obesity

Summary

Summary: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Top Publications

  1. Kraus D, Yang Q, Kong D, Banks A, Zhang L, Rodgers J, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258-62 pubmed publisher
    In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters systemic insulin sensitivity...
  2. Ceperuelo Mallafré V, Duran X, Pachón G, Roche K, Garrido Sanchez L, Vilarrasa N, et al. Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance. J Clin Endocrinol Metab. 2014;99:E908-19 pubmed publisher
    ..Our objective was to define the function of GIP in human adipose tissue in relation to obesity and insulin resistance...
  3. Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, et al. The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry. Nutr Metab Cardiovasc Dis. 2013;23:1043-9 pubmed publisher
    The development of type 2 diabetes (T2D) is influenced both by environmental and by genetic determinants. Obesity is an important risk factor for T2D, mostly mediated by obesity-related insulin resistance...
  4. Park J, Ahmadi S, Streja E, Molnar M, Flegal K, Gillen D, et al. Obesity paradox in end-stage kidney disease patients. Prog Cardiovasc Dis. 2014;56:415-25 pubmed publisher
    In the general population, obesity is associated with increased cardiovascular risk and decreased survival...
  5. Lackey D, Burk D, Ali M, Mostaedi R, Smith W, Park J, et al. Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab. 2014;306:E233-46 pubmed publisher
    ..b>Obesity and adipocyte hypertrophy place a strain on the ECM remodeling machinery, which may promote disordered ECM and ..
  6. Baretić M. Obesity drug therapy. Minerva Endocrinol. 2013;38:245-54 pubmed
    b>Obesity is a chronic disease, and it requires chronic therapy. Hypertension, dyslipidemia, diabetes and cardiovascular diseases are leading causes of mortality in the modern world. All of them are strongly linked to obesity...
  7. Pan L, May A, Wethington H, Dalenius K, Grummer Strawn L. Incidence of obesity among young U.S. children living in low-income families, 2008-2011. Pediatrics. 2013;132:1006-13 pubmed publisher
    To examine the incidence and reverse of obesity among young low-income children and variations across population subgroups. We included 1...
  8. Mauer J, Chaurasia B, Goldau J, Vogt M, Ruud J, Nguyen K, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014;15:423-30 pubmed publisher
    b>Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial...
  9. Hams E, Locksley R, McKenzie A, Fallon P. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191:5349-53 pubmed publisher
    ..visceral adipose tissue (VAT) and release of cytokines by such cells within VAT has been implicated in regulating obesity and metabolic homeostasis...

More Information

Publications55

  1. Mondul A, Giovannucci E, Platz E. A prospective study of obesity, and the incidence and progression of lower urinary tract symptoms. J Urol. 2014;191:715-21 pubmed publisher
    ..Our findings support the notion that obesity may be an important target for lower urinary tract symptom prevention and intervention.
  2. Lappas M. Effect of pre-existing maternal obesity, gestational diabetes and adipokines on the expression of genes involved in lipid metabolism in adipose tissue. Metabolism. 2014;63:250-62 pubmed publisher
    To determine the effect of maternal obesity, gestational diabetes mellitus (GDM) and adipokines on the expression of genes involved in fatty acid uptake, transport, synthesis and metabolism.
  3. Ovsyannikova I, White S, Larrabee B, Grill D, Jacobson R, Poland G. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. Vaccine. 2014;32:881-7 pubmed publisher
    b>Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity...
  4. Thomsen M, Nordestgaard B. Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic syndrome. JAMA Intern Med. 2014;174:15-22 pubmed publisher
    Overweight and obesity likely cause myocardial infarction (MI) and ischemic heart disease (IHD); however, whether coexisting metabolic syndrome is a necessary condition is unknown...
  5. Gaillard R, Steegers E, Duijts L, Felix J, Hofman A, Franco O, et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study. Hypertension. 2014;63:683-91 pubmed publisher
    Maternal prepregnancy obesity is associated with impaired cardiometabolic health in offspring. Whether these associations reflect direct intrauterine causal mechanisms remains unclear...
  6. Karatsoreos I, Thaler J, Borgland S, Champagne F, Hurd Y, Hill M. Food for thought: hormonal, experiential, and neural influences on feeding and obesity. J Neurosci. 2013;33:17610-6 pubmed publisher
    b>Obesity is a growing public health problem. Although convenient, the notion that obesity is simply a problem of will power is increasingly antiquated...
