Summary: Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.

Top Publications

  1. Baba M. Hyperesthesia: an early manifestation of diabetic polyneuropathy. Intern Med. 2002;41:1079-80 pubmed
  2. Svensson P, Graven Nielsen T, Arendt Nielsen L. Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles. Pain. 1998;74:93-100 pubmed
    ..Similar hyperexcitability changes may be part of the pathophysiological mechanisms involved in painful temporomandibular disorders...
  3. de Paiva C, Pflugfelder S. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004;137:109-15 pubmed
    ..To evaluate corneal sensation in different groups: normal subjects, dry eye patients, and patients with and without dry eye after laser in situ keratomileusis (LASIK) using the modified Belmonte gas esthesiometer...
  4. Lee S, Yoon T, Yoo Y, Bang Y, Kim H, Jeoung D, et al. Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury. Biotechnol Lett. 2003;25:2071-8 pubmed
    ..Therefore, a lower creatine kinase B expression level may be important in the development and maintenance of neuropathic pain...
  5. Kupers R, Svensson P, Jensen T. Central representation of muscle pain and mechanical hyperesthesia in the orofacial region: a positron emission tomography study. Pain. 2004;108:284-93 pubmed
    ..jaw-muscle pain and its interference by simultaneous mechanical stimuli, which has been shown to evoke hyperesthesia. Ten healthy subjects participated in a PET study and jaw-muscle pain was induced by bolus injections of 5% ..
  6. Chaplan S, Bach F, Pogrel J, Chung J, Yaksh T. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55-63 pubmed
    ..Threshold measurement using the up-down paradigm, in combination with the neuropathic pain model, represents a powerful tool for analyzing the effects of manipulations of the neuropathic pain state...
  7. Ledeboer A, Sloane E, Milligan E, Frank M, Mahony J, Maier S, et al. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 2005;115:71-83 pubmed
    ..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states...
  8. Graven Nielsen T, Wodehouse T, Langford R, Arendt Nielsen L, Kidd B. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 2012;64:2907-16 pubmed publisher
    ..This study evaluated the importance of ongoing tissue pathology in the maintenance of enhanced central pain processing...
  9. Wasner G, Naleschinski D, Binder A, Schattschneider J, McLachlan E, Baron R. The effect of menthol on cold allodynia in patients with neuropathic pain. Pain Med. 2008;9:354-8 pubmed publisher
    ..We investigated the effects of menthol on preexisting cold allodynia in patients to test whether the allodynia was exacerbated...

More Information

Publications106 found, 100 shown here

  1. Mbelesso P, Yogo M, Yangatimbi E, Paul Sénékian V, Nali N, Preux P. [Outbreak of konzo disease in health region No. 2 of the Central African Republic]. Rev Neurol (Paris). 2009;165:466-70 pubmed publisher
    ..4%). The predominant neurological signs were lower limb paresis (90.0%) and hyperesthesia (66.7%). Konzo is a serious public health problem in this region of the Central African Republic...
  2. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, et al. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive ?-Dicarbonyl Detoxification. Curr Biol. 2016;26:3014-3025 pubmed publisher
    ..comparison to wild-type (N2, Bristol), glod-4 animals rapidly exhibit several pathogenic phenotypes, including hyperesthesia, neuronal damage, reduced motility, and early mortality...
  3. Sakai T, Tomiyasu S, Yamada H, Sumikawa K. Evaluation of allodynia and pain associated with postherpetic neuralgia using current perception threshold testing. Clin J Pain. 2006;22:359-62 pubmed
    ..Therefore, it is suggested that postherpetic neuralgia might be a pain syndrome including both peripheral and central mechanisms. ..
  4. Xing G, Liu F, Qu X, Han J, Wan Y. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Exp Neurol. 2007;208:323-32 pubmed
    ..LTD of synaptic strength in the spinal dorsal horn in SNL rats may contribute to the long-lasting analgesic effects of EA at 2 Hz. ..
