neurotoxicity syndromes


Summary: Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.

Top Publications

  1. Li A, Levine T, Burns C, Anger W. Integration of epidemiology and animal neurotoxicity data for risk assessment. Neurotoxicology. 2012;33:823-32 pubmed publisher
  2. Breckenridge C, Holden L, Sturgess N, Weiner M, Sheets L, Sargent D, et al. Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicology. 2009;30 Suppl 1:S17-31 pubmed publisher
    ..Fenpropathrin and esfenvalerate occupy an intermediate position between these two groups...
  3. Julvez J, Grandjean P. Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy. Ind Health. 2009;47:459-68 pubmed
    ..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health...
  4. Garey J, Paule M. Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats. Neurotoxicol Teratol. 2010;32:220-5 pubmed publisher
  5. Sriram K, Lin G, Jefferson A, Roberts J, Chapman R, Chen B, et al. Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Arch Toxicol. 2010;84:521-40 pubmed publisher
    ..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
  6. Tironi Farinati C, Loidl C, Boccoli J, Parma Y, Fernandez Miyakawa M, Goldstein J. Intracerebroventricular Shiga toxin 2 increases the expression of its receptor globotriaosylceramide and causes dendritic abnormalities. J Neuroimmunol. 2010;222:48-61 pubmed publisher
    ..Rats showed weight variation and motor deficits as compared to controls. We thus suggest that Stx2 induces the expression of Gb(3) in neurons and triggers neuronal dysfunctions...
  7. Raffaele K, Rowland J, May B, Makris S, Schumacher K, Scarano L. The use of developmental neurotoxicity data in pesticide risk assessments. Neurotoxicol Teratol. 2010;32:563-72 pubmed publisher
  8. Zhang L, Gavin T, Barber D, LoPachin R. Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Toxicol Lett. 2011;205:1-7 pubmed publisher
    ..Because a cytoprotective response was not induced in any fraction, nerve terminal vulnerability to ACR cannot be ascribed to the absence of transcription-based defense mechanisms in this neuronal region...
  9. Prueitt R, Goodman J, Bailey L, Rhomberg L. Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos. Crit Rev Toxicol. 2011;41:822-903 pubmed publisher

More Information

Publications102 found, 100 shown here

  1. Sugihara K, Ohtsu A, Shimada Y, Mizunuma N, Lee P, de Gramont A, et al. Safety analysis of FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studies. Clin Colorectal Cancer. 2012;11:127-37 pubmed publisher
    ..As part of the Japanese submission for the adjuvant indication, the safety profile of FOLFOX4 regimen was compared in Asian and Western patients...
  2. Llorens J, Li A, Ceccatelli S, Suñol C. Strategies and tools for preventing neurotoxicity: to test, to predict and how to do it. Neurotoxicology. 2012;33:796-804 pubmed publisher
  3. Kita T, Miyazaki I, Asanuma M, Takeshima M, Wagner G. Dopamine-induced behavioral changes and oxidative stress in methamphetamine-induced neurotoxicity. Int Rev Neurobiol. 2009;88:43-64 pubmed publisher
    ..Thus, we propose that acute behavioral observation of subjects immediately following methamphetamine administration may provide insight into the long-lasting toxicity to dopaminergic neurons...
  4. Ali B. Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literature. Basic Clin Pharmacol Toxicol. 2010;106:272-9 pubmed publisher
    ..None of these drugs have been proven to be effective in large, controlled, clinical trials...
  5. Paul R, Pessah I, Gane L, Ono M, Hagerman P, Brunberg J, et al. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology. 2010;31:399-402 pubmed publisher
  6. Grothey A, Nikcevich D, Sloan J, Kugler J, Silberstein P, Dentchev T, et al. Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7. J Clin Oncol. 2011;29:421-7 pubmed publisher
    ..In a nonrandomized, retrospective study, intravenous (IV) calcium/magnesium (Ca/Mg) was associated with reduced oxaliplatin-induced sNT...
