Summary: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.

Top Publications

  1. Hou R, Samuels E, Langley R, Szabadi E, Bradshaw C. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007;195:41-59 pubmed
    ..arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in...
  2. Genovese R, Benton B, Oubre J, Fleming P, Jakubowski E, Mioduszewski R. Determination of miosis threshold from whole-body vapor exposure to sarin in African green monkeys. Toxicology. 2008;244:123-32 pubmed
    We determined the threshold concentration of sarin vapor exposure producing miosis in African green monkeys (Chlorocebus aethiops). Monkeys (n=8) were exposed to a single concentration of sarin (0.069-0.701mg/m3) for 10min...
  3. Bonfiglio V, Bucolo C, Camillieri G, Drago F. Possible involvement of nitric oxide in morphine-induced miosis and reduction of intraocular pressure in rabbits. Eur J Pharmacol. 2006;534:227-32 pubmed
    The role of mu3 opioid receptors in morphine-induced intraocular pressure (IOP) lowering effect and miosis was evaluated in conscious, dark-adapted New Zealand white (NZW) rabbits using a masked-design study...
  4. Nesin V, Wiley G, Kousi M, Ong E, Lehmann T, Nicholl D, et al. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014;111:4197-202 pubmed publisher
    ..R304W) associated with thrombocytopenia, bleeding diathesis, miosis, and tubular myopathy in patients with Stormorken syndrome, and in ORAI1 (p...
  5. Srinivasan R, Madhavaranga -. Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. J Cataract Refract Surg. 2002;28:517-20 pubmed
    To compare the effect of topical ketorolac tromethamine 0.5% solution and topical diclofenac sodium 0.1% solution on the inhibition of surgically induced miosis.
  6. Mirza S, Alexandridou A, Marshall T, Stavrou P. Surgically induced miosis during phacoemulsification in patients with diabetes mellitus. Eye (Lond). 2003;17:194-9 pubmed
    To assess the incidence of surgically induced miosis during phacoemulsification in diabetic patients.
  7. Mirshahi A, Djalilian A, Rafiee F, Namavari A. Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy. Retina. 2008;28:1215-20 pubmed publisher
    ..A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation...
  8. Kharasch E, Walker A, Hoffer C, Sheffels P. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. J Clin Pharmacol. 2005;45:1187-97 pubmed
    This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition. Results were compared with those for midazolam, an alternative CYP3A probe...
  9. VanDeVoorde R, Witte D, Kogan J, Goebel J. Pierson syndrome: a novel cause of congenital nephrotic syndrome. Pediatrics. 2006;118:e501-5 pubmed
    ..We conclude that Pierson syndrome should be included in the differential diagnosis for congenital nephrotic syndrome, especially in patients with ocular abnormalities. ..

More Information

Publications138 found, 100 shown here

  1. Feil M, Moser B, Abegg M. The interaction of pupil response with the vergence system. Graefes Arch Clin Exp Ophthalmol. 2017;255:2247-2253 pubmed publisher
    ..Neither accommodation nor proximity alone induce a significant pupillary constriction. This suggests that the miosis of the near triad is closely coupled to the vergence system rather than being independently regulated.
  2. Bucolo C, Mangiafico P. Pharmacological profile of a new topical pilocarpine formulation. J Ocul Pharmacol Ther. 1999;15:567-73 pubmed
    ..The pharmacological profile of the new formulation described in this study indicates an increase of efficacy and duration of action compared to the commercial preparation. ..
  3. Moya Romero J, Ochoa Máynez G, Cantero Vergara M, Gómez Cortes C. Femtophacovitrectomy. Case series and description of the technique. Arch Soc Esp Oftalmol. 2016;91:461-8 pubmed publisher
    ..5 LogMAR at 3-months follow-up (P<.05). No patient had visual loss. The intra-operative complication was miosis in 14.28%...
  4. Root B, Schartz D, Calnan D, Hickey W, Bauer D. Cervicothoracic epidural hematoma in a toddler with miosis, ptosis, nonspecific symptoms, and no history of major trauma: case report. Childs Nerv Syst. 2018;34:1259-1262 pubmed publisher
    ..He later developed unilateral miosis and ptosis; MRI discovered a subacute cervicothoracic epidural which was promptly evacuated...
