hypocalcemia

Summary

Summary: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Top Publications

  1. Pesce C, Shiue Z, Tsai H, Umbricht C, Tufano R, Dackiw A, et al. Postoperative hypocalcemia after thyroidectomy for Graves' disease. Thyroid. 2010;20:1279-83 pubmed publisher
    ..that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications...
  2. Onishi A, Muto S, Homma S, Inaba T, Shuto R, Kusano E, et al. Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia. Clin Nephrol. 2010;74:403-8 pubmed
    ..and exhibited elevated levels of serum cortisol and creatinine clearance (CCr) as well as hypouricemia, hypocalcemia, and hypophosphatemia...
  3. Zuberi K, Urquhart A. Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy. Laryngoscope. 2010;120 Suppl 4:S192 pubmed publisher
    ..026). Initial levels or subsequent changes in PTH or ionized calcium were not found to be associated with symptomatic hypocalcaemia. The removal of more than one gland did correlate with symptomatic post operative hypocalcaemia. ..
  4. Guarnieri V, Valentina D Elia A, Baorda F, Pazienza V, Benegiamo G, Stanziale P, et al. CASR gene activating mutations in two families with autosomal dominant hypocalcemia. Mol Genet Metab. 2012;107:548-52 pubmed publisher
    Autosomal dominant hypocalcemia (ADH) is an endocrine disorder caused by activating mutations of the calcium-sensing receptor (CASR) gene which plays a major role in maintaining calcium homeostasis...
  5. De Sanctis V, Soliman A, Fiscina B. Hypoparathyroidism: from diagnosis to treatment. Curr Opin Endocrinol Diabetes Obes. 2012;19:435-42 pubmed publisher
    ..Although the therapy of acute hypocalcaemia is usually readily accomplished, chronic hypocalcaemia remains a very difficult treatment problem. Replacement therapy with PTH could be a therapeutic option for refractory HPT. ..
  6. Kinoshita Y, Hori M, Taguchi M, Watanabe S, Fukumoto S. Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2014;99:E363-8 pubmed publisher
    Autosomal dominant hypocalcemia (ADH) is a congenital isolated hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CASR) gene...
  7. Hallgrimsson P, Nordenström E, Almquist M, Bergenfelz A. Risk factors for medically treated hypocalcemia after surgery for Graves' disease: a Swedish multicenter study of 1,157 patients. World J Surg. 2012;36:1933-42 pubmed publisher
    For reasons that remain unclear, surgery for Graves' disease is associated with a higher risk of hypocalcemia than surgery for benign atoxic goiter...
  8. Engiz O, Kara S, Bagrul D, Lahr G, Alioglu B, Arikan I, et al. Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemia. J Pediatr Endocrinol Metab. 2012;25:1205-7 pubmed publisher
    ..Children with IMO are at risk of developing hypocalcemia, with attendant tetanic seizures. We report the case of a baby boy who presented with neonatal hypocalcemia...
  9. Egi M, Kim I, Nichol A, Stachowski E, French C, Hart G, et al. Ionized calcium concentration and outcome in critical illness. Crit Care Med. 2011;39:314-21 pubmed publisher
    ..001). If hypocalcemia occurred at least once during the intensive care unit stay, the probability of intensive care unit mortality ..

More Information

Publications62

  1. Martuseviciene G, Hofman Bang J, Clausen T, Olgaard K, Lewin E. The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity. Kidney Int. 2011;79:742-8 pubmed publisher
    ..PTH secretion was significantly increased in response to ethylene glycol tetraacetic acid-induced acute hypocalcemia and to the same extent in both vehicle and ouabain groups...
  2. Davidson A. Reproductive causes of hypocalcemia. Top Companion Anim Med. 2012;27:165-6 pubmed publisher
    Reproductive causes of hypocalcemia include puerperal tetany (eclampsia) and mild hypocalcemia during whelping. This article reviews the pathophysiology, signalment, clinical signs, and treatment of eclampsia in the bitch and queen...
  3. Cheung E, George S, Andrade D, Chow E, Silversides C, Bassett A. Neonatal hypocalcemia, neonatal seizures, and intellectual disability in 22q11.2 deletion syndrome. Genet Med. 2014;16:40-4 pubmed publisher
    b>Hypocalcemia is a common endocrinological condition in 22q11.2 deletion syndrome. Neonatal hypocalcemia may affect neurodevelopment...
