sciatic neuropathy

Summary

Summary: Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)

Top Publications

  1. Dubovy P, Klusáková I, Svízenská I, Brazda V. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. Neuron Glia Biol. 2010;6:73-83 pubmed publisher
    ..The results may suggest that unilateral CCI of the sciatic nerve induces bilateral activation of SGC in L4-L5 DRG to transduce IL-6 signalling during neuroinflammation...
  2. Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S. Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation. Pain. 2010;149:305-15 pubmed publisher
    ..In conclusion, we propose a novel critical molecule MIP-1alpha derived from macrophages and Schwann cells that appears to play a crucial role in the development of neuropathic pain induced by PSL...
  3. Mor D, Bembrick A, Austin P, Wyllie P, Creber N, Denyer G, et al. Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve. Neuroscience. 2010;166:1167-84 pubmed publisher
    ..It is possible therefore that the persistent disabilities seen in a subgroup of CCI rats are in part a functional consequence of this specific pattern of astrocyte activation...
  4. Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S. Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. Proc Natl Acad Sci U S A. 2009;106:13076-81 pubmed publisher
    ..This report shows that adipocytes associated with primary afferent neurons may be involved in the development of neuropathic pain through adipokine secretion...
  5. Korte N, Schenk H, Grothe C, Tipold A, Haastert Talini K. Evaluation of periodic electrodiagnostic measurements to monitor motor recovery after different peripheral nerve lesions in the rat. Muscle Nerve. 2011;44:63-73 pubmed publisher
    ..In this study, using a rat model, we assessed the utility of periodic electrodiagnostic measurements for monitoring ongoing motor recovery after peripheral nerve injuries of differing severity...
  6. Stenberg L, Kanje M, Dolezal K, Dahlin L. Expression of activating transcription factor 3 (ATF 3) and caspase 3 in Schwann cells and axonal outgrowth after sciatic nerve repair in diabetic BB rats. Neurosci Lett. 2012;515:34-8 pubmed publisher
    ..Knowledge about signal transduction mechanisms in diabetes after stress may provide new insights into the development of diabetic neuropathy and neuropathic pain...
  7. Dubovy P, Brazda V, Klusáková I, Hradilová Svíženská I. Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve. J Neuroinflammation. 2013;10:55 pubmed publisher
    ..Current research implicates interleukin (IL)-6 as a key component of the nervous-system response to injury with various effects...
  8. Bobinski F, Martins D, Bratti T, Mazzardo Martins L, Winkelmann Duarte E, Guglielmo L, et al. Neuroprotective and neuroregenerative effects of low-intensity aerobic exercise on sciatic nerve crush injury in mice. Neuroscience. 2011;194:337-48 pubmed publisher
    ..This experimental study suggests that physical exercise can restore motor and nerve function to a substantial degree when performed using a prophylactic and therapeutic approach...
  9. Jiang L, Li S, Zhao F, Spanswick D, Lin M. Norepinephrine can act via alpha(2)-adrenoceptors to reduce the hyper-excitability of spinal dorsal horn neurons following chronic nerve injury. J Formos Med Assoc. 2010;109:438-45 pubmed publisher
    ..This study aimed to investigate the effect of bath application of norepinephrine on whole cell patch clamp recordings from spinal cord slices of CCI rats with allodynia...

More Information

Publications77

  1. Sulaiman O, Gordon T. Role of chronic Schwann cell denervation in poor functional recovery after nerve injuries and experimental strategies to combat it. Neurosurgery. 2009;65:A105-14 pubmed publisher
    ..To present our data about the role of chronic denervation (CD) of the distal nerve stumps as compared with muscle denervation atrophy and experimental strategies to promote better functional recovery...
  2. Salegio E, Pollard A, Smith M, Zhou X. Sciatic nerve conditioning lesion increases macrophage response but it does not promote the regeneration of injured optic nerves. Brain Res. 2010;1361:12-22 pubmed publisher
    ..Immune cell surveillance into the CNS compartment was enhanced following peripheral nerve injury...
  3. Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S. Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. Anesth Analg. 2009;109:1305-11 pubmed publisher
    ..In this study, we investigated whether pERK in injured sciatic nerve contributes to neuropathic pain induced by partial sciatic nerve ligation (PSL) in mice...