  5. Huber G, Lampl C. Oxygen therapy influences episodic cluster headache and related cutaneous brush and cold allodynia. Headache. 2009;49:134-6 pubmed publisher
    ..Administration of normobaric oxygen is part of the standard therapy for CH attacks. Here, we describe a young male with a first CH attack and the influence of oxygen on pain and concomitant cutaneous allodynia. ..
  6. Siawash M, Roumen R, Ten W, van Heurn E, Scheltinga M. Diagnostic characteristics of anterior cutaneous nerve entrapment syndrome in childhood. Eur J Pediatr. 2018;177:835-839 pubmed publisher
    ..Hypo-/hyperesthesia (87%) or a positive pinch test (89%) was often found at the skin overlying the painful spot...
  7. Vardanyan A, Wang R, Vanderah T, Ossipov M, Lai J, Porreca F, et al. TRPV1 receptor in expression of opioid-induced hyperalgesia. J Pain. 2009;10:243-52 pubmed publisher
    ..Such information may lead to the discovery of analgesics lacking such adaptations and improving treatment of chronic pain. ..
  8. Maurer P, Otto C, Bock J, Eckert A, Schubert J. [Patient satisfaction with the outcome of surgical orthodontic intervention and effect of esthetic and functional criteria]. Mund Kiefer Gesichtschir. 2002;6:15-8 pubmed
    ..Two-dimensional analysis, however, demonstrated only a weakly significant positive relationship between patient satisfaction and the preserved, or restored, sensation in the trigeminal region. ..
  9. Lowe E, Allmendinger P, Lowe R. Cold sensitivity as a new side effect after sympathicotomy for hyperhidrosis. Ann Thorac Surg. 2005;80:2356-8 pubmed
    ..When exposed to cold, the right hand and forearm become numb and the skin temperature drops to uncomfortable levels, while the left extremity remains comfortably warm. ..
  10. LaBuda C, Fuchs P. Attenuation of negative pain affect produced by unilateral spinal nerve injury in the rat following anterior cingulate cortex activation. Neuroscience. 2005;136:311-22 pubmed
    ..It is concluded that the selective manipulation of the anterior cingulate cortex has different effects on pain affect and sensory processing in a rodent model of neuropathic pain. ..
  11. Burstein R. Should cluster headache be associated with cutaneous allodynia?. Cephalalgia. 2006;26:1041-2 pubmed
  12. Okada E, Nagai Y, Ishikawa O. A case of widespread livedoid vasculopathy with pain but no systemic symptoms. Acta Derm Venereol. 2008;88:298-9 pubmed publisher
  13. Sukhotinsky I, Ben Dor E, Raber P, Devor M. Key role of the dorsal root ganglion in neuropathic tactile hypersensibility. Eur J Pain. 2004;8:135-43 pubmed
    ..The question of how activity in afferent A-neurons, which are not normally nociceptive, might induce allodynia is discussed in light of the current literature. ..
  14. Sjörs A, Larsson B, Persson A, Gerdle B. An increased response to experimental muscle pain is related to psychological status in women with chronic non-traumatic neck-shoulder pain. BMC Musculoskelet Disord. 2011;12:230 pubmed publisher
  15. Baad Hansen L, Pigg M, Ivanovic S, Faris H, List T, Drangsholt M, et al. Chairside intraoral qualitative somatosensory testing: reliability and comparison between patients with atypical odontalgia and healthy controls. J Orofac Pain. 2013;27:165-70 pubmed publisher
    ..6% of the healthy subjects (P < .001). Intraoral qualitative somatosensory testing can detect intraoral sensory disturbances in AO patients, and the reliability is sufficient for initial screening of orofacial somatosensory function. ..
  16. Trevisan C, Klumpp R, Compagnoni R. Risk factors in transient osteoporosis: a retrospective study on 23 cases. Clin Rheumatol. 2016;35:2517-22 pubmed publisher
    ..presence bone marrow edema on MRI in a weight bearing joint without signs of intraarticular lesions; (4) no hyperesthesia and/or allodynia and/or sweeting changes...
