Summary: Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.

Top Publications

  1. Ferrucci L, de Cabo R, Knuth N, Studenski S. Of Greek heroes, wiggling worms, mighty mice, and old body builders. J Gerontol A Biol Sci Med Sci. 2012;67:13-6 pubmed publisher
  2. Matsushima K, Inaba K, Jhaveri V, Cheng V, Herr K, Siboni S, et al. Loss of muscle mass: a significant predictor of postoperative complications in acute diverticulitis. J Surg Res. 2017;211:39-44 pubmed publisher
    Severe muscle mass depletion, sarcopenia, has been shown to be associated with poor operative outcomes. However, its impact on emergency abdominal operations remains unclear...
  3. Cesari M, Marzetti E, Calvani R, Vellas B, Bernabei R, Bordes P, et al. The need of operational paradigms for frailty in older persons: the SPRINTT project. Aging Clin Exp Res. 2017;29:3-10 pubmed publisher
    ..In this context, the recently funded "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) project (largely based on ..
  4. Harada H, Kai H, Shibata R, Niiyama H, Nishiyama Y, Murohara T, et al. New diagnostic index for sarcopenia in patients with cardiovascular diseases. PLoS ONE. 2017;12:e0178123 pubmed publisher
    b>Sarcopenia is an aging and disease-related syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, with the risk of frailty and poor quality of life...
  5. Martone A, Marzetti E, Calvani R, Picca A, Tosato M, Santoro L, et al. Exercise and Protein Intake: A Synergistic Approach against Sarcopenia. Biomed Res Int. 2017;2017:2672435 pubmed publisher
    b>Sarcopenia, the age-dependent loss of muscle mass and function/strength, is increasingly recognized as a major risk factor for adverse outcomes in frail older people...
  6. Šteffl M, Chrudimsky J, Tufano J. Using relative handgrip strength to identify children at risk of sarcopenic obesity. PLoS ONE. 2017;12:e0177006 pubmed publisher
    ..918 (4.243-23.186, p ? 0.001) and was 11.515 (4.280-30.982, p ? 0.001) for boys. The grip-to-BMI ratio can be used to predict the presence of sarcopenic obesity in children, which can play a role in pediatric health interventions. ..
  7. Gielen E, Bergmann P, Bruyère O, Cavalier E, Delanaye P, Goemaere S, et al. Osteoporosis in Frail Patients: A Consensus Paper of the Belgian Bone Club. Calcif Tissue Int. 2017;101:111-131 pubmed publisher
    ..frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old...
  8. McBride M, Foley K, D Souza D, Li Y, Lau T, Hawke T, et al. The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice. Am J Physiol Endocrinol Metab. 2017;313:E222-E232 pubmed publisher
    ..Inflammaging," increased inflammation with advancing age, may contribute to aspects of sarcopenia, but little is known about the participatory immune components...
  9. Hamer M, O Donovan G. Sarcopenic obesity, weight loss, and mortality: the English Longitudinal Study of Ageing. Am J Clin Nutr. 2017;106:125-129 pubmed publisher
    b>Background: Age-related sarcopenia describes the loss of muscle strength and often accompanies an increase in adiposity in the elderly...

More Information


  1. Marzetti E, Calvani R, Tosato M, Cesari M, Di Bari M, Cherubini A, et al. Physical activity and exercise as countermeasures to physical frailty and sarcopenia. Aging Clin Exp Res. 2017;29:35-42 pubmed publisher
    ..In advanced age, physical activity is also effective at mitigating sarcopenia, restoring robustness, and preventing/delaying the development of disability...
  2. Culebras J. Malnutrition in the twenty-first century: an epidemic affecting surgical outcome. Surg Infect (Larchmt). 2013;14:237-43 pubmed publisher
  3. Guillory B, Chen J, Patel S, Luo J, Splenser A, Mody A, et al. Deletion of ghrelin prevents aging-associated obesity and muscle dysfunction without affecting longevity. Aging Cell. 2017;16:859-869 pubmed publisher
    ..These findings highlight the relevance of ghrelin during aging and identify a novel AMPK-dependent mechanism for ghrelin action in muscle. ..
