endarterectomy

..pro- and anti- inflammatory cytokine secretory patterns of T cell cultures isolated from carotid plaque at endarterectomy were stimulated with phytohemaglutinin (PHA) in the presence of irradiated autologous peripheral blood ..

DESCRIPTION (provided by applicant): Each year approximately 100,000 elderly Americans undergo carotid endarterectomy (CEA) to reduce their risk of stroke and death...

..Several recent studies have shown that patients with asymptomatic carotid stenosis benefit from carotid endarterectomy. However, the ACAS trial found that 17 patients needed to be operated on to prevent one stroke or death over ..

DESCRIPTION (provided by applicant): Carotid endarterectomy prevents stroke and reduces mortality...

..in both carotid and coronary circulation, management alternatives include performing either the carotid endarterectomy (CEA) or the CABG first, followed later by a second operation, or performing both operations under the same ..

..N=50 each) with clinically significant carotid stenosis (>70 percent), who will subsequently undergo carotid endarterectomy (CEA), determine the prevalence of hypoperfusion in each hemisphere in relation to luminal narrowing, plaque ..

..N = 50 each) with clinically significant carotid stenosis (>70%) who will subsequently undergo carotid endarterectomy (CEA) will be recruited. These patients will undergo high-resolution MR imaging of the carotid artery at 1...

..hypercholesterolemia in rabbit and baboon arteries as well as fully developed atherosclerosis in human endarterectomy tissue will be probed for Gj protein transcription and translation by in situ hybridization and ..

..The results of this study may provide new means to achieve thromboprophylaxis in surgical settings such as angioplasty and endarterectomy, as well as be a platform for the development of novel forms of antithrombotic therapy.

..indicating whether a patient with carotid stenosis would benefit from surgical intervention such as carotid endarterectomy (CEA) or stenting...

..cognitive improvement in case series studies of patients with carotid stenosis or occlusion treated with endarterectomy or extracranial-intracranial (EC-IC) bypass...

..evolving endovascular treatment for carotid stenosis, and advocates predict that is will replace surgical endarterectomy. The hemodynamic changes following angioplasty (whether the flow remains simple or laminar, or becomes a three-..

..indicating whether a patient with carotid stenosis would benefit from surgical intervention such as carotid endarterectomy (CEA) or stenting...

..cognitive improvement in case series studies of patients with carotid stenosis or occlusion treated with endarterectomy or extracranial-intracranial (EC-IC) bypass...

..studies have shown that elevated plasma Cp is a significant risk factor for atherosclerosis, restenosis after endarterectomy, and myocardial infarction...

..Exposure to focal brain ischemia may occur during neurosurgical resection, during carotid endarterectomy, and during cardiac bypass or total circulatory arrest procedures...

..of additional high-risk plaque features, other than the degree of lumen stenosis, may lead to better selection of patients for intervention, such as carotid endarterectomy, and result in overall reduction in health care costs.

..stroke include antiplatelet therapy, hypertension control, anticoagulation, lipid management, and carotid endarterectomy. Despite these effective strategies, many suitably-treated stroke patients still experience recurrent vascular ..

..stroke include antiplatelet therapy, hypertension control, anticoagulation, lipid management, and carotid endarterectomy. Despite these effective strategies, many suitably-treated stroke patients still experience recurrent vascular ..

DESCRIPTION (provided by applicant): Carotid endarterectomy (CEA), surgery to prevent stroke, is common but potentially risky...

..we will use immunochemical methods, proteomic and DNA array of laser-microdissected macrophage-rich areas of endarterectomy segments of lesioned human carotid arteries...

..one applicable to the ischemia-reperfusion (IR) phenomenon that occurs with lung transplantation, pulmonary endarterectomy, and cardiopulmonary bypass; and the other to non-ischemic diffuse lung injury...

..Thyroid surgery, carotid endarterectomy, cardiothoracic and primary lung procedures may also result in laryngeal paralysis...