  17. Dellon A, Mackinnon S. Injury to the medial antebrachial cutaneous nerve during cubital tunnel surgery. J Hand Surg Br. 1985;10:33-6 pubmed
    ..The anatomical variations of site of this nerve are described, as well as typical examples of injury seen clinically. ..
  18. Gibbs J, Flores C, Hargreaves K. Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors. Pain. 2006;124:167-74 pubmed
    ..These studies indicate that the activation of peripheral Y1 receptors produces anti-allodynia, possibly via the direct inhibition of capsaicin-sensitive fibers. ..
  19. Cady R, Freitag F, Mathew N, Elkind A, Mao L, Fisher A, et al. Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention. Headache. 2009;49:350-63 pubmed publisher
    ..The presence of AAS, which may indicate an early phase of allodynia, did not influence the efficacy of almotriptan therapy. ..
  20. Benoliel R, Zadik Y, Eliav E, Sharav Y. Peripheral painful traumatic trigeminal neuropathy: clinical features in 91 cases and proposal of novel diagnostic criteria. J Orofac Pain. 2012;26:49-58 pubmed
    ..To field-test carefully designed criteria for pain following trigeminal nerve trauma...
  21. Seidel S, Elwischger K, Wöber C. Facial pain, scotomas and hemihypaesthesia as presenting symptoms of type A aortic dissection in a patient with migraine with aura. Cephalalgia. 2012;32:437-9 pubmed publisher
    ..Due to a new onset of atrial fibrillation, he was put on oral anticoagulants. At follow-up after 10 months he still reported episodic and mostly isolated visual auras with a gradual onset. ..
  22. Caissie R, Landry P, Paquin R, Champigny M, Berthod F. Quantitative method to evaluate the functionality of the trigeminal nerve. J Oral Maxillofac Surg. 2007;65:2254-9 pubmed
    ..It also could be used for initial diagnosis and subsequent evaluation of the patient's neurologic status through the course of their condition. ..
  23. Kuhn M, Al Banchaabouchi M, Campillos M, Jensen L, Gross C, Gavin A, et al. Systematic identification of proteins that elicit drug side effects. Mol Syst Biol. 2013;9:663 pubmed publisher
    ..in vivo by confirming our prediction that activation of the serotonin 7 receptor (HTR7) is responsible for hyperesthesia in mice, which, in turn, can be prevented by a drug that selectively inhibits HTR7...
  24. González Hermosillo Cornejo D, Díaz Girón Gidi A, Vélez Pérez F, Lemus Ramírez R, Andrade Martínez Garza P. [Wilkie Syndrome. A case report]. Cir Cir. 2017;85:54-59 pubmed publisher
    ..On examination, he had abdominal wall rigidity and hyperesthesia. Imaging studies were requested, revealing a decreased superior mesenteric artery angle, a shortening of the ..
  25. Wang Z, Gardell L, Ossipov M, Vanderah T, Brennan M, Hochgeschwender U, et al. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. J Neurosci. 2001;21:1779-86 pubmed
    ..Identification of mechanisms that maintain neuropathic pain appears important for strategies to treat neuropathic pain. ..
  26. Pukall C, Baron M, Amsel R, Khalifé S, Binik Y. Tender point examination in women with vulvar vestibulitis syndrome. Clin J Pain. 2006;22:601-9 pubmed
    ..These results suggest that the mechanisms involved in VVS may include those that are genital specific in addition to those that are more generalized, and possibly centrally mediated. ..
  27. Zhang E, Ossipov M, Zhang D, Lai J, Porreca F. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain. 2007;129:143-54 pubmed
  28. Gonzales R, Goldyne M, Taiwo Y, Levine J. Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons. J Neurochem. 1989;53:1595-8 pubmed
  29. Nazif O, Teichman J, Gebhart G. Neural upregulation in interstitial cystitis. Urology. 2007;69:24-33 pubmed
    ..Neural upregulation is known to play a role in the chronicity of pain, urgency, and frequency and represents an exciting area of research that may lead to additional treatments and a better understanding of IC. ..
