muscle hypertonia

Summary

Summary: Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.

Top Publications

  1. Chung S, Vanbellinghen J, Mullins J, Robinson A, Hantke J, Hammond C, et al. Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia. J Neurosci. 2010;30:9612-20 pubmed publisher
    ..This study also reports the first hyperekplexia mutation associated with a GlyR leak conductance, suggesting tonic channel opening as a new mechanism in neuronal ligand-gated ion channels...
  2. Bakheit A, Fheodoroff K, Molteni F. Spasticity or reversible muscle hypertonia?. J Rehabil Med. 2011;43:556-7 pubmed publisher
    ..In this report we propose an alternative terminology and explain the reasons for doing so...
  3. Hobbelen J, Koopmans R, Verhey F, van Peppen R, de Bie R. Paratonia: a Delphi procedure for consensus definition. J Geriatr Phys Ther. 2006;29:50-6 pubmed
    ..For this reason, we initiated a Delphi procedure with known experts in the field to establish an operational consensus definition of paratonia...
  4. Harvey R, Topf M, Harvey K, Rees M. The genetics of hyperekplexia: more than startle!. Trends Genet. 2008;24:439-47 pubmed publisher
  5. Stetkarova I, Yablon S, Kofler M, Stokic D. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010;24:609-19 pubmed publisher
    Intrathecal baclofen (ITB) effectively reduces muscle hypertonia; however, associated complications influence its utility and acceptance.
  6. Chartier Kastler E, Denys P, Chancellor M, Haertig A, Bussel B, Richard F. Urodynamic monitoring during percutaneous sacral nerve neurostimulation in patients with neurogenic detrusor hyperreflexia. Neurourol Urodyn. 2001;20:61-71 pubmed
    ..3 cm H2O, -38%, P < 0.01). Acute temporary SNS in SCI patients has a profound effect on key urodynamics parameters. These neurologically impaired patients with detrusor hyperreflexia may be appropriate candidates for implantable SNS...
  7. Casale R, Glynn C, Buonocore M. Reduction of spastic hypertonia in patients with spinal cord injury: a double-blind comparison of intravenous orphenadrine citrate and placebo. Arch Phys Med Rehabil. 1995;76:660-5 pubmed
    ..This could be relevant in the rehabilitation strategy, although further studies are needed on the duration of its action...
  8. van de Warrenburg B, Cordivari C, Brown P, Bhatia K. Persisting hyperekplexia after idiopathic, self-limiting brainstem encephalopathy. Mov Disord. 2007;22:1017-20 pubmed
    ..Trismus was the presenting feature, but she later developed hyperekplexia. Although most brainstem features resolved spontaneously, the hyperekplexia has persisted...
  9. Altman R, Li K, Brand D. Infections and apparent life-threatening events. Clin Pediatr (Phila). 2008;47:372-8 pubmed

More Information

Publications62

  1. Ben Youssef Turki I, Kraoua I, Gargouri A, Akopova Larbi R, Gouider R, Gouider Khouja N. [Slow channel syndrome: clinical and neurophysiological aspects]. Tunis Med. 2008;86:202-4 pubmed
  2. Torrabadella L, Salgado G, Burns R, Berman I. Manometric study of topical sildenafil (Viagra) in patients with chronic anal fissure: sildenafil reduces anal resting tone. Dis Colon Rectum. 2004;47:733-8 pubmed
    ..This article describes manometric analysis of the effects of a phosphodiesterase-5 inhibitor, topical sildenafil (Viagra) in 19 consecutive patients with chronic anal fissure with no previous treatment history...
  3. Tsai S, Lew H, Date E, Bih L. Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. Arch Phys Med Rehabil. 2002;83:714-7 pubmed
    ..To study the effects of pudendal nerve block with phenol on detrusor-sphincter dyssynergia in patients with spinal cord injury (SCI)...
  4. Pfitzenmeyer P, Martin Hunyadi C, Mourey F, D Athis P, Baudouin N, Mischis Troussard C. Cardiovascular characteristics and cerebral CT findings in elderly subjects with psychomotor disadaptation syndrome. Aging Clin Exp Res. 2002;14:100-7 pubmed
    ..The aim of this study was to complete the clinical picture, record cardiovascular risk factors and provide cerebral CT scan findings in patients with PDS...