  4. Hammerstad S, Norheim I, Paulsen T, Amlie L, Eriksen E. Excessive decrease in serum magnesium after total thyroidectomy for Graves' disease is related to development of permanent hypocalcemia. World J Surg. 2013;37:369-75 pubmed publisher
    Transient postoperative hypocalcemia is one of the most common complications after thyroidectomy. Permanent hypocalcemia, however, is rare, but usually requires life-long treatment and follow-up...
  5. Nesbit M, Hannan F, Howles S, Babinsky V, Head R, Cranston T, et al. Mutations affecting G-protein subunit ?11 in hypercalcemia and hypocalcemia. N Engl J Med. 2013;368:2476-2486 pubmed publisher
    ..function, like the mutations effecting calcium-sensing receptor gain of function that cause autosomal dominant hypocalcemia type 1, may lead to hypocalcemia...
  6. Park S, Mun H, Eom Y, Baek H, Jung T, Kim C, et al. Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914. Clin Endocrinol (Oxf). 2013;78:687-93 pubmed publisher
    Activating mutations of the calcium-sensing receptor (CASR) gene are associated with autosomal dominant hypocalcemia (ADH) characterized by benign hypocalcemia, inappropriately low (PTH) levels and mostly hypercalciuria...
  7. Qasaimeh G, Al Nemri S, Al Omari A. Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemia. Eur Arch Otorhinolaryngol. 2011;268:1047-51 pubmed publisher
    ..Incidence of incidental extirpation of the parathyroid glands during thyroid operations and post-thyroidectomy hypocalcemia were reviewed. Results showed that incidental parathyroidectomy occurred in 8.6%...
  8. Gracia Iguacel C, González Parra E, Rodríguez Osorio L, Sanz A, Almaden Y, de la Piedra C, et al. Correction of hypocalcemia allows optimal recruitment of FGF-23-dependent phosphaturic mechanisms in acute hyperphosphatemia post-phosphate enema. J Bone Miner Metab. 2013;31:703-7 pubmed publisher
    ..PTH increases serum calcium concentration and FGF23 suppresses renal production of calcitriol, favoring hypocalcemia. We report the case of an 83-year-old woman with hyperphosphatemia and hypocalcemia resulting from phosphate-..
  9. Mourad M, Rulli F, Robert A, Scholtes J, De Meyer M, De Pauw L. Randomized clinical trial on Harmonic Focus shears versus clamp-and-tie technique for total thyroidectomy. Am J Surg. 2011;202:168-74 pubmed publisher
    ..Our study showed beneficial effects of Harmonic Focus use in thyroid surgery. Further studies therefore are needed to evaluate cost in the light of savings made in surgical time, materials needed for hemostasis, and human resources. ..
  10. Roh J, Kim J, Park C. Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia. Ann Surg Oncol. 2011;18:1312-8 pubmed publisher
    ..compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation...
  11. Khafif A, Pivoarov A, Medina J, Avergel A, Gil Z, Fliss D. Parathyroid hormone: a sensitive predictor of hypocalcemia following total thyroidectomy. Otolaryngol Head Neck Surg. 2006;134:907-10 pubmed
    To investigate whether monitoring parathyroid hormone (PTH) could predict hypocalcemia following total thyroidectomy or other bilateral thyroid manipulations...
  12. Voets T, Nilius B, Hoefs S, Van Der Kemp A, Droogmans G, Bindels R, et al. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem. 2004;279:19-25 pubmed
    ..member of the transient receptor potential family of cation channels, suffer from hypomagnesemia with secondary hypocalcemia (HSH) as a result of impaired renal and/or intestinal Mg2+ handling...
  13. Proczko Markuszewska M, Kobiela J, Stefaniak T, Lachinski A, Sledzinski Z. Postoperative PTH measurement as a predictor of hypocalcaemia after thyroidectomy. Acta Chir Belg. 2010;110:40-4 pubmed
    ..Pre-emptive calcium supplementation can lead to the avoidance of complications causing prolonged hospital stay and most importantly to prevent severe hypocalcaemia. ..
  14. Sywak M, Palazzo F, Yeh M, Wilkinson M, Snook K, Sidhu S, et al. Parathyroid hormone assay predicts hypocalcaemia after total thyroidectomy. ANZ J Surg. 2007;77:667-70 pubmed
    ..This approach facilitates early discharge and may decrease the need for multiple postoperative blood tests. ..
  15. Iida S. [Case of pseudohypoparathyroidism type 1b diagnosed as having hypocalcemia]. Clin Calcium. 2005;15:689-93 pubmed
    The patient (age 46; female) had hypocalcemia without characteristic physical findings of Albright hereditary osteodystrophy in July, 1998. She had no evidence of tetany...