  30. Sakkas N, Otten J, Gutwald R, Schmelzeisen R. Transposition of the mental nerve by piezosurgery followed by postoperative neurosensory control: a case report. Br J Oral Maxillofac Surg. 2008;46:270-1 pubmed
    ..Caudal transposition of the right mental nerve by piezosurgery resulted in postoperative neurosensory controls of the lower lip showing normal nerve function 2 months later. ..
  31. Brignell J, Chapman V, Kendall D. Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain. Brain Res. 2008;1215:87-96 pubmed publisher
    ..Our data suggests that icilin modulates the mechanosensitivity of dorsal horn neurones. The differing effects of ice and icilin on dorsal horn neurones indicate different mechanisms of action. ..
  32. Ness T, Powell Boone T, Cannon R, Lloyd L, Fillingim R. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol. 2005;173:1983-7 pubmed
    ..We quantified differences in somatic and visceral sensation in healthy subjects and subjects with interstitial cystitis (IC)...
  33. Milligan E, Sloane E, Langer S, Hughes T, Jekich B, Frank M, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 2006;126:294-308 pubmed
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control. ..
  34. Saade N, Al Amin H, Abdel Baki S, Chalouhi S, Jabbur S, Atweh S. Reversible attenuation of neuropathic-like manifestations in rats by lesions or local blocks of the intralaminar or the medial thalamic nuclei. Exp Neurol. 2007;204:205-19 pubmed
  35. de Coppet H, Lambert M, Charlanne H, Launay D, Morell Dubois S, Maillard Lefebvre H, et al. [Superficial cranial venous thromboses preceding the diagnosis of giant cell arteritis]. J Mal Vasc. 2010;35:23-5 pubmed publisher
    ..We then discuss the pathophysiology of venous thrombosis in patients with temporal arteritis. ..
  36. Carbajal Ramírez A, Garcia Macedo R, Diaz Garcia C, Sanchez Soto C, Padrón A, de la Peña J, et al. Neuropathy-specific alterations in a Mexican population of diabetic patients. BMC Neurol. 2017;17:161 pubmed publisher
    ..diabetic patients classified in three groups: sensory polyneuropathy with hypoesthesia (DShP) or hyperesthesia (DSHP), and motor neuropathy (DMN)...
  37. Joris J, Dubner R, Hargreaves K. Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?. Anesth Analg. 1987;66:1277-81 pubmed
    ..005). In contrast, 160 micrograms of dextrorphan was inactive. These results demonstrate that local administration of opiates into an inflamed paw produces a dose-related, stereospecific analgesia restricted to the injected area. ..
  38. Goadsby P. Migraine, allodynia, sensitisation and all of that . Eur Neurol. 2005;53 Suppl 1:10-6 pubmed
    ..Sensitisation may be peripheral, central or disinhibitory. The potential mechanisms of each of these and their possible manipulation by treatments of the acute attack are considered. ..
  39. Mailis Gagnon A. Disrupted central somatosensory processing in CRPS: a unique characteristic of the syndrome?. Pain. 2006;123:3-5 pubmed
  40. Spicher C, Mathis F, Degrange B, Freund P, Rouiller E. Static mechanical allodynia (SMA) is a paradoxical painful hypo-aesthesia: observations derived from neuropathic pain patients treated with somatosensory rehabilitation. Somatosens Mot Res. 2008;25:77-92 pubmed publisher
    ..The location of the axonal lesions is at the periphery, while the mechanism of pain sensitization is probably central and referred peripherally to the skin by a painful hypoaesthesia. ..
  41. Hughes D, Scott D, Riddell J, Todd A. Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models. J Neurosci. 2007;27:2035-44 pubmed
    ..They also suggest that any release of substance P from injured Abeta afferents is unlikely to activate NK1 receptors in the dorsal horn or contribute to neuropathic pain. ..
  42. Thibault K, Van Steenwinckel J, Brisorgueil M, Fischer J, Hamon M, Calvino B, et al. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Pain. 2008;140:305-22 pubmed publisher
    ..These data provide support to the idea that, in vincristine-induced neuropathy, 5-HT2AR are involved in the sensitization of peripheral nociceptors and spinal nociceptive processing. ..
