hypokinesia

Summary

Summary: Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged inactivity due to illness; and other conditions.

Top Publications

  1. Kakuris K, Yerullis K, Afoninos E, Fedorov A. Phosphate balance in phosphate supplemented and unsupplemented health subjects during and after hypokinesia. Clin Invest Med. 2007;30:E200-9 pubmed
    To demonstrate the effect of hypokinesia (HK) and post-HK on phosphate (Pi) imbalance and use of Pi with different Pi imbalance and different Pi consumption: were measured Pi balance, plasma Pi level and Pi loss during HK.
  2. Louter M, Munneke M, Bloem B, Overeem S. Nocturnal hypokinesia and sleep quality in Parkinson's disease. J Am Geriatr Soc. 2012;60:1104-8 pubmed publisher
    To study the relationship between nocturnal hypokinesia and sleep quality in Parkinson's disease (PD).
  3. Zorbas Y, Kakuris K, Deogenov V, Yerullis K. Phosphate homeotasis in healthy subjects during prolonged periodic and continuous hypokinesia. Clin Biochem. 2007;40:460-6 pubmed
    This study aimed to show that during hypokinesia (HK), phosphate (P(i)) imbalance increases more with higher than lower physical activity and that P(i) absorption reduces more with higher than lower P(i) imbalance in subjects with higher ..
  4. Kim J, Lee J, Kwon Y, Kim C, Eom G, Koh S, et al. Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease. Med Biol Eng Comput. 2011;49:365-71 pubmed publisher
    ..01). The results suggest that indices from a gyrosensor can be used as quantitative measures of bradykinesia during the finger taps test...
  5. Chen C, Lin W, Chan H, Hsu Y, Tu P, Lee S, et al. Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson's disease. Exp Neurol. 2011;231:91-6 pubmed publisher
    ..The effect was frequency specific. These data provide direct interventional evidence of a mechanistic link between excessive neuronal synchronization in the beta range and motor impairment in PD...
  6. Cauli O, Rodrigo R, Piedrafita B, Llansola M, Mansouri M, Felipo V. Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. J Neurosci Res. 2009;87:1369-74 pubmed publisher
    Patients with hepatic encephalopathy show altered motor function, psychomotor slowing, and hypokinesia, which are reproduced in rats with portacaval shunts (PCS)...
  7. Ray N, Jenkinson N, Wang S, Holland P, Brittain J, Joint C, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008;213:108-13 pubmed publisher
  8. Mazzoni P, Hristova A, Krakauer J. Why don't we move faster? Parkinson's disease, movement vigor, and implicit motivation. J Neurosci. 2007;27:7105-16 pubmed
    ..We propose that, analogous to the established role of dopamine in explicit reward-seeking behavior, the dopaminergic projection to the striatum provides a signal for implicit "motor motivation."..
  9. Sapir A, Kaplan J, He B, Corbetta M. Anatomical correlates of directional hypokinesia in patients with hemispatial neglect. J Neurosci. 2007;27:4045-51 pubmed
    ..a motor response to targets appearing in the left hemispace, even when using their unaffected arm (directional hypokinesia). Although this impairment is well known, its anatomical correlate has not been established...

More Information

Publications62

  1. Kuhn A, Tsui A, Aziz T, Ray N, Brücke C, Kupsch A, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity. Exp Neurol. 2009;215:380-7 pubmed publisher
  2. Papageorgiou E, Wermund T, Wilhelm H. Pupil perimetry demonstrates hemifield pupillary hypokinesia in a patient with a pretectal lesion causing a relative afferent pupil defect but no visual field loss. J Neuroophthalmol. 2009;29:33-6 pubmed publisher
    ..To investigate this assumption, we looked for hemihypokinesia by means of pupil perimetry...
  3. Reedeker N, van der Mast R, Giltay E, van Duijn E, Roos R. Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning. Mov Disord. 2010;25:1612-8 pubmed publisher
    Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown...
  4. Kuhn A, Trottenberg T, Kivi A, Kupsch A, Schneider G, Brown P. The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease. Exp Neurol. 2005;194:212-20 pubmed
    ..The LFP is therefore likely to represent synchronous activity in populations of neurons in the STN of patients with PD...
  5. Goldberg M, Pisani A, Haburcak M, Vortherms T, Kitada T, Costa C, et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005;45:489-96 pubmed
    ..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
  6. Dobbs S, Charlett A, Dobbs R, Weller C, Iguodala O, Smee C, et al. Antimicrobial surveillance in idiopathic parkinsonism: indication-specific improvement in hypokinesia following Helicobacter pylori eradication and non-specific effect of antimicrobials for other indications in worsening rigidity. Helicobacter. 2013;18:187-96 pubmed publisher
    Following Helicobacter pylori eradication in a placebo-controlled trial, the hypokinesia of idiopathic parkinsonism improved but flexor rigidity worsened.
  7. Moreau C, Delval A, Defebvre L, Dujardin K, Duhamel A, Petyt G, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol. 2012;11:589-96 pubmed publisher
  8. Fogelson N, Kuhn A, Silberstein P, Limousin P, Hariz M, Trottenberg T, et al. Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease. Neurosci Lett. 2005;382:5-9 pubmed
    ..This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia...
  9. Mak M. Reduced step length, not step length variability is central to gait hypokinesia in people with Parkinson's disease. Clin Neurol Neurosurg. 2013;115:587-90 pubmed publisher
    ..The present study aimed to examine whether difference existed in amplitude and variability of step length between control and PD subjects if they walked at a similar speed...
  10. Ling H, Massey L, Lees A, Brown P, Day B. Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease. Brain. 2012;135:1141-53 pubmed publisher
    ..The main finding was hypokinesia without decrement in patients with progressive supranuclear palsy, which differed from the finger tap pattern ..
  11. Weinberger M, Hutchison W, Dostrovsky J. Pathological subthalamic nucleus oscillations in PD: can they be the cause of bradykinesia and akinesia?. Exp Neurol. 2009;219:58-61 pubmed publisher
    ..This commentary reviews some of the recent findings on beta oscillatory activity in PD and highlights the possible role of these pathological oscillations in mediating PD symptoms...
  12. López Azcárate J, Tainta M, Rodriguez Oroz M, Valencia M, Gonzalez R, Guridi J, et al. Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease. J Neurosci. 2010;30:6667-77 pubmed publisher
    ..Our findings suggest that nonlinear coupling between frequencies may not only be a physiological mechanism (as shown previously) but also that it may participate in the pathophysiology of parkinsonism...
  13. Timmermann L, Florin E. Parkinson's disease and pathological oscillatory activity: is the beta band the bad guy? - New lessons learned from low-frequency deep brain stimulation. Exp Neurol. 2012;233:123-5 pubmed publisher
    ..Taken together, the study adds a further piece to the puzzle of understanding the pathophysiology of Parkinson's disease and the mechanisms of deep brain stimulation...
  14. Pogosyan A, Yoshida F, Chen C, Martinez Torres I, Foltynie T, Limousin P, et al. Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization. Neuroscience. 2010;171:245-57 pubmed publisher
    ..In addition, they strengthen the link between pathological synchronization and the different motor features of Parkinsonism...
  15. Carboncini M, Manzoni D, Strambi S, Bonfiglio L, Andre P, Rossi B. Impaired agonists recruitment during voluntary arm movements in patients affected by spasmodic torticollis. Arch Ital Biol. 2004;142:113-24 pubmed
    ..This reduced recruitment in the initial phase of the AG1 appears responsible of the slowness of voluntary movements...
  16. Rodionova N, Polkovenko O, Oganov V. Interactions of cells in zones of bone resorption under microgravity and hypokinesia. J Gravit Physiol. 2004;11:P147-51 pubmed
    ..bone structures of the metaepiphyseal femoral bones of white rats which were during 28 days under experimental hypokinesia conditions, as well as of rats, flown on SLS-2 during 2 weeks...
  17. Spencer K, Rogers M. Speech motor programming in hypokinetic and ataxic dysarthria. Brain Lang. 2005;94:347-66 pubmed
    ..Results provided initial support for processing deficits in speakers with ataxic and hypokinetic dysarthria that are separable from motor execution impairments...
  18. Canu M, Langlet C, Dupont E, Falempin M. Effects of hypodynamia-hypokinesia on somatosensory evoked potentials in the rat. Brain Res. 2003;978:162-8 pubmed
    The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness...
  19. Zorbas Y, Kakurin V, Kuznetsov N, Yarullin V, Andreyev I, Charapakhin K. Phosphate measurements during hypokinesia and phosphate supplements in disclosing phosphate changes in hypokinetic subjects. Panminerva Med. 2002;44:243-51 pubmed
    b>Hypokinesia (diminished movement) induces significant phosphate (P) change, however, little is known about P retention and P depletion during hypokinesia (HK)...
  20. Langlet C, Canu M, Viltart O, Sequeira H, Falempin M. Hypodynamia--hypokinesia induced variations in expression of fos protein in structures related to somatosensory system in the rat. Brain Res. 2001;905:72-80 pubmed
    ..Hypodynamia--hypokinesia is characterized by the absence of weight-bearing and by a decrease in motor activity...
  21. Langlet C, Canu M, Falempin M. Short-term reorganization of the rat somatosensory cortex following hypodynamia-hypokinesia. Neurosci Lett. 1999;266:145-8 pubmed
    This study was performed to determine if hypodynamia-hypokinesia (HH) could induce a reorganization of the rat somatosensory cortex...
  22. Tuisku K, Lauerma H, Holi M, Honkonen T, Rimon R. Akathisia masked by hypokinesia. Pharmacopsychiatry. 2000;33:147-9 pubmed
    ..Our patient was suffering from neuroleptic-induced hypokinesia and akathisia at the same time...
  23. Zorbas Y, Kakurin V, Denogradov S, Luzhkov S, Neofitov A. Muscle electrolyte measurements during and after hypokinesia in determining muscle electrolyte depletion during hypokinesia in the rat. Biol Trace Elem Res. 2002;90:155-73 pubmed
    b>Hypokinesia (diminished movement) induces muscle mineral depletion. However, the mechanism of muscle mineral depletion during hypokinesia (HK) remains unknown...
  24. Zorbas Y, Afonin V, Charapakhin K, Tsiamis C, Denogratov S. Measurements of nuclear size in collecting tubules of the kidney of rats during prolonged hypokinesia and ambulatory conditions. Int Urol Nephrol. 2001;33:423-30 pubmed
    b>Hypokinesia (decreased motor activity) induces significant morphological changes in the kidneys, but little is known about the effect of hypokinesia (HK) on the collecting duct nuclei of the kidney...
  25. Dupont E, Canu M, Falempin M. Atropine prevents the changes in the hindlimb cortical area induced by hypodynamia-hypokinesia. Brain Res. 2002;926:51-7 pubmed
    It has been demonstrated that hypodynamia-hypokinesia (HH), a model of sensory disruption, induced a decrease in the cortical hindpaw representation and an enlargement of the cutaneous receptive fields (RFs)...
  26. Zorbas Y, Kakurin V, Kuznetsov N, Yarullin V, Andreyev I, Charapakhin K. Phosphate deposition capacity of athletes during hypokinesia, phosphate loading, and ambulation. Biol Trace Elem Res. 2002;85:211-26 pubmed
    b>Hypokinesia (diminished movement) induces significant phosphate (P) excretion; however, little is known about the P deposition ability of the body during hypokinesia (HK)...
  27. Hilliard J, Frysinger R, Elias W. Effective subthalamic nucleus deep brain stimulation sites may differ for tremor, bradykinesia and gait disturbances in Parkinson's disease. Stereotact Funct Neurosurg. 2011;89:357-64 pubmed publisher
    ..This study investigates whether improvement for particular PD symptoms varies differentially with respect to stimulation location in the STN...
  28. Bowers D, Miller K, Bosch W, Gokcay D, Pedraza O, Springer U, et al. Faces of emotion in Parkinsons disease: micro-expressivity and bradykinesia during voluntary facial expressions. J Int Neuropsychol Soc. 2006;12:765-73 pubmed
    ..Taken together, the characterization of Parkinson's disease as a model system for the neuroanatomic dissociation between voluntary and spontaneous expressions may be unjustified...