  16. Bellantone R, Lombardi C, Raffaelli M, Boscherini M, Alesina P, De Crea C, et al. Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy?. Surgery. 2002;132:1109-12; discussion 1112-3 pubmed
    ..whether routine oral calcium (OC) and vitamin D (VD) administration can effectively prevent symptoms of hypocalcemia after total thyroidectomy...
  17. Lombardi C, Raffaelli M, Princi P, Santini S, Boscherini M, De Crea C, et al. Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement. Surgery. 2004;136:1236-41 pubmed
    We prospectively evaluated the possibility to make an early prediction of postthyroidectomy hypocalcemia by postoperative intact parathyroid hormone (iPTH) measurements...
  18. Lu K, Yeung L, Lin S, Lin Y, Chu P. Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis. 2003;42:1221-7 pubmed
    ..PTH responses to hypocalcemia and hypercalcemia induced with 1 mEq/L (0...
  19. Payne R, Hier M, Tamilia M, Mac Namara E, Young J, Black M. Same-day discharge after total thyroidectomy: the value of 6-hour serum parathyroid hormone and calcium levels. Head Neck. 2005;27:1-7 pubmed
    ..purpose of this study was to determine whether patients who undergo total thyroidectomy will have postoperative hypocalcemia develop when they reach the critical 6-hour serum levels defined as parathyroid hormone (PTH) > or =28 ng/L ..
  20. Rojas Marcos P, Rubio M, Kreskshi W, Cabrerizo L, Sanchez Pernaute A. Severe hypocalcemia following total thyroidectomy after biliopancreatic diversion. Obes Surg. 2005;15:431-4 pubmed
    ..patient who had undergone the biliopancreatic diversion of Larrad, and presented clinical symptoms of severe hypocalcemia and tetany after total thyroidectomy. Very high doses of i.v...
  21. Nakajima K, Yamazaki K, Kimura H, Takano K, Miyoshi H, Sato K. Novel gain of function mutations of the calcium-sensing receptor in two patients with PTH-deficient hypocalcemia. Intern Med. 2009;48:1951-6 pubmed
    Among 15 patients with PTH-deficient idiopathic hypocalcemia, we found two novel missense mutations in the calcium-sensing receptor (CaSR). Patient 1, who developed severe hypocalcemia (5...
  22. Recker R, Lewiecki E, Miller P, Reiffel J. Safety of bisphosphonates in the treatment of osteoporosis. Am J Med. 2009;122:S22-32 pubmed publisher
    ..safety (particularly with respect to atypical fractures and delayed healing), gastrointestinal intolerance, hypocalcemia, acute-phase (i.e...
  23. Shalitin S, Davidovits M, Lazar L, Weintrob N. Clinical heterogeneity of pseudohypoparathyroidism: from hyper- to hypocalcemia. Horm Res. 2008;70:137-44 pubmed publisher
    ..neonatal presentation is mild primary hypothyroidism secondary to resistance to thyroid-stimulating hormone; hypocalcemia usually develops after age 3-5 years...
  24. Lee I, Sheu W, Tu S, Kuo S, Pei D. Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism. J Bone Miner Metab. 2006;24:255-8 pubmed
    Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization...
  25. Sabour S, Manders E, Steward D. The role of rapid PACU parathyroid hormone in reducing post-thyroidectomy hypocalcemia. Otolaryngol Head Neck Surg. 2009;141:727-9 pubmed publisher
    Post-thyroidectomy parathyroid hormone (PTH) levels have been used to predict hypocalcemia. The goal of this study was to determine whether selective supplementation for post anesthesia care unit (PACU) PTH < 15 mg/dL reduced ..
  26. Cabané P, Gac P, Amat J, Pineda P, Rossi R, Caviedes R, et al. Allotransplant of microencapsulated parathyroid tissue in severe postsurgical hypoparathyroidism: a case report. Transplant Proc. 2009;41:3879-83 pubmed publisher
    ..In this article, we show functionality of the graft for at least 20 months without requirement of endovenous calcium. We report this procedure as a therapeutical alternative in severe hypoparathyroidism...
  27. Abboud B, Sleilaty G, Zeineddine S, Braidy C, Aouad R, Tohme C, et al. Is therapy with calcium and vitamin D and parathyroid autotransplantation useful in total thyroidectomy for preventing hypocalcemia?. Head Neck. 2008;30:1148-54; discussion 1154-5 pubmed publisher
    Routine calcium and vitamin D administration and routine autotransplantation of parathyroid glands can prevent hypocalcemia after total thyroidectomy...