  43. Situ P, Simpson T, Jones L, Fonn D. Effects of silicone hydrogel contact lens wear on ocular surface sensitivity to tactile, pneumatic mechanical, and chemical stimulation. Invest Ophthalmol Vis Sci. 2010;51:6111-7 pubmed publisher
    ..ClinicalTrials.gov number, NCT00455455.). ..
  44. Moriwaki K, Yuge O. Topographical features of cutaneous tactile hypoesthetic and hyperesthetic abnormalities in chronic pain. Pain. 1999;81:1-6 pubmed
    ..We propose that the hyperesthesia is associated with a functional tactile hypoesthesia that is similarly mediated by altered processing by CNS ..
  45. Siddall P, Taylor D, McClelland J, Rutkowski S, Cousins M. Pain report and the relationship of pain to physical factors in the first 6 months following spinal cord injury. Pain. 1999;81:187-97 pubmed
    ..While the presence or absence of pain overall does not appear to be related to physical factors following SCI, there does appear to be a relationship between physical factors and pain when the pain is classified into specific types...
  46. Robinson A, Tannier C, Magnaval J. [Toxocara canis meningoradiculitis]. Rev Neurol (Paris). 2002;158:351-3 pubmed
    ..Etiological diagnosis was oriented by the finding of an eosinophilia in the spinal fluid, then confirmed by the result of the immunodiagnosis of toxocariasis from both serum and spinal fluid...
  47. Kwong K, Cooper L, Bennett L, Burrows W, Gamliel Z, Krasna M. Clinical experience in 397 consecutive thoracoscopic sympathectomies. Ann Thorac Surg. 2005;80:1063-6; discussion 1066 pubmed
    ..The purpose of this study is to evaluate the safety and efficacy of thoracoscopic sympathectomy for the treatment of hyperhidrosis, blushing, reflex sympathetic dystrophy, and digital ischemia...
  48. Rolke R, Baron R, Maier C, Tolle T, Treede R, Beyer A, et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006;123:231-43 pubmed
    ..close to the respective limits of the possible data range, heat hypoalgesia, cold hypoalgesia, and mechanical hyperesthesia can hardly be diagnosed. Nevertheless, these parameters can be used for group comparisons...
  49. Mainero C, Zhang W, Kumar A, Rosen B, Sorensen A. Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Neuroimage. 2007;35:1201-10 pubmed
    ..These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia...
  50. Vartiainen N, Kirveskari E, Forss N. Central processing of tactile and nociceptive stimuli in complex regional pain syndrome. Clin Neurophysiol. 2008;119:2380-8 pubmed publisher
    Patients with complex regional pain syndrome (CRPS) suffer from continuous regional limb pain and from hyperesthesia to touch and pain...
  51. Fessa C, Lee B. An Australian case of surfer's myelopathy. Clin J Sport Med. 2012;22:281-3 pubmed publisher
    ..We present a 19-year-old man who developed lower back pain, profound bilateral lower limb paraparesis, and hyperesthesia during his first learn to surf class. The event was not associated with trauma...
  52. Przewlocka B, Sieja A, Starowicz K, Maj M, Bilecki W, Przewlocki R. Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat. Neurosci Lett. 2002;325:107-10 pubmed
    ..g. receptor desensitization. Moreover, the antisense oligonucleotides targeting beta-arrestin may constitute a new approach to the therapy of neuropathic pain...
  53. Ashkenazi A, Silberstein S, Jakubowski M, Burstein R. Improved identification of allodynic migraine patients using a questionnaire. Cephalalgia. 2007;27:325-9 pubmed
  54. Sraj S, Khoury N, Afeiche N, Abdelnoor J. Thigh pain of 5 years' duration in a 48-year-old man. Clin Orthop Relat Res. 2008;466:2291-5 pubmed publisher
  55. Latremoliere A, Mauborgne A, Masson J, Bourgoin S, Kayser V, Hamon M, et al. Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats. J Neurosci. 2008;28:8489-501 pubmed publisher
    ..Our data further support the idea that different pathophysiological mechanisms contribute to the development of cephalic versus extracephalic neuropathic pain...