  4. St Jacques B, Ma W. Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study. J Neurochem. 2011;118:841-54 pubmed publisher
  5. Jancalek R, Svizenska I, Klusáková I, Dubovy P. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. Neurosci Lett. 2011;501:86-91 pubmed publisher
  6. Xu P, Rosen K, Hedstrom K, Rey O, Guha S, Hart C, et al. Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway. Glia. 2013;61:1029-40 pubmed publisher
    ..Given the potent effects of GDNF on survival and repair of injured peripheral neurons, we propose that targeting these pathways may yield therapeutic tools to treat peripheral nerve injury and neuropathies...
  7. Shibasaki M, Sasaki M, Miura M, Mizukoshi K, Ueno H, Hashimoto S, et al. Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury. Pain. 2010;149:514-21 pubmed publisher
    ..Blocking HMGB-1/RAGE signalling might thus be a promising therapeutic strategy for the management of neuropathic pain...
  8. Eker H, Cok O, Aribogan A. A treatment option for post-injection sciatic neuropathy: transsacral block with methylprednisolone. Pain Physician. 2010;13:451-6 pubmed
    ..The most frequent presentation of sciatic nerve injury includes radicular pain and paresthesia with almost immediate onset of variable motor and sensory deficit...
  9. Guérout N, Duclos C, Drouot L, Abramovici O, Bon Mardion N, Lacoume Y, et al. Transplantation of olfactory ensheathing cells promotes axonal regeneration and functional recovery of peripheral nerve lesion in rats. Muscle Nerve. 2011;43:543-51 pubmed publisher
    ..However, OECs have been less studied after peripheral nerve injury (PNI). The purpose of this investigation was to determine the effect of OEC transplantation on a severe sciatic nerve (SN) lesion...
  10. Rose K, Ooi L, Dalle C, Robertson B, Wood I, Gamper N. Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain. 2011;152:742-54 pubmed publisher
    ..Our work suggests a novel mechanism for neuropathic overexcitability and brings focus on M channels and REST as peripheral targets for the treatment of neuropathic pain...
  11. Jeng S, Rau C, Liliang P, Wu C, Lu T, Chen Y, et al. Profiling muscle-specific microRNA expression after peripheral denervation and reinnervation in a rat model. J Neurotrauma. 2009;26:2345-53 pubmed publisher
  12. Inoue M, Ma L, Aoki J, Chun J, Ueda H. Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol Pain. 2008;4:6 pubmed publisher
    ..Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain...
  13. Ma W, Quirion R. Increased calcitonin gene-related peptide in neuroma and invading macrophages is involved in the up-regulation of interleukin-6 and thermal hyperalgesia in a rat model of mononeuropathy. J Neurochem. 2006;98:180-92 pubmed
    ..Taken together, these data show that increased levels of CGRP in injured neuroma and invading macrophages are involved in the up-regulation of IL-6 in macrophages as well as in the maintenance of neuropathic pain...
  14. Hiraga A, Kuwabara S, Doya H, Kanai K, Fujitani M, Taniguchi J, et al. Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury. J Peripher Nerv Syst. 2006;11:217-24 pubmed
    ..In addition, fasudil does not suppress the myelination of regenerating axons. These findings suggest that RhoA/Rho-kinase may be a practical molecular target to enhance axonal regeneration in human peripheral neuropathies...
  15. Uceyler N, Tscharke A, Sommer C. Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain. Brain Behav Immun. 2007;21:553-60 pubmed
    ..MDL-28170, but not (+)-MK-801 inhibited TNF and IL-1beta upregulation one hour after CCI. This leads us to suggest that calpain is one of the earliest mediators of cytokine upregulation in injured peripheral nerves...
  16. Ruscheweyh R, Forsthuber L, Schoffnegger D, Sandkühler J. Modification of classical neurochemical markers in identified primary afferent neurons with Abeta-, Adelta-, and C-fibers after chronic constriction injury in mice. J Comp Neurol. 2007;502:325-36 pubmed
    ..The extent of up-regulation of NPY showed a strong inverse correlation with the degree of heat hyperalgesia...
  17. Intondi A, Dahlgren M, Eilers M, Taylor B. Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain. Pain. 2008;137:352-65 pubmed
    ..We conclude that NPY acts at spinal Y1 and Y2 receptors to reduce spinal neuron activity and behavioral signs of inflammatory or neuropathic pain...
  18. Barrette B, Hébert M, Filali M, Lafortune K, Vallières N, Gowing G, et al. Requirement of myeloid cells for axon regeneration. J Neurosci. 2008;28:9363-76 pubmed publisher
    ..Therefore, myeloid cells support axonal regeneration and functional recovery by creating a growth-permissive milieu for injured axons...
  19. Pitcher G, Henry J. Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy. Exp Neurol. 2008;214:219-28 pubmed publisher
    ..Our findings reveal that ectopic afferent activity from multiple regions along peripheral nerves may drive CNS changes and the symptoms of pain associated with peripheral neuropathy...
  20. Muthuraman A, Diwan V, Jaggi A, Singh N, Singh D. Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats. J Ethnopharmacol. 2008;120:56-62 pubmed publisher
    ..The present study was aimed at investigating the ameliorative effect of Ocimum sanctum in sciatic nerve transection (axotomy)-induced peripheral neuropathy in rats...
  21. Panseri S, Cunha C, Lowery J, Del Carro U, Taraballi F, Amadio S, et al. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol. 2008;8:39 pubmed publisher
    ..Electrospinning technique makes it possible to spin microfiber and nanofiber flexible tubular scaffolds composed of a number of natural and synthetic components, showing high porosity and remarkable surface/volume ratio...
  22. Tun K, Cemil B, Gurcay A, Kaptanoglu E, Sargon M, Tekdemir I, et al. Ultrastructural evaluation of Pulsed Radiofrequency and Conventional Radiofrequency lesions in rat sciatic nerve. Surg Neurol. 2009;72:496-500; discussion 501 pubmed publisher
    ..In the present study, our main goal was to evaluate and compare the ultrastructure of peripheral nerve tissue that was heated by PRF, CRF with 42 degrees C, and CRF with 70 degrees C...
  23. Martensson L, Gustavsson P, Dahlin L, Kanje M. Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation. Neuroreport. 2007;18:957-61 pubmed
    ..The Erk1/2 inhibitor U0126 inhibited both the increase in p-Erk1/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erk1/2 is required for nerve injury-induced proliferation of Schwann cells...
  24. Sawada T, Sano M, Omura T, Omura K, Hasegawa T, Funahashi S, et al. Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry. Neurosci Lett. 2007;417:55-60 pubmed
    ..These results suggest that the significant change in IL-10 occurred prior to the significant change in TNF and that IL-10 may be the key to the change in TNF...
  25. Gray M, Palispis W, Popovich P, Van Rooijen N, Gupta R. Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury. J Neurosci Res. 2007;85:766-77 pubmed
  26. Zhang J, Shi X, Echeverry S, Mogil J, De Koninck Y, Rivest S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci. 2007;27:12396-406 pubmed
  27. Cheng C, Webber C, Wang J, Xu Y, Martinez J, Liu W, et al. Activated RHOA and peripheral axon regeneration. Exp Neurol. 2008;212:358-69 pubmed publisher
    ..RHOA activation and signaling are features of adult peripheral axon regeneration within its own milieu, independent of myelin. Inhibition of its activation may benefit peripheral axon lesions...
  28. Muthuraman A, Jaggi A, Singh N, Singh D. Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats. Eur J Pharmacol. 2008;587:104-11 pubmed publisher
    ..The observed anti-nociceptive effects of amiloride and pralidoxime may possibly be attributed to inhibition of Na+/Ca2+ and Na+/H+ exchangers with subsequent decrease in Ca2+ ions and oxidative stress...
  29. Zanon R, Oliveira A. MHC I upregulation influences astroglial reaction and synaptic plasticity in the spinal cord after sciatic nerve transection. Exp Neurol. 2006;200:521-31 pubmed
    ..They showed a sharp upregulation of GFAP, mostly when subjected to 500 and 1,000 IU. The present results reinforce the role of MHC class I upregulation on the response to injury, both in vivo and in vitro...
  30. Coronel M, Brumovsky P, Hokfelt T, Villar M. Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerve. J Chem Neuroanat. 2008;35:94-100 pubmed
    ..These results show that galanin expression in DRGs and spinal cord is differentially regulated by different degrees of nerve constriction and further support its modulatory role on neuropathic pain...
  31. Frederick J, Buck M, Matson D, Cortright D. Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury. Biochem Biophys Res Commun. 2007;358:1058-64 pubmed
    ..Our findings support the hypothesis that increased TRP channel expression in sensory neurons may contribute to mechanical and cold hypersensitivity...
  32. Sabha M, Emirandetti A, Cullheim S, de Oliveira A. MHC I expression and synaptic plasticity in different mice strains after axotomy. Synapse. 2008;62:137-48 pubmed
    ..Our results suggest that a more prominent expression of MHC I in the first week after lesion may positively influence the regenerative outcome associated with a more effective axonal regrowth...
  33. Agthong S, Kaewsema A, Tanomsridejchai N, Chentanez V. Activation of MAPK ERK in peripheral nerve after injury. BMC Neurosci. 2006;7:45 pubmed
    ..Nevertheless, whether ERK is also activated in the axons and surrounded Schwann cells which also play a key role in the regeneration process has not been clarified...
  34. Lu M, Ho C, Hsu S, Lee H, Lin J, Yao C, et al. Effects of electrical stimulation at different frequencies on regeneration of transected peripheral nerve. Neurorehabil Neural Repair. 2008;22:367-73 pubmed publisher
    ..Electrical stimulation of damaged peripheral nerve may aid regeneration...
  35. Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008;506:180-93 pubmed
    ..Thus, CNC induces a phenotypic change in the DRG that appears to be temporally associated with increases in GDNF protein expression at and near the site of the compression injury in the nerve...
  36. Jain V, Jaggi A, Singh N. Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats. Pharmacol Res. 2009;59:385-92 pubmed publisher
  37. Xing H, Chen M, Ling J, Tan W, Gu J. TRPM8 mechanism of cold allodynia after chronic nerve injury. J Neurosci. 2007;27:13680-90 pubmed
    ..Together, the gain of TRPM8-mediated cold sensitivity on nociceptive afferent neurons provides a mechanism of cold allodynia...
  38. Haastert K, Ying Z, Grothe C, Gomez Pinilla F. The effects of FGF-2 gene therapy combined with voluntary exercise on axonal regeneration across peripheral nerve gaps. Neurosci Lett. 2008;443:179-83 pubmed publisher
    ..Our results suggest that voluntary exercise could reinforce the beneficial effects of SC transplantation and FGF-2 gene therapy in peripheral nerve reconstruction approaches...
  39. Thiagarajan V, Shanmugam P, Krishnan U, Muthuraman A, Singh N. Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. An Acad Bras Cienc. 2012;84:1091-104 pubmed
    ..These findings may be attributed to its potential anti-oxidative, neuroprotective and calcium channel modulatory actions of Butea monosperma...
  40. Wu R, Wang L, Chen F, Huang Y, Shi J, Zhu X, et al. Evaluation of artificial nerve conduit and autografts in peripheral nerve repair in the rat model of sciatic nerve injury. Neurol Res. 2016;38:461-6 pubmed publisher
    ..It seemed more effective than CCA but inferior to sciatic nerve autograft in repairing sciatic nerve injury in the rat model. ..
  41. Giordano C, Cristino L, Luongo L, Siniscalco D, Petrosino S, Piscitelli F, et al. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cereb Cortex. 2012;22:2495-518 pubmed publisher
    ..We suggest that SNI triggers both TRPV1-dependent and independent glutamate- and caspase-mediated cross-talk among IL-PL cortex neurons and glia, which either participates or counteracts pain. ..
  42. Brenchat A, Zamanillo D, Hamon M, Romero L, Vela J. Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions. Eur J Pain. 2012;16:72-81 pubmed publisher
    ..The antinociceptive effect mediated by central 5-HT(7) receptors seems to predominate over the pronociceptive effect at the periphery when a selective 5-HT(7) receptor agonist is systemically administered. ..
  43. Goddyn C, Passuti N, Leconte R, Redon H, Gouin F. Sciatic nerve compression related to ossification of the sacrospinous ligament secondary to pelvic balance abnomalities. Orthop Traumatol Surg Res. 2009;95:645-8 pubmed publisher
    ..The etiological hypothesis retained was that this osseous metaplasia was a reaction to excessive stresses on the sacrospinous ligament. ..
  44. Cao M, Ji F, Liu L, Li F. Expression changes of parvalbumin and microtubule-associated protein 2 induced by chronic constriction injury in rat dorsal root ganglia. Chin Med J (Engl). 2011;124:2184-90 pubmed
  45. Mehta A, Halder S, Khanna N, Tandon O, Singh U, Sharma K. Role of NMDA and opioid receptors in neuropathic pain induced by chronic constriction injury of sciatic nerve in rats. J Basic Clin Physiol Pharmacol. 2012;23:49-55 pubmed publisher
    ..Thus, our study establishes that neuropathic pain can probably be overcome using higher doses of opioids, and there exists some intimate relationships between NMDA and opioid systems that lead to pain modulation. ..
  46. Al Khatib W, Lee G, Casey K, Lee J. Delayed hypogastric artery pseudoaneurysm following blunt trauma without evidence of pelvic fracture. Ann Vasc Surg. 2012;26:419.e11-4 pubmed publisher
    ..The pseudoaneurysm was successfully treated with selective coil embolization and hematoma evacuation. This study represents only the second reported case of delayed pelvic pseudoaneurysm in the absence of pelvic fracture. ..
  47. Gonçalves N, Teixeira Coelho M, Saraiva M. The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model. Exp Neurol. 2014;257:76-87 pubmed publisher
    ..Taken together, our findings suggest that inflammation is an important target to be considered in therapeutic strategies for FAP. ..
  48. Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H. Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain. J Neurochem. 2010;113:1002-11 pubmed publisher
    ..The present study provides strong evidence that LPA-induced calpain activation plays a crucial role in the manifestation of neuropathic pain through MAG down-regulation in the DR. ..
  49. Claudet I, Marcoux M, Karsenty C, Rittie J, Honorat R, Lelong Tissier M. [Severe hydrogen sulfide intoxication: a pediatric case of survival]. Ann Fr Anesth Reanim. 2012;31:255-8 pubmed publisher
    ..Lessons learned from paediatric accidents should result in better information about this threat for farmers and families living in houses with septic tanks, reducing the risk to their own and their children's safety. ..
  50. da Silva Arrigo J, Balen E, Júnior U, da Silva Mota J, Iwamoto R, Barison A, et al. Anti-nociceptive, anti-hyperalgesic and anti-arthritic activity of amides and extract obtained from Piper amalago in rodents. J Ethnopharmacol. 2016;179:101-9 pubmed publisher
    ..amalago. ..
  51. Miletic G, Driver A, Miyabe Nishiwaki T, Miletic V. Early changes in Homer1 proteins in the spinal dorsal horn are associated with loose ligation of the rat sciatic nerve. Anesth Analg. 2009;109:2000-7 pubmed publisher
  52. Chen J, Chu Y, Chen J, Li B. Synergistic effects of NGF, CNTF and GDNF on functional recovery following sciatic nerve injury in rats. Adv Med Sci. 2010;55:32-42 pubmed publisher
    ..It is demonstrated that differential and complementary biological effects of various neurotrophic factors contribute to synergistic promotion of nervous function recovery. ..
  53. Wang Y, Cheng X, Zhou Z, Wu H, Long L, Gu X, et al. Increased expression of Gem after rat sciatic nerve injury. J Mol Histol. 2013;44:27-36 pubmed publisher
    ..In addition, the peak expression of Gem was in parallel with PCNA, and numerous SCs expressing Gem were PCNA positive. Thus, all of our findings suggested that Gem may be involved in the pathophysiology of sciatic nerve after SNC. ..
  54. Pitcher G, Ritchie J, Henry J. Peripheral neuropathy induces cutaneous hypersensitivity in chronically spinalized rats. Pain Med. 2013;14:1057-71 pubmed publisher
    ..We examined this question by determining the contribution of peripheral/spinal mechanisms, isolated from supraspinal influence(s), in cutaneous hypersensitivity in an animal model of peripheral neuropathy...
  55. Fesli A, Sari A, Yilmaz N, Comelekoglu U, Tasdelen B. Enhancement of nerve healing with the combined use of amniotic membrane and granulocyte-colony-stimulating factor. J Plast Reconstr Aesthet Surg. 2014;67:837-43 pubmed publisher
    ..As a conclusion, both AM wrapping and G-CSF injection have a supportive effect on nerve regeneration, and this effect is further potentialized by their combined use. ..
