated by the white-rot fungus Trametes versicolor. Water Res. 2010;44:521-32 pubmed publisher
    Biological advanced oxidation of the pharmaceuticals clofibric acid (CA), carbamazepine (CBZP), atenolol (ATL) and propranolol (PPL) is reported for the first time...
  20. Lawson G, Cocks E, Tanna S. Quantitative determination of atenolol in dried blood spot samples by LC-HRMS: a potential method for assessing medication adherence. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;897:72-9 pubmed publisher
    ..on the measurement at the accurate mass to charge ratio of the target analyte, was used to ensure specificity for atenolol in the dried blood spot (DBS) samples. A working method was developed and validated...
  21. Dinicolantonio J, Lavie C, Fares H, Menezes A, O Keefe J. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013;111:765-9 pubmed publisher
    ..meta-analysis was performed of randomized, controlled, direct-comparison trials that included adults receiving atenolol, bisoprolol, metoprolol, nebivolol, or carvedilol to evaluate the effects of carvedilol compared to other BBs on ..
  22. Ablad B, Bjurö T, Björkman J, Brax O, Ewaldsson L, Forshult E, et al. Metoprolol, but not atenolol, reduces stress induced neuropeptide Y release in pigs. Scand Cardiovasc J. 2010;44:273-8 pubmed publisher
    To explore if ?-adrenergic receptors in the brain are involved in acute and delayed cardiovascular responses to a brief emotional stress, by comparing the effects of the ?1-blockers metoprolol (lipophilic) and atenolol (hydrophilic).
  23. Sanchez Roman I, Gomez J, Naudi A, Ayala V, Portero Otin M, Lopez Torres M, et al. The ?-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice. Rejuvenation Res. 2010;13:683-93 pubmed publisher
    ..In the present investigation, male C57BL/6 mice were treated with the ?-blocker atenolol in drinking water, and oxidative stress-related parameters were measured in the heart...
  24. Youssef R, Maher H, El Kimary E, Hassan E, Barary M. Validated stability-indicating methods for the simultaneous determination of amiloride hydrochloride, atenolol, and chlorthalidone using HPTLC and HPLC with photodiode array detector. J AOAC Int. 2013;96:313-23 pubmed
    ..chromatographic methods are described for simultaneous determination of amiloride hydrochloride (AMI), atenolol (ATE), and chlorthalidone (CHL) in combined dosage forms...
  25. Trombini M, Hulshof H, Graiani G, Carnevali L, Meerlo P, Quaini F, et al. Early maternal separation has mild effects on cardiac autonomic balance and heart structure in adult male rats. Stress. 2012;15:457-70 pubmed publisher
    ..MS had no effect on cardiac pacemaker intrinsic activity (as revealed by autonomic blockade with scopolamine and atenolol) and did not affect the circadian rhythmicity of heart rate, neither before nor after IRS...
  26. Parakh N, Chaturvedi V, Kurian S, Tyagi S. Effect of ivabradine vs atenolol on heart rate and effort tolerance in patients with mild to moderate mitral stenosis and normal sinus rhythm. J Card Fail. 2012;18:282-8 pubmed publisher
    ..We studied the comparative efficacy of heart rate control with ivabradine or atenolol and its effect on effort tolerance in patients with mild-moderate mitral stenosis in normal sinus rhythm.
  27. Riesen S, Schober K, Cervenec R, Bonagura J. Comparison of the effects of ivabradine and atenolol on heart rate and echocardiographic variables of left heart function in healthy cats. J Vet Intern Med. 2011;25:469-76 pubmed publisher
    ..Ivabradine is a novel negative chronotropic drug used for treatment of ischemic heart disease in people. Little is known about its effects and safety in cats...
  28. Heffernan K, Suryadevara R, Patvardhan E, Mooney P, Karas R, Kuvin J. Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. Clin Cardiol. 2011;34:39-44 pubmed publisher
    We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension.
  29. Ye H, Ling S, Castillo A, Thomas B, Long B, Qian J, et al. Nebivolol induces distinct changes in profibrosis microRNA expression compared with atenolol, in salt-sensitive hypertensive rats. Hypertension. 2013;61:1008-13 pubmed publisher
    ..We compared the effects of nebivolol and atenolol, a first generation ?1-selective blocker, on left ventricular hypertrophy, fibrosis, and function and microRNA ..
  30. McInnes F, Anthony N, Kennedy A, Wheate N. Solid state stabilisation of the orally delivered drugs atenolol, glibenclamide, memantine and paracetamol through their complexation with cucurbit[7]uril. Org Biomol Chem. 2010;8:765-73 pubmed publisher
    The inclusion of the cardiovascular beta-blocker drug atenolol, the antidiabetic drug glibenclamide, the Alzheimer's NMDA glutamate receptor drug memantine and the analgesic/antipyretic drug paracetamol by cucurbit[7]uril (CB[7]) has been ..