  56. Hasegawa T, Tateishi C, Asano M, Takata N, Akashi M, Shigeta T, et al. Changes in the sensitivity of cutaneous points and the oral mucosa after intraoral vertical ramus osteotomy. Int J Oral Maxillofac Surg. 2013;42:1454-61 pubmed publisher
  57. Collins E, Novak C, Mackinnon S, Weisenborn S. Long-term follow-up evaluation of cold sensitivity following nerve injury. J Hand Surg Am. 1996;21:1078-85 pubmed
    ..A significant relationship was found between cold sensitivity and digital amputation injuries (p < or = .05). Thus, cold sensitivity is a common sequela following nerve injury and does not decrease over time...
  58. Chan J, Bergstrom R, Lanza D, Oas J. Lateral sinus thrombosis associated with zoster sine herpete. Am J Otolaryngol. 2004;25:357-60 pubmed
    ..She denied otalgia, otorrhea, and hearing loss. Examination revealed hyperesthesia in the left C2 nerve root distribution without evidence of herpetic rash...
  59. Keizer D, Van Wijhe M, Post W, Wierda J. Quantifying allodynia in patients suffering from unilateral neuropathic pain using von frey monofilaments. Clin J Pain. 2007;23:85-90 pubmed
  60. Liang Y, Huang C, Hsu K. The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. Neuropharmacology. 2007;53:169-77 pubmed
    ..Taken together, these results suggest that cannabinoids may be a useful therapeutic approach for the clinical management of trigeminal neuropathic pain disorders...
  61. Trang T, Beggs S, Salter M. Purinoceptors in microglia and neuropathic pain. Pflugers Arch. 2006;452:645-52 pubmed
    ..Thus, P2X4 receptors and the intracellular signaling mediators in microglia are promising therapeutic targets for the development of novel pharmacological agents in the management of neuropathic pain...
  62. Lee J, Fink D, Mata M. Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathy. Spine (Phila Pa 1976). 2006;31:1555-8 pubmed
    ..A prospective in vivo animal study...
  63. Pingsterhaus J, Peelle M, Sicard G, McDonald D. Pseudoaneurysm from a traumatic osteochondroma leading to rapid neurological compromise. Orthopedics. 2007;30:399-400 pubmed
  64. Eidlitz Markus T, Shuper A, Gorali O, Zeharia A. Migraine and cephalic cutaneous allodynia in pediatric patients. Headache. 2007;47:1219-23 pubmed
    ..The objective of this study was to determine the frequency of allodynia in children with migraine and to identify clinical features specific to this patient group...
  65. Batista P, Werner M, Oliveira E, Burgos L, Pereira P, Brum L, et al. The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. J Pain. 2010;11:1222-9 pubmed publisher
    ..Therefore, we injected the cytokines IL-1? (.1 pg/site) and TNF-? (1 pg/site) intrathecally. (-)-Linalool inhibited the biting response induced by IL-1? and TNF-?...
  66. Waldinger M, Venema P, van Gils A, de Lint G, Schweitzer D. Stronger evidence for small fiber sensory neuropathy in restless genital syndrome: two case reports in males. J Sex Med. 2011;8:325-30 pubmed publisher
    ..So far, ReGS has only been reported in females...
  67. Sakavicius D, Kubilius R, Sabalys G. [Post-traumatic infraorbital nerve neuropathy]. Medicina (Kaunas). 2002;38:47-51 pubmed
    ..The treatment of neuropathy was analysed. In cases of moderate and severe nerve damages, authors recommend to perform decompression of the nerve, because if not applied, the function of nerve does not recover...
  68. Zyluk A. A new clinical severity scoring system for reflex sympathetic dystrophy of the upper limb. J Hand Surg Br. 2003;28:238-41 pubmed
    ..Seventy-four patients (51%) had a score of 4-6, 51 patients (35%) a score of 6.5-8, and 21 patients (14%) a score of 8.5-10. Use of this system will allow more precise analysis of RSD patients and facilitate comparisons between studies...
