etilefrine

Summary

Summary: A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.

Top Publications

  1. Raviele A, Brignole M, Sutton R, Alboni P, Giani P, Menozzi C, et al. Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: a double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study. Circulation. 1999;99:1452-7 pubmed
    b>Etilefrine is an alpha-agonist agent with a potent vasoconstrictor effect, which is potentially useful in preventing vasovagal syncope by reducing venous pooling and/or by counteracting reflex arteriolar vasodilatation...
  2. Muneer A, Minhas S, Arya M, Ralph D. Stuttering priapism--a review of the therapeutic options. Int J Clin Pract. 2008;62:1265-70 pubmed publisher
    ..Stuttering or recurrent priapism is less well understood. This subtype is characterised by short-lived painful erections and is commonly encountered in patients with sickle cell disease...
  3. Virag R, Bachir D, Lee K, Galacteros F. Preventive treatment of priapism in sickle cell disease with oral and self-administered intracavernous injection of etilefrine. Urology. 1996;47:777-81; discussion 781 pubmed
    ..Priapism is a common and currently unsatisfactorily managed complication of sickle cell disease (SCD). In June 1994, 6 SCD patients received a new therapeutic regimen to prevent the occurrence and recurrence of priapism...
  4. Okpala I, Westerdale N, Jegede T, Cheung B. Etilefrine for the prevention of priapism in adult sickle cell disease. Br J Haematol. 2002;118:918-21 pubmed
    ..It is therefore important to prevent this complication of SCD. The alpha-adrenergic agonist etilefrine (50-100 mg/d) produced a good clinical response in 13 of 18 (72%) adults who have recurrent priapism; 17 had SCD ..
  5. Moya A, Permanyer Miralda G, Sagrista Sauleda J, Carne X, Rius T, Mont L, et al. Limitations of head-up tilt test for evaluating the efficacy of therapeutic interventions in patients with vasovagal syncope: results of a controlled study of etilefrine versus placebo. J Am Coll Cardiol. 1995;25:65-9 pubmed
    This study assessed the efficacy of oral etilefrine (10 mg three times a day) in preventing a positive response to head-up tilt testing.
  6. Di Girolamo E, Di Iorio C, Sabatini P, Leonzio L, Barsotti A. [Evaluation of the effects of diverse therapeutic treatments versus no treatment of patients with neurocardiogenic syncope]. Cardiologia. 1998;43:833-7 pubmed
  7. Maitre S, Michel J, Varlet F, Cambazard F. [Priapism in the course of generalized atopic dermatitis]. Ann Dermatol Venereol. 2002;129:1038-41 pubmed
    ..Causes include certain oral medication, perineal trauma, thrombo-embolic process or primary priapism. We report a case of priapism secondary to diffuse general atopic dermatitis...
  8. Raviele A, Gasparini G, Di Pede F, Delise P, Bonso A, Piccolo E. [Syncope of undetermined nature after electrophysiologic study. Usefulness of the head-up tilt test in the diagnosis of vaso-vagal origin and in the choice of treatment]. G Ital Cardiol. 1990;20:185-94 pubmed
  9. Guillem P, Billeret V, Houcke M, Triboulet J. Successful management of post-esophagectomy chylothorax/chyloperitoneum by etilefrine. Dis Esophagus. 1999;12:155-6 pubmed
    ..b>Etilefrine, a sympathomimetic drug used in the management of postural hypotension, also causes smooth muscle contraction of ..

More Information

Publications58

  1. Shimodate Y, Dobashi N, Kudo A, Shinozaki Y, Matsuki A. [Treatment of priapism with intracavernous injection of etilefrine hydrochloride]. Masui. 1990;39:1409-12 pubmed
    ..For the penile erection, intracavernous injection of etilefrine hydrochloride was effective and surgical procedure could be done smoothly...
  2. Duschek S, Hadjamu M, Schandry R. Dissociation between cortical activation and cognitive performance under pharmacological blood pressure elevation in chronic hypotension. Biol Psychol. 2007;75:277-85 pubmed
    ..Effects of the sympathomimetic etilefrine were investigated in 50 hypotensive persons based on a randomized, placebo-controlled double blind design...
  3. Bakry R, el Walily A, Belal S. Spectrophotometric determination of etilefrine hydrochloride and ritodrine hydrochloride through nitrosation and subsequent cobalt chelation. Acta Pharm Hung. 1995;65:113-7 pubmed
    A simple and rapid method for the determination of etilefrine hydrochloride and ritodrine hydrochloride, either in pure form or in pharmaceutical formulations, is described...
