Summary: Chemically-engineered oligonucleotides used to selectively inhibit expression of target genes through sequence-specific binding of corresponding microRNA (miRNA) sites.

Top Publications

  1. Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan S, et al. MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke. Stroke. 2017;48:1941-1947 pubmed publisher
    ..These results suggest that the miR-15a/16-1 cluster is a novel therapeutic target for ischemic stroke. ..
  2. Ma C, Wei F, Xia H, Liu H, Dong X, Zhang Y, et al. MicroRNA-10b mediates TGF-?1-regulated glioblastoma proliferation, migration and epithelial-mesenchymal transition. Int J Oncol. 2017;50:1739-1748 pubmed publisher
    ..Thus, our findings provide a rationale for targeting TGF-?1 or miR-10b for the treatment of GBM. ..
  3. Yang X, He X, Li G, Xu Y. AntagomiR-451 inhibits oxygen glucose deprivation (OGD)-induced HUVEC necrosis via activating AMPK signaling. PLoS ONE. 2017;12:e0175507 pubmed publisher
    ..Together, we suggest that antagomiR-451 activates AMPK to inhibit OGD-induced programmed necrosis in HUVECs. ..
  4. Xue X, Qiu Y, Yang H. Immunoregulatory Role of MicroRNA-21 in Macrophages in Response to Bacillus Calmette-Guerin Infection Involves Modulation of the TLR4/MyD88 Signaling Pathway. Cell Physiol Biochem. 2017;42:91-102 pubmed publisher
  5. Liu T, Wu C, Weng G, Zhao Z, He X, Fu C, et al. Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma. Cell Physiol Biochem. 2017;44:671-681 pubmed publisher
    ..In addition, we identified SPARC as a novel target gene of miR-203. These findings suggest that miR-203 plays an important role in bufalin's ability to inhibit the growth of glioma cells and the development of stem cell-like phenotypes. ..
  6. Guo L, Zhou L, Gao Q, Zhang A, Wei J, Hong D, et al. MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Guérin infection by targeting ATG4a in RAW264.7 macrophage cells. PLoS ONE. 2017;12:e0179772 pubmed publisher
    ..The experimental results of this study reveal a novel role of miR-144-3p in inhibiting autophagy activation by targeting ATG4a and enhancing BCG infection, and provide potential targets for developing improved treatment. ..
  7. Moore C, Parrish J, Jedlicka P. MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth. PLoS ONE. 2017;12:e0178028 pubmed publisher
    ..Together, our studies show that the EWS/Fli1-repressed miR-193b is growth suppressive in Ewing Sarcoma, and identify ErbB4 as a target gene and candidate mediator of this growth suppression. ..
  8. Cao Y, Zhao D, Li P, Wang L, Qiao B, Qin X, et al. MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1. Cell Physiol Biochem. 2017;42:346-356 pubmed publisher
    ..Taken together, our data show the regulation of VCAM-1 expression by miR-181a-5p under IL-17 exposure, predicting a potential way for counteracting cancer metastasis. ..
  9. Zhang M, Gao C, Yang Y, Li G, Dong J, Ai Y, et al. MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1. Cell Physiol Biochem. 2017;42:211-221 pubmed publisher
    ..This study may provide theoretical basis for miR-424 in NSCLC target therapeutic treatment. ..

