fasciculation

Summary

Summary: Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)

Top Publications

  1. Nasseri K, Arastheh M, Shami S. Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation. Middle East J Anaesthesiol. 2010;20:515-9 pubmed
    Succinylcholine is a popular muscle relaxant and one of its most common side effects is muscle fasciculation. The purpose of this study was to evaluate the efficacy of remifentanil in preventing succinylcholine-induced fasciculation in ..
  2. de Carvalho M, Miranda P, Lourdes Sales Luís M, Ducla Soares E. Neurophysiological features of fasciculation potentials evoked by transcranial magnetic stimulation in amyotrophic lateral sclerosis. J Neurol. 2000;247:189-94 pubmed
    We report 13 patients with amyotrophic lateral sclerosis in whom fasciculation potentials (FPs) driven by transcranial magnetic stimulation (TMS) were recorded. A total of 18 different FPs were analyzed...
  3. Schreiber J, Lysakowski C, Fuchs Buder T, Tramer M. Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials. Anesthesiology. 2005;103:877-84 pubmed
    Fifty-two randomized trials (5,318 patients) were included in this meta-analysis. In controls, the incidence of fasciculation was 95%, and the incidence of myalgia at 24 h was 50%...
  4. Mills K. Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome. Brain. 2010;133:3458-69 pubmed publisher
    ..can de distinguished on the basis of their waveforms or firing characteristics, and second to determine how fasciculation parameters evolved with progression of amyotrophic lateral sclerosis...
  5. Kararmaz A, Kaya S, Turhanoglu S, Ozyilmaz M. Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia. Acta Anaesthesiol Scand. 2003;47:180-4 pubmed
  6. Schmitz C, Wacker I, Hutter H. The Fat-like cadherin CDH-4 controls axon fasciculation, cell migration and hypodermis and pharynx development in Caenorhabditis elegans. Dev Biol. 2008;316:249-59 pubmed publisher
    ..Independently of the morphogenetic defects cdh-4 mutant animals also exhibit fasciculation defects in the ventral and dorsal cord, the major longitudinal axon tracts, as well as migration defects of ..
  7. Mills K. Detecting fasciculations in amyotrophic lateral sclerosis: duration of observation required. J Neurol Neurosurg Psychiatry. 2011;82:549-51 pubmed publisher
    ..To answer this question, the intervals between fasciculation potentials (FPs) were recorded from 53 muscles of 19 ALS patients...
  8. Shoroghi M, Zahedi H, Farahbakhsh F, Sheikhvatan M, Abbasi A. The effect of thiopentone on severity and duration of succinylcholine-induced fasciculation. Clin Neuropharmacol. 2009;32:94-6 pubmed publisher
    ..myalgias are concerned; however, a few studies were done in the efficacy of thiopentone on fasciculation induced by succinylcholine...
  9. Miller A, Maurer L, Zou D, Firestein S, Greer C. Axon fasciculation in the developing olfactory nerve. Neural Dev. 2010;5:20 pubmed publisher
    ..and OR-specific markers, we addressed the spatio-temporal properties associated with the onset of homotypic fasciculation in embryonic mice and assessed the degree to which subpopulations of axons remain segregated as they extend ..

More Information

Publications62

  1. Drost G, Kleine B, Stegeman D, van Engelen B, Zwarts M. Fasciculation potentials in high-density surface EMG. J Clin Neurophysiol. 2007;24:301-7 pubmed
    b>Fasciculation potentials (FPs) are observed in healthy individuals, but also in patients with neurogenic disorders...
  2. Burket C, Higgins C, Hull L, Berninsone P, Ryder E. The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes. Dev Biol. 2006;299:193-205 pubmed
    ..We describe fasciculation defects of animals with mutations in the C...
  3. Fradkin L, van Schie M, Wouda R, de Jong A, Kamphorst J, Radjkoemar Bansraj M, et al. The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system. Dev Biol. 2004;272:362-75 pubmed
    ..Finally, we demonstrate that transcriptional repression of wnt5 in AC neurons by the recently described Wnt5 receptor, Derailed, contributes to this largely posterior commissural localization of Wnt5 protein...