  5. Zacny J, Goldman R. Characterizing the subjective, psychomotor, and physiological effects of oral propoxyphene in non-drug-abusing volunteers. Drug Alcohol Depend. 2004;73:133-40 pubmed
    ..Both propoxyphene and morphine produced miosis. There was a lack of statistically significant subjective effects of propoxyphene in the group as a whole, ..
  6. Khan Z, Saberi H. Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. Anesth Analg. 2006;103:503-4 pubmed
  7. Murphy M, Hou L. Recurrent isolated horner syndrome. J Neuroophthalmol. 2006;26:296 pubmed
  8. Singh P, Singh S, Bhargav G, Singh M. Conjunctival flap in manual sutureless small-incision cataract surgery: a necessity or dogmatic. Int Ophthalmol. 2012;32:349-55 pubmed publisher
    ..46 ± 1.69 min) (p value <0.001). In the group without a flap intraoperative pupillary miosis was significantly greater (p value 0...
  9. Whitman J, Dougherty P, Parkhurst G, Olkowski J, Slade S, Hovanesian J, et al. Treatment of Presbyopia in Emmetropes Using a Shape-Changing Corneal Inlay: One-Year Clinical Outcomes. Ophthalmology. 2016;123:466-75 pubmed publisher
    ..Subject satisfaction is improved significantly with minimal ocular or visual symptoms. ..
  10. Adefule Ositelu A, Aribaba O, Adegbehingbe O, Adefule A, Samaila A, Oladigbolu K. Pupillary changes among Nigerian adults following the instillation of Garcinia kola nut extracts: multicentric studies. Niger Postgrad Med J. 2008;15:152-6 pubmed
    ..A multi-centre, open, within-patient controlled study was performed on 106 adult volunteers to investigate the effects of Garcinia kolanut extracts on the pupillary sizes...
  11. Badshah A, Khan S, Saeed U. Spindle Cell Sarcoma Presenting as Pancoast Syndrome. J Coll Physicians Surg Pak. 2016;26:623-5 pubmed publisher
    ..The patient also had ptosis and miosis in the right eye. Right ulnar nerve palsy with atrophy of hand muscles was seen...
  12. Abascal Azanza C, Abarzuza Cortaire R, Plaza Ramos P. [Horner's Syndrome: an unusual ophthalmological presentation of Hodgkin lymphoma]. An Sist Sanit Navar. 2017;40:461-466 pubmed publisher
    Horner's Syndrome (HS) is a neurological syndrome characterised by the triad incomplete pupillary miosis, palpebral ptosis and facial anhidrosis, due to a lesion of the oculosympathetic pathway, formed of three neurons from the ..
  13. Matsuura T, Tsuji N, Kodama Y, Narama I, Ozaki K. Iridal coloboma induces dyscoria during miosis in FLS mice. Vet Ophthalmol. 2013;16:186-91 pubmed publisher
    ..Inferior corectopia upon light-induced miosis was clearly detected in live FLS mice. The deviated pupils were not round but oval-shaped...
  14. Kahane N, Raskansky H, Bdolah Abram T, Ofri R. The effects of topical parasympatholytic drugs on pupil diameter and intraocular pressure in healthy dogs treated with 0.005% latanoprost. Vet Ophthalmol. 2016;19:464-472 pubmed publisher
    Prostaglandin analogs induce miosis and lower intraocular pressure (IOP). As pupils of latanoprost-treated eyes may have to be dilated for ophthalmoscopy or intraocular surgery, we studied whether 0...
  15. Walsh S, Nuzzo P, Babalonis S, Casselton V, Lofwall M. Intranasal buprenorphine alone and in combination with naloxone: Abuse liability and reinforcing efficacy in physically dependent opioid abusers. Drug Alcohol Depend. 2016;162:190-8 pubmed publisher
    ..All active doses produced opioid agonist-like effects (e.g., increased ratings of "liking," and miosis) compared to placebo. The effects of buprenorphine and buprenorphine/naloxone were not reliably dose-dependent...