  31. Lindgren P, Buxton M, Kahan T, Poulter N, Dahlof B, Sever P, et al. The lifetime cost effectiveness of amlodipine-based therapy plus atorvastatin compared with atenolol plus atorvastatin, amlodipine-based therapy alone and atenolol-based therapy alone: results from ASCOT1. Pharmacoeconomics. 2009;27:221-30 pubmed publisher
    ..Cardiac Outcomes Trial) showed in hypertensive patients that blood pressure-lowering treatment with an amlodipine-based regimen reduces events compared with an atenolol-based regimen and that atorvastatin was more effective than placebo.
  32. Del Giaccio A, Eblen Zajjur A. Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. Invest Clin. 2010;51:77-86 pubmed
    ..calcium channel blocker amlodipine for blood hypertension (n=45), beta adrenergic receptor blockers (propranolol, atenolol or pindolol; n=40) for blood hypertension, or digoxin (n=40) for heart failure, were compared to an aparently ..
  33. Jia J, Dong C, Zhang W, Cui Y, Liu J. Evaluation of pharmacokinetic and pharmacodynamic relationship for oral sustained-release atenolol pellets in rats. J Pharm Biomed Anal. 2011;55:342-8 pubmed publisher
    ..to evaluate the in vitro release, pharmacokinetics (PK), pharmacodynamics (PD) and PK-PD relationships of atenolol sustained-release pellets (AT-SRPs), compared with those of atenolol immediate-release pellets (AT-IRPs)...
  34. Ara N, Rashid M, Amran M. Comparison of hypotensive and hypolipidemic effects of Catharanthus roseus leaves extract with atenolol on adrenaline induced hypertensive rats. Pak J Pharm Sci. 2009;22:267-71 pubmed
    ..hypotensive and hypolipidemic effects in adrenaline-induced hypertensive rats (AIHR) and compared with those of Atenolol in a crossover design...
  35. Avanza A, Mansur A, Ramires J. Efficacy of exercise, losartan, enalapril, atenolol and rilmenidine in subjects with blood pressure hyperreactivity at treadmill stress test and left ventricular hypertrophy. J Hum Hypertens. 2009;23:259-66 pubmed publisher
    ..treadmill stress test and LVH, were randomly assigned to supervised physical exercise, rilmenidine 1 mg day(-1), atenolol 50 mg day(-1), enalapril 10 mg day(-1) or losartan 50 mg day(-1)...
  36. Williams A, Kenny D, Wilson D, Fagenello G, Nelson M, Dunstan F, et al. Effects of atenolol, perindopril and verapamil on haemodynamic and vascular function in Marfan syndrome - a randomised, double-blind, crossover trial. Eur J Clin Invest. 2012;42:891-9 pubmed publisher
    ..We therefore performed a prospective, randomised, double-blind, crossover trial to compare the effects of these three agents on large artery function and central aortic pressure in patients with Marfan syndrome...
  37. Kurnik D, Li C, Sofowora G, Friedman E, Muszkat M, Xie H, et al. Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade. Pharmacogenet Genomics. 2008;18:895-902 pubmed publisher
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  38. Pareek A, Karnik N, Salagre S, Zawar S, Joglekar V, Chandurkar N, et al. Clinical effectiveness of low-dose chlorthalidone (6.25 mg) + atenolol combination in stage I hypertensive patients: a multicenter, randomized, controlled study. Curr Med Res Opin. 2008;24:1771-9 pubmed publisher
    To compare the efficacy and safety of low-dose chlorthalidone + atenolol combination with atenolol and atenolol + amlodipine combination in stage I hypertensive patients uncontrolled on active run-in monotherapy.
  39. Boutouyrie P, Achouba A, Trunet P, Laurent S. Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipine-atenolol combination: the EXPLOR study. Hypertension. 2010;55:1314-22 pubmed publisher
    The beta-blocker atenolol is less effective than angiotensin-receptor blockers and calcium-channel blockers for reducing central blood pressure (BP)...
  40. Manisty C, Zambanini A, Parker K, Davies J, Francis D, Mayet J, et al. Differences in the magnitude of wave reflection account for differential effects of amlodipine- versus atenolol-based regimens on central blood pressure: an Anglo-Scandinavian Cardiac Outcome Trial substudy. Hypertension. 2009;54:724-30 pubmed publisher
    ..whether directly measured carotid systolic blood pressure differed between people randomized to amlodipine- and atenolol-based therapies and whether this is accounted for by differences in wave reflection patterns...