  28. Haria D, Sibonga J, Taylor H. Hypocalcemia, hypovitaminosis d osteopathy, osteopenia, and secondary hyperparathyroidism 32 years after jejunoileal bypass. Endocr Pract. 2005;11:335-40 pubmed
    ..Significant hypovitaminosis D osteopathy, osteopenia, and hypocalcemia attributable to vitamin D deficiency may remain a problem in patients with unreversed JIB operations after more ..
  29. Wang O, Xing X, Meng X, Xia W, Li M, Jiang Y, et al. Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitriol: a prospective and self-controlled clinical trial. Chin Med J (Engl). 2009;122:279-83 pubmed
    Parathyroid hormone deficiency or resistance may cause hypocalcemia with related symptoms and signs. Lifelong treatment of calcium combined with vitamin D or its metabolites is always necessary for these patients...
  30. Vargas Poussou R, Huang C, Hulin P, Houillier P, Jeunemaitre X, Paillard M, et al. Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome. J Am Soc Nephrol. 2002;13:2259-66 pubmed
    ..However, in patients with autosomal dominant hypocalcemia (ADH), caused by CaSR gain-of-function mutations, a defect in tubular NaCl reabsorption with renal loss of NaCl ..
  31. Thakker R. Genetics of endocrine and metabolic disorders: parathyroid. Rev Endocr Metab Disord. 2004;5:37-51 pubmed
  32. Roh J, Park C. Routine oral calcium and vitamin D supplements for prevention of hypocalcemia after total thyroidectomy. Am J Surg. 2006;192:675-8 pubmed
    ..was to evaluate the clinical usefulness of routine oral calcium and vitamin D supplements in the prevention of hypocalcemia after total thyroidectomy...
  33. Gourgiotis S, Moustafellos P, Dimopoulos N, Papaxoinis G, Baratsis S, Hadjiyannakis E. Inadvertent parathyroidectomy during thyroid surgery: the incidence of a complication of thyroidectomy. Langenbecks Arch Surg. 2006;391:557-60 pubmed
    ..Information regarding diagnosis, operative details, and postoperative hypocalcemia were collected...
  34. Dalamaga M, Karmaniolas K, Nikolaidou A, Papadavid E. Hypocalcemia, hypomagnesemia, and hypokalemia following hydrofluoric acid chemical injury. J Burn Care Res. 2008;29:541-3 pubmed publisher
    ..This report describes the case of a 48-year-old man who developed hypocalcemia and hypomagnesemia accompanied by hypokalemia-an interesting finding-following a chemical injury with exposure ..
  35. Grodski S, Farrell S. Early postoperative PTH levels as a predictor of hypocalcaemia and facilitating safe early discharge after total thyroidectomy. Asian J Surg. 2007;30:178-82 pubmed
    ..A single PTH measurement at 4-12 hours postoperatively allows for accurate prediction of patients at risk of hypocalcaemia. Patients with a normal postoperative PTH level can be safely discharged on the first postoperative day. ..
  36. Gelfand I, DiMeglio L. Hypocalcemia as a presenting feature of celiac disease in a patient with DiGeorge syndrome. J Pediatr Endocrinol Metab. 2007;20:253-5 pubmed
  37. Berruti A, Tucci M, Generali D, Mosca A, Ardine M, Vana F, et al. Management of the side-effects of intravenous bisphosphonates: targeting the serum parathyroid hormone elevation. Ann Oncol. 2006;17:1854-5 pubmed
  38. McLeod I, Arciero C, Noordzij J, Stojadinovic A, Peoples G, Melder P, et al. The use of rapid parathyroid hormone assay in predicting postoperative hypocalcemia after total or completion thyroidectomy. Thyroid. 2006;16:259-65 pubmed
    ..the rapid parathyroid hormone assay (rPTH) as a perioperative tool in predicting postoperative symptomatic hypocalcemia following thyroidectomy...
  39. Chia S, Weisman R, Tieu D, Kelly C, Dillmann W, Orloff L. Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgery. Arch Otolaryngol Head Neck Surg. 2006;132:41-5 pubmed
    ..perioperative 1,25-dihydroxyvitamin D or parathyroid hormone (PTH) levels will predict the development of hypocalcemia after thyroid and parathyroid surgery. Prospective study. University hospital...
  40. Abboud B, Sargi Z, Akkam M, Sleilaty F. Risk factors for postthyroidectomy hypocalcemia. J Am Coll Surg. 2002;195:456-61 pubmed
    b>Hypocalcemia is a common complication of thyroidectomy. The aim of this study was to evaluate the incidence of hypocalcemia after thyroid operation and its relation to clinical, biologic, and surgical factors...