  16. Stormorken H. [Stormorken's syndrome]. Tidsskr Nor Laegeforen. 2002;122:2853-6 pubmed
    In 1985, a new syndrome with the following characteristics was described: thrombopathia, thrombopenia, asplenia, miosis, headache, ichthyosis, dyslexia, muscle defect, and subsequently also hypocalcaemia...
  17. Abanades S, Farre M, Barral D, Torrens M, Closas N, Langohr K, et al. Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users. J Clin Psychopharmacol. 2007;27:625-38 pubmed
    ..Our results suggest a high abuse liability of GHB and flunitrazepam in club drug users. ..
  18. YANCEY WRONA J, Dallaire B, Bilsky E, Bath B, Burkart J, Webster L, et al. 6?-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011;12:1727-37 pubmed publisher
    ..6?-Naltrexol acts as a potent, peripherally selective opioid antagonist. The compound was well-tolerated in this study and may have clinical potential in the therapy of peripheral opioid effects such as opioid-induced constipation. ..
  19. Coe M, Nuzzo P, Lofwall M, Walsh S. Effects of Short-Term Oxycodone Maintenance on Experimental Pain Responses in Physically Dependent Opioid Abusers. J Pain. 2017;18:825-834 pubmed publisher
    ..in peak Cold Pressor Test threshold compared with placebo, and significantly increased expired breath CO2, miosis, and ratings of abuse liability measures...
  20. Tian X, Li D, Dong S, Liu G, Qi Z, Lu J. [Water quality of closed polyculture of penaeid shrimp with tilapia and constricted tagelus]. Ying Yong Sheng Tai Xue Bao. 2001;12:287-92 pubmed
    ..63% lower. Therefore, it is obvious that closed culture system can greatly decrease the effluent to the coastal waters caused by the pond culture industry, and decrease the pollution to the coastal waters. ..
  21. Isbister G, Whyte I. Atypical presentation of risperidone toxicity. Vet Hum Toxicol. 2002;44:118-9; author reply 119 pubmed
  22. Jean Louis G, Zizi F, Lazzaro D, Wolintz A. Circadian rhythm dysfunction in glaucoma: A hypothesis. J Circadian Rhythms. 2008;6:1 pubmed publisher
    ..g., senile miosis, cataract, diabetic retinopathy, macular degeneration, retinitis pigmentosa, and glaucoma)...
  23. Dumont B, Payseur B. Evolution of the genomic recombination rate in murid rodents. Genetics. 2011;187:643-57 pubmed publisher
  24. Toce M, Stefater M, Breault D, Burns M. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018;56:74-76 pubmed publisher
    ..Overdose can cause miosis, respiratory depression, and central nervous system depression. Rarely, hypoglycemia has been reported...
  25. Medhurst A, Hay D, Parsons A, Martin L, Griswold D. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br J Pharmacol. 1997;122:469-76 pubmed
    ..In addition, an in vivo correlate of this in vitro response, namely NK3 receptor agonist-induced miosis in conscious rabbits, was characterized with some of these antagonists. 2...
  26. Hofeldt G, Simon J. Polycoria, miosis, and amblyopia. J AAPOS. 2002;6:328-9 pubmed
  27. Dietze H, Cox M. Limitations of correcting spherical aberration with aspheric intraocular lenses. J Refract Surg. 2005;21:S541-6 pubmed
    ..Both the model eye and the real eye data predict that age-related miosis reduces spherical aberration in the eye implanted with a spherical IOL to approximately 1/3 of the spherical ..
  28. Kharasch E, Vangveravong S, Buck N, London A, Kim T, Blood J, et al. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clin Pharmacol Ther. 2011;89:562-70 pubmed publisher
    ..CYP) 3A activity, using plasma clearances, single-point concentrations, and noninvasive pupil diameter change (miosis). Assessing intravenous (i.v.) and oral drug disposition typically requires separate dosing...
  29. Torres M, Andaluz A, Garcia F, Fresno L, Moll X. Effects of an intravenous bolus of alfaxalone versus propofol on intraocular pressure in sheep. Vet Rec. 2012;170:226 pubmed publisher
    ..This present study shows that alfaxalone and propofol, administrated as a single intravenous bolus, are good options for maintaining IOP during anaesthesia in sheep, although marked miosis was observed after administration.
