apobec deaminases

Summary

Summary: A family of conserved cytidine deaminases that catalyze the DEAMINATION of CYTIDINE to URIDINE. They are characterized by N and C-terminal zinc-dependent catalytic domains and have important functions in RNA EDITING; EPIGENTIC PROCESSES; and the INNATE IMMUNE RESPONSE against viruses.

Top Publications

  1. Ito F, Fu Y, Kao S, Yang H, Chen X. Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins. J Mol Biol. 2017;429:1787-1799 pubmed publisher
    ..These findings extend our understanding of APOBEC family proteins that have important roles in diverse biological functions and in genetic mutations. ..
  2. Qiao Q, Wang L, Meng F, Hwang J, Alt F, Wu H. AID Recognizes Structured DNA for Class Switch Recombination. Mol Cell. 2017;67:361-373.e4 pubmed publisher
    ..Collectively, our data implicate intrinsic preference of AID for structured substrates and uncover the importance of G4 recognition and oligomerization of AID in CSR. ..