calciphylaxis

Summary

Summary: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.

Top Publications

  1. Meissner M, Bauer R, Beier C, Betz C, Wolter M, Kaufmann R, et al. Sodium thiosulphate as a promising therapeutic option to treat calciphylaxis. Dermatology. 2006;212:373-6 pubmed
    ..Thus, we diagnosed calciphylaxis on the basis of clinical, biochemical and histopathological criteria...
  2. Hayden M, Goldsmith D. Sodium thiosulfate: new hope for the treatment of calciphylaxis. Semin Dial. 2010;23:258-62 pubmed publisher
    b>Calciphylaxis/calcific uremic arteriolopathy is rare but an important cause of morbidity and mortality in patients with chronic and end-stage kidney disease with increasing prevalence...
  3. Subramaniam K, Wallace H, Sinniah R, Saker B. Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosulfate. Australas J Dermatol. 2008;49:30-4 pubmed publisher
    ..on home haemodialysis presented with painful indurated subcutaneous nodules histologically characteristic of calciphylaxis. After failing to respond to conventional treatment, she was commenced on an intravenous infusion of 25 g of ..
  4. Guerra G, Shah R, Ross E. Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrol Dial Transplant. 2005;20:1260-2 pubmed
  5. Mazhar A, Johnson R, Gillen D, Stivelman J, Ryan M, Davis C, et al. Risk factors and mortality associated with calciphylaxis in end-stage renal disease. Kidney Int. 2001;60:324-32 pubmed
    We conducted a case control study to determine risk factors and mortality associated with calciphylaxis in end-stage renal disease. Cases of calciphylaxis diagnosed between December 1989 and January 2000 were identified...
  6. Hayden M, Goldsmith D, Sowers J, Khanna R. Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate. Int Urol Nephrol. 2008;40:443-51 pubmed publisher
    b>Calciphylaxis-calcific uremic arteriolopathy, is a serious disorder of arteriolar calcification of the arteriole media and is associated with endovascular fibrosis and thrombosis in subcutaneous adipose tissue...
  7. Nigwekar S, Wolf M, Sterns R, Hix J. Calciphylaxis from nonuremic causes: a systematic review. Clin J Am Soc Nephrol. 2008;3:1139-43 pubmed publisher
    b>Calciphylaxis, or calcific uremic arteriolopathy, is a well-described entity in end-stage kidney disease and renal transplant patients; however, little systematic information is available on calciphylaxis from nonuremic causes...
  8. Wollina U, Helm C, Hansel G, Koch A, Schönlebe J, Haroske G, et al. Deep ulcer shaving combined with split-skin transplantation in distal calciphylaxis. Int J Low Extrem Wounds. 2008;7:102-7 pubmed publisher
    b>Calciphylaxis is a cause of painful deep ulcers. There is controversy about best wound management in this disease. A retrospective study of inpatients during the 3 years was made. Seven calciphylaxis patients were identified...
  9. Wilmer W, Magro C. Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. Semin Dial. 2002;15:172-86 pubmed
    b>Calciphylaxis is a small vessel vasculopathy involving mural calcification with intimal proliferation, fibrosis, and thrombosis...

More Information

Publications62

  1. Baker B, Fitzgibbons C, Buescher L. Calciphylaxis responding to sodium thiosulfate therapy. Arch Dermatol. 2007;143:269-70 pubmed
  2. Imam A, Mattoo T, Kapur G, Bloom D, Valentini R. Calciphylaxis in pediatric end-stage renal disease. Pediatr Nephrol. 2005;20:1776-80 pubmed
    b>Calciphylaxis is a rare, but life-threatening complication of end-stage renal disease (ESRD) that has been reported mostly in adult patients...
  3. Hayden M, Tyagi S, Kolb L, Sowers J, Khanna R. Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. Cardiovasc Diabetol. 2005;4:4 pubmed
    ..b>Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with ..
  4. Cicone J, Petronis J, Embert C, Spector D. Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis. 2004;43:1104-8 pubmed
    b>Calciphylaxis is a dreaded complication of renal failure characterized by nodular subcutaneous calcification and painful tissue necrosis often leading to ulceration, secondary infection, and high mortality rates...