  30. Kassa J, Karasova J. A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats. Toxicology. 2007;229:136-44 pubmed
    ..Due to their neuroprotective effects, both newly developed oximes (especially K075) appear to be more suitable oximes for the antidotal treatment of acute tabun poisonings than the oxime HI-6. ..
  31. Genovese R, Benton B, Oubre J, Fleming P, Jakubowski E, Mioduszewski R. Evaluation of miosis, behavior and cholinesterase inhibition from low-level, whole-body vapor exposure to soman in African green monkeys (Chlorocebus sabeus). J Med Primatol. 2010;39:318-27 pubmed publisher
    ..028-0.891 mg/m³). EC?? values for miosis were determined to be 0.055 mg/m³ and 0...
  32. Kowal J, Strzałka A, Kubicka Trzaska A, Romanowska Dixon B. [Abnormal pupils' reactions]. Klin Oczna. 2010;112:156-60 pubmed
    ..Early diagnosis and proper treatment can allow to improve prognosis in the analyzed patient group...
  33. Hickenbotham A, Tiruveedhula P, Roorda A. Comparison of spherical aberration and small-pupil profiles in improving depth of focus for presbyopic corrections. J Cataract Refract Surg. 2012;38:2071-9 pubmed publisher
    ..No author has a financial or proprietary interest in any material or method mentioned. ..
  34. Alam P, Sloane J, Koraitim M, Brennan P. Metastatic squamous cell carcinoma in the neck presenting with Horner syndrome - a cause of the condition not previously described. Br J Oral Maxillofac Surg. 2016;54:689-91 pubmed publisher
    Horner syndrome, a combination of pupillary miosis, ptosis and facial anhidrosis, results from damage to the oculosympathetic nerve pathways...
  35. Duan P, Liu Y, Li J. The comparative efficacy and safety of topical non-steroidal anti-inflammatory drugs for the treatment of anterior chamber inflammation after cataract surgery: a systematic review and network meta-analysis. Graefes Arch Clin Exp Ophthalmol. 2017;255:639-649 pubmed publisher
    ..These drugs do not have a steroid structure, but can inhibit surgery-induced miosis, anterior chamber inflammation, and cystoid macular edema (CME)...
  36. Teixeira J, Santos M, Melancia J. T1-T2 Herniated Disk Presenting with Horner Syndrome. World Neurosurg. 2017;107:1050.e13-1050.e15 pubmed publisher
    ..female patient was admitted to the emergency department presenting a sudden-onset history of ptosis and miosis on the left eye (Horner syndrome)...
  37. Kharasch E, Hoffer C, Altuntas T, Whittington D. Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. J Clin Pharmacol. 2004;44:224-33 pubmed
    ..Quinidine did not alter the magnitude or time to maximum miosis, time-specific pupil diameter, or subjective self-assessments after intravenous fentanyl but did increase the area ..
  38. Slawson C, Lakshmanan T, Knapp S, Hart G. A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell. 2008;19:4130-40 pubmed publisher
    ..Together, these data demonstrate that the O-GlcNAc cycling enzymes associate with kinases and phosphatases at M phase to regulate the posttranslational status of vimentin. ..
  39. Fasano C, O Malley G, Lares C, Rowden A. Pediatric ziprasidone overdose. Pediatr Emerg Care. 2009;25:258-9 pubmed publisher
    ..The mechanism of miosis associated with overdose of atypical antipsychotics is unclear but is likely related to interference with central ..
  40. Foy L, Seeyave D, Bradin S. Toxic leukoencephalopathy due to transdermal fentanyl overdose. Pediatr Emerg Care. 2011;27:854-6 pubmed publisher
  41. Sarchahi A, Abbasi N, Gholipour M. Effects of an unfixed combination of latanoprost and pilocarpine on the intraocular pressure and pupil size of normal dogs. Vet Ophthalmol. 2012;15 Suppl 1:64-70 pubmed publisher
    ..b>Miosis and conjunctival hyperemia were observed in the treated eyes of all three groups of animals during the treatment ..
