amino alcohols

Summary

Summary: Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).

Top Publications

  1. Babu B, Endo Y, Bäckvall J. Biomimetic aerobic oxidation of amino alcohols to lactams. Chemistry. 2012;18:11524-7 pubmed publisher
    The right path: N-protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme)...
  2. Wanderley M, Wang C, Wu C, Lin W. A chiral porous metal-organic framework for highly sensitive and enantioselective fluorescence sensing of amino alcohols. J Am Chem Soc. 2012;134:9050-3 pubmed publisher
    ..The fluorescence of 1 can be effectively quenched by amino alcohols via H-bonding with the binaphthol moieties decorating the MOF, leading to a remarkable chiral sensor for amino ..
  3. de Almeida M, Le Hyaric M, Amarante G, Silva Lourenço M, Lima Brandão M. Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents. Eur J Med Chem. 2007;42:1076-83 pubmed
    ..Monoacylated derivatives displayed antitubercular activity...
  4. Ghosn M, Wolf C. Chiral amplification with a stereodynamic triaryl probe: assignment of the absolute configuration and enantiomeric excess of amino alcohols. J Am Chem Soc. 2009;131:16360-1 pubmed publisher
    ..The well-defined chiral amplification in the diimines formed results in intense Cotton effects at high wavelengths that can be used for in situ CD analysis of the absolute configuration and ee of cyclic and acyclic substrates...
  5. Júnior C, Le Hyaric M, Costa C, Corrêa T, Taveira A, Araújo D, et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Mem Inst Oswaldo Cruz. 2009;104:703-5 pubmed
    A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity...
  6. Pruett S, Bushnev A, Hagedorn K, Adiga M, Haynes C, Sullards M, et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008;49:1621-39 pubmed publisher
    ..quot; This category of amino alcohols is now known to encompass hundreds of compounds that are referred to as sphingoid bases and sphingoid base-..
  7. Moberly J, Rohatagi S, Zahir H, Hsu C, Noveck R, Truitt K. Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator. J Clin Pharmacol. 2012;52:996-1006 pubmed publisher
    ..5 mg). Therefore, CS-0777 shows potent activity in humans and may hold potential for treatment of autoimmune conditions such as multiple sclerosis...
  8. Taveira A, Hyaric M, Reis E, Araújo D, Ferreira A, de Souza M, et al. Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives. Bioorg Med Chem. 2007;15:7789-94 pubmed
    A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL...
  9. Donohoe T, Callens C, Flores A, Lacy A, Rathi A. Recent developments in methodology for the direct oxyamination of olefins. Chemistry. 2011;17:58-76 pubmed publisher
    1,2-Amino alcohols are high-value, versatile functional groups that are found in scores of biologically active molecules and other interesting synthetic targets such as ligands and auxiliaries...

More Information

Publications62

  1. Kocsis B, Kustos I, Kilar F, Nyul A, Jakus P, Kerekes S, et al. Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action. Eur J Med Chem. 2009;44:1823-9 pubmed publisher
    The antifungal activity of some known unsaturated Mannich ketones and their amino alcohols has been reported and the mechanism of antifungal action has been studied...
  2. Júnior C, Alves R, Rezende C, da Costa C, Silva H, Le Hyaric M, et al. Trypanocidal activity of lipophilic diamines and amino alcohols. Biomed Pharmacother. 2010;64:624-6 pubmed publisher
    Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth...
  3. Coimbra E, De Almeida M, Júnior C, Taveira A, da Costa C, de Almeida A, et al. Synthesis and antileishmanial activity of lipidic amino alcohols. Chem Biol Drug Des. 2010;75:233-5 pubmed publisher
    In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L...
  4. Cossy J, Pardo D, Dumas C, Mirguet O, Déchamps I, Métro T, et al. Rearrangement of beta-amino alcohols and application to the synthesis of biologically active compounds. Chirality. 2009;21:850-6 pubmed publisher
    Beta-amino alcohols derived from natural amino acids have been used extensively as a powerful source of chirality...
  5. Birrell J, Jacobsen E. A practical method for the synthesis of highly enantioenriched trans-1,2-amino alcohols. Org Lett. 2013;15:2895-7 pubmed publisher
    ..addition of phenyl carbamate to meso-epoxides has been developed to efficiently generate protected trans-1,2-amino alcohols. This transformation is promoted by an oligomeric (salen)Co-OTf catalyst and has been used to prepare two ..