  5. Don B, Chin A. A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol. 2003;59:463-70 pubmed
    Calcific uremic arteriolopathy (calciphylaxis) is one of the more devastating complications that can develop in patients with chronic renal failure...
  6. Hayden M, Kolb L, Khanna R. Calciphylaxis and the cardiometabolic syndrome. J Cardiometab Syndr. 2006;1:76-9 pubmed
  7. Velasco N, MacGregor M, Innes A, MacKay I. Successful treatment of calciphylaxis with cinacalcet-an alternative to parathyroidectomy?. Nephrol Dial Transplant. 2006;21:1999-2004 pubmed
  8. Davis C, Valentine R. Wet gangrene in hemodialysis patients with calciphylaxisis is associated with a poor prognosis. Cardiovasc Surg. 2001;9:565-70 pubmed
    b>Calciphylaxis is a rare syndrome characterized by progressive vascular calcification and ischemic tissue loss in patients with chronic renal failure...
  9. Panuncialman J, Falanga V. Unusual causes of cutaneous ulceration. Surg Clin North Am. 2010;90:1161-80 pubmed publisher
    ..In this article, the authors discuss several examples of inflammatory ulcers and the approach to the diagnosis and treatment of these ulcers. ..
  10. Ross E. Evolution of treatment strategies for calciphylaxis. Am J Nephrol. 2011;34:460-7 pubmed publisher
    Treatment strategies for calciphylaxis are limited by inadequate understanding of its pathophysiology. Mortality reaches 80%, due to progressive skin ischemia, necrosis and infections...
  11. Schlieper G, Brandenburg V, Ketteler M, Floege J. Sodium thiosulfate in the treatment of calcific uremic arteriolopathy. Nat Rev Nephrol. 2009;5:539-43 pubmed publisher
    Calcific uremic arteriolopathy (CUA; also known as calciphylaxis) is a life-threatening condition observed mostly in patients on dialysis...
  12. Brandenburg V, Kramann R, Specht P, Ketteler M. Calciphylaxis in CKD and beyond. Nephrol Dial Transplant. 2012;27:1314-8 pubmed publisher
    b>Calciphylaxis is still an incompletely understood rare disease, which most often affects people on haemodialysis...
  13. Streit M, Paredes B, Rüegger S, Brand C. Typical features of calciphylaxis in a patient with end-stage renal failure, diabetes mellitus and oral anticoagulation. Dermatology. 2000;200:356-9 pubmed
    ..Histology revealed medial calcification of the small arteries typical of calciphylaxis. We found the typical features of the disease with different risk factors like elevated calcium-phosphate ..
  14. Korkmaz C, Dundar E, Zubaroğlu I. Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency. Clin Rheumatol. 2002;21:66-9 pubmed
    b>Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification that is seen almost exclusively in patients with end-stage renal disease and ..
  15. Goli A, Goli S, Shah L, Byrd R, Roy T. Calciphylaxis: a rare association with alcoholic cirrhosis. Are deficiencies in protein C and S the cause?. South Med J. 2005;98:736-9 pubmed
    b>Calciphylaxis is a rare condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification...
  16. Couto F, Chen H, Blank R, Drezner M. Calciphylaxis in the absence of end-stage renal disease. Endocr Pract. 2006;12:406-10 pubmed
    To report a case of calciphylaxis in the absence of renal failure in a patient with secondary hyperparathyroidism and low calcium/phosphorus product, in whom total parathyroidectomy resulted in relief of pain and healing of ulcerations...
  17. Shmidt E, Murthy N, Knudsen J, Weenig R, Jacobs M, Starnes A, et al. Net-like pattern of calcification on plain soft-tissue radiographs in patients with calciphylaxis. J Am Acad Dermatol. 2012;67:1296-301 pubmed publisher
    b>Calciphylaxis is a rare, life-threatening syndrome marked by vascular calcification and cutaneous necrosis. The role of radiographic imaging in assisting in diagnosis has not been established...
  18. Feng J, Gohara M, Lazova R, Antaya R. Fatal childhood calciphylaxis in a 10-year-old and literature review. Pediatr Dermatol. 2006;23:266-72 pubmed
    b>Calciphylaxis is a rare but highly morbid disorder of vascular calcification and skin necrosis, affecting 1% to 4% of adults with end-stage renal disease. Only three affected children have previously been described...
  19. Tokashiki K, Ishida A, Kouchi M, Ishihara S, Tomiyama N, Kohagura K, et al. Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient. Clin Nephrol. 2006;66:140-3 pubmed
    ..Pain relief was sustained and he could walk after 2 weeks of infusion. Our case supports the use of sodium thiosulfate as a novel therapeutic choice for critical limb ischemia with severe vascular calcification in chronic HD patients...
  20. Mwipatayi B, Cooke C, Sinniah R, Abbas M, Angel D, Sieunarine K. Calciphylaxis: emerging concept in vascular patients. Eur J Dermatol. 2007;17:73-8 pubmed
    b>Calciphylaxis is a small vessel vasculopathy with medial calcification associated with intimal proliferation, fibrosis and thrombosis...
  21. Joukhadar R, Bright T. Calciphylaxis in primary hyperparathyroidism: a case report and brief review. South Med J. 2009;102:318-21 pubmed publisher
    ..b>Calciphylaxis is a rare but serious disorder that leads to skin and soft tissue necrosis and requires prompt diagnosis and ..
  22. Weenig R, Sewell L, Davis M, McCarthy J, Pittelkow M. Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol. 2007;56:569-79 pubmed
    b>Calciphylaxis is characterized by ischemic cutaneous ulceration, high mortality, and ineffective treatment...
  23. Milas M, Bush R, Lin P, Brown K, Mackay G, Lumsden A, et al. Calciphylaxis and nonhealing wounds: the role of the vascular surgeon in a multidisciplinary treatment. J Vasc Surg. 2003;37:501-7 pubmed
    b>Calciphylaxis, a disorder of calcium-phosphate metabolism that can result in arterial calcification, skin and solid organ calcium deposits, and nonhealing ulcerations, is associated with significant morbidity and mortality...
  24. Bleyer A, Choi M, Igwemezie B, de la Torre E, White W. A case control study of proximal calciphylaxis. Am J Kidney Dis. 1998;32:376-83 pubmed
    The purpose of this investigation was to describe the clinical presentation of nine patients with calciphylaxis involving the proximal lower extremities or trunk and to compare the clinical characteristics of these patients with those of ..
  25. Soni S, Leslie W. Bone scan findings in metastatic calcification from calciphylaxis. Clin Nucl Med. 2008;33:502-4 pubmed publisher
    ..These findings were typical for calciphylaxis (calcific uremic arteriolopathy), a form of metastatic calcification encountered in patients with chronic ..
  26. Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int. 2002;61:2210-7 pubmed
    b>Calciphylaxis, historically considered rare, seems to be increasing in frequency. In our single center, 36 new cases have accumulated in seven years...
  27. Raymond C, Wazny L. Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis. Am J Health Syst Pharm. 2008;65:1419-29 pubmed publisher
    The use of sodium thiosulfate, bisphosphonates, and cinacalcet for the treatment of calciphylaxis in adults with chronic kidney disease (CKD) is discussed...
  28. Emohare O, Kowal Vern A, Wiley D, Latenser B. Vacuum-assisted closure use in calciphylaxis. J Burn Care Rehabil. 2004;25:161-4 pubmed
    b>Calciphylaxis-induced chronic wounds are difficult to heal. The value of vacuum-assisted closure (VAC) was assessed in two patients with calciphylaxis...
  29. Arenas M, Gil M, Gutierrez M, Malek T, Moledous A, Salinas A, et al. Management of calcific uremic arteriolopathy (calciphylaxis) with a combination of treatments, including hyperbaric oxygen therapy. Clin Nephrol. 2008;70:261-4 pubmed
  30. Roncada E, Abreu M, Pereira M, Oliveira C, Nai G, Soares D. Calciphylaxis, a diagnostic and therapeutic challenge: report of a successful case. An Bras Dermatol. 2012;87:752-5 pubmed
    b>Calciphylaxis, also known as calcific uremic arteriolopathy, is a severe complication often observed in patients with hyperparathyroidism secondary to chronic renal failure, which occurs mainly in women...
  31. Edsall L, English J, Teague M, Patterson J. Calciphylaxis and metastatic calcification associated with nephrogenic fibrosing dermopathy. J Cutan Pathol. 2004;31:247-53 pubmed
    b>Calciphylaxis and metastatic calcification are known complications of chronic renal failure...
  32. Schliep S, Schuler G, Kiesewetter F. Successful treatment of calciphylaxis with pamidronate. Eur J Dermatol. 2008;18:554-6 pubmed publisher
    b>Calciphylaxis is a rare syndrome characterized by calcification of blood vessels and panniculitis in association with ecchymosis and/or skin necrosis. Most commonly, calciphylaxis is seen in patients with chronic renal failure...
  33. Ahmed S, O Neill K, Hood A, Evan A, Moe S. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis. 2001;37:1267-76 pubmed
    b>Calciphylaxis or calcific uremic arteriolopathy (CUA) is a fatal disease in dialysis patients due to calcification of cutaneous blood vessels. The pathogenesis has been attributed to elevated parathyroid hormone (PTH)...
  34. Fukagawa M. Ever-changing concepts of calciphylaxis. Intern Med. 2004;43:7-8 pubmed
  35. Bazari H, Jaff M, MANNSTADT M, Yan S. Case records of the Massachusetts General Hospital. Case 7-2007. A 59-year-old woman with diabetic renal disease and nonhealing skin ulcers. N Engl J Med. 2007;356:1049-57 pubmed
  36. De Roma I, Filotico R, Cea M, Procaccio P, Perosa F. Calciphylaxis in a patient with POEMS syndrome without renal failure and/or hyperparathyroidism. A case report. Ann Ital Med Int. 2004;19:283-7 pubmed
    ..Eight weeks later, she developed skin lesions bioptically shown to be due to calciphylaxis-induced cutaneous vasculitis...
  37. Brucculeri M, Cheigh J, Bauer G, Serur D. Long-term intravenous sodium thiosulfate in the treatment of a patient with calciphylaxis. Semin Dial. 2005;18:431-4 pubmed
    b>Calciphylaxis is a disabling and life-threatening complication that primarily affects patients who are dialysis dependent...
  38. Shiraishi N, Kitamura K, Miyoshi T, Adachi M, Kohda Y, Nonoguchi H, et al. Successful treatment of a patient with severe calcific uremic arteriolopathy (calciphylaxis) by etidronate disodium. Am J Kidney Dis. 2006;48:151-4 pubmed
    ..We report a case of CUA that was improved dramatically by treatment with etidronate. Etidronate therapy should be considered for refractory CUA. ..
  39. Hess C. Calciphylaxis: identification and wound management. Adv Skin Wound Care. 2002;15:64 pubmed
  40. Riegert Johnson D, Kaur J, Pfeifer E. Calciphylaxis associated with cholangiocarcinoma treated with low-molecular-weight heparin and vitamin K. Mayo Clin Proc. 2001;76:749-52 pubmed
    b>Calciphylaxis is a rare disorder of small-vessel calcification and cutaneous infarction associated with chronic renal failure...
  41. Bakkaloglu S, Dursun I, Kaya A, Soylemezoglu O, Hasanoglu E, Buyan N. Digital calciphylaxis progressing to amputation in a child on continuous ambulatory peritoneal dialysis. Ann Trop Paediatr. 2007;27:149-52 pubmed
    b>Calciphylaxis is a rare, life-threatening condition of progressive cutaneous necrosis resulting from medial calcification of the small arterioles. It is usually seen in uraemic patients with secondary hyperparathyroidism...
  42. Hackett B, McAleer M, Sheehan G, Powell F, O Donnell B. Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate. Clin Exp Dermatol. 2009;34:39-42 pubmed publisher
    b>Calciphylaxis is a rare, life-threatening cause of skin necrosis. The condition is primarily reported in patients with end-stage renal disease, and is associated with significant morbidity and mortality...
  43. Polizzotto M, Bryan T, Ashby M, Martin P. Symptomatic management of calciphylaxis: a case series and review of the literature. J Pain Symptom Manage. 2006;32:186-90 pubmed
    b>Calciphylaxis, or calcific uremic arteriopathy, is a rare complication of end-stage renal impairment. It is characterized by the development of small vessel vasculopathy with subcutaneous necrosis and ulceration...
  44. Araya C, Fennell R, Neiberger R, Dharnidharka V. Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clin J Am Soc Nephrol. 2006;1:1161-6 pubmed
    ..STS seems well tolerated in children and young adults with CUA and has mild adverse effects. For determination of its efficacy, optimum dosage, duration of therapy, and dialysis modality, controlled trials are needed. ..
  45. Somorin A, Al Harbi A, Subaity Y, Zaman A. Calciphylaxis: case report and literature review. Afr J Med Med Sci. 2002;31:175-8 pubmed
    Tissue calcification is a well-recognized common metabolic disease, but calciphylaxis still remains an enigmatic rarity. The latter may be induced experimentally and acquired naturally in human diseases...
  46. Girotto J, Harmon J, Ratner L, Nicol T, Wong L, Chen H. Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidism. Surgery. 2001;130:645-50; discussion 650-1 pubmed
    b>Calciphylaxis is a rare but life-threatening condition occasionally affecting patients with secondary hyperparathyroidism. Parathyroidectomy has been advocated as the only potentially curative intervention...
  47. Shapiro C, Coco M. Gastric calciphylaxis in a patient with a functioning renal allograft. Clin Nephrol. 2007;67:119-25 pubmed
    b>Calciphylaxis or calcific uremic arteriolopathy (CUA), not uncommon in the dialysis population, has also been reported in renal transplant recipients with varying stages of renal dysfunction...
  48. Russell R, Brookshire M, Zekonis M, Moe S. Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca x P product and aggressive wound care. Clin Nephrol. 2002;58:238-43 pubmed
    Calcific uremic arteriolopathy (CUA; calciphylaxis), is reported in approximately 4% of patients receiving hemodialysis, and is characterized by skin lesions that may include firm plaques or subcutaneous nodules...
  49. Brandenburg V, Cozzolino M, Ketteler M. Calciphylaxis: a still unmet challenge. J Nephrol. 2011;24:142-8 pubmed
    Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare disease most frequently occurring in patients with advanced chronic kidney disease (CKD)...
  50. Mataic D, Bastani B. Intraperitoneal sodium thiosulfate for the treatment of calciphylaxis. Ren Fail. 2006;28:361-3 pubmed
    Calcific uremic arteriolopathy (or calciphylaxis) is a severe complication of renal failure characterized by subcutaneous calcification of the small arteries and tissue necrosis...
  51. Mohammed I, Sekar V, Bubtana A, Mitra S, Hutchison A. Proximal calciphylaxis treated with calcimimetic 'Cinacalcet'. Nephrol Dial Transplant. 2008;23:387-9 pubmed
    b>Calciphylaxis is a rare condition affecting patients suffering from end-stage renal failure, characterised by cutaneous ischaemia and necrosis...
  52. Kyritsis I, Gombou A, Griveas I, Agroyannis I, Retsa K, Agroyannis B. Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism. Int J Artif Organs. 2008;31:742-4 pubmed
    b>Calciphylaxis (calcific uremic arteriolopathy) is a severe complication of hemodialysis characterized by subcutaneous calcification of the small arteries and tissue necrosis...
  53. Beitz J. Calciphylaxis: a case study with differential diagnosis. Ostomy Wound Manage. 2003;49:28-38; quiz 39-40 pubmed
    b>Calciphylaxis is a relatively rare, but horribly disfiguring, skin condition that is most often associated with end-stage renal disease and long-term dialysis. Unfortunately, calciphylaxis-related morbidity and mortality are significant...