gabaergic neurons


Summary: Neurons whose primary neurotransmitter is GAMMA-AMINOBUTYRIC ACID.

Top Publications

  1. Li J, Han W, Pelkey K, Duan J, Mao X, Wang Y, et al. Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development. Neuron. 2017;96:808-826.e8 pubmed publisher
    ..Our findings reveal how unique postsynaptic CAMs work in concert to control synaptogenesis and establish a general framework for GABAergic synapse development. ..
  2. Volk D, Edelson J, Lewis D. Cortical inhibitory neuron disturbances in schizophrenia: role of the ontogenetic transcription factor Lhx6. Schizophr Bull. 2014;40:1053-61 pubmed publisher
  3. Burke D, Rotstein H, Alvarez V. Striatal Local Circuitry: A New Framework for Lateral Inhibition. Neuron. 2017;96:267-284 pubmed publisher
  4. Birey F, Andersen J, Makinson C, Islam S, Wei W, Huber N, et al. Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54-59 pubmed publisher
    ..stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAergic neurons. These subdomain-specific forebrain spheroids can be assembled in vitro to recapitulate the saltatory ..
  5. Favuzzi E, Marques Smith A, Deogracias R, Winterflood C, Sánchez Aguilera A, Mantoan L, et al. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron. 2017;95:639-655.e10 pubmed publisher
    ..These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function. ..
  6. Du X, Hao H, Yang Y, Huang S, Wang C, Gigout S, et al. Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission. J Clin Invest. 2017;127:1741-1756 pubmed publisher
    ..Our findings indicate that peripheral somatosensory ganglia represent a hitherto underappreciated site of somatosensory signal integration and offer a potential target for therapeutic intervention. ..
  7. Connelly W, Crunelli V, Errington A. Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons. J Neurosci. 2017;37:5319-5333 pubmed publisher
    ..Therefore, backpropagating spikes in these cells can only influence signaling in the proximal part of the dendritic tree. ..
  8. Kodani S, Soya S, Sakurai T. Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice. J Neurosci. 2017;37:7164-7176 pubmed publisher sleep-wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABABNST neurons)...
  9. Barbagallo B, Philbrook A, Touroutine D, Banerjee N, Oliver D, Lambert C, et al. Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit. Development. 2017;144:1807-1819 pubmed publisher
    ..Here, we show that disrupting cholinergic innervation of GABAergic neurons in the C. elegans motor circuit alters GABAergic neuron synaptic connectivity...

More Information


  1. del Pino I, Brotons Mas J, Marques Smith A, Marighetto A, Frick A, Marin O, et al. Abnormal wiring of CCK+ basket cells disrupts spatial information coding. Nat Neurosci. 2017;20:784-792 pubmed publisher
    ..These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding in the hippocampus. ..
  2. Zhou L, Liu M, Li Q, Deng J, Mu D, Sun Y. Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus. Cell Rep. 2017;18:3018-3032 pubmed publisher
    ..we systematically investigated the organization of long-range synaptic inputs to serotonergic neurons and GABAergic neurons in the dorsal raphe nucleus (DRN) of mice with a combination of viral tracing, slice electrophysiological, ..
  3. Ono M, Bishop D, Oliver D. Identified GABAergic and Glutamatergic Neurons in the Mouse Inferior Colliculus Share Similar Response Properties. J Neurosci. 2017;37:8952-8964 pubmed publisher
    b>GABAergic neurons in the inferior colliculus (IC) play a critical role in auditory information processing, yet their responses to sound are unknown...
  4. Flores Barrera E, Thomases D, Cass D, Bhandari A, Schwarcz R, Bruno J, et al. Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid. J Neurosci. 2017;37:7921-7929 pubmed publisher
    ..Therefore, the degree of GABAergic dysregulation in the PFC could be a clinically relevant contributing factor for the onset of cognitive deficits resulting from abnormal increases of cortical KYNA. ..
  5. Lu J, Tucciarone J, Padilla Coreano N, He M, Gordon J, Huang Z. Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. Nat Neurosci. 2017;20:1377-1383 pubmed publisher
    ..Thus, the exquisite connectivity of ChCs not only mediates directional inhibition between local PC ensembles but may also shape communication hierarchies between global networks. ..
  6. Chung S, Weber F, Zhong P, Tan C, Nguyen T, BEIER K, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. 2017;545:477-481 pubmed publisher
    ..labelling, bidirectional optogenetic manipulation, and optrode recording, we show that the preoptic area GABAergic neurons projecting to the tuberomammillary nucleus are both sleep active and sleep promoting...
  7. Sawala A, Gould A. The sex of specific neurons controls female body growth in Drosophila. PLoS Biol. 2017;15:e2002252 pubmed publisher
    ..They also reveal that, even though the sex determination pathways in Drosophila and mammals are different, they both modulate body growth via a combination of tissue-autonomous and nonautonomous inputs...
  8. Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie R, et al. Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice. J Clin Invest. 2017;127:2295-2309 pubmed publisher
    ..In contrast, CB1R deletion from brain GABAergic neurons or hypothalamic glutamatergic neurons did not affect recovery time from anesthesia...
  9. Molnar Z, Butt S. Best-laid schemes for interneuron origin of mice and men. Nat Neurosci. 2013;16:1512-4 pubmed publisher
  10. Wang Y, Wang Y, Chen Z. [The role of central cholinergic system in epilepsy]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:15-21 pubmed
    ..disorder, which is not only related to the imbalance between excitatory glutamic neurons and inhibitory GABAergic neurons, but also related to abnormal central cholinergic regulation...
  11. Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
    ..Monoaminergic modulation of the neural connections between globular cells and PCs could play a role in cerebellar motor coordination. ..
  12. Begum M, Sng J. Molecular mechanisms of experience-dependent maturation in cortical GABAergic inhibition. J Neurochem. 2017;142:649-661 pubmed publisher
  13. Xu T, Zhang M, Hu J, Li Z, Wu T, Bao J, et al. Behavioral deficits and neural damage of Caenorhabditis elegans induced by three rare earth elements. Chemosphere. 2017;181:55-62 pubmed publisher
    ..It indicates that REEs can lead to damage of dopaminergic and GABAergic neurons. Our data suggest that exposure to REEs may cause neurotoxicity of inducing behavioral deficits and neural ..
  14. Yu B, Wang X, Wei S, Fu T, Dzakah E, Waqas A, et al. Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons. Dev Cell. 2017;43:212-226.e7 pubmed publisher
    ..Other genes modulating DD respecification such as lin-14, irx-1, and oig-1 are also found to affect cAMP levels...
  15. Braz J, Juarez Salinas D, Ross S, Basbaum A. Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch. J Clin Invest. 2014;124:3612-6 pubmed publisher
  16. Filiano A, Xu Y, Tustison N, Marsh R, Baker W, Smirnov I, et al. Unexpected role of interferon-? in regulating neuronal connectivity and social behaviour. Nature. 2016;535:425-9 pubmed
  17. Guirao V, Martí Sistac O, DeGregorio Rocasolano N, Ponce J, Davalos A, Gasull T. Specific rescue by ortho-hydroxy atorvastatin of cortical GABAergic neurons from previous oxygen/glucose deprivation: role of pCREB. J Neurochem. 2017;143:359-374 pubmed publisher
    ..Significantly, only these GABAergic neurons showed an increase in phosphorylated CREB (pCREB) early after neuronal cultures were treated post-OGD with o-..
  18. Różycka A, Liguz Lecznar M. The space where aging acts: focus on the GABAergic synapse. Aging Cell. 2017;16:634-643 pubmed publisher
    ..This review focuses on the aging of GABAergic neurons and synapses...
  19. Chang T, Alexopoulos H, McMenamin M, Carvajal González A, Alexander S, Deacon R, et al. Neuronal surface and glutamic acid decarboxylase autoantibodies in Nonparaneoplastic stiff person syndrome. JAMA Neurol. 2013;70:1140-9 pubmed the rate-limiting enzyme in the synthesis of ?-aminobutyric acid (GABA), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS...