  4. Moore D. Keeping older muscle “young” through dietary protein and physical activity. Adv Nutr. 2014;5:599S-607S pubmed
    b>Sarcopenia is characterized by decreases in both muscle mass and muscle function...
  5. Montano Loza A. Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transpl. 2014;20:1424 pubmed publisher
  6. Laviano A. Young blood. N Engl J Med. 2014;371:573-5 pubmed publisher
  7. Morley J. Frailty screening comes of age. J Nutr Health Aging. 2014;18:453-4 pubmed publisher
  8. Miyake M, Morizawa Y, Hori S, Marugami N, Shimada K, Gotoh D, et al. Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder. BMC Cancer. 2017;17:237 pubmed publisher
    ..2, P = 0.02]. Multivariate analyzes identified sarcopenia status at baseline (HR 2.2, P = 0.03) and a ? -10% loss in the psoas muscle (HR 2.4, P = 0...
  9. Šteffl M, Bohannon R, Sontakova L, Tufano J, Shiells K, Holmerová I. Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis. Clin Interv Aging. 2017;12:835-845 pubmed publisher
    Physical activity (PA) has been identified as beneficial for many diseases and health disorders, including sarcopenia. The positive influence of PA interventions on sarcopenia has been described previously on many occasions...
  10. Schaap L, Koster A, Visser M. Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons. Epidemiol Rev. 2013;35:51-65 pubmed publisher
    ..19, 95% CI: 0.98, 1.45). Future intervention research should focus on positive changes in body composition to prevent onset or worsening of functional decline in old age. ..
  11. Elliott J, Doyle S, Murphy C, King S, Guinan E, Beddy P, et al. Sarcopenia: Prevalence, and Impact on Operative and Oncologic Outcomes in the Multimodal Management of Locally Advanced Esophageal Cancer. Ann Surg. 2017;266:822-830 pubmed publisher
    The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.
  12. Williamson D. Normalizing a hyperactive mTOR initiates muscle growth during obesity. Aging (Albany NY). 2011;3:83-4 pubmed
  13. Kizer J. Adiponectin, cardiovascular disease, and mortality: parsing the dual prognostic implications of a complex adipokine. Metabolism. 2014;63:1079-83 pubmed publisher
  14. Hopkins J, Sawyer M. A review of body composition and pharmacokinetics in oncology. Expert Rev Clin Pharmacol. 2017;10:947-956 pubmed publisher
    ..A comprehensive review of the predictive value of low lean mass (sarcopenia) in dose-limiting toxicities is also included...
  15. Malafarina V, Uriz Otano F, Malafarina C, Martinez J, Zulet M. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial. Maturitas. 2017;101:42-50 pubmed publisher
    ..mobility in elderly patients with a hip fracture are associated with a loss of both muscle mass and function (sarcopenia)...
  16. Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry R, et al. Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. J Am Geriatr Soc. 2017;65:1988-1995 pubmed publisher
    To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations. A 24-week, randomized, double-blind, placebo-controlled, parallel-arm, proof-of-concept study...
  17. Beaudart C, Reginster J, Geerinck A, Locquet M, Bruyere O. Current review of the SarQoL®: a health-related quality of life questionnaire specific to sarcopenia. Expert Rev Pharmacoecon Outcomes Res. 2017;17:335-341 pubmed publisher
    b>Sarcopenia, defined by a progressive and generalized loss of muscle mass and muscle function, is associated with many harmful clinical consequences...
  18. Steihaug O, Gjesdal C, Bogen B, Kristoffersen M, Lien G, Ranhoff A. Sarcopenia in patients with hip fracture: A multicenter cross-sectional study. PLoS ONE. 2017;12:e0184780 pubmed publisher
    b>Sarcopenia is prevalent in older persons and is a risk factor for falls, fractures, and mortality...
  19. Toyoshima K, Nakamura M, Adachi Y, Imaizumi A, Hakamada T, Abe Y, et al. Increased plasma proline concentrations are associated with sarcopenia in the elderly. PLoS ONE. 2017;12:e0185206 pubmed publisher
    ..It remains unclear, however, whether plasma amino acid profiles change in patients with sarcopenia. This study therefore aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid ..
