denervation

Summary

Summary: The resection or removal of the nerve to an organ or part.

Top Publications

  1. Thobois S, Ardouin C, Lhommée E, Klinger H, Lagrange C, Xie J, et al. Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation. Brain. 2010;133:1111-27 pubmed publisher
    ..Non-motor fluctuations are related to mesolimbic dopaminergic denervation. Apathy, depression and anxiety can occur after surgery as a delayed dopamine withdrawal syndrome...
  2. Jin Y, Persu A, Staessen J. Renal denervation in the management of resistant hypertension: current evidence and perspectives. Curr Opin Nephrol Hypertens. 2013;22:511-8 pubmed publisher
    Catheter-based renal denervation has emerged as a novel treatment modality for resistant hypertension...
  3. Ott C, Mahfoud F, Schmid A, Ditting T, Sobotka P, Veelken R, et al. Renal denervation in moderate treatment-resistant hypertension. J Am Coll Cardiol. 2013;62:1880-6 pubmed publisher
    This study sought to investigate the effect of renal denervation (RDN) in patients with treatment-resistant hypertension according to the established definition (Joint National Committee VII and European Society of Hypertension/European ..
  4. Fadl Elmula F, Hoffmann P, Fossum E, Brekke M, Gjønnæss E, Hjørnholm U, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension after witnessed intake of medication before qualifying ambulatory blood pressure. Hypertension. 2013;62:526-32 pubmed publisher
    It is unknown whether the decline in blood pressure (BP) after renal denervation (RDN) is caused by denervation itself or concomitantly improved drug adherence...
  5. Hubens L, Verloop W, Joles J, Blankestijn P, Voskuil M. Ischemia and reactive oxygen species in sympathetic hyperactivity states: a vicious cycle that can be interrupted by renal denervation?. Curr Hypertens Rep. 2013;15:313-20 pubmed publisher
    Renal denervation has developed as a new treatment strategy for patients suffering from resistant hypertension...
  6. Verloop W, Vink E, Voskuil M, Vonken E, Rookmaaker M, Bots M, et al. Eligibility for percutaneous renal denervation: the importance of a systematic screening. J Hypertens. 2013;31:1662-8 pubmed publisher
    Percutaneous renal denervation (pRDN) is a new and promising therapy for resistant hypertension...
  7. Gil Bea F, Gerenu G, Aisa B, Kirazov L, Schliebs R, Ramirez M. Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. Neurobiol Dis. 2012;48:439-46 pubmed publisher
    ..The present work is aimed at studying the interactions between cholinergic denervation, APP processing and hippocampal integrity...
  8. Mouradian G, Forster H, Hodges M. Acute and chronic effects of carotid body denervation on ventilation and chemoreflexes in three rat strains. J Physiol. 2012;590:3335-47 pubmed publisher
  9. Kun J, Helyes Z, Perkecz A, Bán A, Polgar B, Szolcsanyi J, et al. Effect of surgical and chemical sensory denervation on non-neural expression of the transient receptor potential vanilloid 1 (TRPV1) receptors in the rat. J Mol Neurosci. 2012;48:795-803 pubmed
    ..Systemic RTX desensitization was used for chemical denervation and transection of the sciatic and saphenous nerves for surgical denervation in rats...

More Information

Publications32

  1. Vlachos A, Becker D, Jedlicka P, Winkels R, Roeper J, Deller T. Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures. PLoS ONE. 2012;7:e32883 pubmed publisher
    b>Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (? 3 weeks old) mouse organotypic entorhino-hippocampal slice cultures...
  2. Vaughan C, Bartness T. Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1049-58 pubmed publisher
    ..Thus the central sensory circuits from IBAT have been delineated for the first time, and impairment of sensory feedback from BAT appears necessary for the appropriate, initial thermogenic response to acute cold exposure. ..
  3. Vlachos A, Bas Orth C, Schneider G, Deller T. Time-lapse imaging of granule cells in mouse entorhino-hippocampal slice cultures reveals changes in spine stability after entorhinal denervation. J Comp Neurol. 2012;520:1891-902 pubmed publisher
    ..synaptic connections and show biphasic changes in their dendritic spine density: during an early phase after denervation spine density decreases and during a late phase spine density recovers again...
  4. Ostrowski S, Belkadi A, Loyd C, Diaconu D, Ward N. Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner. J Invest Dermatol. 2011;131:1530-8 pubmed publisher
    ..nerves innervating dorsal skin of KC-Tie2 animals were surgically axotomized and beginning 1 day after denervation, CD11c(+) cell numbers decreased by 40% followed by a 30% improvement in acanthosis at 7 days and a 30% ..
  5. Schlaich M, Straznicky N, Grima M, Ika Sari C, Dawood T, Mahfoud F, et al. Renal denervation: a potential new treatment modality for polycystic ovary syndrome?. J Hypertens. 2011;29:991-6 pubmed publisher
    ..Here we report on the effects of renal denervation on hemodynamic, metabolic, and renal parameters in two obese PCOS patients with hypertension...
  6. Pokushalov E, Romanov A, Corbucci G, Artyomenko S, Baranova V, Turov A, et al. A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension. J Am Coll Cardiol. 2012;60:1163-70 pubmed publisher
    The aim of this prospective randomized study was to assess the impact of renal artery denervation in patients with a history of refractory atrial fibrillation (AF) and drug-resistant hypertension who were referred for pulmonary vein ..
  7. Schlaich M, Schmieder R, Bakris G, Blankestijn P, Bohm M, Campese V, et al. International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension. J Am Coll Cardiol. 2013;62:2031-45 pubmed publisher
  8. Müller C, Vlachos A, Deller T. Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures. Cell Calcium. 2010;47:242-52 pubmed publisher
    b>Denervation of neurons, e.g. upon traumatic injury or neuronal degeneration, induces transneuronal degenerative events, such as spine loss, dendritic pruning, and even cell loss...
  9. Blain G, Smith C, Henderson K, Dempsey J. Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2). J Physiol. 2010;588:2455-71 pubmed publisher
    ..Neither unilateral CB denervation nor CB perfusion, per se, affected breathing...
  10. Huo S, Xu Z, Zhang X, Zhang J, Cui S. Testicular denervation in prepuberty rat inhibits seminiferous tubule development and spermatogenesis. J Reprod Dev. 2010;56:370-8 pubmed
    ..The results demonstrated that testicular denervation significantly reduced testis mass, cauda epididymal sperm counts and serum testosterone concentrations...
  11. Hart E, McBryde F, Burchell A, Ratcliffe L, Stewart L, Baumbach A, et al. Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans. Hypertension. 2013;62:533-41 pubmed publisher
    Renal denervation has shown promise in the treatment of resistant hypertension, although the mechanisms underlying the blood pressure (BP) reduction remain unclear...
  12. Kõiv K, Zobel R, Raudkivi K, Kivastik T, Harro J. The effect of denervation of the locus coeruleus projections with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on cocaine-induced locomotion and place preference in rats. Behav Brain Res. 2011;216:172-9 pubmed publisher
    ..In Experiment 1, administration of 10 mg/kg of DSP-4 similarly to substantial denervation with 50 mg/kg of DSP-4 significantly attenuated the activating effects of cocaine during the first cocaine-..
  13. Rau C, Jeng J, Jeng S, Lu T, Chen Y, Liliang P, et al. Entrapment neuropathy results in different microRNA expression patterns from denervation injury in rats. BMC Musculoskelet Disord. 2010;11:181 pubmed publisher
    ..after sciatic nerve entrapment using a non-constrictive silastic tube, subsequent surgical decompression, and denervation injury...
  14. Mulder J, Hokfelt T, Knuepfer M, Kopp U. Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats. Am J Physiol Regul Integr Comp Physiol. 2013;304:R675-82 pubmed publisher
    Efferent renal sympathetic nerves reinnervate the kidney after renal denervation in animals and humans...
  15. Quy P, Kuma A, Pierre P, Mizushima N. Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation. J Biol Chem. 2013;288:1125-34 pubmed publisher
    Drastic protein degradation occurs during muscle atrophy induced by denervation, fasting, immobility, and various systemic diseases...
  16. Dinocourt C, Aungst S, Yang K, Thompson S. Homeostatic increase in excitability in area CA1 after Schaffer collateral transection in vivo. Epilepsia. 2011;52:1656-65 pubmed publisher
    ..One feature that is common to many forms of TBI is denervation. We asked whether chronic partial denervation in vivo would lead to a homeostatic increase in the excitability ..
  17. Clayton S, Haack K, Zucker I. Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure. Am J Physiol Renal Physiol. 2011;300:F31-9 pubmed publisher
    ..05) while the blood flow and resistance was not changed in HF rabbits with the surgical renal denervation. Renal AT1R expression was increased by ?67% and AT2R expression was decreased by ?87% in rabbits with HF; ..
  18. Abdala A, McBryde F, Marina N, Hendy E, Engelman Z, Fudim M, et al. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol. 2012;590:4269-77 pubmed publisher
    ..Successful carotid sinus nerve denervation (CSD) was confirmed by testing respiratory responses to hypoxia (10% O(2)) or cardiovascular responses to i.v...
  19. Paille V, Picconi B, Bagetta V, Ghiglieri V, Sgobio C, Di Filippo M, et al. Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition. J Neurosci. 2010;30:14182-93 pubmed publisher
    ..Here we present a model of early PD in which a partial denervation, causing mild motor deficits, selectively affects NMDA-dependent LTP but not LTD and dramatically alters NMDA ..
  20. Estofolete C, Zucoloto S, Oliani S, Polli Lopes A, Gil C. Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis. Dig Dis Sci. 2011;56:1637-44 pubmed publisher
    ..01; P < 0.001; P < 0.001, respectively). These results demonstrate that myenteric denervation downregulates endogenous Gal-1 and -3 expression, which might inhibit tumor development in this experimental ..
  21. Vuksic M, Del Turco D, Vlachos A, Schuldt G, Müller C, Schneider G, et al. Unilateral entorhinal denervation leads to long-lasting dendritic alterations of mouse hippocampal granule cells. Exp Neurol. 2011;230:176-85 pubmed publisher
    ..b>Denervation-induced dendritic reorganization of granule cells was investigated in the dentate gyrus of the Thy1-GFP mouse...
  22. Rönkkö H, Goransson H, Siironen P, Taskinen H, Vuorinen V, Roytta M. The capacity of the distal stump of peripheral nerve to receive growing axons after two and six months denervation. Scand J Surg. 2011;100:223-9 pubmed
    ..Delayed cross-anastomosis paradigm was used to study the axon grow to the distal nerve stump after denervation separately from the influence of prolonged axotomy in the proximal stump...
  23. Rodrigues F, de Oliveira M, Salgado H, Fazan R. Effect of baroreceptor denervation on the autonomic control of arterial pressure in conscious mice. Exp Physiol. 2011;96:853-62 pubmed publisher
    ..in a femoral artery and a jugular vein, were submitted to sino-aortic (SAD), aortic (Ao-X) or carotid sinus denervation (Ca-X), 5 days prior to the experiments...