  20. Andrási T, Veres J, Rovira Esteban L, Kozma R, Vikór A, Gregori E, et al. Differential excitatory control of 2 parallel basket cell networks in amygdala microcircuits. PLoS Biol. 2017;15:e2001421 pubmed publisher
    ..Our data suggest fundamentally different functions for the 2 parallel basket cell networks in circuit operations in the amygdala. ..
  21. Nadadhur A, Emperador Melero J, Meijer M, Schut D, Jacobs G, Li K, et al. Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells. PLoS ONE. 2017;12:e0178533 pubmed publisher
  22. Kurup N, Yan D, Kono K, Jin Y. Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans. PLoS Genet. 2017;13:e1006844 pubmed publisher
    ..Our study delineates temporally distinct signaling pathways that are required for effective neural circuit refinement. ..
  23. Miao C, Cao Q, Moser M, Moser E. Parvalbumin and Somatostatin Interneurons Control Different Space-Coding Networks in the Medial Entorhinal Cortex. Cell. 2017;171:507-521.e17 pubmed publisher
    ..The findings point to distinct roles for PV and SOM interneurons in the local dynamics underlying periodic and aperiodic firing in spatially modulated cells of the MEC. VIDEO ABSTRACT...
  24. Solek C, Feng S, Perin S, Weinschutz Mendes H, Ekker M. Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Dev Biol. 2017;427:131-147 pubmed publisher
    ..lineage analysis of the dlx1a/2a and dlx5a/6a expressing progenitors in the zebrafish brain and lays the foundation for further characterization of the role of these transcription factors beyond the specification of GABAergic neurons.
  25. Mi D, Li Z, Lim L, Li M, Moissidis M, Yang Y, et al. Early emergence of cortical interneuron diversity in the mouse embryo. Science. 2018;360:81-85 pubmed publisher
    ..Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex. ..
  26. François A, Low S, Sypek E, Christensen A, Sotoudeh C, BEIER K, et al. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron. 2017;93:822-839.e6 pubmed publisher
    ..Unexpectedly, we found that RVM GABAergic neurons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic interneurons...
  27. Le T, Zhou Q, Cobos I, Zhang S, Zagozewski J, Japoni S, et al. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017;37:8816-8829 pubmed publisher
    ..gene family are expressed in, and regulate the development of, the basal ganglia primodia from which many GABAergic neurons originate and migrate to other forebrain regions...
  28. Taketo M, Matsuda H. Short-term inhibition of GABAergic IPSCs induced by association of pre- and postsynaptic activation in the neonatal hippocampus. Neuropharmacology. 2017;121:39-48 pubmed publisher
    ..This inhibition is mediated by a mechanism involving mGluRs, mAChRs, and CB1 receptors, and potentiated by NMDA receptor activation. ..
  29. Yang N, Chanda S, Marro S, Ng Y, Janas J, Haag D, et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods. 2017;14:621-628 pubmed publisher
    ..transient expression of the transcription factors Ascl1 and Dlx2 (AD) induces the generation of exclusively GABAergic neurons from human PSCs with a high degree of synaptic maturation...
  30. Liu K, Kim J, Kim D, Zhang Y, Bao H, Denaxa M, et al. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature. 2017;548:582-587 pubmed publisher
    ..Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep ..
  31. Song C, Sandberg K, Andersen L, Blicher J, Rees G. Human Occipital and Parietal GABA Selectively Influence Visual Perception of Orientation and Size. J Neurosci. 2017;37:8929-8937 pubmed publisher
    ..Our findings suggest that GABA level of a cortical region selectively influences perception of visual features that are topographically mapped in this region through intraregional lateral connections. ..
  32. Wang Y, Xu C, Xu Z, Ji C, Liang J, Wang Y, et al. Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. Neuron. 2017;95:92-105.e5 pubmed publisher
    ..and extracellular electrophysiological recording in mouse models, we found that photoactivation of subicular GABAergic neurons retarded sGS acquisition by inhibiting the firing of pyramidal neurons...
  33. Miyake A, Mekata Y, Fujibayashi H, Nakanishi K, Konishi M, Itoh N. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. PLoS ONE. 2017;12:e0176036 pubmed publisher
    ..The present results suggest that Brorin is a secreted Bmp antagonist predominantly expressed in developing neural tissues and that it plays multiple roles in the development of the zebrafish forebrain. ..
  34. Paul A, Crow M, Raudales R, He M, Gillis J, Huang Z. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017;171:522-539.e20 pubmed publisher
    ..We analyzed single-cell transcriptomes of a set of anatomically and physiologically characterized cortical GABAergic neurons and conducted a computational genomic screen for transcriptional profiles that distinguish them from one ..
  35. Pelkey K, Chittajallu R, Craig M, Tricoire L, Wester J, McBain C. Hippocampal GABAergic Inhibitory Interneurons. Physiol Rev. 2017;97:1619-1747 pubmed publisher
  36. Wallace M, Saunders A, Huang K, Philson A, Goldman M, Macosko E, et al. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94:138-152.e5 pubmed publisher
    ..Therefore, we identify previously unknown subdivisions within the EP and reveal the existence of cascading, molecularly distinct projections through striatum and globus pallidus to EP targets within epithalamus and thalamus. ..