  42. Cooper Z, Sullivan M, Vosburg S, Manubay J, Haney M, Foltin R, et al. Effects of repeated oxycodone administration on its analgesic and subjective effects in normal, healthy volunteers. Behav Pharmacol. 2012;23:271-9 pubmed publisher
    ..These data also suggest that intermittent administration may enhance the analgesic effects of oxycodone, while also increasing some of the drug's positive subjective effects related to abuse liability. ..
  43. Sandor C, Li W, Coppieters W, Druet T, Charlier C, Georges M. Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle. PLoS Genet. 2012;8:e1002854 pubmed publisher
    ..We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage...
  44. Musk G, King M, He B. Horner Syndrome in 2 Pigs (Sus scrofa) after Vascular Grafting of the Carotid Artery and Jugular Vein. Comp Med. 2017;67:518-523 pubmed
    The term Horner syndrome refers to the clinical presentation of oculosympathoparesis, comprising miosis, ptosis, and facial anhydrosis. To date, there are 2 reports of postoperative Horner syndrome in pigs...
  45. Heys J, Barocas V, Taravella M. Modeling passive mechanical interaction between aqueous humor and iris. J Biomech Eng. 2001;123:540-7 pubmed
    ..The results compare favorably with clinical observations, supporting the hypothesis that passive iris deformation can produce the iris contours observed using ultrasound biomicroscopy. ..
  46. Pignatello R, Bucolo C, Ferrara P, Maltese A, Puleo A, Puglisi G. Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen. Eur J Pharm Sci. 2002;16:53-61 pubmed
    Topical application of non-steroidal anti-inflammatory drugs on the eye is a common treatment used to contrast the miosis induced by surgical traumas, such as cataract extraction...
  47. Avunduk M, Avunduk A, Oztekin E, Baltaci A, Ozyazgan Y, Mogolkoc R. Etanercept treatment in the endotoxin-induced uveitis of rats. Exp Eye Res. 2004;79:357-65 pubmed
    ..4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uveitis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized...
  48. Freitas L, Casanova F, Bonomo P. Small pupil phacoemulsification using iris sutures: a new method?. Ophthalmic Surg Lasers Imaging. 2004;35:434-7 pubmed
    ..Although other techniques are generally available, this technique may be useful in unique situations where other pupil devices or methods are not available. ..
  49. Ciszowski K, Sein Anand J, Wilimowska J, Jawień W. [The clinical picture of acute olanzapine poisonings]. Przegl Lek. 2011;68:426-33 pubmed
    ..Its multireceptor action (antagonism to dopaminergic D1, D2, D4, serotoninergic 5-HT2A, 5-HT2C, histaminergic H1, cholinergic M1-5, and a1--adrenergic receptors) results in multiple clinical symptoms in the course of acute poisoning...
  50. Goktas A. Evaluation of the effect of tolterodine on pupil diameter and anterior chamber parameters with the Pentacam. Cutan Ocul Toxicol. 2011;30:61-3 pubmed publisher
    ..Most likely, it is an organ-selective agent, inhibiting muscarinic receptors in the bladder rather than in the anterior segment of the eye. ..
  51. Xu R, Thibos L, Bradley A. Effect of Target Luminance on Optimum Pupil Diameter for Presbyopic Eyes. Optom Vis Sci. 2016;93:1409-1419 pubmed
    ..A fixed 2- to 3-mm small pupil or a 30% pupil miosis can both produce near visual acuity gains without significant losses to distance acuity or image quality, and ..
  52. Chen X, Miao H, Naidu R, Wang X, Zhou X. Comparison of early changes in and factors affecting vault following posterior chamber phakic Implantable Collamer Lens implantation without and with a central hole (ICL V4 and ICL V4c). BMC Ophthalmol. 2016;16:161 pubmed publisher
    ..vault observed postoperatively from 1 day to 1 week associated with the declining effects of pharmacological miosis and increasing pupil size...