  4. Huettl R, Huber A. Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1. Dev Biol. 2011;359:230-41 pubmed publisher
    ..Neuropilin-1 (Npn-1) with its repulsive ligand Semaphorin 3A (Sema3A) is crucial for guidance decisions, fasciculation, timing of growth and axon-axon interactions of sensory and motor projections in the embryonic limb...
  5. Sakuraba S, Serita R, Kosugi S, Eriksson L, Lindahl S, Takeda J. Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction. Acta Anaesthesiol Belg. 2006;57:253-7 pubmed
    ..the effects of pretreat ment with magnesium and precurarization of vecuroni um on succinylcholine-induced fasciculation and subse quent tracheal intubation-induced hemodynamic changes during rapid sequence induction...
  6. Kleine B, Stegeman D, Schelhaas H, Zwarts M. Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin. Neurology. 2008;70:353-9 pubmed publisher
    ..We hypothesized that the discharge pattern of fasciculation potentials (FPs) would be different for FPs arising in the motor axon or in the spinal motor neuron.
  7. Jaworski A, Tessier Lavigne M. Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling. Nat Neurosci. 2012;15:367-9 pubmed publisher
    Axons travel to their targets in bundles or fascicles, but the molecules regulating fasciculation remain incompletely characterized...
  8. Fu M, Vohra B, Wind D, Heuckeroth R. BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition. Dev Biol. 2006;299:137-50 pubmed
    ..BMP signaling might also be important for the ENS precursor migration, ganglion cell aggregation, and neurite fasciculation necessary to form the enteric nervous system...
  9. Rosenfeld J. Fasciculations without fibrillations: the dilemma of early diagnosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1 Suppl 1:S53-6 pubmed
    ..e. fibrillation potentials) are critical. Chronic weakness should be proportional to either atrophy or upper motor neuron signs in the affected muscle. This should be true for both early and late recognition of the disease...
  10. Zhou P, Li X, Jahanmiri Nezhad F, Rymer W, Barkhaus P. Duration of observation required in detecting fasciculation potentials in amyotrophic lateral sclerosis using high-density surface EMG. J Neuroeng Rehabil. 2012;9:78 pubmed publisher
    ..that arises when applying HD-SEMG for supporting the diagnosis of ALS; specifically, how long the surface EMG should be recorded before one can be confident that fasciculation potentials (FPs) are absent in a muscle being tested.
  11. Yu H, Huang A, Kolodkin A. Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila. Genetics. 2000;156:723-31 pubmed
  12. Shiga Y, Onodera H, Shimizu H, Kimura I, Ohnuma A, Itoyama Y. Two consecutive fasciculation potentials having different motor unit origins are an electromyographically pathognomonic finding of ALS. Electromyogr Clin Neurophysiol. 2000;40:237-41 pubmed
    To electrophysiologically diagnose amyotrophic lateral sclerosis (ALS), fasciculation potentials (FPs) were evaluated in each wasted muscle in 12 ALS and 14 other neurogenic disorders (non-ALS patients)...
  13. Huettl R, Soellner H, Bianchi E, Novitch B, Huber A. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011;9:e1001020 pubmed publisher
    ..We show that Npn-1 controls the fasciculation of both projections and mediates inter-axonal communication...
  14. Becker T, Becker C, Schachner M, Bernhardt R. Antibody to the HNK-1 glycoepitope affects fasciculation and axonal pathfinding in the developing posterior lateral line nerve of embryonic zebrafish. Mech Dev. 2001;109:37-49 pubmed
    ..We suggest that the HNK-1 glycoepitope is an important modulator of embryonic nerve growth...
  15. Brouns M, Matheson S, Settleman J. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat Cell Biol. 2001;3:361-7 pubmed
    ..We also find that mice lacking functional p190 RhoGAP exhibit defects in axon guidance and fasciculation. p190 RhoGAP is co-enriched with F-actin in the distal tips of axons, and overexpressing p190 RhoGAP in ..