  7. Rössger K, Charpin El Hamri G, Fussenegger M. A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. Nat Commun. 2013;4:2825 pubmed publisher
    Diet-induced obesity is a lifestyle-associated medical condition that increases the risk of developing cardiovascular disease, type 2 diabetes and certain types of cancer...
  8. Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, et al. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci. 2013;33:17166-73 pubmed publisher
    ..This demonstrates that the deletion of GABAB receptors in POMC neurons in the male mice on a HFD results in obesity, insulin resistance, and hypothalamic inflammation...
  9. Chen C, Bench E, Allerton T, Schreiber A, Arceneaux K, Primeaux S. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. Am J Physiol Regul Integr Comp Physiol. 2013;305:R1346-55 pubmed publisher
    ..sensing of dietary fat and fatty acids by the oral cavity is proposed to regulate the susceptibility to obesity. In the current experiments, animals that differ in their susceptibility to obesity were used to investigate the ..
  10. Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, et al. Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity. Arterioscler Thromb Vasc Biol. 2014;34:669-75 pubmed publisher
    ..of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins...
  11. Panzhinskiy E, Hua Y, Lapchak P, Topchiy E, Lehmann T, Ren J, et al. Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J Pharmacol Exp Ther. 2014;349:248-57 pubmed publisher
    ..Docking studies suggest a potential interaction between CNB-001 and PTP1B. Taken together, CNB-001 alleviates obesity-induced glucose intolerance and represents a potential candidate for further development as an antidiabetic agent...
  12. Davidson E, Coppey L, Kardon R, Yorek M. Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats. Invest Ophthalmol Vis Sci. 2014;55:1222-30 pubmed publisher
  13. Lopez Garcia E, Guallar Castillon P, León Muñoz L, Rodriguez Artalejo F. Prevalence and determinants of metabolically healthy obesity in Spain. Atherosclerosis. 2013;231:152-7 pubmed publisher
    b>Obesity is a heterogeneous disorder, so some obese individuals do not have cardiometabolic abnormalities (CA) which mediate the association between obesity and coronary heart disease...
  14. Mirzaei K, Hossein Nezhad A, Keshavarz S, Eshaghi S, Koohdani F, Saboor Yaraghi A, et al. Insulin resistance via modification of PGC1? function identifying a possible preventive role of vitamin D analogues in chronic inflammatory state of obesity. A double blind clinical trial study. Minerva Med. 2014;105:63-78 pubmed
    b>Obesity-induced chronic inflammation is a key component of the pathogenesis of insulin resistance. Mounting evidence has demonstrated anti-inflammatory characteristics for vitamin D...
  15. Foo L, Vijaya K, Sloan R, Ling A. Obesity prevention and management: Singapore's experience. Obes Rev. 2013;14 Suppl 2:106-13 pubmed publisher
    Singapore's obesity prevalence among adult Singapore residents aged 18-69 increased from 6.9% (2004) to 10.8% (2010)...
  16. Popkin B, Monteiro C, Swinburn B. Overview: Bellagio Conference on Program and Policy Options for Preventing Obesity in the Low- and Middle-Income Countries. Obes Rev. 2013;14 Suppl 2:1-8 pubmed publisher
    The Bellagio 'Conference on Program and Policy Options for Preventing Obesity in the Low- and Middle-Income Countries' (LMICs) was organized to pull together the current...
  17. Braithwaite I, Stewart A, Hancox R, Beasley R, Murphy R, Mitchell E. The worldwide association between television viewing and obesity in children and adolescents: cross sectional study. PLoS ONE. 2013;8:e74263 pubmed publisher
    Studies exploring the effect of television viewing on obesity throughout childhood are conflicting. Most studies have been confined to single high-income countries...
  18. Messier S, Mihalko S, Legault C, Miller G, Nicklas B, DeVita P, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310:1263-73 pubmed publisher
    ..a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. To determine whether a ?10% reduction in body weight induced by diet, with or without exercise, would improve ..
  19. Irwin N, Flatt P. Enteroendocrine hormone mimetics for the treatment of obesity and diabetes. Curr Opin Pharmacol. 2013;13:989-95 pubmed publisher
    The utilisation of gastrointestinal-derived hormones as treatment options for obesity-diabetes has been well publicised...