  4. Smati B, Sadok Boudaya M, Marghli A, Mestiri T, Baccari S, Hantous T, et al. [Management of postoperative chylothorax]. Rev Mal Respir. 2006;23:152-6 pubmed
    ..A chylothorax can occur following any intrathoracic procedure. It is generally straightforward to make the diagnosis but optimal management can be problematic...
  5. Fiter Gómez L, Herrero Payo A, Mejías Callaved J, Gimeno Albo F. [Prevention of prolonged drug-induced erection by intracavernous injection of etilefrine]. Actas Urol Esp. 1997;21:128-32 pubmed
    Here in we report the results of intracavernous injection of etilefrine hydrochloride in a group of 12 patients who developed rigid erection after a diagnostic test with intracavernous PGE1 injection or cavernosometry...
  6. Bouaggad A, Harrar R, Bouderka M, Abassi O. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000;17:177-81 pubmed
    This study was designed to determine the efficacy of oral etilefrine in preventing hypotension induced by spinal anaesthesia...
  7. Okpala I. Investigational agents for sickle cell disease. Expert Opin Investig Drugs. 2006;15:833-42 pubmed
    ..Whereas the orally administrable iron-chelating agent deferasirox is likely to increasingly take the place of desferioxamine (which can only be given parenterally), effective treatment of priapism in SCD remains a distressing challenge...
  8. Andrieu V, Dumonceau O, Grange M. Priapism in a patient with unstable hemoglobin: hemoglobin Köln. Am J Hematol. 2003;74:73-4 pubmed
    ..Since emergency treatment may prevent impotence, patients and parents should be educated about this complication...
  9. Olujohungbe A, Adeyoju A, Yardumian A, Akinyanju O, Morris J, Westerdale N, et al. A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: report of an international randomized control trial--the priapism in sickle cell study. J Androl. 2011;32:375-82 pubmed publisher
    ..randomized, placebo-controlled, clinical study looking at medical prophylaxis with 2 oral ?-adrenergic agonists, etilefrine and ephedrine, in preventing stuttering attacks of priapism...
  10. Celenligil Cetin R, Staples R, Stavropoulos P. Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates. Inorg Chem. 2000;39:5838-46 pubmed
    ..The low reactivity and high selectivity (tert/sec = 8) obtained in the oxidation of adamantane suggests that the present type of peroxo species is not directly involved in catalytic Gif-type oxygenations of adamantane...
  11. Gbadoe A, Akakpo Vidah A, Tsolenyanu E, Messie K, Atakouma D, Segbena A, et al. [Intracavernous injections of etilefrin: its efficacy in the treatment of priapism in sickle cell patients]. Presse Med. 1999;28:1283-6 pubmed
    ..Surgical cavernous-venous shunt may be proposed if conservative treatment fails. We examined the efficacy of intracavernous etilefrin injections...
  12. Cormio L, Bettocchi C, Ricapito V, Zizzi V, Traficante A, Selvaggi F. Resistance index as a prognostic factor for prolonged erection after penile dynamic colour Doppler ultrasonography. Eur Urol. 1998;33:94-7 pubmed
    ..To identify an objective and reliable prognostic factor for prolonged erection after penile dynamic colour Doppler ultrasonography (CDU)...
  13. Harti A, Mjahed K, Chlihi A, Lamine A, Laraki M, Barrou L, et al. [Preventive treatment of hemodynamic disorders during conventional spinal anesthesia]. Cah Anesthesiol. 1993;41:217-20 pubmed
    ..148 patients were included and divided into three groups. Group I (n = 50): 2.5 mg IV bolus of etilefrine followed by continuous infusion (0.35 mg.kg-1.h-1). Group II (n = 50): 30 ml...
  14. Bachir D, Virag R, Lee K, Belloy M, de Montalembert M, Denis L, et al. [Prevention and treatment of erectile disorders in sickle cell disease]. Rev Med Interne. 1997;18 Suppl 1:46s-51s pubmed
    ..used a specific approach to prevent the commonly devastating effects of AP, using the alpha adrenergic agent etilefrine. Treatment of AP has been simplified (drainage without aspiration followed by one or two intracavernous ..