  20. Han E, Lee Y, Lee B, Kang E, Cha B. Pre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance: Nationwide Surveys (KNHANES 2008-2011). Medicine (Baltimore). 2017;96:e7165 pubmed publisher
    ..Despite the well-established association between cardiometabolic diseases and sarcopenia, the relationship between renal hyperfiltration and sarcopenia has not yet been assessed...
  21. Zhou C, Zhang F, Zhang F, Yu Z, Chen X, Shen X, et al. Sarcopenia: a new predictor of postoperative complications for elderly gastric cancer patients who underwent radical gastrectomy. J Surg Res. 2017;211:137-146 pubmed publisher
    ..The present study aimed to investigate the predictive effect of sarcopenia on the postoperative complications for elderly patients who underwent radical gastrectomy...
  22. Liao C, Tsauo J, Wu Y, Cheng C, Chen H, Huang Y, et al. Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis. Am J Clin Nutr. 2017;106:1078-1091 pubmed publisher
    ..Clinicians could use nutrition supplement and exercise strategies, especially PS plus RET, to effectively improve the physical activity and health status of all older patients. ..
  23. Cesari M, Vellas B. Sarcopenia: a novel clinical condition or still a matter for research?. J Am Med Dir Assoc. 2012;13:766-7 pubmed publisher
  24. Burd N, Wall B, van Loon L. The curious case of anabolic resistance: old wives' tales or new fables?. J Appl Physiol (1985). 2012;112:1233-5 pubmed publisher
  25. Miyata H, Sugimura K, Motoori M, Fujiwara Y, Omori T, Yanagimoto Y, et al. Clinical Assessment of Sarcopenia and Changes in Body Composition During Neoadjuvant Chemotherapy for Esophageal Cancer. Anticancer Res. 2017;37:3053-3059 pubmed
    ..Forty-four (46.8%) and 50 (53.2%) out of 94 patients were defined as having sarcopenia before and after NAC, respectively...
  26. Wilson D, Jackson T, Sapey E, Lord J. Frailty and sarcopenia: The potential role of an aged immune system. Ageing Res Rev. 2017;36:1-10 pubmed publisher
    Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of muscle mass, quality and strength, is more common in older adults and has been considered a precursor syndrome or the physical manifestation of ..
  27. Cruz Jentoft A, Kiesswetter E, Drey M, Sieber C. Nutrition, frailty, and sarcopenia. Aging Clin Exp Res. 2017;29:43-48 pubmed publisher
    Frailty and sarcopenia are important concepts in the quest to prevent physical dependence, as geriatrics are shifting towards identifications of early stages of disability...
  28. Lin C, Lin W, Meng N, Li C, Liu C, Lin C, et al. Sarcopenia prevalence and associated factors in an elderly Taiwanese metropolitan population. J Am Geriatr Soc. 2013;61:459-62 pubmed publisher
  29. Furushima T, Miyachi M, Iemitsu M, Murakami H, Kawano H, Gando Y, et al. Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women. J Physiol Anthropol. 2017;36:34 pubmed publisher
    ..equations for estimating appendicular skeletal muscle mass (ASM) and to examine the relationship between sarcopenia defined by the prediction equations and risk factors for cardiovascular diseases (CVD) or osteoporosis in ..
  30. Michel J. Sarcopenia: there is a need for some steps forward. J Am Med Dir Assoc. 2014;15:379-80 pubmed publisher
  31. Ebadi M, Martin L, Ghosh S, Field C, Lehner R, Baracos V, et al. Subcutaneous adiposity is an independent predictor of mortality in cancer patients. Br J Cancer. 2017;117:148-155 pubmed publisher
    ..tissue in predicting mortality, importance of visceral and subcutaneous adiposity in the presence and absence of sarcopenia on survival, was investigated...
  32. Lozano Montoya I, Correa Pérez A, Abraha I, Soiza R, Cherubini A, O Mahony D, et al. Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series. Clin Interv Aging. 2017;12:721-740 pubmed publisher
    Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death...
  33. Rosansky S. The sad truth about early initiation of dialysis in elderly patients. JAMA. 2012;307:1919-20 pubmed publisher
  34. Arai H, Akishita M, Chen L. Growing research on sarcopenia in Asia. Geriatr Gerontol Int. 2014;14 Suppl 1:1-7 pubmed publisher
  35. Cruz Jentoft A, Landi F. Sarcopenia. Clin Med (Lond). 2014;14:183-6 pubmed publisher
  36. Parker Autry C, Houston D, Rushing J, Richter H, Subak L, Kanaya A, et al. Characterizing the Functional Decline of Older Women With Incident Urinary Incontinence. Obstet Gynecol. 2017;130:1025-1032 pubmed publisher
    ..characterize change in physical performance and differential prevalence of low skeletal muscle mass and strength (sarcopenia) and lower 25-hydroxyvitamin D concentrations among older women who developed urinary incontinence (UI) symptoms.
  37. Cesari M, Landi F, Calvani R, Cherubini A, Di Bari M, Kortebein P, et al. Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial. Aging Clin Exp Res. 2017;29:81-88 pubmed publisher
    ..article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the "Sarcopenia and Physical Frailty in Older People: Multicomponent ..
  38. Liao C, Tsauo J, Lin L, Huang S, Ku J, Chou L, et al. Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity: A CONSORT-compliant prospective randomized controlled trial. Medicine (Baltimore). 2017;96:e7115 pubmed publisher
    b>Sarcopenia is associated with loss of muscle mass and an increased risk of physical disability in elderly people. However, the prevalence of sarcopenia has increased in obese elderly populations...
  39. Bellumkonda L, Tyrrell D, Hummel S, Goldstein D. Pathophysiology of heart failure and frailty: a common inflammatory origin?. Aging Cell. 2017;16:444-450 pubmed publisher
    ..The condition is associated with circulating inflammatory cytokines and sarcopenia, features that are shared with heart failure (HF)...
  40. Malmstrom T, Morley J. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia. J Am Med Dir Assoc. 2013;14:531-2 pubmed publisher
  41. Moisey L, Mourtzakis M, Cotton B, Premji T, Heyland D, Wade C, et al. Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care. 2013;17:R206 pubmed publisher
    ..93, 95% CI: 0.875-0.997, P = 0.025). In addition, multivariate linear regression showed that sarcopenia, but not muscle index, was associated with decreased ventilator-free (P = 0.004) and ICU-free days (P = 0.002)...
  42. Benoit B, Meugnier E, Castelli M, Chanon S, Vieille Marchiset A, Durand C, et al. Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nat Med. 2017;23:990-996 pubmed publisher mice, FGF19 ameliorates skeletal muscle atrophy induced by glucocorticoid treatment or obesity, as well as sarcopenia. Taken together, these findings provide evidence that the enterokine FGF19 is a novel factor in the regulation ..
  43. Yamada Y, Buehring B, Krueger D, Anderson R, Schoeller D, Binkley N. Electrical Properties Assessed by Bioelectrical Impedance Spectroscopy as Biomarkers of Age-related Loss of Skeletal Muscle Quantity and Quality. J Gerontol A Biol Sci Med Sci. 2017;72:1180-1186 pubmed publisher
    ..This finding underscores the value of S-BIS to measure muscle composition rather than lean mass as measured by DXA and suggests that S-BIS should be highly informative in skeletal muscle physiology. ..
  44. Souza V, Oliveira D, Barbosa S, Corrêa J, Colugnati F, Mansur H, et al. Sarcopenia in patients with chronic kidney disease not yet on dialysis: Analysis of the prevalence and associated factors. PLoS ONE. 2017;12:e0176230 pubmed publisher
    b>Sarcopenia is a chronic condition that is associated with aging and characterized by a reduction of muscle mass, strength, and function...
  45. Alkahtani S. A cross-sectional study on sarcopenia using different methods: reference values for healthy Saudi young men. BMC Musculoskelet Disord. 2017;18:119 pubmed publisher
    The aim of this study was to determine reference values for sarcopenia indices using different methods in healthy Saudi young men. Participants included 232 Saudi men aged between 20 and 35 years...
  46. Hepple R. Muscle atrophy is not always sarcopenia. J Appl Physiol (1985). 2012;113:677-9 pubmed publisher
  47. Phillips S, Dickerson R, Moore F, Paddon Jones D, Weijs P. Protein Turnover and Metabolism in the Elderly Intensive Care Unit Patient. Nutr Clin Pract. 2017;32:112S-120S pubmed publisher
    ..It is likely that the older patient is already experiencing muscle loss due to sarcopenia; however, the period of stay in the ICU represents a greatly accelerated period of muscle loss...