  20. Kuebler M, Yom Tov E, Pelleg D, Puhl R, Muennig P. When overweight is the normal weight: an examination of obesity using a social media internet database. PLoS ONE. 2013;8:e73479 pubmed publisher
  21. Qian Y, Liu S, Lu F, Li H, Dong M, Lin Y, et al. Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese. BMC Genet. 2013;14:86 pubmed publisher
    Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans...
  22. Drgonova J, Jacobsson J, Han J, Yanovski J, Fredriksson R, Marcus C, et al. Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. PLoS ONE. 2013;8:e68245 pubmed publisher
    ..and nucleus of the solitary tract, influence food intake, nutrient preferences, metabolism and development of obesity in ways that often differ between males and females...
  23. Xu J, Cao K, Li Y, Zou X, Chen C, Szeto I, et al. Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet. J Nutr. 2014;144:475-83 pubmed publisher
    ..In the current study, we aimed to explore the effects of BG on mitochondrial function during the development of obesity-associated fatty liver...
  24. Steyn N, McHiza Z. Obesity and the nutrition transition in Sub-Saharan Africa. Ann N Y Acad Sci. 2014;1311:88-101 pubmed publisher
    ..the outcomes of the nutrition transition in Sub-Saharan Africa (SSA) and its association with overweight and obesity; the relationship with the double burden of malnutrition is also explored...
  25. Gunderson C, Java J, Moore K, Walker J. The impact of obesity on surgical staging, complications, and survival with uterine cancer: a Gynecologic Oncology Group LAP2 ancillary data study. Gynecol Oncol. 2014;133:23-7 pubmed publisher
    ..To determine the association of body mass index (BMI) on complications, recurrence, and survival in GOG LAP2, a randomized comparison of laparoscopic versus open staging in clinically early stage uterine cancer (EC)...
  26. Hauff L, Leonard S, Rasmussen K. Associations of maternal obesity and psychosocial factors with breastfeeding intention, initiation, and duration. Am J Clin Nutr. 2014;99:524-34 pubmed publisher
    ..However, these characteristics did not fully explain the association between maternal obesity and breastfeeding outcomes.
  27. Pan C, Lin Y. Overweight, obesity, and age-related cataract: a meta-analysis. Optom Vis Sci. 2014;91:478-83 pubmed publisher
    To examine the longitudinal association of overweight/obesity with age-related cataract.
  28. Blackford K, Jancey J, Howat P, Ledger M, Lee A. Office-based physical activity and nutrition intervention: barriers, enablers, and preferred strategies for workplace obesity prevention, Perth, Western Australia, 2012. Prev Chronic Dis. 2013;10:E154 pubmed publisher
    Workplace health promotion programs to prevent overweight and obesity in office-based employees should be evidence-based and comprehensive and should consider behavioral, social, organizational, and environmental factors...
  29. Nawrocki A, Rodriguez C, Toolan D, Price O, Henry M, Forrest G, et al. Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance. Diabetes. 2014;63:300-11 pubmed publisher
    ..PDE10A-deficient mice are resistant to diet-induced obesity (DIO) and associated metabolic disturbances...
  30. Matias S, Dewey K, Quesenberry C, Gunderson E. Maternal prepregnancy obesity and insulin treatment during pregnancy are independently associated with delayed lactogenesis in women with recent gestational diabetes mellitus. Am J Clin Nutr. 2014;99:115-21 pubmed publisher
    ..Delayed OL was reported by 33% of women and was associated with prepregnancy obesity (OR: 1.56; 95% CI: 1.07, 2.29), older maternal age (OR: 1.05; 95% CI: 1.01, 1.08), insulin GDM treatment (OR: 3...
  31. Vashistha T, Mehrotra R, Park J, Streja E, Dukkipati R, Nissenson A, et al. Effect of age and dialysis vintage on obesity paradox in long-term hemodialysis patients. Am J Kidney Dis. 2014;63:612-22 pubmed publisher
    ..higher body mass index (BMI) is associated with greater survival in patients receiving hemodialysis (HD; "obesity paradox")...
  32. Keaver L, Webber L, Dee A, Shiely F, Marsh T, Balanda K, et al. Application of the UK foresight obesity model in Ireland: the health and economic consequences of projected obesity trends in Ireland. PLoS ONE. 2013;8:e79827 pubmed publisher
    Given the scale of the current obesity epidemic and associated health consequences there has been increasing concern about the economic burden placed on society in terms of direct healthcare costs and indirect societal costs...
