methoxamine

Summary

Summary: An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

Top Publications

  1. Radley S, Chapple C, Bryan N, Clarke D, Craig D. Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebo-controlled, double-blind crossover study. Neurourol Urodyn. 2001;20:43-52 pubmed
    ..Half log incremental doses of intravenous methoxamine or placebo (saline) were administered to a group of women with genuine stress incontinence while measuring ..
  2. Loureiro Silva M, Cadelina G, Iwakiri Y, Groszmann R. A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats. J Hepatol. 2003;39:940-6 pubmed
    ..We tested the hemodynamic effects of a liver-specific NO donor (NCX-1000) derived from ursodeoxycholic acid in portal hypertensive cirrhotic rats...
  3. Armenia A, Sattar M, Abdullah N, Khan M, Johns E. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta Pharmacol Sin. 2008;29:564-72 pubmed publisher
    ..This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats...
  4. Herath C, Mak K, Burrell L, Angus P. Angiotensin-(1-7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver. Am J Physiol Gastrointest Liver Physiol. 2013;304:G99-108 pubmed publisher
    ..Ang II or the alpha 1 agonist methoxamine (MTX) were injected in the presence or absence of Ang-(1-7), and the perfusion pressure response was recorded...
  5. Laleman W, Van Landeghem L, Severi T, Vander Elst I, Zeegers M, Bisschops R, et al. Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine. Am J Physiol Gastrointest Liver Physiol. 2007;292:G556-64 pubmed
    ..were evaluated by in situ perfusion of normal and thioacetamide-treated cirrhotic rat livers stimulated with methoxamine (n = 25 each)...
  6. Waller J, Gardiner S, Bennett T. Regional haemodynamic responses to acetylcholine, methoxamine, salbutamol and bradykinin during lipopolysaccharide infusion in conscious rats. Br J Pharmacol. 1994;112:1057-64 pubmed
    ..renal, superior mesenteric and hindquarters) and received 3 min of infusions of acetylcholine (22 nmol min-1), methoxamine (120 nmol min-1), salbutamol (0.83 nmol min-1) and bradykinin (14...
  7. Abdulla M, Sattar M, Salman I, Abdullah N, Ameer O, Khan M, et al. Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats. Auton Autacoid Pharmacol. 2008;28:87-94 pubmed publisher
    ..blood flow caused by renal nerve stimulation or intrarenal administration of noradrenaline, phenylephrine, methoxamine and angiotensin II. 3 The data showed that there was significantly (all P < 0...
  8. Jacobson I, Carlsson L, Duker G. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. J Pharmacol Toxicol Methods. 2011;63:40-6 pubmed publisher
    ..We examined whether beat-by-beat variability of the QT interval may be a complementary proarrhythmia marker to QT prolongation...
  9. Mizuta K, Mizuta F, Takahashi M, Ishii H, Niioka T, Izumi H. Effects of isoflurane on parasympathetic vasodilatation in the rat submandibular gland. J Dent Res. 2006;85:379-83 pubmed
    ..and time-dependent manner, the effects of continuous administration of the alpha(1)-adrenoceptor agonist methoxamine were markedly different: The reflex vasodilatation was not affected by methoxamine, while the direct ..

More Information

Publications62

  1. Yang W, Benjamin I, Alexander B. Nitric oxide modulates acetylcholine-induced vasodilatation in the hepatic arterial vasculature of the dual-perfused rat liver. Acta Physiol Scand. 2001;171:413-8 pubmed
    ..ATP) (10(-8)-10(-5) M) in the hepatic artery were constructed after the tone was raised by addition of methoxamine (3 micorM L(-1))...
  2. Ralevic V, Jankowski J, Schluter H. Structure-activity relationships of diadenosine polyphosphates (Ap(n)As), adenosine polyphospho guanosines (Ap(n)Gs) and guanosine polyphospho guanosines (Gp(n)Gs) at P2 receptors in the rat mesenteric arterial bed. Br J Pharmacol. 2001;134:1073-83 pubmed
    ..guanosines (Gp(n)Gs), novel families of naturally-occurring signalling molecules, were investigated in methoxamine preconstricted rat isolated perfused mesenteric arterial beds. 2...