  16. Jansen P, van Dijck J, Verbeek A, Durian F, Joosten E. Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population. Eur Arch Psychiatry Clin Neurosci. 1991;241:102-4 pubmed
    A nationwide two-phase survey was carried out of the adult population of the Netherlands regarding fasciculation, muscle pain and muscle cramp...
  17. Peredo D, Hannibal M. The floppy infant: evaluation of hypotonia. Pediatr Rev. 2009;30:e66-76 pubmed publisher
    ..Francisco, 2007; Muensterer, 2000)..
  18. Bokuda K, Shimizu T, Kimura H, Yamazaki T, Kamiyama T, Watabe K, et al. Quantitative analysis of the features of fasciculation potentials and their relation with muscle strength in amyotrophic lateral sclerosis. Neurol Sci. 2016;37:1939-1945 pubmed
    This study aimed to quantitatively analyze fasciculation potentials (FPs) and to investigate their relationship with muscle strength in amyotrophic lateral sclerosis (ALS)...
  19. Liu W, Zheng W, Yuan B, Jiang X. A micropatterned coculture system for axon guidance reveals that Slit promotes axon fasciculation and regulates the expression of L1CAM. Integr Biol (Camb). 2013;5:617-23 pubmed publisher
    Axon fasciculation is essential for wiring the nervous system during development, but its regulation by guidance cues remains unknown...
  20. Takamatsu N, Nodera H, Mori A, Maruyama Saladini K, Osaki Y, Shimatani Y, et al. Which muscle shows fasciculations by ultrasound in patients with ALS?. J Med Invest. 2016;63:49-53 pubmed publisher
    ..Fasciculations tended to be less evident in the advanced disease stage, possibly reflecting muscle degeneration. Appropriate selection of muscles to observe fasciculations is important for diagnosis of ALS...
  21. Gómez Gosálvez F, Smeyers P, Escrivà P, Clemente F, Mallada J, Mulas F, et al. [Familial periodic ataxia with myokymia sensitive to acetazolamide: a family case]. Rev Neurol. 1997;25:1925-7 pubmed
    ..Acetazolamide responsive hereditary paroxysmal cerebellar ataxia with myokymia is a type of autosomal dominant cerebellar ataxia which locus was found to be linked to the short arm of chromosome 12 and the etiology is unknown...
  22. Vos E, Hens J, Lau H, Boon E, Bartelink A. [Poisoning with organophosphate compounds]. Ned Tijdschr Geneeskd. 2002;146:34-7 pubmed
    ..The treatment of these potentially severe intoxications includes rapid decontamination and the administration of high doses of atropine followed by obidoxime. Mechanical ventilation and circulatory support are also indicated...
  23. Shamsadini S, Varesvazirian M, Shamsadini A. Urticaria and lip fasciculation may be prodromal signs of brain malignancy. Dermatol Online J. 2006;12:23 pubmed
    ..We describe a girl who suffered with chronic urticaria for 3 months before lip fasciculation began to be observed...
  24. de Freitas G, Lima M, Andre C. Complex spinal reflexes during transcranial Doppler ultrasound examination for the confirmation of brain death. Acta Neurol Scand. 2003;108:170-3 pubmed
    ..We here describe brain-dead patients who had not shown previous movements, even during apnea testing, but presented complex spinal reflexes during transcranial Doppler (TCD) examination elicited by neck flexion...
  25. Forcelini C, Rotta F, Posenato N, Rovani J, Crusius P, Mallmann A, et al. Benign fasciculations responsive to gabapentin. Arq Neuropsiquiatr. 2007;65:1015-7 pubmed
    ..They also represent the main picture of benign fasciculation syndrome...
  26. Gourie Devi M, Maheshwari S, Panda A, Bala K. Chin fasciculations in Madras motor neuron disease: a new clinical feature. Neurol India. 2013;61:653-5 pubmed publisher
    ..Chin fasciculations, a rare clinical feature, is now described for the first time in Madras motor neuron disease adding a new feature to the clinical constellation of symptoms. ..