  7. Mahaffey K, Sunderland E, Chan H, Choi A, Grandjean P, Mariën K, et al. Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption. Nutr Rev. 2011;69:493-508 pubmed publisher
    ..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
  8. van Thriel C, Westerink R, Beste C, Bale A, Lein P, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology. 2012;33:911-24 pubmed publisher
    ..We envision that future in vitro test systems for developmental neurotoxicity will combine the above approaches with exposure information, and we suggest a strategy for test system development and cell-based risk assessment...
  9. Slotkin T, Card J, Seidler F. Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. Neurotoxicol Teratol. 2012;34:505-12 pubmed publisher
  10. O Farrell E, Mackenzie J, Collins B. Clearing the air: a review of our current understanding of "chemo fog". Curr Oncol Rep. 2013;15:260-9 pubmed publisher
    ..This review examines the evolution of "chemo fog" research with a look at methodological issues, the status of our current understanding, and suggestions for future research. ..
  11. Murray M, Sharmin R. Groundwater arsenic and education attainment in Bangladesh. J Health Popul Nutr. 2015;33:20 pubmed publisher
    ..Bangladeshi public health measures to shift drinking from unsafe to safe wells not only advance good health but also increase males' education attainment. ..
  12. Samukawa M, Ichihara G, Oka N, Kusunoki S. A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents. Arch Intern Med. 2012;172:1257-60 pubmed publisher
    ..To our knowledge, this is the first report that describes nerve biopsy findings in a human case. ..
  13. Fournier K, Baumont E, Glorennec P, Bonvallot N. Relative toxicity for indoor semi volatile organic compounds based on neuronal death. Toxicol Lett. 2017;279:33-42 pubmed publisher
    ..Lack of comparable toxicity datasets limits the number of SVOCs that can be included. More standardized protocols in terms of cell lines, species and exposure duration should be developed with a view to cumulative risk assessment. ..
  14. Wu B, Song B, Yang H, Huang B, Chi B, Guo Y, et al. Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology. 2013;35:62-70 pubmed publisher
    ..Further studies will be needed with non-lethal dose of PQ to confirm these results and demonstrate the direct CNS toxicity of PQ. ..
  15. Dai C, Li J, Li J. New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues. Exp Toxicol Pathol. 2013;65:941-8 pubmed publisher
    ..5 and 5 mg/kg groups. The results suggested that mitochondrial dysfunction might partly account for the mechanism of neurotoxicity induced by colistin sulfate. ..
  16. Ye H, Shi H, Yin S. Mechanisms underlying taurine protection against glutamate-induced neurotoxicity. Can J Neurol Sci. 2013;40:628-34 pubmed
  17. Tankovic J, Timinskas A, Janulaitiene M, Zilnyte M, Baudel J, Maury E, et al. Gardnerella vaginalis bacteremia associated with severe acute encephalopathy in a young female patient. Anaerobe. 2017;47:132-134 pubmed publisher
    ..vaginalis isolates. We hypothesize that this toxin, if produced in high amounts in blood, is able to disrupt the blood-brain barrier and exert a toxic activity on brain cells. ..
  18. McCormick A, Wheeler J, Guthrie C, Liachko N, Kraemer B. Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol Psychiatry. 2013;73:464-71 pubmed publisher
    ..These results suggest dopamine D2 receptor antagonism holds promise as a potential neuroprotective strategy for targeting tau aggregation and neurotoxicity. ..
  19. Zhang J, Huang C, Li H, Yao Q, Xu J, Yuan J, et al. Antibiotic-induced neurotoxicity in dialysis patients: a retrospective study. Ren Fail. 2013;35:901-5 pubmed publisher
    ..Neurotoxicity could be prevented in high-risk cases with dosage adjustments. Better prognosis can be achieved with early and proper diagnosis, decisive withdrawal, and aggressive treatment including enhanced HD. ..