  3. Lu H, Van Ammel K, Vlaminckx E, De Clerck F. QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement. J Pharmacol Toxicol Methods. 2004;49:71-9 pubmed
    ..measurement of the surface ECG accurately detects dispersion of QT and JT in comparison with multi-lead assessments in anaesthetized rabbits, challenged with methoxamine and additionally infused intravenously with solvent or dofetilide.
  4. Sand C, Peters S, Pfaffendorf M, van Zwieten P. Effects of hypochlorite and hydrogen peroxide on cardiac autonomic receptors and vascular endothelial function. Clin Exp Pharmacol Physiol. 2003;30:249-53 pubmed
    ..of hypochlorite (300 micro mol/L), the positive inotropic response of alpha1-adrenoceptor stimulation by methoxamine (300 micro mol/L) was converted into a negative inotropic response...
  5. Tatchum Talom R, Martel C, Labrie F, Marette A. Acute vascular effects of the selective estrogen receptor modulator EM-652 (SCH 57068) in the rat mesenteric vascular bed. Cardiovasc Res. 2003;57:535-43 pubmed
    ..The effects of SERMs on the mesenteric vasculature are unknown. In the present study, the vascular effects of EM-652 and E2 on the rat mesentery were investigated...
  6. González Hernández A, Muñoz Islas E, Lozano Cuenca J, Ramírez Rosas M, Sánchez López A, Centurión D, et al. Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats. Eur J Pharmacol. 2010;637:131-7 pubmed publisher
    ..min) followed by i.v. continuous infusions of methoxamine (20 microg/kg min), and then by saline (0.02 ml/min) or CP-93,129 (a rodent 5-HT(1B) receptor agonist; 0...
  7. Kamikihara S, Mueller A, Lima V, Akinaga J, Nojimoto F, Castilho A, et al. alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats. Naunyn Schmiedebergs Arch Pharmacol. 2007;376:117-26 pubmed
    ..segments of tail arteries from reserpinised rats were three- to sixfold more sensitive to phenylephrine and methoxamine than were arteries from control rats (n = 6-2; p < 0.05)...
  8. Huang Z, Dai D, Li N, Na T, Ji M, Dai Y. Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clin Exp Pharmacol Physiol. 2007;34:310-7 pubmed
    ..4. CPU228 is able to block I(Ca,L), contributing to decreased TDP, while also blocking I(Kr) activity. By combined blockade of I(Kr) and I(Ca,L), CPU228 shares the property of complex Class III anti-arrhythmic agents...
  9. Jin X, Otonashi Satoh Y, Zamami Y, Koyama T, Sun P, Kitamura Y, et al. Endothelial modulation of agonist-induced vasoconstriction in mesenteric microcirculation. Yakugaku Zasshi. 2010;130:723-8 pubmed
    ..Therefore, our recent studies investigated the role of the vascular endothelium in the regulation of methoxamine (alpha(1)-adrenoceptor agonist)-induced vasoconstriction and their age-related changes in rat mesenteric ..
  10. Yue Y, Qu Y, Boutjdir M. Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC. Biochem Biophys Res Commun. 2004;314:749-54 pubmed
    ..condition, (2) beta-adrenoceptor agonist, isoproterenol (ISO), and (3) ISO plus alpha(1)-adrenoceptor agonist, methoxamine. The present results are the first to demonstrate that chronic in vivo activation of epsilonPKC leads to ..
  11. Nalos L, Varkevisser R, Jonsson M, Houtman M, Beekman J, van der Nagel R, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol. 2012;165:467-78 pubmed publisher
  12. Eldor J. A new proposal of CPR based on coronary perfusion pressure. Resuscitation. 1992;23:71-6 pubmed
    ..which encompass the following items besides closed chest massage and tracheal intubation: (a) use of high dose methoxamine (instead of epinephrine), (b) use of continuous abdominal pressure (instead of intermittent pressure), (c) ..
