cholinergic neurons


Summary: Neurons whose primary neurotransmitter is ACETYLCHOLINE.

Top Publications

  1. Dickson D, Murray M. Intraneuronal amyloid-? accumulation in basal forebrain cholinergic neurons: a marker of vulnerability, yet inversely related to neurodegeneration. Brain. 2015;138:1444-5 pubmed publisher
  2. Mena Segovia J, Bolam J. Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function. Neuron. 2017;94:7-18 pubmed publisher
    ..of its different neuronal subtypes on their various targets, we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the behavioral state as a result of changes in environmental contingencies...
  3. Sharma R, Sahota P, Thakkar M. Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption. J Neurochem. 2017;142:710-720 pubmed publisher
    ..Since the basal forebrain (BF) cholinergic neurons are implicated in the homeostatic regulation of sleep, we hypothesized that the BF cholinergic neurons may ..
  4. Voss K, Koren J, Dickey C. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. Am J Pathol. 2011;179:2148-51 pubmed publisher
  5. Kania A. Concocting cholinergy. PLoS Genet. 2014;10:e1004313 pubmed publisher
  6. Chinnery P, Craven L, Mitalipov S, Stewart J, Herbert M, Turnbull D. The challenges of mitochondrial replacement. PLoS Genet. 2014;10:e1004315 pubmed publisher
  7. Girasole A, Nelson A. Probing striatal microcircuitry to understand the functional role of cholinergic interneurons. Mov Disord. 2015;30:1306-18 pubmed publisher
  8. Jeong D, Lee J, Chang W, Chang J. Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze. BMC Neurosci. 2017;18:29 pubmed publisher
    ..Rats were administered 192 IgG-saporin to lesion cholinergic neurons. Stimulation was delivered at different times in different groups of rats: 5 days before the Morris water ..
  9. Mikami M, Zhang Y, Kim B, Worgall T, Groeben H, Emala C. Dexmedetomidine's inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation. BMC Anesthesiol. 2017;17:52 pubmed publisher
    ..Dexmedetomidine also attenuated both exogenous acetylcholine-induced contraction and C-fiber mediated contraction, suggesting a direct airway smooth muscle effect and an underlying mechanism for cough suppression, respectively. ..

More Information


  1. Barbagallo B, Philbrook A, Touroutine D, Banerjee N, Oliver D, Lambert C, et al. Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit. Development. 2017;144:1807-1819 pubmed publisher
    ..Our findings reveal that GABAergic signaling is regulated by cholinergic neuronal activity, probably through distinct mechanisms in the developing and mature nervous system. ..
  2. Wang Y, Wang Y, Chen Z. [The role of central cholinergic system in epilepsy]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:15-21 pubmed
    ..With the development of optogenetics and other techniques, dissect and regulate cholinergic related epilepsy circuit has become a hotspot of epilepsy research. ..
  3. Pitchers K, Phillips K, Jones J, Robinson T, Sarter M. Diverse Roads to Relapse: A Discriminative Cue Signaling Cocaine Availability Is More Effective in Renewing Cocaine Seeking in Goal Trackers Than Sign Trackers and Depends on Basal Forebrain Cholinergic Activity. J Neurosci. 2017;37:7198-7208 pubmed publisher
    ..Thereafter, half of the rats received an immunotoxic lesion that destroyed 40-50% of basal forebrain cholinergic neurons and later, after extinction training, were tested for the ability of noncontingent presentations of the DS<..
  4. López Hernández G, Ananth M, Jiang L, Ballinger E, Talmage D, Role L. Electrophysiological properties of basal forebrain cholinergic neurons identified by genetic and optogenetic tagging. J Neurochem. 2017;142 Suppl 2:103-110 pubmed publisher
    ..genetically modified mouse lines have allowed precise identification and selective stimulation of cholinergic neurons in vivo...
  5. Bardóczi Z, Pál B, KÅ‘szeghy Ã, Wilheim T, Watanabe M, Záborszky L, et al. Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons. J Neurosci. 2017;37:9534-9549 pubmed publisher
    ..Potential neuronal as well as glial sources of glycine were indicated in the extracellular space of cholinergic neurons by glycine transporter type 1 (GLYT1)- and GLYT2-IR processes found in apposition to ChAT-IR cells...
  6. Zhai Q, Lai D, Cui P, Zhou R, Chen Q, Hou J, et al. Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway. Crit Care Med. 2017;45:e1075-e1082 pubmed publisher
    Basal forebrain cholinergic neurons are proposed as a major neuromodulatory system in inflammatory modulation...
  7. Joachim S, Renner M, Reinhard J, Theiss C, May C, Lohmann S, et al. Protective effects on the retina after ranibizumab treatment in an ischemia model. PLoS ONE. 2017;12:e0182407 pubmed publisher
    ..004). Our findings demonstrate that photoreceptors and RGCs are protected by ranibizumab treatment. Only amacrine cells cannot be rescued. They seem to be particularly sensitive to ischemic damage and need maybe an earlier intervention. ..
  8. Alam M, McGinty D. Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for 'Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption' on page. J Neurochem. 2017;142:620-623 pubmed publisher
    ..This editorial highlights the study entitled, "Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption" by Sharma and colleagues...
  9. Muramatsu I, Uwada J, Masuoka T, Yoshiki H, Sada K, Lee K, et al. Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. J Neurochem. 2017;143:76-86 pubmed publisher
    ..In addition, these data suggest that the recycling of ACh-derived choline may be minor in cholinergic terminals. This study reveals a new mechanism of cholinergic transmission in the central nervous system. ..
  10. Boppana S, Kendall N, Akinrinsola O, White D, Patel K, Lawal H. Immunolocalization of the vesicular acetylcholine transporter in larval and adult Drosophila neurons. Neurosci Lett. 2017;643:76-83 pubmed publisher
    ..Together, these findings help establish the vesicular localization of VAChT in cholinergic neurons in Drosophila and present an important molecular tool with which to dissect the function of the transporter ..
  11. Johnson K, Mateo Y, Lovinger D. Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum. Neuropharmacology. 2017;117:114-123 pubmed publisher
  12. Cole W. ANO1-ther brick in the wall--role of Ca2+-activated Cl- channels of interstitial cells of Cajal in cholinergic motor control of gastrointestinal smooth muscle. J Physiol. 2011;589:4641-2 pubmed publisher