  6. Giordani R, De Almeida M, Fernandes E, França da Costa C, De Carli G, Tasca T, et al. Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives. Biomed Pharmacother. 2009;63:613-7 pubmed publisher
    ..vaginalis trophozoites. Furthermore, the cytotoxicity of 1 did not present statistically significant difference when compared to metronidazole in the same range of concentration (0.1-1.5 microg/mL)...
  7. Li X, Tanasova M, Vasileiou C, Borhan B. Fluorinated porphyrin tweezer: a powerful reporter of absolute configuration for erythro and threo diols, amino alcohols, and diamines. J Am Chem Soc. 2008;130:1885-93 pubmed publisher
    ..and sensitive nonempirical protocol to determine the absolute configurations of erythro and threo diols, amino alcohols, and diamines is reported...
  8. Lemini C, Franco Y, Avila M, Jaimez R. Contrasting effects of estradiol and 17 beta-aminoestrogens on blood clotting time in rats and mice. Eur J Pharmacol. 2005;510:229-33 pubmed
    ..The maximum procoagulant effect of estradiol was obtained after 72 h with 10 microg/animal/day (-45%; P<0.01). 17 Beta-aminoestrogens always produced opposite effects to those of estradiol on blood coagulation...
  9. Matsunaga S, Yoshida T, Morimoto H, Kumagai N, Shibasaki M. Direct catalytic asymmetric Mannich-type reaction of hydroxyketone using a Et2Zn/linked-BINOL complex: synthesis of either anti- or syn-beta-amino alcohols. J Am Chem Soc. 2004;126:8777-85 pubmed
    ..N-Diphenylphosphinoyl (Dpp) imine 3 gave anti-beta-amino alcohols in anti/syn = up to >98/2, up to >99% yield, and up to >99...
  10. Fullam E, Abuhammad A, Wilson D, Anderton M, Davies S, Russell A, et al. Analysis of ?-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorg Med Chem Lett. 2011;21:1185-90 pubmed publisher
    The synthesis and inhibitory potencies of a novel series of ?-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of ..
  11. Yonesu K, Kubota K, Tamura M, Inaba S, Honda T, Yahara C, et al. Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes. J Biol Chem. 2011;286:24765-75 pubmed publisher
    ..Identification of the kinases responsible for CS-0777 activation will permit a better understanding of the pharmacokinetics and pharmacodynamics of this promising new drug...
  12. Lemini C, Canchola E. Effects of 17beta-aminoestrogens on the sexual behavior of female rats. Physiol Behav. 2009;96:662-6 pubmed publisher
    ..AEs LQDE50 values correlate with previous Uw DE50, LH ID50 and binding studies indicates mediation of the response by estrogen receptors. AEs facilitate sexual behavior of Ovx rats as partial estrogenic agonists...
  13. Chaubey A, Parshad R, Gupta P, Taneja S, Qazi G, Rajan C, et al. Arthrobacter sp. lipase immobilization for preparation of enantiopure masked beta-amino alcohols. Bioorg Med Chem. 2009;17:29-34 pubmed publisher
    ..Present work demonstrates a facile method for the preparation of enantiopure beta-amino alcohols by modulation of ABL enzyme properties via immobilization on insoluble as well as soluble supports using ..
  14. Tewari N, Tiwari V, Tripathi R, Chaturvedi V, Srivastava A, Srivastava R, et al. Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents. Bioorg Med Chem Lett. 2004;14:329-32 pubmed
    The galactopyranosyl amino alcohols (3-16) were synthesised by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities...
  15. Fraunhoffer K, White M. syn-1,2-Amino alcohols via diastereoselective allylic C-H amination. J Am Chem Soc. 2007;129:7274-6 pubmed
  16. Fan Y, Kwon O. Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and ?-amino alcohols. Molecules. 2011;16:3802-25 pubmed publisher
    ..oxizolidines through 1,3-bis(diphenylphosphino)-propane (DPPP)-catalyzed mixed double-Michael reactions of ?-amino alcohols with electron-deficient acetylenes...
  17. Vora H, Moncecchi J, Epstein O, Rovis T. Nucleophilic carbene catalyzed synthesis of 1,2 amino alcohols via azidation of epoxy aldehydes. J Org Chem. 2008;73:9727-31 pubmed publisher
    ..Both products are formed in modest to good yields and diastereoselectivities. The use of an enantioenriched triazolium catalyst leads to modest asymmetric induction...
  18. List B, Pojarliev P, Biller W, Martin H. The proline-catalyzed direct asymmetric three-component Mannich reaction: scope, optimization, and application to the highly enantioselective synthesis of 1,2-amino alcohols. J Am Chem Soc. 2002;124:827-33 pubmed
    ..Reaction conditions have been optimized, and the mechanism and source of asymmetric induction are discussed. We further present application of our reaction to the highly enantioselective synthesis of 1,2-amino alcohols.