  13. Helmlin H, Brenneisen R. Determination of psychotropic phenylalkylamine derivatives in biological matrices by high-performance liquid chromatography with photodiode-array detection. J Chromatogr. 1992;593:87-94 pubmed
    ..g. plant materials and urine). Mescaline-containing cactus samples were extracted with basic methanol, using methoxamine as internal standard; the extraction and clean-up of urine samples were performed on cation-exchange solid-..
  14. Hasumi H, Matsuda R, Shimamoto K, Hata Y, Kaneko N. K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization. Eur J Pharmacol. 2007;555:54-60 pubmed
    ..can be induced in rabbits by treatment with clofilium in the presence of the alpha1-adrenoreceptor agonist methoxamine. In this study we examined the effects of K201 with and without methoxamine on the QT and QTc intervals, and ..
  15. Bedi G. The effect of adrenergic agonists and antagonists on cysteine-proteinase inhibitor (cystatin) in rat saliva. Arch Oral Biol. 1991;36:611-8 pubmed
    ..The findings suggest that the induction of salivary cystatin is regulated, in part, by beta 1-adrenergic receptor stimulation...
  16. Castillo E, Ortíz C, López R, Ruiz A, Vélez J, Castillo C. Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors. Fundam Clin Pharmacol. 2006;20:339-49 pubmed
    ..Moreover, clonidine and UK 14304-induced relaxation of endothelium-denuded arteries precontracted with methoxamine but not with serotonin...
  17. Graupera M, García Pagán J, Abraldes J, Peralta C, Bragulat M, Corominola H, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology. 2003;37:172-81 pubmed
    ..the response of the intrahepatic circulation of cirrhotic rat livers to the alpha(1)-adrenergic vasoconstrictor methoxamine and the mechanisms involved in its regulation...
  18. Longhurst P. Functional development of the rat urinary bladder after pre- or postpubertal castration. Pharmacology. 2003;67:72-82 pubmed
    ..of bladder strips from immature females or males to the adrenergic agonists, isoproterenol, norepinephrine, or methoxamine. Bladders from the pre- and postpubertally castrated rats and their controls relaxed fully in response to ..
  19. Ralevic V. Sympathoinhibition by adenosine A(1) receptors, but not P2 receptors, in the hamster mesenteric arterial bed. Eur J Pharmacol. 2000;387:287-93 pubmed
    ..6; n=6-7). In methoxamine raised-tone mesenteries CPA (0...
  20. He G. Contractility of the human internal mammary artery at the distal section increases toward the end. Emphasis on not using the end of the internal mammary artery for grafting. J Thorac Cardiovasc Surg. 1993;106:406-11 pubmed
    ..response to vasoconstrictor agents U46619, potassium chloride, alpha-adrenoceptor agonists norepinephrine, methoxamine, and phenylephrine were recorded or calculated...
  21. Gardiner S, Nunez D, Baer P, Brown K, Bennett T. Regional hemodynamic effects of the N-(2-benzoylphenyl)-L-tyrosine peroxisome proliferator-activated receptor-gamma ligand, GI 262570 [(S)-2-(2-benzoylphenylamino)-3-[4-[2-(5-methyl-2-phenyl-2-oxazol-4-yl)ethoxy]phenyl]propionic acid], in conscious r. J Pharmacol Exp Ther. 2004;310:1226-33 pubmed
    ..In the presence of GI 262570, vasodilator responses to acetylcholine and vasoconstrictor responses to methoxamine were normal...
  22. Lin A, Kato K, Monson F, Wein A, Levin R. Pharmacological responses of rabbit urinary bladder after subtotal cystectomy. J Urol. 1989;142:409-12 pubmed
    ..the same in both groups, the response to bethanechol was less for cystectomized bladder, and the response to methoxamine was greater for the cystectomized bladder...
  23. Hernandez E, Jimenez J, Payne D, Adashi E. Adrenergic regulation of ovarian androgen biosynthesis is mediated via beta 2-adrenergic theca-interstitial cell recognition sites. Endocrinology. 1988;122:1592-602 pubmed
    ..Qualitatively similar stimulation was obtained using beta (isoproterenol)- but not alpha (methoxamine)-selective adrenergic agonists...
  24. Sikorski B, Hodgson W, King R. Thromboxane A2 receptor stimulation similarly potentiates pressor responses to 5-hydroxytryptamine in perfused hindquarters of non-diabetic and alloxan diabetic rats. Clin Exp Pharmacol Physiol. 1991;18:237-44 pubmed
    ..3. In Krebs'-perfused hindquarters of non-diabetic rats, infusion of the alpha 1-adrenoceptor agonist methoxamine (8...
  25. Rodriguez Tolra J, Cuadrado Campaña J, Fumadó Ciutat L, Franco Miranda E. [Intracavernosal methoxamine self-injection for the treatment of low-flow recurrent priapism]. Actas Urol Esp. 2006;30:324-5 pubmed
    We report the case of a young man with a recurrent idiopathic priapism, successfully treated with methoxamine intracarvenosal self-injections...
  26. Levin R, Saito M, Wein A, Packard D, Cohen A, Haugaard N. Effect of partial outlet obstruction on choline acetyltransferase activity in the rat and rabbit. Neurourol Urodyn. 1993;12:255-61 pubmed
    ..In the rat, partial outlet obstruction induced a mild 2-fold increase in bladder mass.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. Tsuchimoto T, Miyazaki H, Suzuki E, Maekawa N. [Case report : Severe anaphylactic shock followed by positive skin-prick-test to multiple vasoconstrictors]. Masui. 2010;59:788-91 pubmed
    ..Injecting of ephedrine 8 mg was not effective, and we injected a total of 3 mg of methoxamine. Then SAS dropped to 50 mmHg. We injected epinephrine 0...
  28. Ishine T, Lee T. Norepinephrine attenuates serotonin inhibition of pial venous tone. Eur J Pharmacol. 1996;313:97-102 pubmed
    ..This effect of norepinephrine was mimicked by clonidine (an alpha 2-adrenoceptor agonist), but not by methoxamine (an alpha 1-adrenoceptor agonist)...
  29. de la Lande I. Evidence for a 5-HT1-like receptor mediating the amplifying action of 5-HT in the rabbit ear artery. Br J Pharmacol. 1992;107:550-5 pubmed
    1. The nature of the 5-hydroxytryptamine (5-HT) receptors which amplify the vasoconstrictor effect of methoxamine was examined in the rabbit isolated perfused ear artery with intact endothelium...
  30. Loureiro Silva M, Cadelina G, Groszmann R. Deficit in nitric oxide production in cirrhotic rat livers is located in the sinusoidal and postsinusoidal areas. Am J Physiol Gastrointest Liver Physiol. 2003;284:G567-74 pubmed
    ..we studied the effect of the NO synthase blocker N(omega)-nitro-l-arginine (l-NNA) on the response to methoxamine (alpha(1)-adrenoreceptor agonist) in different segments of the intrahepatic circulation of normal and cirrhotic ..
  31. Brooks V, Clow K, O Hagan K. Pregnancy and acute baroreflex resetting in conscious rabbits. Am J Physiol Regul Integr Comp Physiol. 2002;283:R429-40 pubmed
    ..and HR after arterial pressure is raised [~25 mmHg for 30 min, due to infusion of phenylephrine (PE) or methoxamine (Meth)] is greater in late pregnant compared with nonpregnant conscious rabbits...
  32. Gaynullina D, Lubomirov L, Sofronova S, Kalenchuk V, Gloe T, Pfitzer G, et al. Functional remodelling of arterial endothelium during early postnatal development in rats. Cardiovasc Res. 2013;99:612-21 pubmed publisher
    ..Therefore, the hypothesis was tested that the impact of the anti-contractile effect of the endothelium on agonist-induced contractions changes during early postnatal development...
  33. Liedtke C, Papay R, Cole T. Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1151-9 pubmed
    ..The alpha(1)-adrenergic agonist methoxamine (MOX) and hypertonic sucrose increased Cl and increased or decreased intracellular volume, respectively, ..