  48. Zhang N, Valentine J, Zhou Y, Li M, Zhang Y, Bhattacharya A, et al. Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell. 2017;16:847-858 pubmed publisher
    Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown...
  49. Tamaki H, Yotani K, Ogita F, Hayao K, Nakagawa K, Sugawara K, et al. Electrical Stimulation of Denervated Rat Skeletal Muscle Ameliorates Bone Fragility and Muscle Loss in Early-Stage Disuse Musculoskeletal Atrophy. Calcif Tissue Int. 2017;100:420-430 pubmed publisher
  50. Bouchi R, Fukuda T, Takeuchi T, Nakano Y, Murakami M, Minami I, et al. Insulin Treatment Attenuates Decline of Muscle Mass in Japanese Patients with Type 2 Diabetes. Calcif Tissue Int. 2017;101:1-8 pubmed publisher
    b>Sarcopenia is defined as an age-related loss of skeletal muscle mass and strength, and is a major cause of disability and mobility limitations...
  51. Lucassen E, de Mutsert R, le Cessie S, Appelman Dijkstra N, Rosendaal F, van Heemst D, et al. Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study. PLoS ONE. 2017;12:e0176685 pubmed publisher
    Sleep deprivation has detrimental metabolic consequences. Osteopenia and sarcopenia usually occur together and increase risk of fractures and disease...
  52. Bondi M, Germinario E, Pirazzini M, Zanetti G, Cencetti F, Donati C, et al. Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity. Am J Physiol Cell Physiol. 2017;313:C54-C67 pubmed publisher
    ..We conclude that in the absence of S1P3, soleus muscle is protected from the decrease in muscle mass and force, and the attenuation of regenerative capacity, all of which are typical characteristics of aging. ..
  53. Roshanravan B, Gamboa J, Wilund K. Exercise and CKD: Skeletal Muscle Dysfunction and Practical Application of Exercise to Prevent and Treat Physical Impairments in CKD. Am J Kidney Dis. 2017;69:837-852 pubmed publisher
  54. Conlon J, Newton R, Tufano J, Peñailillo L, Banyard H, Hopper A, et al. The efficacy of periodised resistance training on neuromuscular adaptation in older adults. Eur J Appl Physiol. 2017;117:1181-1194 pubmed publisher
    ..Consequently, periodisation strategies are not essential for optimising neuromuscular adaptations during the initial stages of resistance training in the aging population. ..
  55. Reijnierse E, de van der Schueren M, Trappenburg M, Doves M, Meskers C, Maier A. Lack of knowledge and availability of diagnostic equipment could hinder the diagnosis of sarcopenia and its management. PLoS ONE. 2017;12:e0185837 pubmed publisher
    b>Sarcopenia is an emerging clinical challenge in an ageing population and is associated with serious negative health outcomes...
  56. Kim G, Kang S, Kim M, Baik S. Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0186990 pubmed publisher
    b>Sarcopenia is a common syndrome in chronic diseases such as liver cirrhosis. The association between sarcopenia and outcomes, such as complications and survival has recently been described in various patient groups...
  57. Bamba S, Sasaki M, Takaoka A, Takahashi K, Imaeda H, Nishida A, et al. Sarcopenia is a predictive factor for intestinal resection in admitted patients with Crohn's disease. PLoS ONE. 2017;12:e0180036 pubmed publisher
    ..of skeletal muscles at the level of the third lumbar (L3) vertebra to the height squared, was used to identify sarcopenia. Sarcopenia, defined as a low SMI, was observed in 42% of all IBD patients (37% with Crohn's disease (CD) and 48%..
  58. Sebastian D, Palacin M, Zorzano A. Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging. Trends Mol Med. 2017;23:201-215 pubmed publisher
    ..We propose that the dysregulation of mitochondrial dynamics leads to age-induced accumulation of unhealthy mitochondria and contributes to alterations linked to aging, such as diabetes and neurodegeneration. ..
  59. Chastin S, Ferriolli E, Stephens N, Fearon K, Greig C. Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults. Age Ageing. 2012;41:111-4 pubmed publisher