deanol

Summary

Summary: An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.

Top Publications

  1. Grossman R. The role of dimethylaminoethanol in cosmetic dermatology. Am J Clin Dermatol. 2005;6:39-47 pubmed
    ..Here, we review available data on one such agent - 2-dimethylaminoethanol (DMAE) or deanol - that has recently been evaluated in a placebo-controlled trial...
  2. Uhoda I, Faska N, Robert C, Cauwenbergh G, Pierard G. Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res Technol. 2002;8:164-7 pubmed
    ..The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE.
  3. Gragnani A, Giannoccaro F, Sobral C, Moraes A, França J, Ferreira A, et al. Dimethylaminoethanol affects the viability of human cultured fibroblasts. Aesthetic Plast Surg. 2007;31:711-8 pubmed
  4. Waite K, Vance D. Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet. Biochim Biophys Acta. 2004;1636:175-82 pubmed
    ..We conclude that although PC and PDME exhibit similar physical properties, the three methyl groups of choline are required for hepatic function in mice...
  5. Schmaljohann J, Schirrmacher E, Wängler B, Wängler C, Schirrmacher R, Guhlke S. Fully automated SPE-based synthesis and purification of 2-[18F]fluoroethyl-choline for human use. Nucl Med Biol. 2011;38:165-70 pubmed publisher
    ..To allow a wider dissemination of this tracer, finding a purification method avoiding HPLC is highly desirable and would result in easier accessibility and more reliable production of [(18)F]FECH...
  6. Andriamampandry C, Freysz L, Kanfer J, Dreyfus H, Massarelli R. Conversion of ethanolamine, monomethylethanolamine and dimethylethanolamine to choline-containing compounds by neurons in culture and by the rat brain. Biochem J. 1989;264:555-62 pubmed
    ..Phosphocholine and the monomethyl and dimethyl derivatives of ethanolamine were detected in the brain 15 min after injection...
  7. Tadini K, Campos P. In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Pharmazie. 2009;64:818-22 pubmed
    ..Mechanical properties were not significantly modified. So, we can suggest that DMAE action is related to its effects on the dermis as observed in the histopathological and histometric studies and showed hydration effects on skin...
  8. Klonne D, Dodd D, Pritts I, Nachreiner D, Fowler E, Troup C, et al. Dimethylethanolamine: acute, 2-week, and 13-week inhalation toxicity studies in rats. Fundam Appl Toxicol. 1987;9:512-21 pubmed
    ..Thus, 24 ppm was considered to be the no-observable-effect level...
  9. Guo Y, Meng L, Zhang Y, Tang W, Zhang W, Xia Y, et al. Sensitive determination of four tetracycline antibiotics in pig plasma by field-amplified sample stacking open-tubular capillary electrochromatography with dimethylethanolamine aminated polychloromethyl styrene nano-latex coated capillary column. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;942-943:151-7 pubmed publisher
    ..The LODs ranged from 3 to 7ng/mL, the recoveries for the four TCA were all more than 80%. The developed method was successfully applied for the determination of TCs in the actual pig plasma samples. ..

More Information

Publications62

  1. Yasumiba S, Tazuma S, Ochi H, Kajiyama G, Mdt -. Modifying hepatic phospholipid synthesis associates with biliary phospholipid secretion rate in a transporter-independent manner in rats: relation to canalicular membrane fluidity. Dig Dis Sci. 2001;46:1290-8 pubmed
  2. Kanerva L, Estlander T, Jolanki R, Tarvainen K. Occupational allergic contact dermatitis and contact urticaria caused by polyfunctional aziridine hardener. Contact Dermatitis. 1995;33:304-9 pubmed
    ..As test substance, 0.5% PFA hardener in pet. is recommended for patch testing. Testing should be performed in patients with contact dermatitis if exposure to PFA has occurred. Skin prick tests may be of help to detect contact urticaria...