  27. Brigo F, Storti M, Lochner P, Nardone R. Transitory stapedial myoclonus in a patient with benign fasciculation syndrome. J Laryngol Otol. 2013;127:605-6 pubmed publisher
    We report a previously undescribed association between transitory stapedial myoclonus, objective tinnitus and benign fasciculation syndrome.
  28. Huettl R, Haehl T, Huber A. Fasciculation and guidance of spinal motor axons in the absence of FGFR2 signaling. PLoS ONE. 2012;7:e41095 pubmed publisher
    ..In previous studies, FGF receptor 2 (FGFR2) was found to interact with axon bound molecules involved in axon fasciculation and extension, thus rendering this receptor an interesting candidate for the promotion of proper peripheral ..
  29. Jett D. Neurotoxic pesticides and neurologic effects. Neurol Clin. 2011;29:667-77 pubmed publisher
    ..Examples of case studies are included to illustrate their toxicity. A discussion of the possible contribution of occupational and other pesticide exposures to neurologic diseases and disorders is also included...
  30. Turan A, Mendoza M, Gupta S, You J, Gottlieb A, Chu W, et al. Consequences of succinylcholine administration to patients using statins. Anesthesiology. 2011;115:28-35 pubmed publisher
  31. Singh V, Gibson J, McLean B, Boggild M, Silver N, White R. Fasciculations and cramps: how benign? Report of four cases progressing to ALS. J Neurol. 2011;258:573-8 pubmed publisher
    ..We propose that a diagnosis of benign cramps and fasciculations should not be considered secure without a minimum follow up of 4-5 years...
  32. Lee C, Park J, You S, Hwang J, Choi S, Kim C. Dysesthesia and fasciculation: unusual complications following face-lift with cog threads. Dermatol Surg. 2007;33:253-5; discussion 255 pubmed
  33. Benatar M, Chapman K, Rutkove S. Repetitive nerve stimulation for the evaluation of peripheral nerve hyperexcitability. J Neurol Sci. 2004;221:47-52 pubmed
    ..To examine the utility of repetitive nerve stimulation (RNS) in the evaluation of peripheral nerve hyperexcitability (PNH)...
  34. Kaji S, Kawarai T, Miyamoto R, Nodera H, Pedace L, Orlacchio A, et al. Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral sclerosis. J Neurol Sci. 2016;364:45-9 pubmed publisher
    ..Electromyography in the 2 symptomatic members revealed evidence of lower motor neuron involvement and fasciculation potentials in distal muscles...
  35. Abbas N, Tariq S, Khan A, Murtaza G, Naqvi N, Khanzada A. To asses the effects of rocuronium pretreatment on succinylcholine induced fasciculations and postoperative myalgias. J Pak Med Assoc. 2009;59:847-50 pubmed
    ..To asses the effects of Rocuronium pretreatment on Succinylcholine induced Fasciculations and postoperative Myalgias...
  36. Ptacek L. Ion channel shake-down. Nat Genet. 1994;8:111-2 pubmed
  37. Richardson R, Weiss M. Unilateral myokymia of the tongue after radiation therapy for cervical nodal melanoma. J Clin Neuromuscul Dis. 2009;10:122-5 pubmed publisher
    ..The earlier onset of myokymia than previous cases may represent more direct radiation exposure due to radiation site or the higher radiation dosage administered for treatment of melanomas...
  38. de Carvalho M, Turkman A, Swash M. Sensitivity of MUP parameters in detecting change in early ALS. Clin Neurophysiol. 2014;125:166-9 pubmed publisher
    ..We aimed to identify the most appropriate MUP parameter to evaluate reinnervation in very early ALS...
  39. Sato K, Shimizu S, Oka H, Nakahara K, Utsuki S, Fujii K. Usefulness of transcervical approach for surgical treatment of hypoglossal schwannoma with paraspinal extension: case report. Surg Neurol. 2006;65:397-401, discussion 401 pubmed
    ..Usefulness of transcervical approach to hypoglossal schwannoma with paraspinal extension is described herein...