  20. Kono T, Hata T, Morita S, Munemoto Y, Matsui T, Kojima H, et al. Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double?blind, placebo?controlled trial of goshajinkigan to prevent oxaliplatin?induced neuropathy. Cancer Chemother Pharmacol. 2013;72:1283-90 pubmed
    ..51, 0.14–1.92). No concerns regarding toxicity emerged with TJ-107 treatment. TJ-107 appears to have an acceptable safety margin and a promising effect in delaying the onset of grade 2 or greater OPN without impairing FOLFOX efficacy. ..
  21. Azar N, Bangalore Vittal N, Arain A, Abou Khalil B. Tiagabine-induced stupor in patients with psychogenic nonepileptic seizures: nonconvulsive status epilepticus or encephalopathy?. Epilepsy Behav. 2013;27:330-2 pubmed publisher
    ..Habitual seizures were found to be psychogenic, with no interictal evidence for epilepsy. Tiagabine-related stupor may represent a form of toxic encephalopathy in some cases rather than nonconvulsive status epilepticus. ..
  22. Ahrens C, Manno E. Neurotoxicity of commonly used hepatic drugs. Handb Clin Neurol. 2014;120:675-82 pubmed publisher
    ..While the mechanisms of action are poorly elucidated, they are discussed along with treatment strategies. ..
  23. Emerick G, Ehrich M, Jortner B, Oliveira R, Deoliveira G. Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis. Toxicology. 2012;302:88-95 pubmed publisher
    ..m.) and one dose of calcium gluconate (5mg/kg, i.v.). The treatment decreased the effect of OPIDN-inducing TOCP and (+)-methamidophos on calpain activity, spinal cord lesions and clinical signs. ..
  24. Lv T, Li Y, Jia J, Shi Z, Bai J. Protective effect of geranylgeranylacetone against methamphetamine-induced neurotoxicity in rat pheochromocytoma cells. Pharmacology. 2013;92:131-7 pubmed publisher
    ..Our previous study demonstrated that geranylgeranylacetone (GGA) was an inducer of thioredoxin-1 (Trx-1) and heat shock protein 70 (Hsp70), which played a cytoprotective role against neurotoxicity...
  25. Guo Y, Jones D, Palmer J, Forman A, Dakhil S, Velasco M, et al. Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. Support Care Cancer. 2014;22:1223-31 pubmed publisher
    ..Future studies to explore ALA as a neuroprotective agent should take heed of the barriers confronted in this study. ..
  26. Song Q, Ma Y, Song J, Chen Q, Xia G, Ma J, et al. Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling. Genet Mol Res. 2015;14:18059-68 pubmed publisher
    ..These data suggest that sevoflurane induces neurotoxicity in young mice through FAS-FASL signaling. ..
  27. Esmaeili M, Movahedi M, Faraji A, Haghdoost Yazdi H. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicol Teratol. 2012;34:489-94 pubmed publisher
  28. Hassan I, Chibber S, Khan A, Naseem I. Cisplatin-induced neurotoxicity in vivo can be alleviated by riboflavin under photoillumination. Cancer Biother Radiopharm. 2013;28:160-8 pubmed publisher
    ..Hence, inclusion of RF in CP-based chemoradiotherapy can be an effective strategy to counter CP-induced neurotoxicity. ..
  29. Afanador L, Mexhitaj I, Diaz C, Ordonez D, Baker L, Angulo J. The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice. Brain Res. 2013;1510:38-47 pubmed publisher
    ..However, SST failed to prevent the toxicity of the dopamine terminals suggesting that pre- and post-synaptic striatal damage occur via independent mechanisms. ..
  30. Sison Young R, Kia R, Heslop J, Kelly L, Rowe C, Cross M, et al. Human pluripotent stem cells for modeling toxicity. Adv Pharmacol. 2012;63:207-56 pubmed publisher
    ..This article will review the advances and challenges of using human pluripotent stem cells for modeling metabolism and toxicity, and offer some perspectives as to where its future may lie. ..