  53. Adamo P, Cantile C, Steinberg H. Evaluation of progesterone and estrogen receptor expression in 15 meningiomas of dogs and cats. Am J Vet Res. 2003;64:1310-8 pubmed
    ..Results indicate a high proportion of progesterone receptors in cells of meningiomas of the CNS in dogs and cats. Antiprogesterone treatment may have a role in the treatment of unresectable or recurrent meningiomas in dogs and cats. ..
  54. Gesundheit B, Greenberg M. Medical mystery: brown eye and blue eye--the answer. N Engl J Med. 2005;353:2409-10 pubmed
  55. Kothari M, Mody K, Walinjkar J, Madia J, Kaul S. Paralysis of the near-vision triad in a child. J AAPOS. 2009;13:202-3 pubmed publisher
    The near-vision triad, or complex, consists of convergence, miosis, and accommodation. Neuronal pathways that control each of these components are distinct but interrelated...
  56. Jevremovic V, Yousuf A, Hussain Z, Abboud A, Chedrawy E. A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. J Med Case Rep. 2017;11:61 pubmed publisher
    ..He had ptosis and miosis of his left eye. His breath sounds were decreased and coarse at the left apex...
  57. Skarke C, Jarrar M, Schmidt H, Kauert G, Langer M, Geisslinger G, et al. Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics. 2003;13:651-60 pubmed
    ..This was accompanied by a tendency toward higher plasma loperamide in TT3435 carriers. Our data support a functional importance of the ABCB1 mutations for plasma concentrations and central nervous actions of the opioid loperamide. ..
  58. Hodge C, Jewell M, Gummin D, Leikin J. Atypical presentation of risperidone toxicity. Vet Hum Toxicol. 2001;43:339-41 pubmed
    ..Both patients presented with fatigue, orthostasis, dry mucous membranes, and the unusual finding of miosis. The pathophysiology and clinical presentation of overdose with this agent are discussed.
  59. Szkudlarek H, Herdzina O, Lewandowski M. Ultra-slow oscillatory neuronal activity in the rat olivary pretectal nucleus: comparison with oscillations within the intergeniculate leaflet. Eur J Neurosci. 2008;27:2657-64 pubmed publisher
    ..Alternatively, IGL might be involved in pupil diameter regulation. ..
  60. Hulet S, Sommerville D, Crosier R, Dabisch P, Miller D, Benton B, et al. Comparison of low-level sarin and cyclosarin vapor exposure on pupil size of the Gottingen minipig: effects of exposure concentration and duration. Inhal Toxicol. 2006;18:143-53 pubmed
    The current studies estimated effective (miosis) concentrations of the nerve agents' sarin (GB) and cyclosarin (GF) as a function of exposure duration in the Gottingen minipig and determined dependency of the median effective dosage (..
  61. Kummer O, Hammann F, Moser C, Schaller O, Drewe J, Krahenbuhl S. Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Eur J Clin Pharmacol. 2011;67:63-71 pubmed publisher
    ..Pharmacodynamic changes associated with CYP3A4 inhibition may be clinically important in patients treated with oxycodone. ..
  62. Matouskova O, Slanar O, Chytil L, Perlik F. Pupillometry in healthy volunteers as a biomarker of tramadol efficacy. J Clin Pharm Ther. 2011;36:513-7 pubmed publisher
    ..This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers...
  63. Gouveia R, Parreira E, Pavão Martins I. Autonomic features in cluster headache. Exploratory factor analysis. J Headache Pain. 2005;6:20-3 pubmed
    ..analysis: parasympathetic activation (lacrimation, conjunctival injection and rhinorrhoea), sympathetic defect (miosis and ptosis) and parasympathetic mediated effect (nasal congestion, eyelid oedema and forehead sweating)...
  64. Dey M, Madill S, Pagano D, Matthews T. Transient visual loss secondary to retinitis pigmentosa and opioid-induced miosis. Anaesthesia. 2008;63:888 pubmed publisher
  65. Duquaine S, Kitchell E, Tate T, Tannen R, Wickremasinghe I. Central nervous system toxicity associated with ertapenem use. Ann Pharmacother. 2011;45:e6 pubmed publisher
    ..To report stroke-like symptoms and unusual central nervous system adverse effects in 2 elderly patients receiving ertapenem...
  66. Hysek C, Liechti M. Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex. Psychopharmacology (Berl). 2012;224:363-76 pubmed publisher
    ..Clonidine did not significantly reduce the mydriatic effects of MDMA, although it produced miosis when administered alone. Carvedilol and doxazosin did not alter the effects of MDMA on pupillary function...
  67. Altoaimi B, Almutairi M, Kollbaum P, Bradley A. Accommodative Behavior of Eyes Wearing Aspheric Single Vision Contact Lenses. Optom Vis Sci. 2017;94:971-980 pubmed publisher
    ..Interestingly, in this study, pupil miosis was fully or partially able to compensate for the additional accommodation-induced negative SA...
  68. Guandalini P. The efferent connections of the pupillary constriction area in the rat medial frontal cortex. Brain Res. 2003;962:27-40 pubmed
    ..These findings led us to assume that, in the medial frontal cortex of the rat, besides controlling pupillary constriction, the pupillary constriction area may also be involved in controlling orientation and exploring behavior. ..
  69. Dabisch P, Horsmon M, Muse W, Mioduszewski R, Thomson S. Muscarinic receptor dysfunction induced by exposure to low levels of soman vapor. Toxicol Sci. 2007;100:281-9 pubmed
    ..Rats exposed to low levels of soman vapor dose-dependently developed miosis (threshold dose between 4.1 and 6.1 mg-min/m3)...
  70. Charman W, Radhakrishnan H. Accommodation, pupil diameter and myopia. Ophthalmic Physiol Opt. 2009;29:72-9 pubmed publisher
    ..to explore the possibilities that pupil diameters with relaxed accommodation were larger, and that accommodative miosis was weaker, in the myopic group...
  71. Szabadi E, Bradshaw C, Freeman C, Scaife J, Hou R, Langley R. The histaminergic system of the brain: its roles in arousal and autonomic regulation. Neuropsychopharmacol Hung. 2004;6:163-4 pubmed
  72. Straetmans J, Lok W, Stokroos R. Horner's syndrome as a complication of acute otitis media. B-ENT. 2006;2:181-4 pubmed
    A seventeen-year-old girl presented with acute otitis media, unilateral miosis and ptosis (partial Horner's syndrome) and tenderness of the ipsilateral jugular vein...
  73. Timby N, Stattin E, Kristiansen I, Eriksson U, Erikson A. Early onset autosomal dominant spinocerebellar ataxia with miosis: four cases. Eur J Paediatr Neurol. 2008;12:38-40 pubmed
    ..describe a family with four members through three generations with autosomal dominant ataxia in combination with miosis and hyperreflexia...
  74. Asakawa K, Shoji N, Ishikawa H, Tanakadate A. [Evaluation of age-related pupil constriction in pupil perimetry]. Nippon Ganka Gakkai Zasshi. 2009;113:727-31 pubmed
    ..Percentage of pupil constriction at each point was approximately 25%. Pupil miosis has hardly changed with age...
  75. Matsui M, Motomura D, Fujikawa T, Jiang J, Takahashi S, Manabe T, et al. Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci. 2002;22:10627-32 pubmed
    ..These results collectively suggest that an additional mechanism operates in the control of pupillary constriction-dilatation...
  76. Tokmakov A, Iwasaki T, Itakura S, Sato K, Shirouzu M, Fukami Y, et al. Regulation of Src kinase activity during Xenopus oocyte maturation. Dev Biol. 2005;278:289-300 pubmed
    ..Our data suggest that the Src kinase acts through the MAPK pathway to accelerate oocyte maturation...
  77. Cambron M, Maertens H, Crevits L. Apraclonidine and my pupil. Clin Auton Res. 2011;21:347-51 pubmed publisher
    ..Therefore, the effect of apraclonidine on pupillary parameters was investigated in 14 healthy volunteers...
  78. Giffin N, Goadsby P. Basilar artery aneurysm with autonomic features: an interesting pathophysiological problem. J Neurol Neurosurg Psychiatry. 2001;71:805-8 pubmed
    ..The relevant anatomy and proposed mechanism of autonomic involvement of what may be considered--from a pathophysiological perspective as a secondary trigeminal-autonomic cephalgia--is discussed..