  69. Sekiguchi M, Kikuchi S, Myers R. Experimental spinal stenosis: relationship between degree of cauda equina compression, neuropathology, and pain. Spine (Phila Pa 1976). 2004;29:1105-11 pubmed
    ..An analysis of pathologic changes after different degrees of cauda equina compression...
  70. Kim S, Park J, Bae S, Kim J, Hwang B, Min B, et al. Effects of electroacupuncture on cold allodynia in a rat model of neuropathic pain: mediation by spinal adrenergic and serotonergic receptors. Exp Neurol. 2005;195:430-6 pubmed
  71. Guy N, Marques A, Orliaguet T, Lanteri Minet M, Dallel R, Clavelou P. Are there differences between cephalic and extracephalic cutaneous allodynia in migraine patients?. Cephalalgia. 2010;30:881-6 pubmed publisher
    ..03; P = 0.002), extracephalic CA being mostly thermal (75%) whereas cephalic CA was mostly mechanical (92%). This suggests that cephalic and extracephalic CAs involve different mechanisms...
  72. Chan C, Facer P, Davis J, Smith G, Egerton J, Bountra C, et al. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet. 2003;361:385-91 pubmed
    ..We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities...
  73. Edwards R, Smith M, Stonerock G, Haythornthwaite J. Pain-related catastrophizing in healthy women is associated with greater temporal summation of and reduced habituation to thermal pain. Clin J Pain. 2006;22:730-7 pubmed
    ..We assessed, for the first time, catastrophizing's association with the magnitude of temporal summation of pain, a primary marker for central nervous system sensitizability...
  74. Tokunaga S, Takeda Y, Shinomiya K, Yamamoto W, Utsu Y, Toide K, et al. Changes of sleep patterns in rats with chronic constriction injury under aversive conditions. Biol Pharm Bull. 2007;30:2088-90 pubmed
    ..In addition, it was found that CCI rats placed on sandpaper as an aversive condition can serve as a new sleep disturbance model...
  75. Lovati C, D AMICO D, Bertora P, Raimondi E, Rosa S, Zardoni M, et al. Correlation between presence of allodynia and sleep quality in migraineurs. Neurol Sci. 2010;31 Suppl 1:S155-8 pubmed publisher
    ..These results suggest that allodynia is strongly related to sleep quality, in a bi-directional way: sleep disturbances may favour central sensitisation, and, in turn, allodynia may impair sleep...
  76. Thomas T, Hinzman J, Gerhardt G, Lifshitz J. Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry. J Neurotrauma. 2012;29:187-200 pubmed publisher
    ..Effective therapies to modulate presynaptic glutamate function in diffuse-injured circuits may translate into improvements in essential brain function and behavioral performance in other brain-injured circuits in rodents and in humans...
  77. van Wilgen C, Konopka K, Keizer D, Zwerver J, Dekker R. Do patients with chronic patellar tendinopathy have an altered somatosensory profile? A Quantitative Sensory Testing (QST) study. Scand J Med Sci Sports. 2013;23:149-55 pubmed publisher
    ..From this explorative study, we conclude that sensitization may play a prominent role in the pain during and after sports activity in patella tendinopathy patients...
  78. Hubscher C, Johnson R. Changes in neuronal receptive field characteristics in caudal brain stem following chronic spinal cord injury. J Neurotrauma. 1999;16:533-41 pubmed
    ..The observed plasticity is likely part of the central reorganization producing the multitude of sensory disturbances that surface following spinal cord injury...
  79. Chen Y, Li G, Wang C, Gu Y, Huang L. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain. 2005;119:38-48 pubmed
    ..Thus, the enhancement of trafficking of P2X3 receptors is likely an important mechanism contributing to the increase in receptor function after nerve injury...
  80. Ladda J, Straube A, Förderreuther S, Krause P, Eggert T. Quantitative sensory testing in cluster headache: increased sensory thresholds. Cephalalgia. 2006;26:1043-50 pubmed
  81. Cascio C, McGlone F, Folger S, Tannan V, Baranek G, Pelphrey K, et al. Tactile perception in adults with autism: a multidimensional psychophysical study. J Autism Dev Disord. 2008;38:127-37 pubmed
    ..These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies...