  31. Khudoerkov R, Voronkov D, Yamshchikova N. Immunohistochemical and morphological changes in neurons and neuroglia in the cerebral nigrostriatal structures under conditions of experimental nigral neurodegeneration. Bull Exp Biol Med. 2012;153:893-7 pubmed
    ..Hence, unilateral destruction of the nigral dopamine-containing neurons stimulated the neuroglia (particularly astroglia) in the caudate nuclei, especially on the side of damage. ..
  32. Catalani S, Apostoli P. [Neurotoxic effects of cobalt: an open question]. G Ital Med Lav Ergon. 2011;33:57-60 pubmed
    ..The studies of these cases have revealed a typical symptomatology of cobalt probably due to its ability to induce oxidative stress and mitochondrial alterations. ..
  33. Hermanns Clausen M, Angerer V, Kithinji J, Grumann C, Auwärter V. Bad trip due to 25I-NBOMe: a case report from the EU project SPICE II plus. Clin Toxicol (Phila). 2017;55:922-924 pubmed publisher
    ..The finding of 2C-I in the serum sample 50?minutes after intake indicates a fast metabolic breakdown of 25I-NBOMe due to first-pass metabolism. ..
  34. Rui G, Guangjian Z, Yong W, Jie F, Yanchao C, Xi J, et al. High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats. Behav Brain Res. 2013;237:263-9 pubmed publisher
    ..This might shed some light on the mechanism by which EA affects the DA neurotransmitter system. ..
  35. Boyette Davis J, Cata J, Driver L, Novy D, Bruel B, Mooring D, et al. Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine. Cancer Chemother Pharmacol. 2013;71:619-26 pubmed publisher
    ..Decreases in Meissner's corpuscles and ENFs indicate a possible mechanism for the neuropathy. ..
  36. Bolden A, Rochester J, Kwiatkowski C. Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?. Toxicol Lett. 2017;280:181-189 pubmed publisher
    ..The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure. ..
  37. Ares Santos S, Granado N, Moratalla R. The role of dopamine receptors in the neurotoxicity of methamphetamine. J Intern Med. 2013;273:437-53 pubmed publisher
  38. Ceccatelli S, Bose R, Edoff K, Onishchenko N, Spulber S. Long-lasting neurotoxic effects of exposure to methylmercury during development. J Intern Med. 2013;273:490-7 pubmed publisher
  39. Thrash Williams B, Ahuja M, Karuppagounder S, Uthayathas S, Suppiramaniam V, Dhanasekaran M. Assessment of therapeutic potential of amantadine in methamphetamine induced neurotoxicity. Neurochem Res. 2013;38:2084-94 pubmed publisher
    ..Overall results from the present study suggest that amantadine should not be used concomitantly with methamphetamine as it may results in excessive neurotoxicity. ..
  40. Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, et al. JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2. Toxicol Lett. 2017;277:32-40 pubmed publisher
    ..Further investigations revealed that the protective effect of JWA mostly involves regulation of the MEK/PI3K-Nrf2 axis. Our results suggest that JWA may be a novel target for the prevention and treatment of PQ-induced PD. ..
  41. Wang W, Jia L, Luo Y, Zhang H, Cai F, Mao H, et al. Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling. Mol Neurobiol. 2016;53:216-230 pubmed publisher
  42. Wu T, He K, Zhan Q, Ang S, Ying J, Zhang S, et al. MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both. Nanoscale. 2015;7:20460-73 pubmed publisher
    ..elegans induced by long-term QD exposure, resulting in more severe behavioral impairments. ..
  43. Capela J, da Costa Araújo S, Costa V, Ruscher K, Fernandes E, Bastos M, et al. The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. Neurotoxicology. 2013;34:254-63 pubmed publisher
    ..Death was dependent, at least in part, on the stimulation of the 5-HT(2A)-receptors...