  56. Sheng Q, Wang Z, Zhang J, Zhang Y. Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport. 2013;24:217-23 pubmed publisher
    ..The results showed that SDS achieved functionally successful nerve regeneration in the rat sciatic nerve crush injury model, indicating that SDS holds potential as a neuroprotective agent for peripheral nerve therapies...
  57. Chu J, Nagata M, Chen X, Solomon S, González Aguirre A, Garcia Aguilar J, et al. Irreversible electroporation-induced sciatic neuropathy observed by intraoperative neuromonitoring. Clin Neurophysiol. 2016;127:2770-2 pubmed publisher
  58. Sherman D, Wu L, Grove M, Gillespie C, Brophy P. Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. J Neurosci. 2012;32:9419-28 pubmed publisher
    ..We conclude that the primary role of the dystroglycan complex in appositions is to stabilize and limit the radial growth of myelin. ..
  59. Ventimiglia B, Tsirgiotis A, Fanzone I, Coco T, Privitera S. [Urinary incontinence after radical prostatectomy. Neurophysiological and urodynamic diagnosis]. Urologia. 2011;78:82-5 pubmed publisher
    ..Urinary incontinence after radical prostatectomy presents different clinical features. We propose to clarify the etiology and the therapeutic approaches...
  60. Distad B, Weiss M. Clinical and electrodiagnostic features of sciatic neuropathies. Phys Med Rehabil Clin N Am. 2013;24:107-20 pubmed publisher
    b>Sciatic neuropathy is the second most common neuropathy of the lower extremity and a common cause of foot drop. This article reviews the anatomy, clinical features, pathophysiology, and electrodiagnostic assessment of sciatic neuropathies...
  61. Liou J, Yuan H, Mao C, Lai Y, Day Y. Absence of C-C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model. Pain. 2012;153:1283-91 pubmed publisher
    ..Collectively, the present study results suggest that CCL5 receptor antagonists may ultimately provide a novel class of analgesics for therapeutic intervention in chronic neuropathic pain...
  62. Wadhwa V, Thakkar R, Maragakis N, Hoke A, Sumner C, Lloyd T, et al. Sciatic nerve tumor and tumor-like lesions - uncommon pathologies. Skeletal Radiol. 2012;41:763-74 pubmed publisher
    ..In this article, the authors discuss normal anatomy of the sciatic nerve and MRI findings of the above-mentioned lesions...
  63. Girolami E, Bouhy D, Haber M, Johnson H, David S. Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve. Exp Neurol. 2010;223:173-82 pubmed publisher
    ..These data suggest that SOCS1 and SOCS3 may play different roles in WD and provide a better understanding of some of the potential regulatory mechanisms that may control inflammation and regeneration in the injured peripheral nerve...
  64. Berg A, Zelano J, Pekna M, Wilhelmsson U, Pekny M, Cullheim S. Axonal regeneration after sciatic nerve lesion is delayed but complete in GFAP- and vimentin-deficient mice. PLoS ONE. 2013;8:e79395 pubmed publisher
    ..Thus, the absence of GFAP and vimentin in glial cells does not seem to affect the outcome after peripheral motoneuron injury but may have an important effect on the response dynamics. ..
  65. Walsh S, Biernaskie J, Kemp S, Midha R. Supplementation of acellular nerve grafts with skin derived precursor cells promotes peripheral nerve regeneration. Neuroscience. 2009;164:1097-107 pubmed publisher
    ..We therefore conclude that SKPs represent an easily accessible, autologous source of stem cells for transplantation therapies which act as functional Schwann cells and show great promise in improving regeneration following nerve injury...
  66. Yan H, Li C, Li Y, Gong Z. [Effect of spinal glutamate transporter 1 on chronic constriction injury of sciatic nerve and morphine tolerance of rats]. Yao Xue Xue Bao. 2009;44:581-5 pubmed
    ..In conclusion, change of spinal GLT-1 expression and function has close correlation with the development of neuropathic pain and morphine tolerance...
  67. Obara I, Gunduz Cinar O, Starowicz K, Benyhe S, Borsodi A, Przewlocka B. Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats. J Neural Transm (Vienna). 2010;117:421-9 pubmed publisher
  68. You H, Wei L, Liu Y, Oudega M, Jiao S, Feng S, et al. Olfactory ensheathing cells enhance Schwann cell-mediated anatomical and functional repair after sciatic nerve injury in adult rats. Exp Neurol. 2011;229:158-67 pubmed publisher
    ..This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair...