neurogenic inflammation

Summary

Summary: Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.

Top Publications

  1. Butler C, Heaney L. Neurogenic inflammation and asthma. Inflamm Allergy Drug Targets. 2007;6:127-32 pubmed
    Over the past number of decades there has been considerable interest in the role of neurogenic inflammation in asthma with the identification of many biologically active neuropeptides in the lung...
  2. Amann R, Egger T, Schuligoi R. The tachykinin NK(1) receptor antagonist SR140333 prevents the increase of nerve growth factor in rat paw skin induced by substance P or neurogenic inflammation. Neuroscience. 2000;100:611-5 pubmed
    ..The aim of this study was therefore to investigate the possible effect of exogenous substance P, or neurogenic inflammation on the nerve growth factor concentration in the skin of the rat hindpaw...
  3. Steinhoff M, Ständer S, Seeliger S, Ansel J, Schmelz M, Luger T. Modern aspects of cutaneous neurogenic inflammation. Arch Dermatol. 2003;139:1479-88 pubmed
    ..Understanding the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases...
  4. Levine J, Khasar S, Green P. Neurogenic inflammation and arthritis. Ann N Y Acad Sci. 2006;1069:155-67 pubmed
  5. Vera Portocarrero L, Westlund K. Role of neurogenic inflammation in pancreatitis and pancreatic pain. Neurosignals. 2005;14:158-65 pubmed
    ..In this review, neurogenic inflammation is presented as a possible amplifier of the noxious signal from peripheral organs including the pancreas...
  6. Pisi G, Olivieri D, Chetta A. The airway neurogenic inflammation: clinical and pharmacological implications. Inflamm Allergy Drug Targets. 2009;8:176-81 pubmed
    ..The neurogenic inflammation may play a key role in allergic diseases, such as asthma, as well as in COPD, a smoking-related disease...
  7. Carmichael N, Dostrovsky J, Charlton M. Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin. Pain. 2010;149:316-24 pubmed publisher
    ..Peptide-mediated delivery of BoNT-A is an easy and non-invasive way of administering the toxin that may prove to be useful in clinical practice...
  8. Seegers H, Hood V, Kidd B, Cruwys S, Walsh D. Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther. 2003;306:8-12 pubmed
    ..play a role in inflammation, in part through the release of substance P from peripheral nerve terminals (neurogenic inflammation)...
  9. Kim H, Hahm D, Sohn B, Choi Y, Pyun K, Lee H, et al. Skin on GV01 acupoint in colonic inflammatory states: tenderness and neurogenic inflammation. J Physiol Sci. 2006;56:317-20 pubmed
    ..The present study showed that skin on the GV01 acupoint reveals tenderness and neurogenic inflammation in colonic inflammatory states, but not in normal healthy states.

More Information

Publications62

  1. Yonehara N, Yoshimura M. Influence of painful chronic neuropathy on neurogenic inflammation. Pain. 2001;92:259-65 pubmed
    The effect of topical application of capsaicin cream on neurogenic inflammation was investigated in a neuropathic pain model in rat. The neuropathic state was induced by loose ligation of the sciatic nerve with a chromic gut suture...
  2. Miller M, Vergnolle N, McKnight W, Musah R, Davison C, Trentacosti A, et al. Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado. J Invest Dermatol. 2001;117:725-30 pubmed
    ..This study was designed to determine if the Amazonian medicinal sangre de grado, confers benefit by suppressing the activation of sensory afferent nerves...
  3. Mantelli F, Micera A, Sacchetti M, Bonini S. Neurogenic inflammation of the ocular surface. Curr Opin Allergy Clin Immunol. 2010;10:498-504 pubmed publisher
    The purpose of the present review is to describe the involvement of neurogenic inflammation in ocular surface diseases and to outline recent advances in understanding the complex interaction of neuromediators and inflammatory cells in ..
  4. Karlsen T, Iversen V, Forsberg E, Kjellen L, Reed R, Gjerde E. Neurogenic inflammation in mice deficient in heparin-synthesizing enzyme. Am J Physiol Heart Circ Physiol. 2004;286:H884-8 pubmed
    Mast cell activation, or neurogenic inflammation, is known to induce lowering of interstitial fluid pressure (P(if)) and plasma protein extravasation (PPE) in several tissues from both rats and mice...
  5. Nemeth J, Reglodi D, Pozsgai G, Szabo A, Elekes K, Pinter E, et al. Effect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and mice. Neuroscience. 2006;143:223-30 pubmed
    ..and calcitonin gene-related peptide (CGRP), released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation, while somatostatin exerts systemic anti-inflammatory actions...
  6. Tóth D, Szoke E, Bölcskei K, Kvell K, Bender B, Bosze Z, et al. Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice. Cell Mol Life Sci. 2011;68:2589-601 pubmed publisher
    ..Thermoregulatory behaviour in response to heat was inhibited, but enhanced hyperthermia was not observed...
  7. Wang H, Papoiu A, Coghill R, Patel T, Wang N, Yosipovitch G. Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation. Br J Dermatol. 2010;162:1023-9 pubmed publisher
    ..Topical application of capsaicin commonly produces burning, stinging and itching as well as hyperalgesia to heat stimuli via activation of transient receptor potential vanilloid subtype 1...
  8. Ferretti M, Allard S, Partridge V, Ducatenzeiler A, Cuello A. Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation. 2012;9:62 pubmed publisher
    ..The role of such a pro-inflammatory process in the progression of the pathology remained to be elucidated...
  9. Krämer H, He L, Lu B, Birklein F, Sommer C. Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase. Neurobiol Dis. 2009;35:177-83 pubmed publisher
    The complex regional pain syndrome (CRPS) is characterized by enhanced neurogenic inflammation, mediated by neuropeptides. Neutral endopeptidase (NEP) is a key enzyme in neuropeptide catabolism...
  10. Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008;118:2574-82 pubmed publisher
    ..hypothesized that 2 alpha,beta-unsaturated aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ion channel coexpressed with TRPV1 on capsaicin-sensitive nociceptors...
  11. Geppetti P, Capone J, Trevisani M, Nicoletti P, Zagli G, Tola M. CGRP and migraine: neurogenic inflammation revisited. J Headache Pain. 2005;6:61-70 pubmed
    For more than a century neurogenic inflammation has been proposed to have a role in various human diseases...
  12. Joachim R, Handjiski B, Blois S, Hagen E, Paus R, Arck P. Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration: key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions. Am J Pathol. 2008;173:1379-88 pubmed publisher
    ..We have previously shown in mice that stress induces nerve growth factor- and substance P-dependent neurogenic inflammation, which includes the prominent clustering of MHC class II(+) cells...
  13. Turner R, Vink R. Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke. Timely Top Med Cardiovasc Dis. 2007;11:E24 pubmed
    ..Levels of substance P are increased following CNS injury, indicative of neurogenic inflammation, and this is associated with injury to the blood-brain barrier, the development of cerebral edema, cell ..
  14. Hegde A, Bhatia M. Neurogenic inflammation in acute pancreatitis. JOP. 2005;6:417-21 pubmed
    ..Substance P, the proinflammatory neuropeptide, has a role in the initiation of neurogenic inflammation. Substance P and its receptor neurokinin-1 receptor (NK-1R) are involved in the development of local as ..
  15. Vergnolle N, Cenac N, Altier C, Cellars L, Chapman K, Zamponi G, et al. A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. Br J Pharmacol. 2010;159:1161-73 pubmed publisher
    ..Here, we investigated whether the osmosensitive channel, transient receptor potential vanilloid 4 (TRPV4), mediates inflammation to hypotonic stimuli by a neurogenic mechanism...
  16. Huang C, Kuo I, Xu H, Lee Y, Chua K. Mite allergen induces allergic dermatitis with concomitant neurogenic inflammation in mouse. J Invest Dermatol. 2003;121:289-93 pubmed
    ..Here we describe a mouse model for atopic dermatitis with concomitant neurogenic inflammation, by epicutaneous sensitization with a dust mite allergen...
  17. Wedde Beer K, Hu C, Rodriguez M, Piedimonte G. Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1143-50 pubmed
    Respiratory syncytial virus (RSV) infection potentiates neurogenic inflammation in rat airways...
  18. Wei H, Koivisto A, Pertovaara A. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010;479:253-6 pubmed publisher
    ..TRPA1 channel antagonist to test the hypothesis that spinal TRPA1 channels contribute to cutaneous neurogenic inflammation induced by sustained noxious stimulation...
  19. Pereira U, Boulais N, Lebonvallet N, Lefeuvre L, Gougerot A, Misery L. Development of an in vitro coculture of primary sensitive pig neurons and keratinocytes for the study of cutaneous neurogenic inflammation. Exp Dermatol. 2010;19:931-5 pubmed publisher
    Cutaneous neurogenic inflammation (CNI) is often associated with skin disorders. Activated sensory neurons secrete neuropeptides, such as substance P (SP), which initiate or aggravate inflammation in the skin...
  20. Costa R, Marotta D, Manjavachi M, Fernandes E, Lima Garcia J, Paszcuk A, et al. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol. 2008;154:1094-103 pubmed publisher
    We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic inflammation components in this response.
  21. Birklein F, Schmelz M. Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS). Neurosci Lett. 2008;437:199-202 pubmed publisher
    ..b>Neurogenic inflammation regularly accompanies excitation of primary afferent nociceptors...
  22. Rosenkranz M, Davidson R, MacCoon D, Sheridan J, Kalin N, Lutz A. A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun. 2013;27:174-84 pubmed publisher
    ..Moreover, mindfulness practice, in particular, may be more efficacious in symptom relief than the well-being promoting activities cultivated in the HEP program...
  23. Carmichael N, Charlton M, Dostrovsky J. Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin. Pain. 2008;134:97-105 pubmed
    Activation of the 5-HT(1B/D) receptor inhibits cerebrovascular neurogenic inflammation (NI). The aim of this study was to determine if the 5-HT(1B/D) receptor agonist sumatriptan can also inhibit NI in other regions of the body...
  24. Schmelz M, Petersen L. Neurogenic inflammation in human and rodent skin. News Physiol Sci. 2001;16:33-7 pubmed
    ..of vasodilation and protein extravasation following activation of nociceptors has been termed "neurogenic inflammation." In contrast to rodents, no neurogenic protein extravasation can be elicited in healthy human skin...
  25. Williamson D, Hargreaves R. Neurogenic inflammation in the context of migraine. Microsc Res Tech. 2001;53:167-78 pubmed
    ..based on preclinical observations, is that activation of trigeminal sensory fibers leads to a painful neurogenic inflammation within the meningeal (dural) vasculature mediated by neuropeptide release from trigeminal sensory fibres ..
  26. Liddle R, Nathan J. Neurogenic inflammation and pancreatitis. Pancreatology. 2004;4:551-9; discussion 559-60 pubmed
    ..Pathological activation of sensory neurons and the inflammatory sequelae are known as neurogenic inflammation and appear to be important in many organ systems, including the pancreas...
  27. Sumikura H, Andersen O, Drewes A, Arendt Nielsen L. A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans. Neurosci Lett. 2003;337:147-50 pubmed
    ..and dynamic hyperalgesia) around the injection site; and (2) to correlate the sensory changes to the neurogenic inflammation assessed by laser-doppler blood flowmetry...
  28. McDougall J, Baker C, Hermann P. Attenuation of knee joint inflammation by peripherally administered endomorphin-1. J Mol Neurosci. 2004;22:125-37 pubmed
    ..These anti-inflammatory effects are mediated by micro-opioid receptors located on capsaicin-sensitive afferent nerves...
  29. Prandota J. Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different. Am J Ther. 2007;14:63-105 pubmed
    ..This may help to avoid overlooking this treatable cause of the CNS disease, markedly reduce costs of hospitalization, diagnosis and treatment, and eventually prevent developing serious neurologic and psychiatric disorders...
  30. Le Filliatre G, Sayah S, Latournerie V, Renaud J, Finet M, Hanf R. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001;132:1581-9 pubmed
    ..the role of arachidonic acid metabolism and assessed the participation of mast cells and leukocytes in neurogenic inflammation in rat paw skin...
  31. Peroutka S. Neurogenic inflammation and migraine: implications for the therapeutics. Mol Interv. 2005;5:304-11 pubmed
    Significant recent advances in molecular pharmacology have elucidated the molecular pathways involved in neurogenic inflammation (NI)...
  32. Cattaruzza F, Cottrell G, Vaksman N, Bunnett N. Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Br J Pharmacol. 2009;156:730-9 pubmed publisher
    ..We investigated whether ECE-1 regulates NK(1) receptor re-sensitization and the pro-inflammatory effects of SP in the endothelium...
  33. Pertovaara A, Koivisto A. TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation. Eur J Pharmacol. 2011;666:1-4 pubmed publisher
    ..Additionally, blockade of the spinal TRPA1 channel reduced cutaneous neurogenic inflammation, presumably by decreasing drive of spinal interneurons that induce a proinflammatory dorsal root reflex...
  34. Killough S, Lundy F, Irwin C. Substance P expression by human dental pulp fibroblasts: a potential role in neurogenic inflammation. J Endod. 2009;35:73-7 pubmed publisher
    b>Neurogenic inflammation describes the local release of neuropeptides, notably substance P (SP), from afferent neurons and might play a role in the pathogenesis of pulpal disease...
  35. Lacroix J, Landis B. Neurogenic inflammation of the upper airway mucosa. Rhinology. 2008;46:163-5 pubmed
    ..upper airway mucosa is most likely caused by multiple factors, but is frequently associated with local neurogenic inflammation. This phenomenon can be induced by the inhalation of exogenous particles and chemicals present in our ..
  36. Zegarska B, Lelińska A, Tyrakowski T. Clinical and experimental aspects of cutaneous neurogenic inflammation. Pharmacol Rep. 2006;58:13-21 pubmed
    The aim of this paper is to present the state of knowledge on cutaneous neurogenic inflammation. Peripheral effector functions served by afferent sensory neurons underlie the so-called neurogenic inflammation...
  37. Willis W. Dorsal root potentials and dorsal root reflexes: a double-edged sword. Exp Brain Res. 1999;124:395-421 pubmed
    ..There is then a discussion of neurogenic inflammation, including the role of the release of neuropeptides such as substance P and calcitonin gene-related ..
  38. Akaishi S, Ogawa R, Hyakusoku H. Keloid and hypertrophic scar: neurogenic inflammation hypotheses. Med Hypotheses. 2008;71:32-8 pubmed publisher
    ..Hence, we introduce our "neurogenic inflammation hypothesis" in this paper. Our hypothesis is as follows...
  39. Geppetti P, Nassini R, Materazzi S, Benemei S. The concept of neurogenic inflammation. BJU Int. 2008;101 Suppl 3:2-6 pubmed publisher
    ..b>Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of ..
  40. Vinuesa A, Sancho R, García Limones C, Behrens A, Ten Dijke P, Calzado M, et al. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer. Cancer Res. 2012;72:1705-16 pubmed publisher
    ..Together, our findings argue that by limiting neuroinflammatory processes, TRPV-1 exerts a protective role that restricts the initiation and progression of colon cancer...
  41. Szczepankiewicz A, Sobkowiak P, Rachel M, Breborowicz A, Schoneich N, Bruce K, et al. Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control study. J Asthma. 2012;49:329-35 pubmed publisher
    ..Since neurogenic inflammation is emerging as a candidate factor in the pathogenesis of asthma, the aim of the study was to investigate ..