  44. Wei H, Inan S. Dual effects of neuroprotection and neurotoxicity by general anesthetics: role of intracellular calcium homeostasis. Prog Neuropsychopharmacol Biol Psychiatry. 2013;47:156-61 pubmed publisher
  45. Wu T, Zhang T, Chen Y, Tang M. Research advances on potential neurotoxicity of quantum dots. J Appl Toxicol. 2016;36:345-51 pubmed publisher
  46. Wu X, Xue R, Liu X, Jia F, Ruan M, Zhang B. [Protective effect of 2,4-dihydroxybenzophenone on cocaine-induced hepatotoxicity and neurotoxicity in mice]. Beijing Da Xue Xue Bao Yi Xue Ban. 2012;44:421-5 pubmed
    ..BP-1 has protective effect on acute hepatotoxicity and neurotoxicity of mice induced by cocaine. Its mechanisms might be associated with its antioxidant activity. ..
  47. Bernardi M, Dias S, Barbosa V. Neurotoxicity of neem commercial formulation (Azadirachta indica A. Juss) in adult zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2013;36:1276-82 pubmed publisher
    ..Thus, no impairment was observed in this behavioral test. We conclude that neem reduced general activity and increased anxiety-like behavior but did not affect learning and memory. ..
  48. Yamaguchi K, Fukuoka N, Kimura S, Shinohara N, Tatsumichi T, Tai T, et al. [Case of encephalopathy seemingly caused by tacrolimus at blood concentration near the upper limit of therapeutic range]. Yakugaku Zasshi. 2012;132:845-8 pubmed
  49. Bornhorst J, Meyer S, Weber T, Böker C, Marschall T, Mangerich A, et al. Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response. Mol Nutr Food Res. 2013;57:1255-69 pubmed publisher
    ..Moreover, exposure to high Mn levels is known to cause adverse neurological effects in humans, which are yet mechanistically not well understood...
  50. Djukic M, Jovanovic M, Ninkovic M, Stevanovic I, Curcic M, Topic A, et al. Intrastriatal pre-treatment with L-NAME protects rats from diquat neurotoxcity. Ann Agric Environ Med. 2012;19:666-72 pubmed
    ..Target organs are liver and kidney in humans. To-date, the mechanism of DQ-induced neurotoxicity has not been rationalized...
  51. FitzGerald K, Bronstein A. Adderall® (amphetamine-dextroamphetamine) toxicity. Top Companion Anim Med. 2013;28:2-7 pubmed publisher
    ..This article discusses our present understanding of Adderall(®) intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug...
  52. Angoa Perez M, Kane M, Herrera Mundo N, Francescutti D, Kuhn D. Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus. Life Sci. 2014;97:31-6 pubmed publisher
    ..When co-administered with methamphetamine or MDMA, drugs that are often co-abused with mephedrone by humans, toxicity is not increased as is the case for dopamine nerve endings when these drugs are taken together. ..
  53. Tarskikh M, Klimatskaya L, Kolesnikov S. Pathogenesis of neurotoxicity of acrylates acrylonitrile and acrylamide: from cell to organism. Bull Exp Biol Med. 2013;155:451-3 pubmed
    ..This scheme explained specific features of clinical syndromes induced by acute and chronic exposure to these toxic agents. ..
  54. Park S, Goldstein D, Krishnan A, Lin C, Friedlander M, Cassidy J, et al. Chemotherapy-induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin. 2013;63:419-37 pubmed publisher
    ..The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies...
  55. Pei Y, Peng J, Behl M, Sipes N, Shockley K, Rao M, et al. Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Res. 2016;1638:57-73 pubmed publisher
    ..This article is part of a Special Issue entitled SI: PSC and the brain. ..
  56. Basant N, Gupta S, Singh K. Predicting the acute neurotoxicity of diverse organic solvents using probabilistic neural networks based QSTR modeling approaches. Neurotoxicology. 2016;53:45-52 pubmed publisher
    ..The results suggest the ability of the developed QSTR models to reliably predict binary neurotoxicity classes and the endpoint neurotoxicities of the structurally diverse organic solvents. ..
