obesity

Summary

Summary: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Top Publications

  1. Kraus D, Yang Q, Kong D, Banks A, Zhang L, Rodgers J, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258-62 pubmed publisher
    In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters systemic insulin sensitivity...
  2. Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, et al. The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry. Nutr Metab Cardiovasc Dis. 2013;23:1043-9 pubmed publisher
    The development of type 2 diabetes (T2D) is influenced both by environmental and by genetic determinants. Obesity is an important risk factor for T2D, mostly mediated by obesity-related insulin resistance...
  3. Park J, Ahmadi S, Streja E, Molnar M, Flegal K, Gillen D, et al. Obesity paradox in end-stage kidney disease patients. Prog Cardiovasc Dis. 2014;56:415-25 pubmed publisher
    In the general population, obesity is associated with increased cardiovascular risk and decreased survival...
  4. Lackey D, Burk D, Ali M, Mostaedi R, Smith W, Park J, et al. Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab. 2014;306:E233-46 pubmed publisher
    ..b>Obesity and adipocyte hypertrophy place a strain on the ECM remodeling machinery, which may promote disordered ECM and ..
  5. Pan L, May A, Wethington H, Dalenius K, Grummer Strawn L. Incidence of obesity among young U.S. children living in low-income families, 2008-2011. Pediatrics. 2013;132:1006-13 pubmed publisher
    To examine the incidence and reverse of obesity among young low-income children and variations across population subgroups. We included 1...
  6. Mauer J, Chaurasia B, Goldau J, Vogt M, Ruud J, Nguyen K, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014;15:423-30 pubmed publisher
    b>Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial...
  7. Hams E, Locksley R, McKenzie A, Fallon P. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191:5349-53 pubmed publisher
    ..visceral adipose tissue (VAT) and release of cytokines by such cells within VAT has been implicated in regulating obesity and metabolic homeostasis...
  8. Mondul A, Giovannucci E, Platz E. A prospective study of obesity, and the incidence and progression of lower urinary tract symptoms. J Urol. 2014;191:715-21 pubmed publisher
    ..Our findings support the notion that obesity may be an important target for lower urinary tract symptom prevention and intervention.
  9. Steyn N, McHiza Z. Obesity and the nutrition transition in Sub-Saharan Africa. Ann N Y Acad Sci. 2014;1311:88-101 pubmed publisher
    ..the outcomes of the nutrition transition in Sub-Saharan Africa (SSA) and its association with overweight and obesity; the relationship with the double burden of malnutrition is also explored...

More Information

Publications32

  1. Hauff L, Leonard S, Rasmussen K. Associations of maternal obesity and psychosocial factors with breastfeeding intention, initiation, and duration. Am J Clin Nutr. 2014;99:524-34 pubmed publisher
    ..However, these characteristics did not fully explain the association between maternal obesity and breastfeeding outcomes.
  2. Keaver L, Webber L, Dee A, Shiely F, Marsh T, Balanda K, et al. Application of the UK foresight obesity model in Ireland: the health and economic consequences of projected obesity trends in Ireland. PLoS ONE. 2013;8:e79827 pubmed publisher
    Given the scale of the current obesity epidemic and associated health consequences there has been increasing concern about the economic burden placed on society in terms of direct healthcare costs and indirect societal costs...
  3. Blackford K, Jancey J, Howat P, Ledger M, Lee A. Office-based physical activity and nutrition intervention: barriers, enablers, and preferred strategies for workplace obesity prevention, Perth, Western Australia, 2012. Prev Chronic Dis. 2013;10:E154 pubmed publisher
    Workplace health promotion programs to prevent overweight and obesity in office-based employees should be evidence-based and comprehensive and should consider behavioral, social, organizational, and environmental factors...
  4. Matias S, Dewey K, Quesenberry C, Gunderson E. Maternal prepregnancy obesity and insulin treatment during pregnancy are independently associated with delayed lactogenesis in women with recent gestational diabetes mellitus. Am J Clin Nutr. 2014;99:115-21 pubmed publisher
    ..Delayed OL was reported by 33% of women and was associated with prepregnancy obesity (OR: 1.56; 95% CI: 1.07, 2.29), older maternal age (OR: 1.05; 95% CI: 1.01, 1.08), insulin GDM treatment (OR: 3...
  5. Xu J, Cao K, Li Y, Zou X, Chen C, Szeto I, et al. Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet. J Nutr. 2014;144:475-83 pubmed publisher
    ..In the current study, we aimed to explore the effects of BG on mitochondrial function during the development of obesity-associated fatty liver...
  6. Gunderson C, Java J, Moore K, Walker J. The impact of obesity on surgical staging, complications, and survival with uterine cancer: a Gynecologic Oncology Group LAP2 ancillary data study. Gynecol Oncol. 2014;133:23-7 pubmed publisher
    ..To determine the association of body mass index (BMI) on complications, recurrence, and survival in GOG LAP2, a randomized comparison of laparoscopic versus open staging in clinically early stage uterine cancer (EC)...
  7. Vashistha T, Mehrotra R, Park J, Streja E, Dukkipati R, Nissenson A, et al. Effect of age and dialysis vintage on obesity paradox in long-term hemodialysis patients. Am J Kidney Dis. 2014;63:612-22 pubmed publisher
    ..higher body mass index (BMI) is associated with greater survival in patients receiving hemodialysis (HD; "obesity paradox")...
  8. Nawrocki A, Rodriguez C, Toolan D, Price O, Henry M, Forrest G, et al. Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance. Diabetes. 2014;63:300-11 pubmed publisher
    ..PDE10A-deficient mice are resistant to diet-induced obesity (DIO) and associated metabolic disturbances...
  9. Pan C, Lin Y. Overweight, obesity, and age-related cataract: a meta-analysis. Optom Vis Sci. 2014;91:478-83 pubmed publisher
    To examine the longitudinal association of overweight/obesity with age-related cataract.
  10. Sangiao Alvarellos S, Pena Bello L, Manfredi Lozano M, Tena Sempere M, Cordido F. Perturbation of hypothalamic microRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance. Endocrinology. 2014;155:1838-50 pubmed publisher
    ..Although deregulated function of such circuits might be a major contributing factor in obesity, the molecular mechanisms responsible for the hypothalamic control of energy balance remain partially unknown...
  11. Barry V, Baruth M, Beets M, Durstine J, Liu J, Blair S. Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis. 2014;56:382-90 pubmed publisher
    ..Furthermore, the obesity paradox may not influence fit individuals...
  12. Bastien M, Poirier P, Lemieux I, Despres J. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014;56:369-81 pubmed publisher
    The prevalence of obesity has increased worldwide and is a source of concern since the negative consequences of obesity start as early as in childhood...
  13. Luoto R, Collado M, Salminen S, Isolauri E. Reshaping the gut microbiota at an early age: functional impact on obesity risk?. Ann Nutr Metab. 2013;63 Suppl 2:17-26 pubmed publisher
    Overweight and obesity can currently be considered a major threat to human health and well-being...
  14. Amano S, Cohen J, Vangala P, Tencerova M, Nicoloro S, Yawe J, et al. Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab. 2014;19:162-171 pubmed publisher
    ..AT (VAT), but not those in other tissues (including liver and spleen), displayed increased proliferation in obesity. Importantly, depletion of blood monocytes had no impact on ATM content, whereas their proliferation in situ ..
  15. Kang K, Chou C, Weng W, Lee P, Hsu W. Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea. PLoS ONE. 2013;8:e78666 pubmed publisher
    To investigate the contributions of adenoid and tonsil size to childhood obstructive sleep apnea (OSA) and the interactions between adenotonsillar hypertrophy, age, and obesity in children with OSA.
  16. Tang Péronard J, Heitmann B, Andersen H, Steuerwald U, Grandjean P, Weihe P, et al. Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands. Am J Clin Nutr. 2014;99:5-13 pubmed publisher
    ..exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age. From 1997 to 2000, 656 pregnant Faroese women were recruited...
  17. Song X, Jousilahti P, Stehouwer C, Soderberg S, Onat A, Laatikainen T, et al. Comparison of various surrogate obesity indicators as predictors of cardiovascular mortality in four European populations. Eur J Clin Nutr. 2013;67:1298-302 pubmed publisher
    ..used surrogate marker for evaluating the risk of cardiovascular disease (CVD) mortality in relation to general obesity, while abdominal obesity indicators have been proposed to be more informative in risk prediction...
  18. Kouvonen A, Kivimaki M, Oksanen T, Pentti J, De Vogli R, Virtanen M, et al. Obesity and occupational injury: a prospective cohort study of 69,515 public sector employees. PLoS ONE. 2013;8:e77178 pubmed publisher
    b>Obesity and overweight are suggested to increase the risk of occupational injury but longitudinal evidence to confirm this is rare. We sought to evaluate obesity and overweight as risk factors for occupational injuries...
  19. Bandsma R, Sokollik C, Chami R, Cutz E, Brubaker P, Hamilton J, et al. From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics. J Clin Gastroenterol. 2013;47:834-43 pubmed publisher
    ..The aim of this report is to delineate the clinical, pathologic, and enteroendocrine (EE) features of prohormone convertase 1/3 (PC1/3) deficiency in children...
  20. Orr J, Kennedy A, Anderson Baucum E, Webb C, Fordahl S, Erikson K, et al. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes. 2014;63:421-32 pubmed publisher
    ..Several studies have implicated recruited M1 ATMs in the metabolic consequences of obesity; however, little is known regarding the role of alternatively activated resident M2 ATMs in AT homeostasis or how ..
  21. Samad F, Ruf W. Inflammation, obesity, and thrombosis. Blood. 2013;122:3415-22 pubmed publisher
    Clinical and epidemiological studies support a connection between obesity and thrombosis, involving elevated expression of the prothrombotic molecules plasminogen activator inhibitor-1 and tissue factor (TF) and increased platelet ..
  22. Boon M, van den Berg S, Wang Y, Van den Bossche J, Karkampouna S, Bauwens M, et al. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE. 2013;8:e74083 pubmed publisher
    ..in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity ..
  23. Switonski M, Mankowska M. Dog obesity--the need for identifying predisposing genetic markers. Res Vet Sci. 2013;95:831-6 pubmed publisher
    Incidence of overweight and obesity in dogs exceeds 30%, and several breeds are predisposed to this heritable phenotype...