  29. Saito Y, Hayashi M, Miyazono Y, Shimogama T, Ohno K. Arthrogryposis multiplex congenita with callosal agenesis and dentato-olivary dysplasia. Brain Dev. 2006;28:261-4 pubmed
    ..The differential diagnoses for the clinical and pathological characteristics of this patient are discussed...
  30. Kravitz A, Freeze B, Parker P, Kay K, Thwin M, Deisseroth K, et al. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature. 2010;466:622-6 pubmed publisher
  31. Manukian A, Simonian M, Simonian R, Simonian G. [Regulating effect of gamma-aminobutyric acid and pyrrolidone-2 on endogenous blood metalloproteins with anti- and pro-oxidant activity in hypoxia]. Eksp Klin Farmakol. 2004;67:28-31 pubmed
    Various stages of hypokinesia are marked by specific changes in the level and activity of endogenous metalloproteins with anti- (MAA) and prooxidant action (MPA)...
  32. Blomstedt P, Fytagoridis A, Aström M, Linder J, Forsgren L, Hariz M. Unilateral caudal zona incerta deep brain stimulation for Parkinsonian tremor. Parkinsonism Relat Disord. 2012;18:1062-6 pubmed publisher
    ..The aim of the current study was to evaluate cZi DBS in tremor-dominant Parkinson's disease...
  33. Plaha P, Ben Shlomo Y, Patel N, Gill S. Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain. 2006;129:1732-47 pubmed
    ..We discuss the implications of this finding and the potential role played by the ZI in Parkinson's disease...
  34. Mercado R, Constantoyannis C, Mandat T, Kumar A, Schulzer M, Stoessl A, et al. Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation. Mov Disord. 2006;21:1457-61 pubmed
    ..The results presented support the role of expectation and placebo effects in STN-DBS in Parkinson's disease patients...
  35. Gunzler S, Stoessl A, Egan R, Weleber R, Wang P, Nutt J. Joubert syndrome surviving to adulthood associated with a progressive movement disorder. Mov Disord. 2007;22:262-5 pubmed
    ..This case demonstrates that a patient with Joubert syndrome may survive into adulthood and present as a chronic neurologic disorder with subacute extrapyramidal signs...
  36. Louter M, van Sloun R, Pevernagie D, Arends J, Cluitmans P, Bloem B, et al. Subjectively impaired bed mobility in Parkinson disease affects sleep efficiency. Sleep Med. 2013;14:668-74 pubmed publisher
    ..Here we assessed the influence of subjectively IBM on both subjective and objective sleep parameters in insomnia PD patients with (PD+IBM) and without (PD-IBM) concerns of IBM and controls with primary insomnia...
  37. Anastasopoulos D, Ziavra N, Pearce R, Bronstein A. Trunk bradykinesia and foveation delays during whole-body turns in spasmodic torticollis. J Neurol. 2013;260:2057-65 pubmed publisher
    ..Eye movements per se are intact and compensate for the reduced head/trunk performance in an adaptive manner...
  38. Ghaziuddin N, Dhossche D, Marcotte K. Retrospective chart review of catatonia in child and adolescent psychiatric patients. Acta Psychiatr Scand. 2012;125:33-8 pubmed publisher
    ..Identify the frequency of catatonia among at-risk children and adolescents receiving psychiatric treatment...
  39. Ni M, Signorile J, Balachandran A, Potiaumpai M. Power training induced change in bradykinesia and muscle power in Parkinson's disease. Parkinsonism Relat Disord. 2016;23:37-44 pubmed publisher
    ..The 3-month PWT program significantly reduced bradykinesia and increased muscle strength and power in older patients with PD. Power training is an effective training modality to improve physical function and quality of life for PD. ..
  40. Reyhani Rad S, Mahmoudi J. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat. Acta Cir Bras. 2016;31:133-7 pubmed publisher
    ..Adenosine A2AR antagonists improve 6-OHDA-motor deficit and this effect seems to be mediated by the inhibition of A2A presynaptic receptors in substantia nigra pars compacta. ..