  34. Abdulla M, Sattar M, Abdullah N, Khan A, Anand Swarup K, Rathore H, et al. Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats. Ups J Med Sci. 2011;116:18-25 pubmed publisher
    ..This study examined the effect of renal sympathetic innervation on adrenergically and angiotensin II (Ang II)-induced renal vasoconstriction in Wistar-Kyoto (WKY) rats...
  35. Davy J, Weissenburger J, Chezalviel F, Ertzbischoff O. [Experimental models of torsades de pointes]. Arch Mal Coeur Vaiss. 1992;85 Spec No 4:15-21 pubmed
    ..Induction protocols were described, which appeared to involve an inotropic potentiation following burst or repetitive extrastimuli. A more accurate evaluation of arrhythmogenic risk associated with new drugs could be developed...
  36. Yamazaki R, Tsuchida K, Aihara H. Effects of alpha-adrenoceptor agonists on cardiac output and blood pressure in spinally anesthetized ganglion-blocked dogs. Arch Int Pharmacodyn Ther. 1988;295:80-93 pubmed
    ..alpha-adrenoceptor agonist ST-1059 (2-amino-1-(2,5-dimethoxyphenyl) ethanol), the alpha 1-adrenoceptor agonist methoxamine, the alpha 2-adrenoceptor agonist clonidine and a nonselective alpha-adrenoceptor agonist norepinephrine, all ..
  37. Centurión D, de la Cruz S, Gutiérrez Lara E, Beltrán Ornelas J, Sánchez López A. Pharmacological evidence that NaHS inhibits the vasopressor responses induced by stimulation of the preganglionic sympathetic outflow in pithed rats. Eur J Pharmacol. 2016;770:40-5 pubmed publisher
    ..03-10Hz); (2) i.v. bolus injections of exogenous noradrenaline (0.03-3μg/kg); or (3) methoxamine (1-100μg/kg)...
  38. Hirafuji M, Ogawa T, Kato K, Hamaue N, Endo T, Parvez H, et al. Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors. Eur J Pharmacol. 2001;432:149-52 pubmed
    ..at a higher concentration (10 microM) also stimulated 5-HT release, while alpha(1)-adrenoceptor agonists, methoxamine and phenylephrine, had no effect...
  39. Denola N, Quiming N, Saito Y, Jinno K. Simultaneous enantioseparation and sensitivity enhancement of basic drugs using large-volume sample stacking. Electrophoresis. 2007;28:3542-52 pubmed
    Simultaneous enantioseparation with sensitive detection of four basic drugs, namely methoxamine, metaproterenol, terbutaline and carvedilol, using a 20-mum ID capillary with native beta-CD as the chiral selector was demonstrated by the ..
  40. Duarte J, Perez Vizcaino F, Zarzuelo A, Jimenez J, Tamargo J. Aminophylline preferentially inhibits chloroethylclonidine-insensitive alpha-adrenoceptor-mediated contractions in rat aorta. Gen Pharmacol. 1993;24:1359-64 pubmed
    1. In rat thoracic aortae, contractions induced by methoxamine were inhibited by chloroethylclonidine, whereas oxymetazoline-induced contractions, which were more dependent on Ca(2+)-entry, were insensitive to chloroethylclonidine. 2...
  41. Kumar V, Vetrivelan R, Mallick H. Alpha-1 adrenergic receptors in the medial preoptic area are involved in the induction of sleep. Neurochem Res. 2006;31:1095-102 pubmed
    ..Intrapreoptic injection of alpha(1) agonist, methoxamine could induce sleep, when the hypothermia, which was simultaneously produced, was behaviorally compensated for ..
  42. Moss R, Parmar N, Tighe D, Davies D. Adrenergic agents modify cerebral edema and microvessel ultrastructure in porcine sepsis. Crit Care Med. 2004;32:1916-21 pubmed
    ..To investigate the effects of adrenergic agents on the cerebral response to sepsis...
  43. Randall M, March J. Characterization of endothelium-dependent relaxations in mesenteries from transgenic hypertensive rats. Eur J Pharmacol. 1998;358:31-40 pubmed
    ..It is suggested that the recently identified reciprocal relationship between NO and EDHF is upregulated in the mesenteries from the TGH rats...