  57. Pasternak J, Lanier W. Snapshot of 1973 and 1974: critical thinkers and contemporary research ideas in neurosurgical anesthesia during the first years of SNACC. J Neurosurg Anesthesiol. 2012;24:300-11 pubmed publisher
    ..Our hypothesis is that a review of these publications will identify the foundations of research and practice concepts that persist until today and will also identify concepts that have dwindled or outright disappeared...
  58. Ghorbani M, Moallem S, Abnous K, Tabatabaee Yazdi S, Movassaghi A, Azizzadeh M, et al. The effect of granulocyte colony-stimulating factor administration on carbon monoxide neurotoxicity in rats. Drug Chem Toxicol. 2013;36:102-8 pubmed publisher
    ..01 for 50 µg/kg and P < 0.001 for other doses). Administration of G-CSF after CO poisoning attenuates brain cell damage through remyelination. G-CSF also decreases levels of related biomarkers, such as S100? and GFAP...
  59. Ferreira P, Nogueira T, Costa V, Branco P, Ferreira L, Fernandes E, et al. Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells. Toxicol Lett. 2013;216:159-70 pubmed publisher
    ..In conclusion, MDMA catechol metabolites promote differential toxic effects to differentiated dopaminergic human SH-SY5Y cells...
  60. Smith N, Freebairn R, Park M, Wallis S, Roberts J, Lipman J. Therapeutic drug monitoring when using cefepime in continuous renal replacement therapy: seizures associated with cefepime. Crit Care Resusc. 2012;14:312-5 pubmed
    ..We suggest that therapeutic drug monitoring in critically ill patients may be a useful intervention to avoid antibiotic-related toxicities...
  61. Lucchini R, Porro A. [Development of neurobehavioral toxicology in the last century and its historical roots]. G Ital Med Lav Ergon. 2011;33:475-8 pubmed
    ..These methods have been further developed in the following years toward a global and integrated approach to the different life stages of individuals...
  62. Bonda Shkedi E, Arush M, Kaplinsky C, Ash S, Goshen Y, Yaniv I, et al. The correlation between dose of folinic acid and neurotoxicity in children and adolescents treated for osteosarcoma with high-dose methotrexate (HDMTX): a neuropsychological and psychosocial study. J Pediatr Hematol Oncol. 2013;35:271-5 pubmed publisher
    ..The patients received 300 to 600 mg/m or 120 to 250 mg/m FA in their protocols...
  63. Tayeboon G, Tavakoli F, Hassani S, Khanavi M, Sabzevari O, Ostad S. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell Dev Biol Anim. 2013;49:706-15 pubmed publisher
    ..citratus essential oil and F. assa-foetida extracts as therapies for neurologic disorders...
  64. Gilchrist L, Marais L, Tanner L. Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children. Support Care Cancer. 2014;22:359-66 pubmed publisher
  65. Takanashi J, Taneichi H, Misaki T, Yahata Y, Okumura A, Ishida Y, et al. Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan. Neurology. 2014;82:564-72 pubmed publisher
    ..To elucidate the clinical and radiologic features and analyze factors associated with neurologic outcomes of encephalopathy secondary to Shiga toxin-producing Escherichia coli (STEC) O111...
  66. Godderis L, De Raedt K, Tabish A, Poels K, Maertens N, De Ruyck K, et al. Epigenetic changes in lymphocytes of solvent-exposed individuals. Epigenomics. 2012;4:269-77 pubmed publisher
    ..POPULATION & METHODS: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients...
  67. Chen C, Chen S, Su C, Yen C, Tseng T, Jinn T, et al. Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. Toxicology. 2013;303:72-82 pubmed publisher
    ..Taken together, these data suggest that oxidative stress-induced p38-MAPK activated pathway-regulated mitochondria-dependent apoptosis plays an important role in CA-caused neuronal cell death...
  68. Boucher O, Simard M, Muckle G, Rouget F, Kadhel P, Bataille H, et al. Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants. Neurotoxicology. 2013;35:162-8 pubmed publisher
  69. Sprowl J, Ciarimboli G, Lancaster C, Giovinazzo H, Gibson A, Du G, et al. Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2. Proc Natl Acad Sci U S A. 2013;110:11199-204 pubmed publisher
    ..These findings provide a rationale for the development of targeted approaches to mitigate this debilitating toxicity. ..
  70. Morris D, Levenson C. Zinc in traumatic brain injury: from neuroprotection to neurotoxicity. Curr Opin Clin Nutr Metab Care. 2013;16:708-11 pubmed publisher
  71. Griffith K, Couture D, Zhu S, Pandya N, Johantgen M, Cavaletti G, et al. Evaluation of chemotherapy-induced peripheral neuropathy using current perception threshold and clinical evaluations. Support Care Cancer. 2014;22:1161-9 pubmed publisher
    ..This study evaluated associations between clinical and self-report measurements and current perception threshold (CPT), a neuroselective measure of sensory nerve function that may detect asymptomatic CIPN damage...
  72. Wahlberg K, Kippler M, Alhamdow A, Rahman S, Smith D, Vahter M, et al. Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function. Toxicol Sci. 2016;149:473-83 pubmed publisher
    ..Moreover, the SNPs appeared to influence neurological functions independent of blood Mn concentrations, suggesting that SLC30A10 could regulate brain Mn levels. ..
  73. Prado M, Marchot P, Silman I. Preface: Cholinergic Mechanisms. J Neurochem. 2017;142 Suppl 2:3-6 pubmed publisher
    ..This is the Preface for the special issue XVth International Symposium on Cholinergic Mechanisms...
  74. Baranowska Bosiacka I, Struzynska L, Gutowska I, Machalinska A, Kolasa A, Kłos P, et al. Perinatal exposure to lead induces morphological, ultrastructural and molecular alterations in the hippocampus. Toxicology. 2013;303:187-200 pubmed publisher
    ..Our findings contribute to further understanding of the mechanisms underlying Pb neurotoxicity and cognition impairment in a Pb-exposed developing brain...
  75. de Graan A, Elens L, Sprowl J, Sparreboom A, Friberg L, van der Holt B, et al. CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity. Clin Cancer Res. 2013;19:3316-24 pubmed publisher
    ..Neurotoxicity is one of the most prominent side effects of paclitaxel. This study explores potential predictive pharmacokinetic and pharmacogenetic determinants for the onset and severity of neurotoxicity...
  76. David M, Jones D, Tayebi M. Potential candidate camelid antibodies for the treatment of protein-misfolding diseases. J Neuroimmunol. 2014;272:76-85 pubmed publisher
    ..These antibodies could prove to be a valuable tool for the neutralization/clearance of PrP(Sc), A? and tau proteins in cellular compartments of affected neurons and could potentially have wider applicability for the treatment of PMDs. ..
  77. Pisani S, Neese S, Katzenellenbogen J, Schantz S, Korol D. Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner. Endocrinology. 2016;157:292-303 pubmed publisher
    ..These results are consistent with the detection of ER? and ER? in the hippocampus and striatum and suggest that learning is modulated via activation of either ER subtype. ..
  78. Prakash C, Soni M, Kumar V. Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: A review. J Appl Toxicol. 2016;36:179-88 pubmed publisher
    ..The ameliorative measures undertaken in arsenic-induced mitochondrial dysfunction have also been highlighted...
  79. Lee S, Yang M, Kim J, Son Y, Kim J, Kang S, et al. Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull. 2016;121:48-58 pubmed publisher
    ..Thus, we suggest that BDNF/ERK signaling pathways may be associated with cell differentiation and survival of immature progenitor neurons, and will eventually lead to spontaneous recovery in TMT-induced hippocampal neurodegeneration...
  80. Moszczynska A, Callan S. Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment. J Pharmacol Exp Ther. 2017;362:474-488 pubmed publisher
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