  5. Sakakibara R, Ito T, Uchiyama T, Asahina M, Liu Z, Yamamoto T, et al. Lower urinary tract function in dementia of Lewy body type. J Neurol Neurosurg Psychiatry. 2005;76:729-32 pubmed
    ..Lower urinary tract (LUT) function in DLB has not been fully delineated. We investigated LUT function in DLB by evaluating clinical and urodynamic data...
  6. Yang T, Fu C, Kao N, Chan R, Chen S. Effect of botulinum toxin type A on cerebral palsy with upper limb spasticity. Am J Phys Med Rehabil. 2003;82:284-9 pubmed
    ..The objective of this study was to investigate the effects of botulinum toxin type A injections in reducing upper limb muscular spasticity and in improving motor function in children with cerebral palsy...
  7. Lannin N, Novak I, Cusick A. A systematic review of upper extremity casting for children and adults with central nervous system motor disorders. Clin Rehabil. 2007;21:963-76 pubmed
    ..To summarize evidence on the use of upper extremity casting designed to achieve reductions in contracture, tone, pain, function, oedema or spasticity in the elbow, wrist or hand of adults and children with neurological conditions...
  8. Zhang J, Wang Z, Zhang X. [Treatment of dyskinetic disorders with tremor by lesioning and DBS of Vim]. Zhonghua Yi Xue Za Zhi. 2001;81:792-3 pubmed
    ..To explore the effect of stereotactic operation in treatment of dyskinetic disorders with tremor as the main symptom and to study the value of anatomic location and microelectrode functional location...
  9. Fehlings D, Novak I, Berweck S, Hoare B, Stott N, Russo R. Botulinum toxin assessment, intervention and follow-up for paediatric upper limb hypertonicity: international consensus statement. Eur J Neurol. 2010;17 Suppl 2:38-56 pubmed publisher
    ..BoNT injections were generally found to be safe and well tolerated with the most common side effect identified as a transient decrease in grip strength...
  10. Drobyshevsky A, Luo K, Derrick M, Yu L, Du H, Prasad P, et al. Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. J Neurosci. 2012;32:5500-9 pubmed publisher
    ..The etiological link between early injury and later motor deficits can thus be investigated by MRI, and allows us to distinguish between critical oxidative stress that causes motor deficits and noncritical oxidative stress that does not...
  11. Shirado O, Kawase M, Minami A, Strax T. Quantitative evaluation of long sitting in paraplegic patients with spinal cord injury. Arch Phys Med Rehabil. 2004;85:1251-6 pubmed
    ..To evaluate the characteristics of long sitting (ie, sitting with legs extended) in patients with spinal cord injury (SCI) and to compare these results with able-bodied control subjects...
  12. Schönberger B. [Overactive bladder--which diagnosis investigations are necessary before initiating primary treatment?]. Urologe A. 2003;42:787-92 pubmed
    ..An ex iuvantibus therapy with anticholinergic drugs--even if limited to 3 months--is not acceptable if the diagnostic minimal program is not used...
  13. Patel K, Macharia R, Amthor H. Molecular mechanisms involving IGF-1 and myostatin to induce muscle hypertrophy as a therapeutic strategy for Duchenne muscular dystrophy. Acta Myol. 2005;24:230-41 pubmed
  14. Schurch B, Schmid D, Karsenty G, Reitz A. Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury?. Urology. 2005;65:243-6 pubmed
  15. Chaliha C, Digesu G, Hutchings A, Khullar V. Changes in urethral function with bladder filling in the presence of urodynamic stress incontinence and detrusor overactivity. Am J Obstet Gynecol. 2005;192:60-5 pubmed
    ..The purpose of this study was to assess the effect of detrusor overactivity and bladder filling on urethral function with the use of urethral profilometry...
  16. Engel J, Jacobs D, Konsur B, Megaridis C, Bushman W. Urodynamic evaluation of the human bladder response to an increase in outlet resistance. Neurourol Urodyn. 2002;21:524-8 pubmed
    ..We prospectively evaluated the response of the human bladder to a chronic increase in urethral resistance according to the indices of pressure, volume flow rate, total (external) bladder work, and maximum and average detrusor power...
  17. Romoli M, Ridi R, Giommi A. [Electromyographic changes in bruxism after auricular stimulation. A randomized controlled clinical trial]. Minerva Med. 2003;94:9-15 pubmed
    ..The aim of this study was to verify in bruxism patients the possible efficacy of auricular stimulation in reducing the hypertonicity of some masticatory muscles...
  18. Leonard C. Childhood motor disorders. Pediatrics. 2003;112:1462-3; author reply 1462-3 pubmed
  19. Shenoy S, Pradeep G. Neurodevelopmental outcome of neonates with vertically transmitted Chikungunya fever with encephalopathy. Indian Pediatr. 2012;49:238-40 pubmed
    ..Neurodevelopmental follow-up of neonates with vertically transmitted Chikungunya fever has been infrequently reported. We herein report neurodevelopment follow up of two such babies at 3 year of age...
  20. Grippo A, Carrai R, Hawamdeh Z, Falsini C, Aito S, Pinto F, et al. Biomechanical and electromyographic assessment of spastic hypertonus in motor complete traumatic spinal cord-injured individuals. Spinal Cord. 2011;49:142-8 pubmed publisher
    ..Between-groups design with repeated measures...
  21. Chung S, Van Rey E, Bai Z, Rymer W, Roth E, Zhang L. Separate quantification of reflex and nonreflex components of spastic hypertonia in chronic hemiparesis. Arch Phys Med Rehabil. 2008;89:700-10 pubmed publisher
  22. Sheean G, Lannin N, Turner Stokes L, Rawicki B, Snow B. Botulinum toxin assessment, intervention and after-care for upper limb hypertonicity in adults: international consensus statement. Eur J Neurol. 2010;17 Suppl 2:74-93 pubmed publisher
    ..More research is needed to resolve many unknown issues of assessment and treatment, using research methods appropriate to the question...
  23. Jusić A. Differential diagnosis and treatment of muscle hypertonia as practiced in Zagreb's Centre/Institute for Neuromuscular Diseases. Acta Myol. 2013;32:170-3 pubmed
    Because I am a neuromyologist that has dealt for many years with muscle hypertonia, I decided to write my memories in order to motivate younger researchers to try to duplicate the same observations and experiences...
  24. Celik Y, Temizoz O, Genchellac H, Cakir B, Asil T. A non-alcoholic patient with acute Marchiafava-Bignami disease associated with gynecologic malignancy: paraneoplastic Marchiafava-Bignami disease?. Clin Neurol Neurosurg. 2007;109:505-8 pubmed
    ..Most of the reported cases of MBD are related to chronic ingestion of red wine and/or related with a nutritional cause. We suggest that this patient may suffer a MBD possible related to the ovarian cancer...
  25. Lobera E, Campistol J, Garcia Garcia J, Colomer J, Riverola A. [Congenital hyperekplexia as a cause of neonatal hypertonia]. Rev Neurol. 1997;25:86-8 pubmed
    ..Neurophysiological findings can give guidance to diagnosis. It's an autosomal dominant transmission disease, but sporadic cases can appear. Clonazepam is the drug of choice, obtaining a marked improvement in a lot of patients...
  26. Suzuki T, Saitoh E, Tani M, Nabeta R, Daikuya S, Hirose H, et al. Effect of continued stretching of the affected arm in patients with cerebrovascular diseases by examining H-reflex characteristics. Electromyogr Clin Neurophysiol. 2003;43:51-6 pubmed
    ..It is suggested that excitability of spinal neural function during 1 min. continued stretching was inhibited in the patients with moderately increased muscle tonus caused by CVD...
  27. McIntosh S, Drinnan M, Griffiths C, Robson W, Ramsden P, Pickard R. Noninvasive assessment of bladder contractility in men. J Urol. 2004;172:1394-8 pubmed
    ..We report on a large scale validation of a novel noninvasive assessment of detrusor contractility...
  28. Yeh C, Chen J, Tsai K. Quantitative analysis of ankle hypertonia after prolonged stretch in subjects with stroke. J Neurosci Methods. 2004;137:305-14 pubmed
    ..05). The present results suggested that the application of PMS with a constant torque could reduce not only the elasticity of the hypertonic muscles, but also their viscosity in the stroke patients...
  29. Iwabe C, Piovesana A. [Comparative study of muscular tonus in spastic tetraparetic cerebral palsy in children with predominantly cortical and subcortical lesions in computerized tomography of the skull]. Arq Neuropsiquiatr. 2003;61:617-20 pubmed
    ..To compare distribution and intensity of muscular tonus in spastic tetraparetic cerebral palsy (CP), correlating the clinical data with lesion location in the central nervous system...
  30. Zhao A, Urban J, Morimoto M, Elfrey J, Madden K, Finkelman F, et al. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Gastroenterology. 2006;131:568-78 pubmed
    ..Serotonin (5-HT) is involved in the physiologic regulation of gut function. The present study investigated the contribution of 5-HT and its receptors in nematode-induced intestinal smooth muscle hypercontractility...
  31. Rattan S, de Godoy M, Patel C. Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter. Gastroenterology. 2006;131:108-16 pubmed
    ..An increase in Rho kinase (ROK) activity has been associated with agonist-induced sustained contraction of the smooth muscle, but its role in the pathophysiology of spontaneously tonic smooth muscle is not known...
  32. Sharma S, Sarna A, Mukhopadhyay S. Neonatal hyperekplexia: the Stiff-Baby syndrome. Indian Pediatr. 2006;43:539-41 pubmed
    ..While the long-term prognosis is relatively benign, sudden death due to severe spasms have been seen in sporadic cases. We report a case of hyperekplexia with some typical and some unusual findings...
  33. Kessler T, Lackner J, Kiss G, Rehder P, Madersbacher H. Predictive value of initial urodynamic pattern on urinary continence in patients with myelomeningocele. Neurourol Urodyn. 2006;25:361-7 pubmed
    ..To investigate whether the initial urodynamic pattern may predict urinary continence and the need for adjunctive incontinence surgery in patients with myelomeningocele...
  34. Jundt K, Friese K. [Female urinary incontinence]. MMW Fortschr Med. 2005;147:26-9 pubmed
    ..Anticholinergics are the primary medication used in the treatment of urge incontinence. Local estrogens, low frequency electrical stimulation, phytotherapeutics and the like have supportive effects...
  35. Denys P, Even Schneider A, Thiry Escudie I, Ben Smail D, Ayoub N, Chartier Kastler E. [Efficacy of botulinum toxin A for the treatment of detrusor hyperreflexia]. Ann Readapt Med Phys. 2003;46:326-8 pubmed
    ..To determinate the efficacy of botulinum toxin to treat refractory urinary incontinence due to bladder hyperreflexia...
  36. Messina M, Amato G, Meucci D, Molinaro F, Nardi N. Topical application of isosorbide dinitrate in patients with persistent constipation after pull-through surgery for Hirschsprung's disease. Eur J Pediatr Surg. 2007;17:62-5 pubmed
  37. Gray M. Traces: making sense of urodynamics testing--Part 11: quantitative analysis of micturition via the voiding pressure flow study: pressure-flow nomograms. Urol Nurs. 2012;32:159-65, 147 pubmed
    ..This article discusses quantitative analysis of the voiding pressure flow study using nomograms that measure the magnitude of urethral resistance (bladder outflow obstruction) and/or detrusor contraction strength...
  38. Connaghan K, Moore C. Indirect estimates of jaw muscle tension in children with suspected hypertonia, children with suspected hypotonia, and matched controls. J Speech Lang Hear Res. 2013;56:123-36 pubmed publisher
    ..In this study, the authors compared indirect estimates of jaw-muscle tension in children with suspected muscle-tone abnormalities with age- and gender-matched controls...
  39. Delp S. What causes increased muscle stiffness in cerebral palsy?. Muscle Nerve. 2003;27:131-2 pubmed
  40. Miano S, Castaldo R, Ferri R, Peraita Adrados R, Paolino M, Montesano M, et al. Sleep cyclic alternating pattern analysis in infants with apparent life-threatening events: a daytime polysomnographic study. Clin Neurophysiol. 2012;123:1346-52 pubmed publisher
    ..The aim of this study was to analyze the development of cyclic alternating pattern parameters in a group of infants with apparent life-threatening events...
  41. Olesen A, Drewes A. Validated tools for evaluating opioid-induced bowel dysfunction. Adv Ther. 2011;28:279-94 pubmed publisher
    ..This article gives an overview of the different evaluation regimes for OIBD with a particular focus on the most frequently reported symptom; constipation...
  42. Millard R. Clinical efficacy of tolterodine with or without a simplified pelvic floor exercise regimen. Neurourol Urodyn. 2004;23:48-53 pubmed
  43. Gilbert S, Zhang L, Forster M, Anderson J, Iwase T, Soliven B, et al. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet. 2006;38:245-50 pubmed
    ..Our data implicate Trak1 as a crucial regulator of GABA(A) receptor homeostasis and underscore the importance of hyrt mice as a model for studying the molecular etiology of hypertonia associated with human neurological diseases...
  44. Maan Z, Al Singary W, Shergill I, Joseph J, Arya M, Patel H. Alternative use of botulinum toxin in urology. Expert Opin Pharmacother. 2004;5:1015-21 pubmed
    ..Here the literature is reviewed chronologically, the established and emerging indications for the urological use of botulinum toxin evaluated and future applications are also considered...
  45. Rosenbaum T. Physical therapy treatment of persistent genital arousal disorder during pregnancy: a case report. J Sex Med. 2010;7:1306-10 pubmed publisher
    ..Whether the etiology of this disorder is essentially central or peripheral is unclear; however, a presenting symptom may be persistent engorgement of genital erectile and vascular tissue...
  46. Masi A, Sierakowski S, Kim J. Jacques Forestier's vanished bowstring sign in ankylosing spondylitis: a call to test its validity and possible relation to spinal myofascial hypertonicity. Clin Exp Rheumatol. 2005;23:760-6 pubmed
    ..Critical, controlled assessment of Forestier's bowstring sign and biomechanical investigations of the dorsolumbar muscles in AS promise to offer new insights into the early physiopathogenesis of this unique disease...
  47. Bhardwaj P, Sabapathy S. Treatment of upper limb extensor hypertonia: case report. J Hand Surg Am. 2013;38:1983-6 pubmed publisher
    ..This report emphasizes the important role of regional nerve blocks in assessment and in operative decision making in a case of extensor hypertonia of the upper limb. ..
  48. Huang H, Lin Y, Chen J, Yeh C, Chung K. The impact of abnormal muscle tone from hemiplegia on reclining wheelchair positioning: a sliding and pressure evaluation. Eur J Phys Rehabil Med. 2013;49:619-28 pubmed
    ..Little is known about the influence of existing muscle tone abnormality on the sitting posture of stroke patients in reclining wheelchairs...
  49. Groutz A, Samandarov A, Gold R, Pauzner D, Lessing J, Gordon D. Role of urethrocystoscopy in the evaluation of refractory idiopathic detrusor instability. Urology. 2001;58:544-6 pubmed
    ..To assess the role of diagnostic urethrocystoscopy in the evaluation of women with idiopathic detrusor instability (DI) refractory to conventional pharmacologic management...
  50. Galli M, Cimolin V, Rigoldi C, Castori M, Celletti C, Albertini G, et al. Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type: a kinematic and kinetic evaluation using 3D gait analysis. Res Dev Disabil. 2011;32:1663-8 pubmed publisher
    ..These findings help to elucidate the complex biomechanical changes in JHS/EDS-HT and may have a major role in the multidimensional evaluation and tailored management of these patients...
  51. Chow J, Yablon S, Stokic D. Electromyogram-lengthening velocity relation in plantar flexors during stance phase of gait in patients with hypertonia after acquired brain injury. Arch Phys Med Rehabil. 2012;93:2287-94 pubmed publisher
    ..To examine the velocity-dependent change in medial gastrocnemius (MG) activity during the stance phase of gait in patients with moderate to severe resting hypertonia after stroke or traumatic brain injury (TBI)...
  52. Chang Y, Fang C, Hsu M, Lien H, Wong M. Decrease of hypertonia after continuous passive motion treatment in individuals with spinal cord injury. Clin Rehabil. 2007;21:712-8 pubmed
    ..To examine the effect of ankle continuous passive motion on the reflex excitability and overall hypertonia of calf muscles in individuals with chronic spinal cord injury and without physical disabilities...
  53. Copley J, Kuipers K, Fleming J, Rassafiani M. Individualised resting hand splints for adults with acquired brain injury: a randomized, single blinded, single case design. NeuroRehabilitation. 2013;32:885-98 pubmed publisher
    ..To evaluate the effect of individualized resting mitt splints on hypertonicity (spasticity and tissue stiffness) and passive range of motion (PROM)...