  41. Sartori P, De Fina S, Colombo G, Pugliese F, Romano F, Cesana G, et al. Ligasure versus Ultracision in thyroid surgery: a prospective randomized study. Langenbecks Arch Surg. 2008;393:655-8 pubmed publisher
    ..05). There was no difference in recurrent laryngeal nerve palsies and in intraoperative blood losses (p = ns). According to our experience, the only real advantage of new hemostatic technologies was a shorter operation time with HS. ..
  42. Camadoo L, Tibbott R, Isaza F. Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions. Nutr J. 2007;6:23 pubmed
    ..The correlation between maternal vitamin D, neonatal vitamin D and hypocalcaemia is not well documented. ..
  43. Kar P, Ogoe B, Poole R, Meeking D. Di-George syndrome presenting with hypocalcaemia in adulthood: two case reports and a review. J Clin Pathol. 2005;58:655-7 pubmed
    ..These two patients show that Di-George syndrome can present in adulthood with hypocalcaemia. This is an important observation because the condition has profound implications for health and family planning. ..
  44. Jain A, Agarwal R, Sankar M, Deorari A, Paul V. Hypocalcemia in the newborn. Indian J Pediatr. 2010;77:1123-8 pubmed publisher
    b>Hypocalcemia is a frequently observed clinical and laboratory abnormality in neonates...
  45. Kimura K, Reinhardt T, Goff J. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J Dairy Sci. 2006;89:2588-95 pubmed
    ..demands for calcium are increased; these increased demands for calcium can result in subclinical or clinical hypocalcemia. Periparturient cows also experience significant immune suppression...
  46. Roh J, Park C. Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy. Head Neck. 2006;28:990-7 pubmed
    Rapid parathyroid hormone (PTH) assay has been applied to predict hypocalcemia after thyroidectomy compared with conventional close monitoring of serum calcium levels...
  47. Rosen C, Brown S. Severe hypocalcemia after intravenous bisphosphonate therapy in occult vitamin D deficiency. N Engl J Med. 2003;348:1503-4 pubmed
  48. Vescan A, Witterick I, Freeman J. Parathyroid hormone as a predictor of hypocalcemia after thyroidectomy. Laryngoscope. 2005;115:2105-8 pubmed
    ..by levels immediately thereafter in the recovery room and the morning after surgery are a reliable predictor of hypocalcemia at our institution...
  49. Poomthavorn P, Ongphiphadhanakul B, Mahachoklertwattana P. Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism. Eur J Pediatr. 2008;167:431-4 pubmed
    Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism...
  50. Loke S, Kanesvaran R, Yahya R, Fisal L, Wong T, Loong Y. Efficacy of an intravenous calcium gluconate infusion in controlling serum calcium after parathyroidectomy for secondary hyperparathyroidism. Ann Acad Med Singapore. 2009;38:1074-80 pubmed
    ..Monitoring was discontinued if no hypocalcaemia developed in the fi rst 4 days after surgery. If hypocalcaemia persisted 6 days after surgery, then the infusion was stopped with further monitoring for 24 hours. ..
  51. Soon P, Magarey C, Campbell P, Jalaludin B. Serum intact parathyroid hormone as a predictor of hypocalcaemia after total thyroidectomy. ANZ J Surg. 2005;75:977-80 pubmed
    ..Calcium support was given to 25 patients, of whom 14 also required calcitriol. Serum PTH 1-h after total thyroidectomy is a reliable predictor of hypocalcaemia and can allow safe early discharge of patients from hospital. ..
  52. Lombardi C, Raffaelli M, Princi P, Dobrinja C, Carrozza C, Di Stasio E, et al. Parathyroid hormone levels 4 hours after surgery do not accurately predict post-thyroidectomy hypocalcemia. Surgery. 2006;140:1016-23; discussion 1023-5 pubmed
    ..reliability of intact parathyroid hormone (iPTH) levels 4 hours after thyroidectomy (4h-iPTH) as a predictor of hypocalcemia in a large series of patients...
  53. Akcakus M, Gunes T, Kurtoglu S, Cetin N, Ozkul Y, Narin N, et al. Asymmetric crying facies associated with congenital hypoparathyroidism and 22q11 deletion. Turk J Pediatr. 2004;46:191-3 pubmed
    ..CATCH 22 is a medical acronym for cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcemia and a variable deletion on chromosome 22q11...