  42. Kramer J, Spurney C, Iantorno M, Tziros C, Mak I, Tejero Taldo M, et al. Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia. Am J Med Sci. 2009;338:22-7 pubmed publisher
    ..In view of the clinical prevalence of hypomagnesemia, new treatments, beyond magnesium repletion, may be needed to diminish deleterious neurogenic and prooxidative components described in this article...
  43. Raychaudhuri S, Raychaudhuri S. Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. Prog Brain Res. 2004;146:433-7 pubmed
    A contributing role of neurogenic inflammation has provided a new dimension in understanding the pathogenesis of various cutaneous and systemic inflammatory diseases such as atopic dermatitis, urticaria, rheumatoid arthritis, ulcerative ..
  44. Chiu I, von Hehn C, Woolf C. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012;15:1063-7 pubmed publisher
    ..The line between them is, however, becoming increasingly blurred by new insights into neurogenic inflammation. Nociceptor neurons possess many of the same molecular recognition pathways for danger as immune cells, ..
  45. Kramer H, Schmidt K, Leis S, Schmelz M, Sommer C, Birklein F. Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation. Exp Neurol. 2005;195:179-84 pubmed
    ..NEP) and angiotensin-converting enzyme (ACE) are involved in neuropeptide degradation and may modulate neurogenic inflammation. We therefore explored the effect of specific blockers of NEP and ACE on the intensity of neurogenic ..
  46. Borzsei R, Pozsgai G, Bagoly T, Elekes K, Pinter E, Szolcsanyi J, et al. Inhibitory action of endomorphin-1 on sensory neuropeptide release and neurogenic inflammation in rats and mice. Neuroscience. 2008;152:82-8 pubmed publisher
    ..and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation in the innervated area...
  47. Ramalho R, Almeida J, Beltrão M, Pirraco A, Costa R, Sokhatska O, et al. Neurogenic inflammation in allergen-challenged obese mice: A missing link in the obesity-asthma association?. Exp Lung Res. 2012;38:316-24 pubmed publisher
    ..Controversy remains on the mechanisms supporting this association. In this study we aimed to assess neurogenic inflammation in a model of diet-induced obesity and allergen-challenged mice.
  48. Pavlovic S, Daniltchenko M, Tobin D, Hagen E, Hunt S, Klapp B, et al. Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol. 2008;128:434-46 pubmed
    ..This dramatic pathologic exacerbation is associated with increased neurogenic inflammation (degranulated mast cells; interstitial neuropeptidergic dense core granules, mast cell apoptosis, ..
  49. Ebersberger A, Schaible H, Averbeck B, Richter F. Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache?. Ann Neurol. 2001;49:7-13 pubmed
    ..It was proposed that CSD generates a sterile neurogenic inflammation in the meninges, which may then lead to the activation or sensitization of nociceptors, thus generating ..
  50. Andreev Y, Vassilevski A, Kozlov S. Molecules to selectively target receptors for treatment of pain and neurogenic inflammation. Recent Pat Inflamm Allergy Drug Discov. 2012;6:35-45 pubmed
    ..Development of molecules capable to selectively modulate these receptors, their in vitro and in vivo effects, as well as perspectives for practical application described in patents and research articles are reviewed in this paper...
  51. Leis S, Weber M, Schmelz M, Birklein F. Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome. Neurosci Lett. 2004;359:163-6 pubmed
    ..Recently, we have been able to show facilitated neurogenic inflammation on the affected limb...
  52. Chen S, Tsai M, Wang H, Yu H, Chang L. Involvement of substance P and neurogenic inflammation in arsenic-induced early vascular dysfunction. Toxicol Sci. 2007;95:82-8 pubmed
    ..Based on our previous studies, we hypothesized that arsenic exerted its action on blood vessels via the neurogenic inflammation process involving release of a neuropeptide (substance P) and activation of endothelial Neurokinin 1 (NK-..
  53. Ang S, Moochhala S, Bhatia M. Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Crit Care Med. 2010;38:619-28 pubmed publisher
    ..Its contribution in neurogenic inflammation has been suggested in normal airways and urinary bladder...