  44. Gibbs M, Summers R. Stimulation of alpha1-adrenoceptors inhibits memory consolidation in the chick. Eur J Neurosci. 2001;14:1369-76 pubmed
    ..studies show that the inhibition of memory by high doses of noradrenaline is mimicked by the alpha1-AR agonist methoxamine, and the dose-response curve is shifted to the right by pretreatment with the alpha1-AR antagonist prazosin...
  45. Oshita M, Kigoshi S, Muramatsu I. Pharmacological characterization of two distinct alpha 1-adrenoceptor subtypes in rabbit thoracic aorta. Br J Pharmacol. 1993;108:1071-6 pubmed
    ..Noradrenaline, but not methoxamine, showed slightly higher affinity for the prazosin-high affinity site than for the low affinity site. 4...
  46. van den Buuse M, Catanzariti R. Stimulation of the ventral tegmental area enhances the effect of vasopressin on blood pressure in conscious rats. Br J Pharmacol. 2000;129:29-36 pubmed
    ..of neurotensin had no effect on the pressor response and bradycardia induced by intravenous angiotensin II or methoxamine. In conclusion, these results suggest that the mesolimbic dopamine system, in addition to its well-known role ..
  47. Nusuetrong P, Sotanaphun U, Tep Areenan P. Effects of Phikud Navakot extract on vascular reactivity in the isolated rat aorta. J Med Assoc Thai. 2012;95 Suppl 12:S1-7 pubmed
    ..examined in the presence of indomethacin (10 microM), N(G)-nitro L-arginine methyl ester (L-NAME, 300 microM), methoxamine (0.1-300 microM), carbachol (1 nanoM-30 microM), or sodium nitroprusside (0.1 nanoM-10 microM)...
  48. Brien S, Smallegange C, Gofton W, Heaton J, Adams M. Development of a rat model of sexual performance anxiety: effect of behavioural and pharmacological hyperadrenergic stimulation on APO-induced erections. Int J Impot Res. 2002;14:107-15 pubmed
    ..In a separate group, adrenergic stress was simulated using a sympathomimetic, methoxamine (MXA) given prior to APO testing...
  49. Huang S, Huganir R, Kirkwood A. Adrenergic gating of Hebbian spike-timing-dependent plasticity in cortical interneurons. J Neurosci. 2013;33:13171-8 pubmed publisher
    ..By doing so, neuromodulators may allow coordinated plastic changes in FS and pyramidal cells. ..
  50. Luo X, Zheng M, Tian G, Zhong H, Zou X, Jian D. Comparison of the treatment effects of methoxamine and combining methoxamine with atropine infusion to maintain blood pressure during spinal anesthesia for cesarean delivery: a double blind randomized trial. Eur Rev Med Pharmacol Sci. 2016;20:561-7 pubmed
    ..We aimed to assess the effect of methoxamine-atropine therapy in treating spinal anesthesia hypotension for cesarean section...
  51. Vetrivelan R, Mallick H, Kumar V. Sleep induction and temperature lowering by medial preoptic alpha(1) adrenergic receptors. Physiol Behav. 2006;87:707-13 pubmed
    Changes in sleep-wakefulness (S-W) and body temperature (T(b)) on administration of alpha(1) agonist (methoxamine) and antagonist (prazosin) into the medial preoptic area (mPOA) were studied in rats...
  52. Abdulla M, Sattar M, Abdullah N, Khan M, Anand Swarup K, Johns E. The effect of losartan and carvedilol on vasopressor responses to adrenergic agonists and angiotensin II in the systemic circulation of Sprague Dawley rats. Auton Autacoid Pharmacol. 2011;31:13-20 pubmed publisher
    ..or change in heart rate (HR) in response to intravenous injections of noradrenaline (NA), phenylephrine (PE), methoxamine (ME) and Ang II were determined...
  53. Iwakiri Y, Tsai M, McCabe T, Gratton J, Fulton D, Groszmann R, et al. Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol. 2002;282:H2084-90 pubmed
    ..Mesenteric arterial beds from PVL rats had an approximately 60-70% decrease in response to methoxamine (an alpha(1)-agonist and vasoconstrictor) compared with the sham group (P < 0.01)...