  82. Sterling M, Pedler A, Chan C, Puglisi M, Vuvan V, Vicenzino B. Cervical lateral glide increases nociceptive flexion reflex threshold but not pressure or thermal pain thresholds in chronic whiplash associated disorders: A pilot randomised controlled trial. Man Ther. 2010;15:149-53 pubmed publisher
    ..There was no difference between interventions for pain ratings with the NFR test, PPTs at the Median Nerve or Tibialis Anterior, heat or cold TPT. SMT may be effective in reducing spinal hyperexcitability in chronic WAD...
  83. Bozynski C, Vasquez L, O Brien D, Johnson G. Compressive myelopathy associated with ectasia of the vertebral and spinal arteries in a dog. Vet Pathol. 2012;49:779-83 pubmed publisher
    A 4-year-old dog was presented for acute, progressive tetraparesis and cervical hyperesthesia. Symmetrical tubular structures coursing along the lateroventral aspects of the spinal cord at the fourth and fifth cervical vertebrae were ..
  84. Merwin R, Moskovich A, Wagner H, Ritschel L, Craighead L, Zucker N. Emotion regulation difficulties in anorexia nervosa: Relationship to self-perceived sensory sensitivity. Cogn Emot. 2013;27:441-52 pubmed publisher
    ..Findings suggest that hypersensitivity may be a persisting feature in AN, and that weight restoration may involve improved ability to cope with sensation...
  85. Vissers K. The clinical challenge of chronic neuropathic pain. Disabil Rehabil. 2006;28:343-9 pubmed
    ..A correct management of chronic neuropathic pain requires a thorough understanding of the potential causes, the diagnosis and the pathophysiological mechanisms...
  86. Rahman W, Suzuki R, Webber M, Hunt S, Dickenson A. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain. 2006;123:264-74 pubmed
  87. Banissy M, Walsh V, Ward J. Enhanced sensory perception in synaesthesia. Exp Brain Res. 2009;196:565-71 pubmed publisher
    ..These findings suggest the possibility that a hyper-sensitive concurrent perceptual system is a general property of synaesthesia and are discussed in relation to theories of the condition...
  88. Drac P, Cizmar I, Hrbek J. Is the dorsal percutaneous approach well-founded for osteosynthesis of scaphoid fractures?. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009;153:225-7 pubmed
    ..To compare complications associated with dorsal percutaneous and limited dorsal approaches in the surgical treatment of fractured scaphoid bone...
  89. Wennman Larsen A, Alexanderson K, Olsson M, Nilsson M, Petersson L. Sickness absence in relation to breast and arm symptoms shortly after breast cancer surgery. Breast. 2013;22:767-72 pubmed publisher
    ..Women (n = 511), aged 26-63 years, who worked ? 75% before a BC diagnosis, were included within 12 weeks of surgery...
  90. Polizzotto M, Bryan T, Ashby M, Martin P. Symptomatic management of calciphylaxis: a case series and review of the literature. J Pain Symptom Manage. 2006;32:186-90 pubmed
    ..Intense pain and cutaneous hyperesthesia are prominent features. Mortality rates are high, and the resulting morbidity is significant...
  91. Bailey K, Ng J, Hwang P, Saulny S, Holck D, Rubin P. Infraorbital nerve surgical decompression for chronic infraorbital nerve hyperesthesia. Ophthalmic Plast Reconstr Surg. 2007;23:49-51 pubmed
    To present three cases of chronic infraorbital nerve hyperesthesia relieved by surgical decompression of the infraorbital nerve.
  92. Atherton D, Taherzadeh O, Elliot D, Anand P. Age-dependent development of chronic neuropathic pain, allodynia and sensory recovery after upper limb nerve injury in children. J Hand Surg Eur Vol. 2008;33:186-91 pubmed publisher
    ..60, P<0.0001). These findings indicate that young children show better sensory recovery and are less likely to develop long-term chronic neuropathic pain syndromes than adults following nerve injury...