  3. Sonesson A, Oqvist B, Hagstam P, Björkman Burtscher I, Miörner H, Petersson A. An immunosuppressed patient with systemic vasculitis suffering from cerebral abscesses due to Nocardia farcinica identified by 16S rRNA gene universal PCR. Nephrol Dial Transplant. 2004;19:2896-900 pubmed
  4. Heinze B, Hoven N, O Connell T, Maurer K, Bartsch S, Bornscheuer U. Recovery of choline oxidase activity by in vitro recombination of individual segments. Appl Microbiol Biotechnol. 2008;81:275-82 pubmed publisher
    ..0 and at 37 degrees C. Furthermore, the substrate specificity was examined using N,N-dimethylethanolamine, N-methylethanolamine and 3,3-dimethyl-1-butanol...
  5. Sanz J, Lopez R, Garcia J. Structural requirements of choline derivatives for 'conversion' of pneumococcal amidase. A new single-step procedure for purification of this autolysin. FEBS Lett. 1988;232:308-12 pubmed
  6. Kier A, Parker M, Schroeder F. Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice. Biochim Biophys Acta. 1988;938:434-46 pubmed
    ..In summary, membrane alterations of LM tumor cells in vitro (1) were not completely reversed in vivo, and (2) affected metastatic ability...
  7. Haug B, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)?. Eur Neurol. 1991;31:423-5 pubmed
    ..is presented, which has been treated successfully with the acetylcholine precursor 2-dimethylaminoethanol (deanol) for 10 years...
  8. Kuye R, Donham K, Marquez S, Sanderson W, Fuortes L, Rautiainen R, et al. Pesticide handling and exposures among cotton farmers in the gambia. J Agromedicine. 2007;12:57-69 pubmed
    ..The aim of this study was to investigate how cotton farmers are exposed to pesticides in The Gambia and quantify their pesticide exposures and provide information for the formulation of a policy on pesticide safety for the country...
  9. Misdaq M, Karime M. Analysis of 238U, 232Th, 222Rn, and 220Rn in different medical drug preparations by using CR-39 and LR-115 typE II SSNTDs and resulting radiation doses to adult patients. Health Phys. 2009;96:27-36 pubmed publisher
    ..The maximum total committed effective dose due to 238U, 232Th, and 222Rn from the ingestion of the studied medical drug preparations, prepared from unpolluted waters, by adult patients was found equal to 1.44 microSv y...
  10. Slaets D, De Bruyne S, Dumolyn C, Moerman L, Mertens K, de Vos F. Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization. Eur J Nucl Med Mol Imaging. 2010;37:2136-45 pubmed publisher
    ..Due to high levels of dimethylaminoethanol (DMAE) remaining in [(18)F]FCho solutions synthesized by currently available methods, tumour visualization might be compromised...
  11. Artemyev M, Kisiel D, Abmiotko S, Antipina M, Khomutov G, Kislov V, et al. Self-organized, highly luminescent CdSe nanorod-DNA complexes. J Am Chem Soc. 2004;126:10594-7 pubmed
    ..DNA-CdSe-nanorod filaments possess strongly linearly polarized photoluminescence due to the unidirectional orientation of nanorods along the filaments...
  12. Qiao D, Nikitina L, Buznikov G, Lauder J, Seidler F, Slotkin T. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environ Health Perspect. 2003;111:1730-5 pubmed
    ..The sea urchin model may thus be useful in high-throughput screening of suspected developmental neurotoxicants...
  13. Abebe W, Maddux W, Schuster G, Lewis J. Vascular responsiveness to dimethylaminoethyl methacrylate and its degradation products. J Biomed Mater Res A. 2003;66:155-61 pubmed
    ..These effects may play a role in tissue homeostasis and certain adverse conditions associated with the use of dental resin materials containing DMAEMA and/or DME...
  14. Watkins A, Roussel E, Webster G, Parkes R, Sass H. Choline and N,N-dimethylethanolamine as direct substrates for methanogens. Appl Environ Microbiol. 2012;78:8298-303 pubmed publisher
    ..These results extend the known substrates that can be directly utilized by some methanogens, giving them the advantage that they would not be reliant on bacterial syntrophs for their substrate supply...
  15. L Haridon S, Chalopin M, Colombo D, Toffin L. Methanococcoides vulcani sp. nov., a marine methylotrophic methanogen that uses betaine, choline and N,N-dimethylethanolamine for methanogenesis, isolated from a mud volcano, and emended description of the genus Methanococcoides. Int J Syst Evol Microbiol. 2014;64:1978-83 pubmed publisher
    ..The name Methanococcoides vulcani sp. nov. is proposed for this novel species, with strain SLH33(T) (?=?DSM 26966(T)?=?JCM 19278(T)) as the type strain. An emended description of the genus Methanococcoides is also proposed...
  16. Takano M, Katsura T, Tomita Y, Yasuhara M, Hori R. Transport mechanism of choline in rat renal brush-border membrane. Biol Pharm Bull. 1993;16:889-94 pubmed
  17. Kiss Z, Crilly K, Anderson W. Protein kinase C inhibitors enhance the synergistic mitogenic effects of ethanolamine analogues and insulin in NIH 3T3 fibroblasts. Biochem Biophys Res Commun. 1996;220:125-30 pubmed
    ..9-fold) enhanced by GF 109203X (3 microM), a specific inhibitor of protein kinase C. The results suggest that ethanolamine analogues enhance insulin-induced DNA synthesis by a mechanism which is inhibited by the protein kinase C system...
  18. Fisher M, Zeisel S, Mar M, Sadler T. Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J. 2002;16:619-21 pubmed
    ..Results suggest that endogenous PtdCho synthesis is important during neurulation and that perturbed choline metabolism contributes to neural tube defects produced by DMAE and ET-18-OCH3...
  19. Sampels V, Hartmann A, Dietrich I, Coppens I, Sheiner L, Striepen B, et al. Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. J Biol Chem. 2012;287:16289-99 pubmed publisher
    ..The observed plasticity of gene expression and membrane biogenesis can ensure a faithful replication and adaptation of T. gondii in disparate host or nutrient environments...
  20. Leung H, Tyl R, Ballantyne B, Klonne D. Developmental toxicity study in Fischer 344 rats by whole-body exposure to N,N-dimethylethanolamine vapor. J Appl Toxicol. 1996;16:533-8 pubmed
    ..Hence, the no-observed-adverse-effect level is around 10 ppm for maternal toxicity and at or above 100 ppm for embryofetal toxicity and teratogenicity...
  21. Jamil H, Vance D. Head-group specificity for feedback regulation of CTP:phosphocholine cytidylyltransferase. Biochem J. 1990;270:749-54 pubmed
    ..The results provide further evidence for feedback regulation of phosphatidylcholine biosynthesis by phosphatidylcholine...
  22. Dimpfel W, Hofmann H, Prohaska A, Schober F, Schellenberg R. Source density analysis of functional topographical EEG: monitoring of cognitive drug action. Eur J Med Res. 1996;1:283-90 pubmed
    ..A second perspective arises from the fact that it should be possible to recognize mental impairments at a very early stage by using this method, thus providing the possibility of an early treatment...
  23. Litvintsev S, Shamreĭ V, Reznik A, Arbuzov A. [Perspectives on the treatment of organic mental disorders by the use of nootropic agents]. Voen Med Zh. 2002;323:59-62 pubmed
  24. Leung H, Ballantyne B. Evaluation of the genotoxic potential of alkylalkanolamines. Mutat Res. 1997;393:7-15 pubmed
    ..These results indicate that N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine are not genotoxic in the tests conducted...
  25. Shekh Ahmad T, Bialer M, Yavin E. Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. Epilepsy Res. 2012;98:238-46 pubmed publisher
    ..2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analogue of VPA that serves as a starting material for the synthesis of CNS-active compounds...
  26. Kiss Z, Crilly K. Ethanolamine analogues stimulate DNA synthesis by a mechanism not involving phosphatidylethanolamine synthesis. FEBS Lett. 1996;381:67-70 pubmed
    ..These results suggest that ethanolamine and its analogues, formed by phospholipase D-mediated hydrolysis of ethanolamine phospholipids, may have growth regulatory functions independent of their role as phospholipid precursors...
  27. Rimland B. Controversies in the treatment of autistic children: vitamin and drug therapy. J Child Neurol. 1988;3 Suppl:S68-72 pubmed
    ..5 parents reporting behavioral improvement to every one reporting behavioral worsening. Deanol (n = 121) was next most highly rated, with 1.8 parents reporting improvement to each one reporting worsening...