  41. Fauchier L, Eder V, Casset Senon D, Marie O, Babuty D, Cosnay P, et al. Segmental wall motion abnormalities in idiopathic dilated cardiomyopathy and their effect on prognosis. Am J Cardiol. 2004;93:1504-9 pubmed
    ..Thus, segmental wall motion abnormalities are frequent in IDC and are associated with severe systolic dysfunction and a worse prognosis...
  42. Singh A, Mehrkens J, Bötzel K. Effect of micro lesions of the basal ganglia on ballistic movements in patients with deep brain stimulation. J Neurol Sci. 2012;314:175-7 pubmed publisher
    Bradykinesia and hypokinesia are the prominent symptoms of substantia nigra degeneration in Parkinson's disease (PD). In segmental dystonia, movements of not affected limbs are not impaired...
  43. Oskarsson B, Pelak V, Quan D, Hall D, Foster C, Galetta S. Stiff eyes in stiff-person syndrome. Neurology. 2008;71:378-80 pubmed publisher
  44. Treffort N, Picquet F, Petit J, Falempin M. The structure and response properties of Golgi tendon organs in control and hypodynamia-hypokinesia rats. Exp Neurol. 2005;195:313-21 pubmed
    ..A 14-day period of hypodynamia, absence of weight bearing and hypokinesia, and reduction of motor activity (HH) is known to induce changes in postural muscles such as the soleus...
  45. Alam M, Danysz W, Schmidt W, Dekundy A. Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. Toxicol Appl Pharmacol. 2009;240:198-207 pubmed publisher
    ..Treatment-related effects on parkinsonian-like behaviours, such as hypokinesia/rigidity and locomotor activity, were evaluated...
  46. Lobachik V, Gordeev I, Nosovskii A, Pishchulina G, Chupushtanov S, Korol kov V, et al. [Body fluids ratio and postural stability of head-down tilted apes in the periods of transition into the active vertical position]. Aviakosm Ekolog Med. 2006;40:24-8 pubmed
  47. Cannon J, Tapias V, Na H, Honick A, Drolet R, Greenamyre J. A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis. 2009;34:279-90 pubmed
    ..In summary, this version of the rotenone model is highly reproducible and may provide an excellent tool to test new neuroprotective strategies...
  48. Goetz C, Stebbins G, Wolff D, DeLeeuw W, Bronte Stewart H, Elble R, et al. Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at-home testing device. Mov Disord. 2009;24:551-6 pubmed publisher
  49. Kozlova T. [Hypodynamia and spontaneous venous thromboses]. Klin Med (Mosk). 2007;85:36-9 pubmed
    ..Besides, the authors discuss a range of questions concerning terminology of low physical activity, distinguishing the reasons for hypodynamia, and evaluation of existing questionnaires for measuring the levels of physical activity...
  50. Zorbas Y, Deogenov V, Merkov P, Federenko Y. Chronic periodic fluid redistribution effect on muscle calcium in healthy subjects during prolonged hypokinesia. J Physiol Sci. 2012;62:233-9 pubmed publisher
    ..To determine if chronic periodic fluid and volume shifting upwards can affect muscle calcium (Ca(2+)) during hypokinesia (HK) we measured muscle Ca(2+) content, plasma Ca(2+) concentration, and Ca(2+) losses in urine and feces...
  51. Japaridze N, Okuneva V, Qsovreli M, Surmava A, Lordkipanidze T, Kiladze M, et al. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron. 2012;43:948-53 pubmed publisher
  52. Carron R, Fraix V, Maineri C, Seigneuret E, Piallat B, Krack P, et al. High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a review. J Neural Transm (Vienna). 2011;118:915-24 pubmed publisher
  53. Stogov M. Creatine metabolism in skeletal muscles during hypokinesia. Bull Exp Biol Med. 2009;148:26-8 pubmed
    ..Addition of a mixture of amino acids-precursors of creatine and branch-chained amino acids in the ratio 1:1 to ration prevented creatine and creatine-phosphate loss in muscles under the used experimental conditions...