  15. Beyene N, van Staden J, Stefan R. Sequential injection spectrophotometric determination of etilefrine hydrochloride. Farmaco. 2004;59:1005-10 pubmed
    A simple, fast, economical and automated sequential injection spectrophotometric method for the determination of etilefrine hydrochloride is developed...
  16. Pertek J, Coissard A, Artis M. [Management of intraoperative erection by penile block]. Ann Fr Anesth Reanim. 1995;14:352-5 pubmed
    ..In this case report, the erection was first treated with intracavernous injection of etilefrine (8 mg) and detumescence was obtained rapidly. However, one hour later, the erection occurred again...
  17. Hendolin H, Poikolainen E, Mattila M, Alhava E, Hänninen A, Puttonen E, et al. Effect of dihydroergotamine on leg blood flow during combined epidural and general anaesthesia and postoperative deep vein thrombosis after cholecystectomy. Acta Anaesthesiol Scand. 1993;37:288-95 pubmed
    ..e. increased the electrical impedance, probably due to venous vasoconstriction. Simultaneously the need for etilefrine hydrochloride was reduced...
  18. Strumper D, Gogarten W, Durieux M, Hartleb K, Van Aken H, Marcus M. Effects of cafedrine/theodrenaline, etilefrine and ephedrine on uterine blood flow during epidural-induced hypotension in pregnant sheep. Fetal Diagn Ther. 2005;20:377-82 pubmed
    ..Therefore, we evaluated the maternal and fetal hemodynamic effects of two potential alternatives to ephedrine...
  19. Passavanti G, Bragaglia A, Paolini R. From methylene blue (methylthionine chloride) to Al-Ghorab procedure: the therapy of priapism (our experience). Arch Ital Urol Androl. 2009;81:242-4 pubmed
    ..The better knowledge concerning the anatomo-physiology of erection has brought important changes to the management of priapism. We experimented with a staged therapeutic protocol forthis condition...
  20. Brignole M. Randomized clinical trials of neurally mediated syncope. J Cardiovasc Electrophysiol. 2003;14:S64-9 pubmed
    ..disopyramide, scopolamine, clonidine, theophylline, fludrocortisone, ephedrine, dihydroergotamine, etilefrine, midodrine, clonidine, serotonin reuptake inhibitors, enalapril)...
  21. Cicogna R, Bonomi F, Mascioli G, Ferrari R, Turelli A, Benigno M, et al. [Hemodynamic and neuroendocrine profile of 2 different cardiovascular responses in vasodepressor syncope induced by the head-up tilt test]. G Ital Cardiol. 1992;22:1367-79 pubmed
  22. Lermite E, Thouveny F. [A complicated course after esophagogastrectomy]. J Chir (Paris). 2007;144:241-5 pubmed
  23. Liao Y, Li X, Zhang Y, Chen S, Tang C, Du J. alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data. Acta Paediatr. 2009;98:1194-200 pubmed publisher
    ..The present study was aimed at evaluating present randomized controlled trials (RCTs) regarding the effect of alpha-adrenoceptor agonists on vasovagal syncope (VVS)...
  24. Bobadilla González P, Pérez Rangel I, García Menaya J, Sánchez Vega S, Cordobés Durán C, Zambonino Carreiras M. Type IV reaction due to phenylephrine administered nasally with cross-reactivity with ethylephrine. J Investig Allergol Clin Immunol. 2011;21:69-72 pubmed
    ..To our knowledge, this is the first report of a type IV reaction to nasally administered phenylephrine with cross-reactivity with ethylephrine detected by patch testing...
  25. Serrate R, Prats J, Regué R, Rius G. The usefulness of ethylephrine (Efortil-R) in the treatment of priapism and intraoperative penile erections. Int Urol Nephrol. 1992;24:389-92 pubmed
    ..We consider that this treatment is very useful in the management of patients with persistent erections or priapism because of the excellent results obtained without adverse effects...
  26. Yamazaki R, Tsuchida K, Otomo S. Effects of dihydroergotamine and etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990;13:519-24 pubmed
    The effects of dihydroergotamine and etilefrine on experimentally-induced postural hypotension were examined. Although dihydroergotamine at 3 and 10 micrograms/kg (i.v.) increased blood pressure (BP), it did not affect cardiac output (CO)...
  27. Aly F, al Tamimi S, Alwarthan A. Determination of phenolic sympathomimetic drugs in pharmaceutical samples and biological fluids by flow-injection chemiluminescence. J AOAC Int. 2000;83:1299-305 pubmed
    ..flow-injection chemiluminometric method was developed for determination of 3 sympathomimetic drugs, namely, etilefrine hydrochloride, isoxsuprine hydrochloride, and prenalterol hydrochloride...
  28. Gratadour P, Viale J, Parlow J, Sagnard P, Counioux H, Bagou G, et al. Sympathovagal effects of spinal anesthesia assessed by the spontaneous cardiac baroreflex. Anesthesiology. 1997;87:1359-67 pubmed
    ..The purpose of this study was to follow the effects of spinal anesthesia on spontaneous baroreflex sensitivity...
  29. Gbadoe A, Atakouma Y, Kusiaku K, Assimadi J. Management of sickle cell priapism with etilefrine. Arch Dis Child. 2001;85:52-3 pubmed
    Intracavernous injections of etilefrine were effective in seven children with acute sickle cell priapism, and stuttering priapism resolved in five children after one to seven months of oral etilefrine...
  30. Schwerk C, Schulz M, Schwerk N, Bluher S, Kiess W, Siekmeyer W. Etilefrinhydrochloride tablet ingestion: successful therapy by endoscopic removal of tablet conglomerate. Klin Padiatr. 2009;221:93-6 pubmed publisher
  31. Ishikura F, Miki A, Iwata A, Toshida T, Shakudo M, Asanuma T, et al. Effect of systemic blood pressure on microcollateral circulation evaluated by real-time contrast echocardiography. J Am Soc Echocardiogr. 2008;21:765-9 pubmed publisher
    ..Management of systemic blood pressure (sBP) related to maintain collateral circulation is still difficult. The aim of this study was to reveal the influence of sBP on the rescue of area at risk by collateral circulation...
  32. Hohmann M, Kunzel W. Etilefrine and amezinium reduce uterine blood flow of pregnant guinea pigs. Eur J Obstet Gynecol Reprod Biol. 1989;30:173-81 pubmed
    b>Etilefrine and Amezinium are used during pregnancy to prevent hypotension and fetal growth retardation. The effect of these drugs on uterine blood flow (UBF), uterine vascular resistance (UVR) and fetal growth are, however, unknown...
  33. Platis I, Nwogu C. Chylothorax. Thorac Surg Clin. 2006;16:209-14 pubmed
    ..The need to prevent the occurrence of a chylothorax by careful dissection techniques and liberal clipping of lymphatic vessels particularly in areas of high anatomic risk during the initial operation cannot be overemphasized...
  34. Lippert T, Schneider Zeh S, Voelter W. The action of relaxin, fenoterol and etilefrine on uterine motility of the rat. Int J Clin Pharmacol Ther Toxicol. 1987;25:565-6 pubmed
    ..rats, the inhibitory action of the peptide hormone relaxin has been compared with the actions of fenoterol and etilefrine. At molecular levels, relaxin and fenoterol showed similar uterine inhibitory activity...
  35. Mori M, Yamamoto H, Hattori S, Miyakawa H, Noguchi T. Effect of ephedrine on auditory-evoked potentials during light general anaesthesia. Anaesthesia. 2000;55:523-7 pubmed
    ..We compared the effect of ephedrine on auditory-evoked potentials with that of etilefrine, a sympathomimetic drug that lacks an amphetamine-like effect, in patients undergoing abdominal surgery under ..
  36. Gbadoe A, Akakpo Vidah A, Pitche P, Assimadi J. [Sickle cell disease priapism: treatment with intracavernous injections of etilefrine]. Med Trop (Mars). 2000;60:53-6 pubmed
    ..From January 1996 through September 1998, 19 patients with sickle cell disease were treated by ICI of etilefrine for one or several episodes of low-flow priapism lasting between 2 hours and 15 days...
  37. Seiler L, Braune S, Borm K, Magerkurth C, Talazko J, Peters T, et al. Autonomic failure mimicing dopamine agonist induced vertigo in a patient with macroprolactinoma. Exp Clin Endocrinol Diabetes. 2002;110:364-9 pubmed
    ..s.) and etilephrin (10 mg q.d.s.), which enabled him to cope with daily activities without syncope. This case shows that vertigo in a patient with macroprolactinoma is not always related to drug therapy but may be related to other causes...
  38. Stamatiadis D, Gounari P, Balitsari A, Bokos J, Stathakis C. Hypotension on CAPD: can use of vasoconstrictive drugs be harmful?. Perit Dial Int. 2002;22:94-5 pubmed
  39. Teloken C, Ribeiro E, Chammas M, Teloken P, Souto C. Intracavernosal etilefrine self-injection therapy for recurrent priapism: one decade of follow-up. Urology. 2005;65:1002 pubmed
    ..We describe a case of a young patient with recurrent idiopathic priapism who has used etilefrine self-injection for the past 10 years with good efficacy and libido and erectile function preservation...
  40. Valli J, Pirhonen J, Aantaa R, Erkkola R, Kanto J. The effects of regional anaesthesia for caesarean section on maternal and fetal blood flow velocities measured by Doppler ultrasound. Acta Anaesthesiol Scand. 1994;38:165-9 pubmed
    ..the systolic blood pressure was maintained within 15% limits of the preoperative values using prophylactic etilefrine infusion in Groups S and SE...
  41. Röcken M, Schubert C, Mosel G, Litzke L. Indications, surgical technique, and long-term experience with laparoscopic closure of the nephrosplenic space in standing horses. Vet Surg. 2005;34:637-41 pubmed
    ..To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses...
  42. Pinel M, Ocete M, Miro M, Jimenez J, Risco S. Changes in etilefrine-induced CNS effects when associated with theophylline. Pharm Acta Helv. 1994;69:91-5 pubmed
    ..motor activity, swimming ability, body temperature) was used to study theophylline (T)-induced changes in CNS etilefrine (E). T antagonized the depressive effects produced by high doses of E...
  43. Cormio L, Nisen H, Ruutu M, Selvaggi F. Etilefrine in the prevention of prolonged erection after diagnostic pharmacological stimulation. Ann Chir Gynaecol. 1996;85:247-50 pubmed
    The aim of this study was to verify the efficacy and safety of intracavernous injection of etilefrine hydrochloride in the prevention of pharmacologically induced prolonged erection...
  44. López Laur J, Parisi J, Sanchez G. [Penile erection after spinal anesthesia. Treatment with intracavernous ethyladrianol]. Arch Esp Urol. 1990;43:241-3 pubmed
    ..All patients presented easily controllable arterial hypertension. This is a simple, easy and practically risk-free technique that has the advantage of achieving a high response rate thereby permitting surgery...
  45. Guillem P, Triboulet J. Management of thoracic duct injuries after oesophagectomy (Br J Surg 2001: 88: 1442-8). Letter 1. Br J Surg. 2002;89:809 pubmed
  46. Janky E, Poirier L, Hocke C, Leng J, Sangla N, Meynard J. [Use of etilefrin as local vasoconstrictor in lower gynecologic surgery ]. J Gynecol Obstet Biol Reprod (Paris). 1991;20:661-4 pubmed
    ..study the authors have compared the effectiveness and side-effects of two local vasoconstrictor agents, etilefrine (Effortil) and ornithine 8 vasopressin (Por 8) in vaginal gynaecological surgery...
  47. Taivainen T. Comparison of ephedrine and etilefrine for the treatment of arterial hypotension during spinal anaesthesia in elderly patients. Acta Anaesthesiol Scand. 1991;35:164-9 pubmed
    ..07 mg kg-1 or etilefrine 0.03 mg kg-1 boluses i.v. when MAP decreased by 25% from the preanaesthetic reference value...
  48. Karasawa Y, Furukawa Y, Murakami M, Ren L, Takayama S, Chiba S. Pharmacological analysis of positive chronotropic and inotropic responses to etilefrine in isolated dog heart preparations. Heart Vessels. 1992;7:24-30 pubmed
    Positive chronotropic and inotropic responses to etilefrine (alpha-[(ethylamino)methyl]-m-hydroxybenzyl alcohol), an orally active cardiovascular agent, were investigated in isolated dog right atrial and left ventricular preparations...
  49. Kurihara J, Takata Y, Suzuki S, Okubo Y, Kato H. Effect of midodrine on chlorpromazine-induced orthostatic hypotension in rabbits: comparison with amezinium, etilefrine and droxidopa. Biol Pharm Bull. 2000;23:1445-9 pubmed
    ..d.) was investigated in comparison with amezinium (10 and 30 mg/kg, i.d.), etilefrine (10 and 30 mg/kg, i.d.) and droxidopa (30 and 100 mg/kg, i.d.)...