  28. Alvaro D, Cantafora A, Gandin C, Masella R, Santini M, Angelico M. Selective hepatic enrichment of polyunsaturated phosphatidylcholines after intravenous administration of dimethylethanolamine in the rat. Biochim Biophys Acta. 1989;1006:116-20 pubmed
    ..The selective hepatic enrichment with polyunsaturated PC species after DME infusion may offer a new experimental tool for studying hepatic membrane metabolism...
  29. Fisher M, Zeisel S, Mar M, Sadler T. Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology. 2001;64:114-22 pubmed
    ..The demand by an embryo or fetus for choline may place a pregnant woman and, subsequently, the developing conceptus at risk for choline deficiency...
  30. Bevan C, Kinne R. Choline transport in collecting duct cells isolated from the rat renal inner medulla. Pflugers Arch. 1990;417:324-8 pubmed
    ..Furthermore, the increase in the GPC content under hyperosmotic conditions is not associated with increased activity of the transport systems of biosynthetic precursors...
  31. Stenback F, Weisburger J, Williams G. Effect of lifetime administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice. Mech Ageing Dev. 1988;42:129-38 pubmed
    ..Also, there was no statistically significant difference between control and treated animals in the age of onset or the type of specific neoplasms. Dimethylaminoethanol did not induce any neoplasms...
  32. Blin O, Audebert C, Pitel S, Kaladjian A, Casse Perrot C, Zaim M, et al. Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies. Psychopharmacology (Berl). 2009;207:201-12 pubmed publisher
  33. Batista I, Gonçalves M, Singh A, Hackmann E, Santoro M. Quantitative determination of dimethylaminoethanol in cosmetic formulations by nuclear magnetic resonance spectroscopy. J AOAC Int. 2008;91:1303-8 pubmed
    ..0023 and 0.0071 g for DMAE acetamidobenzoate, respectively. The proposed method is simple, precise, and accurate and can be used in the quality control of raw materials and cosmetic gels containing these compounds as active substances...
  34. Yao Z, Vance D. Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytes. J Biol Chem. 1989;264:11373-80 pubmed
    ..2 mM) and homocysteine (0.2 mM), indicating the utilization of a methyl group from betaine for PC formation via methylation of PE...
  35. Clares B, Ruiz M, Morales M, Tamayo J, Lara V. Structural characterization and stability of dimethylaminoethanol and dimethylaminoethanol bitartrate for possible use in cosmetic firming. J Cosmet Sci. 2010;61:269-78 pubmed
    2-Dimethylaminoethanol (DMAE) (also known as deanol) has been used as an ingredient in skin care, and in cognitive function- and mood-enhancing products...
  36. Leung H, Blaszcak D. The skin sensitization potential of four alkylalkanolamines. Vet Hum Toxicol. 1998;40:65-7 pubmed
    ..None of the remaining 3 alkylalkanolamines exhibited clear skin responses suggestive of sensitization...
  37. Morissette G, Germain L, Marceau F. The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology. Br J Dermatol. 2007;156:433-9 pubmed
    ..The 'cosmeceutical' agent 2-dimethylaminoethanol (DMAE) is a tertiary amine found in high concentration in numerous topical antiwrinkle preparations...
  38. Dimpfel W, Wedekind W, Keplinger I. Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Eur J Med Res. 2003;8:183-91 pubmed
  39. Dubois B, Zaim M, Touchon J, Vellas B, Robert P, Murphy M, et al. Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's disease. J Alzheimers Dis. 2012;29:527-35 pubmed publisher
    ..Lessons learned in AD study design optimization, including those presented in this paper, could be valuable for further investigation with pro-cholinergic drugs such as V0191...
  40. Alvaro D, Angelico M, Cantafora A, Gaudio E, Gandin C, Santini M, et al. Improvement of estradiol 17 beta-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the rat. Hepatology. 1991;13:1158-72 pubmed
    ..Dilatation of canaliculi and loss of microvilli were evident in estradiol 17 beta-D-glucuronide controls 180 min after estradiol 17 beta-D-glucuronide administration.(ABSTRACT TRUNCATED AT 400 WORDS)..
  41. Cao Z, Kanfer J. Partial purification and characterization of monomethylethanolamine kinase and dimethylethanolamine kinase activities from rat liver. Biochem Int. 1991;23:1133-41 pubmed
    ..4. The purification fold of MEA kinase and DEA kinase are different from each other and from that of choline kinase and ethanolamine kinase...
  42. McMaster C, Tardi P, Choy P. Modulation of phosphatidylethanolamine biosynthesis by exogenous ethanolamine and analogues in the hamster heart. Mol Cell Biochem. 1992;116:69-73 pubmed
  43. Houston K, Babayan S, Allen J, Harnett W. Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?. Parasitology. 2008;135:55-61 pubmed
    ..Overall our results raise the previously unconsidered but intriguing possibility that in L. sigmodontis, choline may be the precursor of DMAE...
  44. Fu Z, Wang L, Wang Y. Capillary electrophoresis-electrochemiluminescent detection of N,N-dimethyl ethanolamine and its application in impurity profiling and stability investigation of meclophenoxate. Anal Chim Acta. 2009;638:220-4 pubmed publisher
    ..A primary stability investigation of meclophenoxate in aqueous solution was also carried out at different temperatures, and the results showed that the degradation of meclophenoxate accelerated at the higher temperature...
  45. Romanova S, Shtil A, Serebrennikova G. [Synthesis and cytotoxicity of novel phosphorusless analogues of edelfosine]. Bioorg Khim. 2008;34:827-30 pubmed
    ..The cytotoxic characteristics of the compounds synthesized were studied...
  46. Sommerfeld B. Randomised, placebo-controlled, double-blind, split-face study on the clinical efficacy of Tricutan on skin firmness. Phytomedicine. 2007;14:711-5 pubmed
    ..The results show that Tricutan can increase skin firmness both objectively and subjectively. Further studies are warranted, especially to investigate if Tricutan can delay the need for surgical face-lift procedures...
  47. Davydova N, Kuznetsova T, Borisova S, Abdulkadyrova M. [Effects of nootropic agents on visual functions and lacrimal antioxidative activity in patients with primary open-angle glaucoma]. Vestn Oftalmol. 2006;122:42-5 pubmed
    ..These agents have been found to have a beneficial effect on the functional activity of the retina and optic nerve, light sensitivity, hemo- and hydrodynamics of the eye...
  48. Kaech A, Vallotton N, Egli T. Isolation and characterization of heterotrophic bacteria able to grow aerobically with quaternary ammonium alcohols as sole source of carbon and nitrogen. Syst Appl Microbiol. 2005;28:230-41 pubmed
    ..DM 2 was also utilizing TM as sole source of carbon and nitrogen. However, all of the isolated bacteria were growing with the natural and structurally related compound choline...
  49. Moeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. Am J Physiol. 1997;272:F94-9 pubmed
    ..We concluded that betaine synthesized in the kidney can be accumulated in the medulla and that the medullary concentrations of newly synthesized betaine are closely related to the hydration state of the animal...
  50. Zs Nagy I. Pharmacological interventions against aging through the cell plasma membrane: a review of the experimental results obtained in animals and humans. Ann N Y Acad Sci. 2002;959:308-20; discussion 463-5 pubmed
    ..A modified, developed version of CPH coded as BCE-001 is also reported...
  51. Brand A, Gil S, Seger R, Yavin E. Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. J Neurochem. 2001;76:910-8 pubmed
    ..Thus, the membrane lipid composition ultimately modulates ERK activation and translocation and therefore can promote or prevent apoptotic cell death...
  52. Jacobs T, Passarello B, Horwitz J. Increased levels of methylated intermediates of phosphatidylcholine lead to enhanced phospholipase D activity. Neurochem Res. 1998;23:1099-105 pubmed
    ..Finally, this effect is not due to some generalized enhancement of receptor coupling because incubation of the cells with methylethanolamine does not lead to an increase in bradykinin stimulated inositol phosphate production...
  53. Malewicz B, Mukherjee J, Crilly K, Baumann W, Kiss Z. Phosphorylation of ethanolamine, methylethanolamine, and dimethylethanolamine by overexpressed ethanolamine kinase in NIH 3T3 cells decreases the co-mitogenic effects of ethanolamines and promotes cell survival. Eur J Biochem. 1998;253:10-9 pubmed
    ..In vector control cells, only Me2Etn in combination with insulin had similar effects on cell survival. The data suggest that phosphorylated ethanolamines may function as promoters of cell survival...