More Information


  1. Hu X, Xie Q, Chen C, Zhang W, Yu B. Let-7a Inhibits T-Cell Proliferation and IFN-? Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis. Cell Physiol Biochem. 2017;42:115-125 pubmed publisher
    ..Our results demonstrated that let-7a inhibits T-cell proliferation and IFN-? secretion by down-regulating STAT3 in psoriasis. ..
  2. Ma N, Zhang W, Qiao C, Luo H, Zhang X, Liu D, et al. The Tumor Suppressive Role of MiRNA-509-5p by Targeting FOXM1 in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2016;38:1435-46 pubmed publisher
    ..Collectively, these findings provide further evidence that miR-509-5p may be considered as a novel and potential target for the diagnosis, prognosis and treatment of NSCLC. ..
  3. Jin X, Jin H, Shi Y, Guo Y, Zhang H. Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway. Cell Physiol Biochem. 2017;42:295-305 pubmed publisher
    ..These results provide evidence that the KCNQ1OT1-miR-214-caspase-1 regulatory network is a novel mechanism for promoting cataract formation. ..
  4. Sun J, Gao X, Meng D, Xu Y, Wang X, Gu X, et al. Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo. Cell Physiol Biochem. 2017;43:636-643 pubmed publisher
    ..The present study aims to investigate the effects of antagomirs targeting miroRNA-134 (Ant-134) on limk1 expression and the binding of miR-134 and limk1 in experimental seizure...
  5. Tang X, Lin J, Wang G, Lu J. MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression. PLoS ONE. 2017;12:e0179860 pubmed publisher
    ..Conclusively, our findings further emphasized the vital role of miR-433-3p in DKK1/WNT/?-catenin pathway through decreasing DKK1 expression and inducing osteoblasts differentiation. ..
  6. Jiang L, Zhao Z, Zheng L, Xue L, Zhan Q, Song Y. Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1. Genomics Proteomics Bioinformatics. 2017;15:208-217 pubmed publisher
    ..Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. ..
  7. Deng H, Song Z, Xu H, Deng X, Zhang Q, Chen H, et al. MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression. Cell Physiol Biochem. 2017;41:2183-2193 pubmed publisher
  8. Li J, Wang H, Yao Y, Sun Q, Liu Z, Liu S, et al. Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway. J Cell Mol Med. 2017;21:1482-1491 pubmed publisher
    ..These findings indicate that up-regulation of miR-138 alleviates HCAEC injury and inflammatory response by inhibiting the PI3K/Akt/eNOS signalling pathway. ..
  9. Chen J, Xu Y, Tao L, Pan Y, Zhang K, Wang R, et al. MiRNA-26a Contributes to the Acquisition of Malignant Behaviors of Doctaxel-Resistant Lung Adenocarcinoma Cells through Targeting EZH2. Cell Physiol Biochem. 2017;41:583-597 pubmed publisher
    ..MiR-26a/EZH2 signal pathway makes contribute to the malignant phenotype of docetaxel-resistant of LAD cells which indicated that miR-26a exerts pivotal functions in the molecular etiology of chemoresistant lung adenocarcinoma. ..
  10. Fan P, He L, Hu N, Luo J, Zhang J, Mo L, et al. Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis. Cell Physiol Biochem. 2017;42:145-155 pubmed publisher
    ..Our study demonstrated that 1,25-(OH)2D3 inhibits the proliferation of FLS and alleviates inflammatory response in RA rats by down-regulating miR-22. ..
  11. Hu C, Du P, Zhang H, Huang G. Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145. Cell Physiol Biochem. 2017;42:13-21 pubmed publisher
    ..CRNDE acted as a growth-promoting lncRNA in GC and maybe a potential target of GC treatment. ..
  12. Deng H, Chu X, Song Z, Deng X, Xu H, Ye Y, et al. MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1. Cell Physiol Biochem. 2017;41:2171-2182 pubmed publisher
    ..The results revealed the impact of miR-1185 on endothelial apoptosis, suggesting that miR-1185 may be a potential target for the prevention and treatment of atherosclerosis. ..
  13. Lu Z, Wu J, Jiang W, Xiao J, Tao K, Ma L, et al. MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression. World J Gastroenterol. 2017;23:976-985 pubmed publisher
    ..MiR-155 promotes experimental colitis by repressing SHIP-1 expression. Thus, the inhibition of miR-155 might be a promising strategy for therapy. ..
  14. Chandrasekaran K, Sathyanarayanan A, Karunagaran D. miR-214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells. Cell Biochem Funct. 2017;35:464-471 pubmed publisher
    ..Hence, it is proposed that miR-214 might act as a tumour suppressor by regulating several aberrant signalling pathways through HMGA1. This knowledge has the potential to help design novel therapeutic strategies in CaCx and CRC...
  15. Bai J, Xiao X, Zhang X, Cui H, Hao J, Han J, et al. Erythropoietin Inhibits Hypoxia-Induced Epithelial-To-Mesenchymal Transition via Upregulation of miR-200b in HK-2 Cells. Cell Physiol Biochem. 2017;42:269-280 pubmed publisher
    ..miR-200 mediates the protective effects of EPO on EMT in hypoxic HK-2 cells. EPO attenuated hypoxia-induced EMT by increasing miR-200 expression via the repression of Ets-1. ..
  16. Wang D, Shi L, Xin W, Xu J, Xu J, Li Q, et al. Activation of PPAR? inhibits pro-inflammatory cytokines production by upregulation of miR-124 in vitro and in vivo. Biochem Biophys Res Commun. 2017;486:726-731 pubmed publisher
  17. Gaudelot K, Gibier J, Pottier N, Hemon B, Van Seuningen I, Glowacki F, et al. Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma. Tumour Biol. 2017;39:1010428317707372 pubmed publisher
    ..In renal cell carcinoma, targeting miR-21 is a potential new therapeutic strategy to improve chemotherapy efficacy and consequently patient outcome. ..
  18. Dai X, Li M, Geng F. Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis. Biochemistry (Mosc). 2017;82:826-833 pubmed publisher
    ..In summary, these results suggest that PUFAs enhance dexamethasone sensitivity to MM cells through the p53/miR-34a axis with a likely contribution of Bcl-2 suppression. ..
  19. Li P, Sun Y, Liu Q. MicroRNA-340 Induces Apoptosis and Inhibits Metastasis of Ovarian Cancer Cells by Inactivation of NF-x03BA;B1. Cell Physiol Biochem. 2016;38:1915-27 pubmed publisher
    ..miR-340 induced cell apoptosis and inhibited metastasis in OC cells by down-regulation of NF-x03BA;B1. ..
  20. Sun W, Zhao L, Song X, Zhang J, Xing Y, Liu N, et al. MicroRNA-210 Modulates the Cellular Energy Metabolism Shift During H2O2-Induced Oxidative Stress by Repressing ISCU in H9c2 Cardiomyocytes. Cell Physiol Biochem. 2017;43:383-394 pubmed publisher
    ..The aim of this study was to investigate whether microRNA(miR-210) regulates the energy metabolism shift during oxidative stress in H9c2 cardiomyocytes...
  21. Zhou L, Xu Z, Ren X, Chen K, Xin S. MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1). Cell Physiol Biochem. 2016;38:1785-95 pubmed publisher
    ..More importantly, increased ROCK1 expression or inhibited miR-124 expression may constitute effective new therapeutic strategies for the treatment of renal cancer in the future. ..