  79. Dabisch P, Miller D, Reutter S, Mioduszewski R, Thomson S. Miotic tolerance to sarin vapor exposure: role of the sympathetic and parasympathetic nervous systems. Toxicol Sci. 2005;85:1041-7 pubmed
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  81. Morgan M, Hackett L, Isbister G. Olanzapine overdose: a series of analytically confirmed cases. Int Clin Psychopharmacol. 2007;22:183-6 pubmed
    ..Olanzapine overdose was characterized by tachycardia (73%), central nervous system depression (43%), miosis (39%) and delirium (54%), which were either present on admission or developed within 6 h...
  82. Islam N, Mehta J, Plant G. True polycoria or pseudo-polycoria?. Acta Ophthalmol Scand. 2007;85:805-6 pubmed
  83. Adoni A, McNett M. The pupillary response in traumatic brain injury: a guide for trauma nurses. J Trauma Nurs. 2007;14:191-6; quiz 197-8 pubmed
    ..A case study is provided to illustrate the application of this information among patients with TBI...
  84. Garbo G, Harmatz A, Isaacson G. Incomplete Horner syndrome: Report of a case and description of the sympathetic nervous system anatomy involved in Horner syndrome. Ear Nose Throat J. 2011;90:E16 pubmed
    Horner syndrome, in which ptosis, miosis, and anhidrosis occur concomitantly, can arise from injury to the sympathetic nerve pathways anywhere from the brain to the end organs. Incomplete Horner syndrome lacks the sign of anhidrosis...
  85. Liou S, Chen C. Maintenance of mydriasis with one bolus of epinephrine injection during phacoemulsification. J Ocul Pharmacol Ther. 2001;17:249-53 pubmed
    Surgically-induced miosis commonly occurs during cataract extraction surgery, complicating removal of lens cortex and placement of a posterior chamber intraocular lens...
  86. Okudera H. Clinical features on nerve gas terrorism in Matsumoto. J Clin Neurosci. 2002;9:17-21 pubmed
    ..b>Miosis was the most common finding in the affected people...
  87. Songsasen N, Yu I, Gomez M, Leibo S. Effects of meiosis-inhibiting agents and equine chorionic gonadotropin on nuclear maturation of canine oocytes. Mol Reprod Dev. 2003;65:435-45 pubmed
    ..This study showed that in vitro maturation of canine oocytes can be somewhat improved by short exposure of oocytes to eCG. However, further studies are still required to derive effective methods to mature canine oocytes in vitro...
  88. Ramprasad V, Sripriya S, Ronnie G, Nancarrow D, Saxena S, Hemamalini A, et al. Genetic homogeneity for inherited congenital microcoria loci in an Asian Indian pedigree. Mol Vis. 2005;11:934-40 pubmed
    ..In the current study, a three generation Asian Indian family with 15 congenital microcoria (pupils with a diameter <2 mm) affected members was studied for linkage to candidate microsatellite markers at the 13q31-q32 locus...
  89. Jones J, Francis P. Ophthalmic utility of topical bromfenac, a twice-daily nonsteroidal anti-inflammatory agent. Expert Opin Pharmacother. 2009;10:2379-85 pubmed publisher
    ..Bromfenac and other NSAIDs are seeing expanded use for the treatment and prevention of cystoid macular edema, and could have clinical utility in other diseases of vascular permeability...
  90. Yang C, Lee J, Wu C, Tsai J, Chou S, Huang M. Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. Chest. 2012;142:246-251 pubmed publisher
  91. Kaufman T. A Short History and Description of Drosophila melanogaster Classical Genetics: Chromosome Aberrations, Forward Genetic Screens, and the Nature of Mutations. Genetics. 2017;206:665-689 pubmed publisher
    ..These are a book by Ralph Greenspan and a review article by John Roote and Andreas Prokop, which should be required reading for any new student entering a fly lab for the first time. ..
  92. Tassorelli C, Spampinato D, Caruso P, Cavaliere S, Micieli G, Drago F, et al. Neurotensin-induced miosis: the role of dopaminergic pathways. Peptides. 1990;11:1309-11 pubmed
    ..Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin...