octopamine

Summary

Summary: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

Top Publications

  1. Selcho M, Pauls D, El Jundi B, Stocker R, Thum A. The role of octopamine and tyramine in Drosophila larval locomotion. J Comp Neurol. 2012;520:3764-85 pubmed publisher
    ..The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, ..
  2. Behrends A, Scheiner R. Octopamine improves learning in newly emerged bees but not in old foragers. J Exp Biol. 2012;215:1076-83 pubmed publisher
    ..By increasing the sensitivity for sucrose through octopamine, we selectively improved the learning performance of insensitive newly emerged bees...
  3. Tinikul Y, Mercier A, Sobhon P. Distribution of dopamine and octopamine in the central nervous system and ovary during the ovarian maturation cycle of the giant freshwater prawn, Macrobrachium rosenbergii. Tissue Cell. 2009;41:430-42 pubmed publisher
    Dopamine (DA), octopamine (OA) and serotonin (5-HT) are the key neurotransmitters that control gonadal development in decapod crustaceans. 5-HT stimulates, while DA and OA delay gonadal development in Macrobrachium rosenbergii...
  4. Rodríguez Valentín R, López González I, Jorquera R, Labarca P, Zurita M, Reynaud E. Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic. J Cell Physiol. 2006;209:183-98 pubmed
    ..In insects, two neuroactive substances are important for oviduct contraction: octopamine (OA), a monoamine that inhibits oviduct contraction, and glutamate (Glu), a neurotransmitter that induces ..
  5. Kutsukake M, Komatsu A, Yamamoto D, Ishiwa Chigusa S. A tyramine receptor gene mutation causes a defective olfactory behavior in Drosophila melanogaster. Gene. 2000;245:31-42 pubmed
    ..1990. Neuron 2, 343-354). Electrophysiological responses to octopamine and tyramine were examined by measuring the excitatory junctional potential (EJP) amplitude from larval body-..
  6. Stevenson P, Hofmann H, Schoch K, Schildberger K. The fight and flight responses of crickets depleted of biogenic amines. J Neurobiol. 2000;43:107-20 pubmed
    ..AMTP) and alpha-methyl-p-tyrosine (AMT) to specifically deplete serotonin, respectively dopamine and octopamine. Standard immunocytochemical techniques were used to verify depletion from central nervous tissue, and determine ..
  7. Petrascheck M, Ye X, Buck L. A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. Ann N Y Acad Sci. 2009;1170:698-701 pubmed publisher
    ..It also requires a serotonin receptor and an octopamine receptor, both of which are inhibited by the drug...
  8. Zumstein N, Forman O, Nongthomba U, Sparrow J, Elliott C. Distance and force production during jumping in wild-type and mutant Drosophila melanogaster. J Exp Biol. 2004;207:3515-22 pubmed
    ..0 ms and the peak force should be 274 microN (137 microN leg(-1)). We predicted, from the role of octopamine in enhancing muscle tension in several locust muscles, that if stored elastic energy plays no part in force ..
  9. Kim G, Nalini M, Kim Y, Lee D. Octopamine and 5-hydroxytryptamine mediate hemocytic phagocytosis and nodule formation via eicosanoids in the beet armyworm, Spodoptera exigua. Arch Insect Biochem Physiol. 2009;70:162-76 pubmed publisher
    b>Octopamine and 5-hydroxytryptamine (5-HT) have been known to mediate cellular immune responses, such as hemocytic phagocytosis and nodule formation, during bacterial invasion in some insects...

More Information

Publications62

  1. Vierk R, Pflueger H, Duch C. Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009;195:265-77 pubmed publisher
    The biogenic amine, octopamine, modulates a variety of aspects of insect motor behavior, including direct action on the flight central pattern generator...
  2. Smedema J, Muller G. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98:372-3 pubmed
  3. Schwaerzel M, Monastirioti M, Scholz H, Friggi Grelin F, Birman S, Heisenberg M. Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila. J Neurosci. 2003;23:10495-502 pubmed
    ..Here we investigate, in the fly Drosophila melanogaster, the role of dopamine and octopamine (the presumed arthropod homolog of norepinephrine) during the formation of appetitive and aversive olfactory ..
  4. Monastirioti M. Distinct octopamine cell population residing in the CNS abdominal ganglion controls ovulation in Drosophila melanogaster. Dev Biol. 2003;264:38-49 pubmed
    b>Octopamine is an important neuroactive substance that modulates several physiological functions and behaviors of invertebrate species...
  5. Sinakevitch I, Strausfeld N. Comparison of octopamine-like immunoreactivity in the brains of the fruit fly and blow fly. J Comp Neurol. 2006;494:460-75 pubmed
    A serum raised against conjugated octopamine reveals structurally comparable systems of perikarya and arborizations in protocerebral neuropils of two species of Diptera, Drosophila melanogaster and Phaenicia sericata; the latter is used ..
  6. Reale V, Hannan F, Midgley J, Evans P. The expression of a cloned Drosophila octopamine/tyramine receptor in Xenopus oocytes. Brain Res. 1997;769:309-20 pubmed
    The expression of a cloned Drosophila octopamine/tyramine receptor (OctyR99AB) is described in Xenopus oocytes...
  7. Rosenberg L, Glusman J, Libersat F. Octopamine partially restores walking in hypokinetic cockroaches stung by the parasitoid wasp Ampulex compressa. J Exp Biol. 2007;210:4411-7 pubmed
    ..In the present study we investigate the effect of an octopamine receptor agonist and an antagonist on the locomotor behavior of stung and control cockroaches...
  8. Scheiner R, Plückhahn S, Oney B, Blenau W, Erber J. Behavioural pharmacology of octopamine, tyramine and dopamine in honey bees. Behav Brain Res. 2002;136:545-53 pubmed
    ..We tested whether the biogenic amines octopamine, tyramine and dopamine, and the dopamine receptor agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,..
  9. Artyukhin A, Yim J, Srinivasan J, Izrayelit Y, Bose N, von Reuss S, et al. Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans. J Biol Chem. 2013;288:18778-83 pubmed publisher
    ..we identified novel ascarosides incorporating a side chain derived from succinylation of the neurotransmitter octopamine. These compounds, named osas#2, osas#9, and osas#10, are produced predominantly by L1 larvae, where they serve ..
  10. Barron A, Schulz D, Robinson G. Octopamine modulates responsiveness to foraging-related stimuli in honey bees (Apis mellifera). J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002;188:603-10 pubmed
    The biogenic amine neurochemical octopamine is involved in the onset of foraging behaviour in honey bees...
  11. Saraswati S, Fox L, Soll D, Wu C. Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae. J Neurobiol. 2004;58:425-41 pubmed
    ..in both vertebrates and invertebrates, little is known about the effects of trace amines like tyramine and octopamine. We investigated how trace amines affect behaviors using quantitative morphometric methods on Drosophila Tbetah(..
  12. Isiegas C, McDonough C, Huang T, Havekes R, Fabian S, Wu L, et al. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci. 2008;28:6220-30 pubmed publisher
    ..we have developed a novel conditional genetic system in mice based on the heterologous expression of an Aplysia octopamine receptor, a G-protein-coupled receptor whose activation by its natural ligand octopamine leads to rapid and ..
  13. Adamo S, Baker J. Conserved features of chronic stress across phyla: the effects of long-term stress on behavior and the concentration of the neurohormone octopamine in the cricket, Gryllus texensis. Horm Behav. 2011;60:478-83 pubmed publisher
    ..predator induced a transient increase in the hemolymph (blood) concentration of the insect stress neurohormone, octopamine. Repeated exposure to the mock predator increased basal levels of octopamine, similar to the effects of chronic ..
  14. Nagaya Y, Kutsukake M, Chigusa S, Komatsu A. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Neurosci Lett. 2002;329:324-8 pubmed
    ..is a G protein-coupled receptor for trace amines, cloned in Drosophila melanogaster, and claimed to be either an octopamine receptor or a tyramine receptor...
  15. Rubinstein C, Wolfner M. Drosophila seminal protein ovulin mediates ovulation through female octopamine neuronal signaling. Proc Natl Acad Sci U S A. 2013;110:17420-5 pubmed publisher
    ..Ovulation requires octopamine (OA) signaling from the central nervous system to coordinate an egg's release from the ovary and its passage ..
  16. Reyes Colón D, Vázquez Acevedo N, Rivera N, Jezzini S, Rosenthal J, Ruíz Rodríguez E, et al. Cloning and distribution of a putative octopamine/tyramine receptor in the central nervous system of the freshwater prawn Macrobrachium rosenbergii. Brain Res. 2010;1348:42-54 pubmed publisher
    There is ample evidence linking octopamine (OA) and tyramine (TA) to several neurophysiological functions in arthropods...
  17. Noble T, Stieglitz J, Srinivasan S. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell Metab. 2013;18:672-84 pubmed publisher
    ..elegans and show that the effects of 5-HT require signaling from octopamine, the invertebrate analog of adrenaline, to sustain body fat loss...
  18. Huang J, Hamasaki T, Ozoe F, Ozoe Y. Single amino acid of an octopamine receptor as a molecular switch for distinct G protein couplings. Biochem Biophys Res Commun. 2008;371:610-4 pubmed publisher
    b>Octopamine (OA) is thought to be the invertebrate counterpart of noradrenaline and regulates various behavioral patterns of invertebrates by activating OA receptors...
  19. Barrozo R, Jarriault D, Simeone X, Gaertner C, Gadenne C, Anton S. Mating-induced transient inhibition of responses to sex pheromone in a male moth is not mediated by octopamine or serotonin. J Exp Biol. 2010;213:1100-6 pubmed publisher
    ..To test our hypothesis, we studied the effects of octopamine (OA) and serotonin (5-hydroxytryptamine, 5-HT) on the coding properties of pheromone-sensitive AL neurons in ..
  20. Sinakevitch I, Niwa M, Strausfeld N. Octopamine-like immunoreactivity in the honey bee and cockroach: comparable organization in the brain and subesophageal ganglion. J Comp Neurol. 2005;488:233-54 pubmed publisher
    A serum raised against octopamine reveals in cockroaches and honey bees structurally comparable systems of perikarya and their extensive yet discrete systems of arborizations in neuropils...
  21. Spivak M, Masterman R, Ross R, Mesce K. Hygienic behavior in the honey bee (Apis mellifera L.) and the modulatory role of octopamine. J Neurobiol. 2003;55:341-54 pubmed
    ..Because the neuromodulator octopamine (OA) plays a pivotal role in olfactory-based behaviors of honey bees, we examined whether bees bred for hygienic ..
  22. Gallant P, Malutan T, McLean H, Verellen L, Caveney S, Donly C. Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth. Eur J Biochem. 2003;270:664-74 pubmed
    ..TrnDAT shares only 45% amino acid sequence identity with an octopamine transporter (TrnOAT) cloned recently from this moth...
  23. Blais V, Bounif N, Dubé F. Characterization of a novel octopamine receptor expressed in the surf clam Spisula solidissima. Gen Comp Endocrinol. 2010;167:215-27 pubmed publisher
    We have cloned and sequenced a cDNA from the surf clam (Spisula solidissima, a pelecypod mollusc) that encodes an octopamine receptor which we have named Spi-OAR...
  24. Torkkeli P, Panek I, Meisner S. Ca²(+) /calmodulin-dependent protein kinase II mediates the octopamine-induced increase in sensitivity in spider VS-3 mechanosensory neurons. Eur J Neurosci. 2011;33:1186-96 pubmed publisher
    G-protein-coupled octopamine (OA) receptors mediate their effects by Ca²(+) signaling or adjusting intracellular cAMP levels...
  25. Balfanz S, Strünker T, Frings S, Baumann A. A family of octopamine [corrected] receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster. J Neurochem. 2005;93:440-51 pubmed
    In invertebrates, the biogenic-amine octopamine is an important physiological regulator. It controls and modulates neuronal development, circadian rhythm, locomotion, 'fight or flight' responses, as well as learning and memory...
  26. Wragg R, Hapiak V, Miller S, Harris G, Gray J, Komuniecki P, et al. Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors. J Neurosci. 2007;27:13402-12 pubmed
    ..In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but not dilute (30%) octanol...
  27. Roeder T. Octopamine in invertebrates. Prog Neurobiol. 1999;59:533-61 pubmed
    b>Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates...
  28. Roeder T. Tyramine and octopamine: ruling behavior and metabolism. Annu Rev Entomol. 2005;50:447-77 pubmed
    b>Octopamine (OA) and tyramine (TA) are the invertebrate counterparts of the vertebrate adrenergic transmitters. They are decarboxylation products of the amino acid tyrosine, with TA as the biological precursor of OA...
  29. Gruntenko N, Chentsova N, Bogomolova E, Karpova E, Glazko G, Faddeeva N, et al. The effect of mutations altering biogenic amine metabolism in Drosophila on viability and the response to environmental stresses. Arch Insect Biochem Physiol. 2004;55:55-67 pubmed
    ..The role of biogenic amines in the stress reaction development and adaptation to environmental stresses in Drosophila is discussed. Arch. Insect Biochem. Physiol. 55:55-67, 2004...
  30. Price D, Berry M. Comparison of effects of octopamine and insecticidal essential oils on activity in the nerve cord, foregut, and dorsal unpaired median neurons of cockroaches. J Insect Physiol. 2006;52:309-19 pubmed
    ..Eugenol has been reported to exert its insecticidal properties via a low-dose activation of octopamine receptors...
  31. Pedetta S, Kaczer L, Maldonado H. Individual aggressiveness in the crab Chasmagnathus: Influence in fight outcome and modulation by serotonin and octopamine. Physiol Behav. 2010;101:438-45 pubmed publisher
    ..analysing the proximate roots of aggression, addressing the influence of the biogenic amines serotonin (5HT) and octopamine (OA) in crab's agonistic behaviour. To achieve these purposes, the following experiments were carried out...
  32. Busch S, Tanimoto H. Cellular configuration of single octopamine neurons in Drosophila. J Comp Neurol. 2010;518:2355-64 pubmed publisher
    Individual median octopamine neurons in the insect central nervous system serve as an excellent model system for comparative neuroanatomy of single identified cells...
  33. Blenau W, Baumann A. Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol. 2001;48:13-38 pubmed
    ..In insects, amines like dopamine, tyramine, octopamine, serotonin, and histamine exert their effects by binding to specific membrane proteins that primarily belong to ..
  34. Pophof B. Octopamine enhances moth olfactory responses to pheromones, but not those to general odorants. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002;188:659-62 pubmed
    Effects of octopamine on responses of olfactory receptor neurons of Bombyx mori males and females, specialized to the reception of pheromone components and general odorants, respectively, were compared...
  35. Kononenko N, Wolfenberg H, Pflüger H. Tyramine as an independent transmitter and a precursor of octopamine in the locust central nervous system: an immunocytochemical study. J Comp Neurol. 2009;512:433-52 pubmed publisher
    b>Octopamine and its precursor tyramine are biogenic amines that are found ubiquitously in insects, playing independent but opposite neuromodulatory roles in a wide spectrum of behaviors, ranging from locomotion and aggression to learning ..
  36. Stevenson P, Dyakonova V, Rillich J, Schildberger K. Octopamine and experience-dependent modulation of aggression in crickets. J Neurosci. 2005;25:1431-41 pubmed
    ..We present evidence that a form of experience-dependent plasticity of aggression in crickets is mediated by octopamine, the invertebrate counterpart of noradrenaline...
  37. Erion R, DiAngelo J, Crocker A, Sehgal A. Interaction between sleep and metabolism in Drosophila with altered octopamine signaling. J Biol Chem. 2012;287:32406-14 pubmed
    ..b>Octopamine promotes wakefulness in the fly by acting through the insulin-producing cells (IPCs) in the fly brain...
  38. Vehovszky A, Szabó H, Elliott C. Octopamine increases the excitability of neurons in the snail feeding system by modulation of inward sodium current but not outward potassium currents. BMC Neurosci. 2005;6:70 pubmed
    Although octopamine has long been known to have major roles as both transmitter and modulator in arthropods, it has only recently been shown to be functionally important in molluscs, playing a role as a neurotransmitter in the feeding ..
  39. Rauschenbach I, Chentsova N, Alekseev A, Gruntenko N, Adonyeva N, Karpova E, et al. Dopamine and octopamine regulate 20-hydroxyecdysone level in vivo in Drosophila. Arch Insect Biochem Physiol. 2007;65:95-102 pubmed
    ..virilis and demonstrated that an increase in JH titre results in a steep increase of 20E level. The supposition that biogenic amines act as intermediary between JH and 20E in the control of Drosophila reproduction is discussed...
  40. D Andrea G, Nordera G, Pizzolato G, Bolner A, Colavito D, Flaibani R, et al. Trace amine metabolism in Parkinson's disease: low circulating levels of octopamine in early disease stages. Neurosci Lett. 2010;469:348-51 pubmed publisher
    Recent evidence suggests that trace amines such as tyramine and octopamine, alternative products of tyrosine metabolism (an aminoacid parent of dopamine and noradrenaline), play a role in the homeostasis of the extrapyramidal system...
  41. Dacks A, Dacks J, Christensen T, Nighorn A. The cloning of one putative octopamine receptor and two putative serotonin receptors from the tobacco hawkmoth, Manduca sexta. Insect Biochem Mol Biol. 2006;36:741-7 pubmed
    Serotonin and octopamine (OA) are biogenic amines that are active throughout the nervous systems of insects, affecting sensory processing, information coding and behavior...
  42. Lehman H, Schulz D, Barron A, Wraight L, Hardison C, Whitney S, et al. Division of labor in the honey bee (Apis mellifera): the role of tyramine beta-hydroxylase. J Exp Biol. 2006;209:2774-84 pubmed publisher
    The biogenic amine octopamine (OA) is involved in the regulation of honey bee behavioral development; brain levels are higher in foragers than bees working in the hive, especially in the antennal lobes, and treatment causes precocious ..
  43. Python F, Stocker R. Immunoreactivity against choline acetyltransferase, gamma-aminobutyric acid, histamine, octopamine, and serotonin in the larval chemosensory system of Dosophila melanogaster. J Comp Neurol. 2002;453:157-67 pubmed
    We have studied the distribution of choline acetyltransferase (ChAT), gamma-aminobutyric acid (GABA), histamine, octopamine and serotonin in the larval chemosensory system of Drosophila melanogaster...
  44. Sneddon L, Taylor A, Huntingford F, Watson D. Agonistic behaviour and biogenic amines in shore crabs Carcinus maenas. J Exp Biol. 2000;203:537-45 pubmed
    ..A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass ..
  45. Brembs B, Christiansen F, Pflüger H, Duch C. Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. J Neurosci. 2007;27:11122-31 pubmed
    ..It is modulated on multiple levels by the biogenic amine octopamine. Within the CNS, octopamine acts directly on the flight central pattern generator, and it affects motivational ..
  46. Armstrong G, Shoemaker K, Money T, Robertson R. Octopamine mediates thermal preconditioning of the locust ventilatory central pattern generator via a cAMP/protein kinase A signaling pathway. J Neurosci. 2006;26:12118-26 pubmed
    ..Levels of octopamine (OA) and dopamine (DA) in the metathoracic ganglion decreased during heat stress...
  47. Thevis M, Koch A, Sigmund G, Thomas A, Schanzer W. Analysis of octopamine in human doping control samples. Biomed Chromatogr. 2012;26:610-5 pubmed publisher
    The biogenic amine octopamine [4-(2-amino-1-hydroxyethyl)phenol] is prohibited in sports owing to its stimulating and performance-enhancing properties...
  48. Huang J, Wu S, Li X, Adamo S, Ye G. The characterization of a concentration-sensitive ?-adrenergic-like octopamine receptor found on insect immune cells and its possible role in mediating stress hormone effects on immune function. Brain Behav Immun. 2012;26:942-50 pubmed publisher
    b>Octopamine (OA), the insect equivalent of norepinephrine, links the nervous system and immune system in insects. This study examines the underlying molecular mechanisms (i.e...
  49. Suver M, Mamiya A, Dickinson M. Octopamine neurons mediate flight-induced modulation of visual processing in Drosophila. Curr Biol. 2012;22:2294-302 pubmed publisher
    ..However, the mechanisms underlying these phenomena remain poorly characterized...
  50. Carpene C, Galitzky J, Fontana E, Atgie C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1999;359:310-21 pubmed
    ..b>Octopamine was the only amine fully stimulating lipolysis in rat, hamster and dog fat cells, while inefficient in guinea-..
  51. Crocker A, Sehgal A. Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci. 2008;28:9377-85 pubmed publisher
    ..Here we show that a Drosophila biogenic amine, octopamine, is a potent wake-promoting signal...
  52. Araki M, Nagayama T, Sprayberry J. Cyclic AMP mediates serotonin-induced synaptic enhancement of lateral giant interneuron of the crayfish. J Neurophysiol. 2005;94:2644-52 pubmed
    ..Recent studies suggested that the biogenic amines serotonin and octopamine modulate the time course of recovery and/or re-depression of the LG response after habituation...
  53. Chen A, Ng F, Lebestky T, Grygoruk A, Djapri C, Lawal H, et al. Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster. Genetics. 2013;193:159-76 pubmed publisher
    ..Rescue of major aspects of adult locomotion and startle behavior required octopamine, but a complementary role was observed for serotonin...