  41. Jug M, Becirevic Lacan M, Bengez S. Novel cyclodextrin-based film formulation intended for buccal delivery of atenolol. Drug Dev Ind Pharm. 2009;35:796-807 pubmed publisher
    ..Unknown influence of cyclodextrin on the properties of the film formulation aimed for buccal application...
  42. Carr D, Tran L, Brateng D, Kawamura C, Shofer J, Karumanchi S, et al. Hemodynamically-directed atenolol therapy is associated with a blunted rise in maternal sFLT-1 levels during pregnancy. Hypertens Pregnancy. 2009;28:42-55 pubmed publisher
    Cardiac output and sFlt-1 are elevated prior to clinical evidence of preeclampsia. Early treatment of high cardiac output with atenolol decreases the risk for preeclampsia. We hypothesized that atenolol would impact circulating sFlt-1.
  43. Bangalore S, Messerli F, Cohen J, Bacher P, Sleight P, Mancia G, et al. Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy. Am Heart J. 2008;156:241-7 pubmed publisher
    ..The purpose of the study was to compare a beta-blocker-based strategy with a heart rate-lowering calcium antagonists-based strategy in patients with prior MI...
  44. de Cavanagh E, Ferder L, Ferder M, Stella I, Toblli J, Inserra F. Vascular structure and oxidative stress in salt-loaded spontaneously hypertensive rats: effects of losartan and atenolol. Am J Hypertens. 2010;23:1318-25 pubmed publisher
    ..We investigated whether angiotensin II (Ang-II) type 1 (AT1)-receptor blockade (losartan) could protect the aorta and renal arteries from combined hypertension- and high dietary salt-related oxidative stress...
  45. Bhushan R, Tanwar S. Direct TLC resolution of atenolol and propranolol into their enantiomers using three different chiral selectors as impregnating reagents. Biomed Chromatogr. 2008;22:1028-34 pubmed publisher
    Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure L-tartaric acid, (R)-mandelic acid and (-)-erythromycin as chiral selectors...
  46. Nerla R, Di Franco A, Milo M, Pitocco D, Zaccardi F, Tarzia P, et al. Differential effects of heart rate reduction by atenolol or ivabradine on peripheral endothelial function in type 2 diabetic patients. Heart. 2012;98:1812-6 pubmed publisher
    ..To assess whether reduction of heart rate (HR) has beneficial effects on endothelial function in patients with type 2 diabetes mellitus (T2DM)...
  47. Riesen S, Schober K, Cervenec R, Bonagura J. Effects of treatment with ivabradine and atenolol on reproducibility of echocardiographic indices of left heart size and function in healthy cats. J Vet Cardiol. 2012;14:323-32 pubmed publisher
    ..The objectives were therefore to investigate the effects of ivabradine and atenolol on reproducibility of echocardiographic indices of left heart function.
  48. Panda S, Kar A, Banerjee T, Sharma N. Combined effects of quercetin and atenolol in reducing isoproterenol-induced cardiotoxicity in rats: possible mediation through scavenging free radicals. Cardiovasc Toxicol. 2012;12:235-42 pubmed publisher
    In this investigation, combined effects of quercetin and atenolol in the regulation of isoproterenol (ISO)-induced cardiotoxicity have been evaluated in rats...
  49. Saad M, Abbas A, Boshra V, Elkhateeb M, El Aal I. Effect of angiotensin II type 1 receptor blocker, candesartan, and beta 1 adrenoceptor blocker, atenolol, on brain damage in ischemic stroke. Acta Physiol Hung. 2010;97:159-71 pubmed publisher
    ..using angiotensin II type 1(AT1) receptor blocker (ARB), candesartan, and beta 1 adrenoreceptor blocker atenolol, which inhibits renin secretion, in Wistar rats subjected to middle cerebral artery occlusion. Methods ...
  50. Rizos E, Bairaktari E, Kostoula A, Hasiotis G, Achimastos A, Ganotakis E, et al. The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study. J Cardiovasc Pharmacol Ther. 2003;8:127-34 pubmed
    ..This dual mechanism of action could result in minimum interference with lipid metabolism compared to atenolol, a classic beta1-selective blocker...
  51. Oh Y, Lee J, Kim J, Song J, Hong Y, Kwak Y. The haemodynamic effects of propranolol and atenolol medication on dobutamine infusion in patients with coronary artery obstructive disease. J Int Med Res. 2005;33:329-36 pubmed
    ..All patients had been taking propranolol (n = 30) or atenolol (n = 30) pre-operatively for at least 1 month...
  52. Vogelpoel H, Welink J, Amidon G, Junginger H, Midha K, Moller H, et al. Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol. J Pharm Sci. 2004;93:1945-56 pubmed
    ..Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochloride, and atenolol in the form of BCS-monographs...
  53. Chaitman B, Pepine C, Parker J, Skopal J, Chumakova G, Kuch J, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004;291:309-16 pubmed