  40. Xu Y, Zheng J, Zhang S, Bao S, Fan D. [Role of fasciculation potentials in the diagnosis of amyotrophic lateral sclerosis]. Zhonghua Yi Xue Za Zhi. 2011;91:482-4 pubmed
    To explore the role of fasciculation potentials in the diagnosis of amyotrophic lateral sclerosis (ALS).
  41. Namburete A, Rana M, Wakeling J. Computational methods for quantifying in vivo muscle fascicle curvature from ultrasound images. J Biomech. 2011;44:2538-43 pubmed publisher
    ..026 m?¹, and this is about 1% of the maximum curvatures observed in fascicles of contracting muscle...
  42. Ørngreen M, Gideon P, Pedersen H, Olsen D, Vissing J. [Juvenile asymmetrical segmental spinal muscular atrophy]. Ugeskr Laeger. 2002;164:4073-5 pubmed
    ..EMG and muscle biopsy showed neurogenic changes. MRI of the medulla and plasma creatine kinase were normal. Genetic testing for SMA-III was negative...
  43. Kuwabara S, Kanai K. [Altered axonal ion channel function in amyotrophic lateral sclerosis]. Brain Nerve. 2007;59:1109-15 pubmed
    b>Fasciculation is a characteristic feature of amyotrophic lateral sclerosis (ALS)...
  44. Almeida V, Ohana B, de Carvalho M, Swash M. Patrikios syndrome in two patients with treatable flail-leg weakness. J Clin Neurosci. 2012;19:318-21 pubmed publisher
    ..We stress the importance of fasciculations in the diagnosis of ALS, and the study of nerve root conduction in the differential diagnosis...
  45. Mateen F, Sorenson E, Daube J. Comparison of clinical methods for fasciculation detection in amyotrophic lateral sclerosis. Muscle Nerve. 2007;36:404-5 pubmed
  46. van Baalen A, Stephani U. Fibration, fibrillation, and fasciculation: say what you see. Clin Neurophysiol. 2007;118:1418-20 pubmed
  47. Erkola O. Effects of precurarisation on suxamethonium-induced postoperative myalgia during the first trimester of pregnancy. Acta Anaesthesiol Scand. 1990;34:63-7 pubmed
  48. Dumitru D, Diaz C, King J. Prevalence of denervation in paraspinal and foot intrinsic musculature. Am J Phys Med Rehabil. 2001;80:482-90 pubmed
  49. Namburete A, Wakeling J. Regional variations in fascicle curvatures within a muscle belly change during contraction. J Biomech. 2012;45:2835-40 pubmed publisher
  50. Misawa S, Noto Y, Shibuya K, Isose S, Sekiguchi Y, Nasu S, et al. Ultrasonographic detection of fasciculations markedly increases diagnostic sensitivity of ALS. Neurology. 2011;77:1532-7 pubmed publisher
    ..New diagnostic criteria for ALS, the Awaji algorithm, reintroduced fasciculations as evidence of acute denervation equivalent to that of fibrillations and positive sharp waves...
  51. El Bitar M, Muwakkit S, Abboud M, Sawaya R, Boustany R. Morvan syndrome following B-cell lymphoma. J Child Neurol. 2010;25:1038-41 pubmed publisher
    ..He achieved complete remission following 7 consecutive, monthly intravenous immunoglobulin injections. The present case is described in the context of the available literature...
  52. Suzuki Y, Washio N, Hashimoto M, Ohtsuka K. Three-dimensional eye movement analysis of superior oblique myokymia. Am J Ophthalmol. 2003;135:563-5 pubmed
    ..To confirm the idea that sole contraction of the superior oblique muscle causes attacks of superior oblique myokymia (SOM)...
  53. Bania T, Chu J. Physostigmine does not effect arousal but produces toxicity in an animal model of severe gamma-hydroxybutyrate intoxication. Acad Emerg Med. 2005;12:185-9 pubmed
    ..The authors hypothesized that in the setting of severe GHB intoxication, physostigmine would reverse sedation without producing adverse effects such as a decrease in heart rate, seizures, and fasciculations...