  33. Sangiao Alvarellos S, Pena Bello L, Manfredi Lozano M, Tena Sempere M, Cordido F. Perturbation of hypothalamic microRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance. Endocrinology. 2014;155:1838-50 pubmed publisher
    ..Although deregulated function of such circuits might be a major contributing factor in obesity, the molecular mechanisms responsible for the hypothalamic control of energy balance remain partially unknown...
  34. Switonski M, Mankowska M. Dog obesity--the need for identifying predisposing genetic markers. Res Vet Sci. 2013;95:831-6 pubmed publisher
    Incidence of overweight and obesity in dogs exceeds 30%, and several breeds are predisposed to this heritable phenotype...
  35. Boon M, van den Berg S, Wang Y, Van den Bossche J, Karkampouna S, Bauwens M, et al. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE. 2013;8:e74083 pubmed publisher
    ..in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity ..
  36. Samad F, Ruf W. Inflammation, obesity, and thrombosis. Blood. 2013;122:3415-22 pubmed publisher
    Clinical and epidemiological studies support a connection between obesity and thrombosis, involving elevated expression of the prothrombotic molecules plasminogen activator inhibitor-1 and tissue factor (TF) and increased platelet ..
  37. Orr J, Kennedy A, Anderson Baucum E, Webb C, Fordahl S, Erikson K, et al. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes. 2014;63:421-32 pubmed publisher
    ..Several studies have implicated recruited M1 ATMs in the metabolic consequences of obesity; however, little is known regarding the role of alternatively activated resident M2 ATMs in AT homeostasis or how ..
  38. Bandsma R, Sokollik C, Chami R, Cutz E, Brubaker P, Hamilton J, et al. From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics. J Clin Gastroenterol. 2013;47:834-43 pubmed publisher
    ..The aim of this report is to delineate the clinical, pathologic, and enteroendocrine (EE) features of prohormone convertase 1/3 (PC1/3) deficiency in children...
  39. Kouvonen A, Kivimaki M, Oksanen T, Pentti J, De Vogli R, Virtanen M, et al. Obesity and occupational injury: a prospective cohort study of 69,515 public sector employees. PLoS ONE. 2013;8:e77178 pubmed publisher
    b>Obesity and overweight are suggested to increase the risk of occupational injury but longitudinal evidence to confirm this is rare. We sought to evaluate obesity and overweight as risk factors for occupational injuries...
  40. Song X, Jousilahti P, Stehouwer C, Soderberg S, Onat A, Laatikainen T, et al. Comparison of various surrogate obesity indicators as predictors of cardiovascular mortality in four European populations. Eur J Clin Nutr. 2013;67:1298-302 pubmed publisher
    ..used surrogate marker for evaluating the risk of cardiovascular disease (CVD) mortality in relation to general obesity, while abdominal obesity indicators have been proposed to be more informative in risk prediction...
  41. Tang Péronard J, Heitmann B, Andersen H, Steuerwald U, Grandjean P, Weihe P, et al. Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands. Am J Clin Nutr. 2014;99:5-13 pubmed publisher
    ..exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age. From 1997 to 2000, 656 pregnant Faroese women were recruited...
  42. Barry V, Baruth M, Beets M, Durstine J, Liu J, Blair S. Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis. 2014;56:382-90 pubmed publisher
    ..Furthermore, the obesity paradox may not influence fit individuals...
  43. Bastien M, Poirier P, Lemieux I, Despres J. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014;56:369-81 pubmed publisher
    The prevalence of obesity has increased worldwide and is a source of concern since the negative consequences of obesity start as early as in childhood...
  44. Kang K, Chou C, Weng W, Lee P, Hsu W. Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea. PLoS ONE. 2013;8:e78666 pubmed publisher
    To investigate the contributions of adenoid and tonsil size to childhood obstructive sleep apnea (OSA) and the interactions between adenotonsillar hypertrophy, age, and obesity in children with OSA.
  45. Luoto R, Collado M, Salminen S, Isolauri E. Reshaping the gut microbiota at an early age: functional impact on obesity risk?. Ann Nutr Metab. 2013;63 Suppl 2:17-26 pubmed publisher
    Overweight and obesity can currently be considered a major threat to human health and well-being...
  46. Amano S, Cohen J, Vangala P, Tencerova M, Nicoloro S, Yawe J, et al. Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab. 2014;19:162-171 pubmed publisher
    ..AT (VAT), but not those in other tissues (including liver and spleen), displayed increased proliferation in obesity. Importantly, depletion of blood monocytes had no impact on ATM content, whereas their proliferation in situ ..