  19. Clark R, Garson M, Hooper J. Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp. J Nat Prod. 2001;64:1568-71 pubmed
    Three new amino alcohols presumably deriving from L-alanine were isolated from the tropical marine sponge Haliclona n. sp. and characterized by 2D NMR, while a fourth amino alcohol was characterized as an acetamide derivative...
  20. Wipf P, Wang X. Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols. J Comb Chem. 2002;4:656-60 pubmed
    ..Free carboxylic acids were directly condensed with amino alcohols and aminothiols in the presence of 3-nitrophenylboronic acid as a dehydration catalyst...
  21. Ichihashi M, Mori K. Determination of the absolute configuration of (+)-xestoaminol C [(2S, 3R)-2-amino-3-tetradecanol], a metabolite of Fiji sponge, Xestospongia sp., by the synthesis of its N,O-diacetyl derivative. Biosci Biotechnol Biochem. 2003;67:329-33 pubmed
    ..The N,O-diacetyl derivative of (+)-xestoaminol C (2-amino-3-tetradecanol, 1), an inhibitor of reverse transcriptase isolated from Xestospongia sp., was synthesized from (S)-alanine, and its absolute configuration was determined as 2S, 3R...
  22. Del Olmo E, Alves M, Lopez J, Inchaustti A, Yaluff G, Rojas de Arias A, et al. Leishmanicidal activity of some aliphatic diamines and amino-alcohols. Bioorg Med Chem Lett. 2002;12:659-62 pubmed
    ..Some SAR considerations have been deduced...
  23. Nicholas G, Li R, Macmillan J, Molinski T. Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. Bioorg Med Chem Lett. 2002;12:2159-62 pubmed
    ..The dimeric bi-functionalized lipids exhibited activity about approximately 10-fold higher higher than D-sphingosine, which is a larger factor than expected from the simple additive effects of vicinal aminoalcohols groups...
  24. Nagahashi M, Ramachandran S, Kim E, Allegood J, Rashid O, Yamada A, et al. Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res. 2012;72:726-35 pubmed publisher
    ..Taken together, our findings show that SphK1-produced S1P is a crucial mediator of breast cancer-induced hemangiogenesis and lymphangiogenesis. Our results implicate SphK1 along with S1P as therapeutic targets in breast cancer...
  25. Taguchi T, Tomoeda M, Koga T. Studies in stereochemistry. XIII. di-Phenylserinols: a new synthesis and its stereochemical findings (5). Pharm Bull. 1957;5:189-95 pubmed
  26. D Hooghe M, Dekeukeleire S, Mollet K, Lategan C, Smith P, Chibale K, et al. Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity. J Med Chem. 2009;52:4058-62 pubmed publisher
    ..Eleven compounds exhibited antimalarial activity with IC(50) values of <or=30 microM, and the majority of these compounds did not show cytotoxicity at the concentrations tested...
  27. Tacon C, Guantai E, Smith P, Chibale K. Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents. Bioorg Med Chem. 2012;20:893-902 pubmed publisher
    ..Selected compounds were shown to affect erythrocyte morphology, inhibit erythrocyte invasion and trigger CQ accumulation...
  28. Gilmore N, Jones S, Muldowney M. Synthetic applicability and in situ recycling of a B-methoxy oxazaborolidine catalyst derived from cis-1-amino-indan-2-ol. Org Lett. 2004;6:2805-8 pubmed
    ..A method for reducing the effective catalyst loading by "in situ recycling" is also presented. [structure: see text]..
  29. Pedrosa R, Sayalero S, Vicente M, Maestro A. An efficient synthesis of enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols with quaternary stereocenters by diastereoselective addition of TMSCF3 to chiral 2-acyl-1,3-perhydrobenzoxazines. J Org Chem. 2006;71:2177-80 pubmed
    ..Further transformation of the addition products yields enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols.
  30. Kang C, Bian Z, He Y, Han F, Qiu X, Gao L. An organogel formed from a cyclic ?-aminoalcohol. Chem Commun (Camb). 2011;47:10746-8 pubmed publisher
    ..A new organogelator with unique structural feature of a cyclic ?-aminoalcohol is presented as the first example of gelation by aminoalcohol through hydrogen-bonding between hydroxy and amine...
  31. Molinaro C, Guilbault A, Kosjek B. Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis. Org Lett. 2010;12:3772-5 pubmed publisher
    ..Furthermore, these intermediates were used for the preparation of enantiomerically enriched amino alcohols and aziridines containing a tertiary center.
  32. Cannon J, Frederich J, Overman L. Palladacyclic imidazoline-naphthalene complexes: synthesis and catalytic performance in Pd(II)-catalyzed enantioselective reactions of allylic trichloroacetimidates. J Org Chem. 2012;77:1939-51 pubmed publisher
    ..complexes) were prepared in good overall yield in three steps from 2-iodo-1-naphthoic acid and enantiopure ?-amino alcohols. Three of these PIN complexes were characterized by single-crystal X-ray analysis...
  33. König M, Müller C, Bracher F. Stereoselective synthesis of a new class of potent and selective inhibitors of human ?8,7-sterol isomerase. Bioorg Med Chem. 2013;21:1925-43 pubmed publisher
    ..methyl group at C-3a, followed by a plethora of functionalisations at C-4 and C-5 led to cis-configured amino alcohols as a new chemotype of inhibitors of cholesterol biosynthesis...
  34. De Souza Fernandes F, Fernandes T, da Silveira L, Caneschi W, Lourenço M, Diniz C, et al. Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols. Eur J Med Chem. 2016;108:203-210 pubmed publisher
    ..The best results were obtained for amino alcohols 10 and 11 against Staphylococcus epidermidis (MIC = 2 μg/mL)...
  35. Lemini C, Canchola E. Induction of sexual behavior in female rats by the 17beta-aminoestrogens prolame, butolame and pentolame. Proc West Pharmacol Soc. 2009;52:39-42 pubmed
    ..After the second and third injections and P administration the AEs LQs were 92-100 (p<0.01) similarly to E2 (95; p<0.01) and BE (96; p<0.01). The facilitation of sexual behavior by AEs was time and dose-dependent...
  36. Kurono N, Arai K, Uemura M, Ohkuma T. [Ru(phgly)2(binap)]/Li2CO3: a highly active, robust, and enantioselective catalyst for the cyanosilylation of aldehydes. Angew Chem Int Ed Engl. 2008;47:6643-6 pubmed publisher
  37. Pu L. Enantioselective fluorescent sensors: a tale of BINOL. Acc Chem Res. 2012;45:150-63 pubmed publisher
    ..diverse, chiral fluorescent sensors to carry out highly enantioselective, sensitive recognition of chiral amino alcohols, ?-hydroxycarboxylic acids, and amino acid derivatives...
  38. Concellón J, Bernad P, Del Solar V, Suarez J, García Granda S, Díaz M. Synthesis of enantiopure (alphaS,betaS)- or (alphaR,betaS)-beta-amino alcohols by complete regioselective opening of aminoepoxides by organolithium reagents LiAlH4 or LiAlD4. J Org Chem. 2006;71:6420-6 pubmed
    ..with a variety of organolithium compounds to obtain the corresponding (alphaS,betaS)- or (alphaR,betaS)- beta-amino alcohols in enantiopure form is reported...
  39. Babić K, Driessen G, van der Ham A, de Haan A. Chiral separation of amino-alcohols using extractant impregnated resins. J Chromatogr A. 2007;1142:84-92 pubmed
    ..The column was regenerated by water with only atmospheric carbon dioxide dissolved which proved to be sufficient. After several cycles the breakthrough profiles remain unchanged suggesting that these EIRs will be sufficiently stable...
  40. Bodnar B, Miller M. Reactions of nitroso hetero-Diels-Alder cycloadducts with azides: stereoselective formation of triazolines and aziridines. J Org Chem. 2007;72:3929-32 pubmed
    ..The reaction is greatly affected by the level of alkene strain, while sterically demanding azides do not hinder the reaction. Conversion of the triazolines to aziridines is also described...
  41. Mayani V, Abdi S, Kureshy R, Khan N, Agrawal S, Jasra R. Synthesis and characterization of mesoporous silica modified with chiral auxiliaries for their potential application as chiral stationary phase. J Chromatogr A. 2008;1191:223-30 pubmed publisher
    ..It was observed that the porosity and surface area of the stationary phase play an important role in the chiral separation...
  42. Kozlowski M, Dixon S, Panda M, Lauri G. Quantum mechanical models correlating structure with selectivity: predicting the enantioselectivity of beta-amino alcohol catalysts in aldehyde alkylation. J Am Chem Soc. 2003;125:6614-5 pubmed
    ..that provide consistently reliable predictions for the asymmetric addition of Et2Zn to PhCHO catalyzed by beta-amino alcohols. Statistically valid two-variable linear regression models that correlate the structures of the chiral ..
  43. Cunico W, Gomes C, Ferreira M, Ferreira T, Cardinot D, De Souza M, et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. Eur J Med Chem. 2011;46:974-8 pubmed publisher
    ..Two amino alcohols displayed significant activity when compared with first line drug ethambutol (EMB)...
  44. Makarevic J, Jokić M, Raza Z, Stefanić Z, Kojić Prodić B, Zinić M. Chiral bis(amino alcohol)oxalamide gelators-gelation properties and supramolecular organization: racemate versus pure enantiomer gelation. Chemistry. 2003;9:5567-80 pubmed
  45. André C, Calmes M, Escale F, Amblard M, Martinez J, Songis O. New 1,3-amino alcohols derived from enantiopure bridgehead ?-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acids. Amino Acids. 2012;43:415-21 pubmed publisher
    ..reaction of the (R)-benzyl-4-(3-acryloyloxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)-benzoate and the 1-(benzyloxycarbonylamino)cyclohexadiene provide original templates for the construction of new rigid enantiopure 1,3-amino alcohols.
  46. Hui X, Chen C, Gau H. Synthesis of new N-sulfonylated amino alcohols and application to the enantioselective addition of diethylzinc to aldehydes. Chirality. 2005;17:51-6 pubmed
    A series of N-sulfonylated amino alcohols were prepared and the enantioselective addition of diethylzinc to aldehydes catalyzed by titanium(IV) complexes of those ligands were carried out...
  47. Pulici M, Quartieri F, Felder E. Trifluoroacetic anhydride-mediated solid-phase version of the Robinson-Gabriel synthesis of oxazoles. J Comb Chem. 2005;7:463-73 pubmed
    ..amide resin; reductive amination of the latter with alpha-keto aldehydes; reaction of MAMP resin with alpha-amino alcohols, followed by oxidation; and protection of Rink amide resin with either 2,4-dinitrosulfonyl or allyl group, ..
  48. Ribeiro J, de Campos L, Alves R, Lages G, Pianetti G. Efavirenz related compounds preparation by hydrolysis procedure: setting reference standards for chromatographic purity analysis. J Pharm Biomed Anal. 2007;43:298-303 pubmed
    ..Quinoline derivative was of high purity degree (100%) and amino alcohol was 98.74% pure. Both were set as reference standards in chromatographic related compounds test for efavirenz drug substance and tablets analyses...
  49. Seayad A, Ramalingam B, Chai C, Li C, Garland M, Yoshinaga K. Self-supported chiral titanium cluster (SCTC) as a robust catalyst for the asymmetric cyanation of imines under batch and continuous flow at room temperature. Chemistry. 2012;18:5693-700 pubmed publisher
    ..Synthetically useful ee values were also obtained for challenging ?-branched aliphatic aldehyde by using the three-component continuous Strecker reaction...
  50. Kashida H, Sano K, Hara Y, Asanuma H. Modulation of pK(a) of Brooker's merocyanine by DNA hybridization. Bioconjug Chem. 2009;20:258-65 pubmed publisher
    ..1 to 9.7 by the stacking of two BMs in an antiparallel manner. Thus, control of the microenvironment around the BM molecule allowed modulation of its pK(a), which is applicable to the sequence-specific recognition of target DNA...
  51. Fernandes F, Rezende Júnior C, Fernandes T, da Silveira L, Rezende C, De Almeida M, et al. Anthelmintic effects of alkylated diamines and amino alcohols against Schistosoma mansoni. Biomed Res Int. 2013;2013:783490 pubmed publisher
    ..The aim of this work was to evaluate the schistosomicidal activity of different N-alkylated diamines (3a-3h), amino alcohols (4a-4d), and glycosylated amino alcohols (10a-10d)...
  52. Xu G, Chen B, Guo B, He D, Yao S. Detection of intermediates for the Eschweiler-Clarke reaction by liquid-phase reactive desorption electrospray ionization mass spectrometry. Analyst. 2011;136:2385-90 pubmed publisher
    ..Thus, the liquid-phase reactive DESI-MS technique allows the direct analysis of reaction intermediates occurring in complex liquid solutions without sample preparation to provide a valuable insight into chemical reaction mechanisms...
  53. Lin G, Xu M, Zhong Y, Sun X. An advance on exploring N-tert-butanesulfinyl imines in asymmetric synthesis of chiral amines. Acc Chem Res. 2008;41:831-40 pubmed publisher
    ..of N- tert-butanesulfinyl imines and aldehydes, which provides ready access to enantiopure anti-1,2-amino alcohols. The synthetic applicability of this reaction was demonstrated through its use in the facile total syntheses ..