..In patients with metabolic syndrome but advanced atherosclerosis who are undergoing carotid endarterectomy, we will use molecular MR techniques to determine evidence of inflammation and plaque vulnerability and ..

..Clinical trials have demonstrated a clear benefit of carotid endarterectomy (CEA) over medical management in patients with TIA or minor stroke and severe ICA stenosis...

DESCRIPTION (provided by applicant): Carotid endarterectomy (CEA), surgery to prevent stroke, is common but potentially risky...

..Clinical trials have demonstrated a clear benefit of carotid endarterectomy (CEA) over medical management in patients with TIA or minor stroke and severe ICA stenosis...

..we have compared the expression of 21 genes in stable (femoral) and unstable (carotid) plaques obtained from endarterectomy. Not surprisingly, genes involved in the breakdown of the extracellular matrix were elevated in the unstable ..

..we will use immunochemical methods, proteomic and DNA array of laser-microdissected macrophage-rich areas of endarterectomy segments of lesioned human carotid arteries...

..Currently some 140,000 carotid endarterectomy (CEA) surgeries are performed annually in the U.S. to prevent these events...

..Currently, we investigate carotid plaque in patients undergoing carotid endarterectomy using this technique...

..Currently some 140,000 carotid endarterectomy (CEA) surgeries are performed annually in the U.S. to prevent these events...

..Currently, we investigate carotid plaque in patients undergoing carotid endarterectomy using this technique...

..However, randomized clinical trial data contrasting the efficacy of CAS and carotid endarterectomy (CEA), the gold standard treatment for carotid atherosclerosis, are not available except in restricted ..

..However, randomized clinical trial data contrasting the efficacy of CAS and carotid endarterectomy (CEA), the gold standard treatment for carotid atherosclerosis, are not available except in restricted ..

..by fibdn glue or by matrix collagen targeting in well characterized animal models of bypass grafting and of endarterectomy. We strongly believe that results will be directly clinically applicable in vascular interventions and should ..

..the optimized MRI-based iron detection technique in a prospective study of patients undergoing carotid endarterectomy. Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients ..

..as diabetes, hypertension, cardiovascular disease, and lifestyle; in patients with severe stenosis, carotid endarterectomy may be indicated...

..of the Zn2+ toxicity via NO modulation could be used as therapeutic pretreatment in cardiac bypass and carotid endarterectomy procedures...

..Studies comparing the in vivo transcriptomes of monocytes purified from patients undergoing carotid endarterectomy and normal subjects by using the serial analysis of gene expression technique revealed that (1) KLF2 is ..

..Studies comparing the in vivo transcriptomes of monocytes purified from patients undergoing carotid endarterectomy and normal subjects by using the serial analysis of gene expression technique revealed that (1) KLF2 is ..

..vessels that supply the brain is a relatively new treatment that may be a viable alternative to carotid endarterectomy. Based on the extensive history of coronary artery stenting, it can be surmised that restenosis will be a key ..

..Those objectives are consistent with the mission of the NIBIB. Forty patients scheduled to undergo carotid endarterectomy will be recruited to participate in this study with proper consent...

..Finally, annexin imaging will be performed in a pilot clinical study in patients undergoing carotid endarterectomy. The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens ..

DESCRIPTION: (provided by applicant) Carotid endarterectomy (CEA) is extremely efficacious in preventing stroke- and reducing death due to the low incidence of major surgical complications (2-5 percent incidence of stroke)...

..At least 50% of strokes arise from plaque at the carotid bifurcation. Removing plaque (a "carotid endarterectomy") from asymptomatic patients who have significant carotid stenoses reduces their stroke rate over the next ..

..CONCLUSION: Breath-hold MR-techniques enable non-invasive assessment of pulmonary hemodynamics in patients with CTEPH. For postoperative follow-up studies MRI could be considered the modality of choice...

..parameters, modified New York Heart Association functional class at diagnosis, CTEPH type, pulmonary endarterectomy, and anti-cardiolipin antibodies/lupus anticoagulant. During a median observation time of 22.1 (range, 0...

..Factors predictive of a beneficial response, and whether this intervention influences either morbidity or mortality associated with pulmonary thromboendarterectomy, remain to be established...

..Patients with CTEPH and Rup value <60% appear to be at highest risk...

..function in patients with chronic thromboembolic pulmonary hypertension can almost be normalized by pulmonary endarterectomy. The procedure involves the removal of organized and incorporated fibrous obstructive tissue from the ..

..Pulmonary angiography confirms the diagnosis and determines the feasibility of endarterectomy according to the location of the disease, proximal versus distal...

..CONCLUSION: Breath-hold MR imaging techniques enable morphologic and semiquantitative functional assessment of patients with CTEPH...

RATIONALE: There are few follow-up studies on long-term cardiopulmonary function after pulmonary endarterectomy (PEA), the operation of choice for chronic thromboembolic pulmonary hypertension (CTEPH)...

..Patient age and clinical deterioration of pulmonary hypertension are considerable preoperative factors influencing hospital mortality. Inadequate postoperative hemodynamic improvement is affected by severity of disease and female sex...

..DIAGNOSIS: High-grade intimal sarcoma of the pulmonary artery. TREATMENT: Pulmonary endarterectomy.

..The absence of central thrombi is a significant risk factor for inadequate hemodynamic improvement...

..with thromboembolic pulmonary hypertension was investigated to clarify the long-term effects of pulmonary endarterectomy. This capacity was assessed by measuring cardiopulmonary factors during cardiopulmonary exercise testing at ..

OBJECTIVE: Pulmonary endarterectomy is the best treatment for patients with chronic thromboembolic pulmonary hypertension...

..six minute walking distance (6MWD) in the pre- and post-operative assessment of subjects undergoing pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH)...

..Furthermore, these differences resolved after pulmonary thromboendarterectomy. MR imaging enables the accurate estimation of flow in the bronchial arteries in patients with chronic thromboembolic pulmonary hypertension...

..To investigate whether deep (<20 degrees C) hypothermia is necessary in patients undergoing pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension...

..Axillary vein cannulation is thought to be a feasible method when PCPS is required for a patient with previous IVC filter placement...

..Eighteen patients are still being followed up; the clinical and scintigraphic and/or angiographic improvement is clearcut in the majority of cases...

..Of all the causes of pulmonary hypertension, chronic thromboembolic cor pulmonary should be systematically looked for because curative surgical treatment is possible in some cases...

..The accurate diagnosis and selection criteria for surgery are crucial...

..Medical therapy is palliative and only surgery can modify its natural history. Pulmonary endarterectomy (PEA) is the treatment of choice and lung transplantation should be considered only when PEA is ..

Pulmonary endarterectomy surgery (PEA) offers the possibility of a cure for patients suffering from chronic thromboembolic pulmonary hypertension (CTEPH)...

..Pulmonary endarterectomy (PEA) is the treatment of choice. Lung transplantation is indicated only in few cases when PEA is not feasible...

..hypertension (CTEPH) is unknown, nor whether ET-1 levels correlate with hemodynamic outcome after pulmonary endarterectomy (PEA). METHODS AND RESULTS: ET-1 levels were determined by ELISA...

BACKGROUND: Pulmonary endarterectomy is the accepted therapy for thromboembolic pulmonary hypertension...

..pulmonary vascular tree predicts the hemodynamic result and clinical outcome in patients undergoing pulmonary endarterectomy. METHODS: From 1998 to 2000, 202 patients with pulmonary hypertension and pulmonary vascular resistance ..

..As an alternative to lung transplantation, PTE offers patients with chronic TPH an improved quality of life...

..For those who did not require ECMO support, hospital mortality was 4.2%. CONCLUSIONS: Early venoarterial ECMO support has a role as rescue therapy post-PTE in patients with severe compromise who would probably otherwise die...

INTRODUCTION: Currently pulmonary endarterectomy is considered the method of choice in patients with chronic thromboembolic pulmonary hypertension (CTEPH)...

..the surgical treatment choice in chronic thromboembolic pulmonary hypertension (CTEPH) consists in a pulmonary endarterectomy (PEA)...

..Patients with high pulmonary vascular resistance can be treated effectively by thromboendarterectomy, with acceptable morbidity and mortality...

..sec.cm(-5). To conclude fractional pulse pressure in addition to pulmonary vascular resistance might be useful in predicting for the outcome of surgery, especially in patients with severe haemodynamic impairment...

To evaluate the time course of reversed remodeling after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension(CTPEH), we studied 22 patients (age: 60 +/- 13 years) with MRI immediately before, 1 ..

..CONCLUSION: The initial experience with pulmonary thromboendarterectomy for patients with cor pulmonale due to chronic pulmonary emboli demonstrated satisfactory mid-term follow-up data...

..06). Mid-term follow-up showed that the cardiac function of the patients fell into NYHA class I (n = 3) or II (n = 5), with significant improvement in quality of life. CONCLUSION: PTE is effective treatment in the management of CTE-PH...

..We concluded that pulmonary thromboendarterectomy could dramatically improve hemodynamic indices, NYHA functional status and quality of life in patients with CTEPH...

..1 +/- 22.4) mm Hg vs (42.6 +/- 10.7) mm Hg, (P < 0.01). CONCLUSION: PTE provides substantial improvement in survival, function and quality of life in most CTEPH patients...

..CONCLUSIONS: These data suggest that changes in the ET signaling system in PHT caused by thromboembolic disease are not limited to an increased production of ET-1: they also affect ET receptor gene expression...

..Right-sided specimens were significantly larger than left-sided specimens, and lower lobe involvement was more common than involvement elsewhere. Resected tissues most commonly exhibited old organized thrombus...

..We studied the effect of pulmonary endarterectomy on the restoration of right ventricular remodeling in patients with chronic thromboembolic pulmonary ..

..defined as CTEPH-related death, lung transplantation or persistent pulmonary hypertension after pulmonary endarterectomy (PEA). Baseline H-FABP levels in plasma ranged from 0.69-24.3 ng x mL(-1) (median (IQR) 3.41 (2.28-4...

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..Pulmonary endarterectomy (PEA) remains the treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH)...

..21) volumes occurred, with little change in mean LV EF (0.05 +/- 0.07 vs 0.00 +/- 0.10). CONCLUSIONS: SPECT ERNA is an accurate method for measuring RV and LV volume and EF before and after thromboendarterectomy...

..Published by Elsevier Science Ltd. All rights reserved...

..Further the paper describes the role and responsibilities of critical care nurses, specialist nurses in palliative care and pulmonary hypertension when caring for these patients before and after surgery...

..Pulmonary endarterectomy is an operation that corrects the pulmonary hypertension resulting from chronic thromboemboli...

..Post-operatively the patient had considerable subjective and functional improvement returning to activities of daily living. He however passed away some 9 months later...

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..CONCLUSIONS: Pulmonary thromboendarterectomy offers better QOL even in those patients with relatively peripheral type of CTEPH, although operative mortality must be reduced...

..CONCLUSION: The IV administration of prostacyclin caused beneficial hemodynamic effects in patients with severe CTEPH and may serve as pretreatment for patients undergoing pulmonary thromboendarterectomy...

..Pulmonary endarterectomy was performed using cycles of 15-minute intermittent circulatory arrest followed by 10-minute reperfusion at ..

..However, hemodynamics were transiently suppressed and overall oxygen delivery did not change...

..Plasma TM measurements may be useful in distinguishing CTEPH with severe pulmonary hypertension from recurrent APTE...

..Postoperatively, it significantly reduces mPAP and PVR, and enhances CI. Following PTE, inhalation of iloprost is useful to improve early postoperative hemodynamics...