hyperkinesis

Summary

Summary: Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.

Top Publications

  1. Paciorkowski A, Traylor R, Rosenfeld J, Hoover J, Harris C, Winter S, et al. MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways. Neurogenetics. 2013;14:99-111 pubmed publisher
    ..A spectrum of neurofunctional deficits emerges, with hyperkinesis a consistent finding...
  2. Viggiano D. The hyperactive syndrome: metanalysis of genetic alterations, pharmacological treatments and brain lesions which increase locomotor activity. Behav Brain Res. 2008;194:1-14 pubmed publisher
    ..We suggest that the increased locomotor activity in many psychiatric diseases may derive from the interference with the development of this brain axis during a specific postnatal time window...
  3. Maubourguet N, Lesne A, Changeux J, Maskos U, Faure P. Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration. PLoS Comput Biol. 2008;4:e1000229 pubmed publisher
  4. Gelegen C, Pjetri E, Campbell I, Collier D, Oppelaar H, Kas M. Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule. Eur Neuropsychopharmacol. 2010;20:317-26 pubmed publisher
    ..Therefore, our data open new roads for interspecies genetic studies of AN and for unraveling novel mechanisms and potential effective treatment strategies for these neurobehavioral traits...
  5. Belforte J, Zsiros V, Sklar E, Jiang Z, Yu G, Li Y, et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 2010;13:76-83 pubmed publisher
    ..These findings suggest that early postnatal inhibition of NMDAR activity in corticolimbic GABAergic interneurons contributes to the pathophysiology of schizophrenia-related disorders. ..
  6. Graham D, Sidhu A. Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior. J Neurosci Res. 2010;88:1777-83 pubmed publisher
    ..These results indicate a possible role of the A53T alpha-Syn mutation in anxiety-like and hyperactive behaviors in a PD mouse model, suggesting that these behaviors might be comorbid with this disease...
  7. Garami A, Pakai E, Oliveira D, Steiner A, Wanner S, Almeida M, et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci. 2011;31:1721-33 pubmed publisher
    ..overweight and includes hypometabolism, enhanced skin vasoconstriction, decreased thermopreferendum, and hyperkinesis. The latter may be one of the primary deficiencies in Trpv1 KO mice...
  8. Pingault J, Tremblay R, Vitaro F, Carbonneau R, Genolini C, Falissard B, et al. Childhood trajectories of inattention and hyperactivity and prediction of educational attainment in early adulthood: a 16-year longitudinal population-based study. Am J Psychiatry. 2011;168:1164-70 pubmed publisher
    ..The aim of the present study was to differentiate the unique, additive, or interactive contributions of inattention and hyperactivity symptoms to educational attainment...
  9. Uutela M, Lindholm J, Louhivuori V, Wei H, Louhivuori L, Pertovaara A, et al. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes Brain Behav. 2012;11:513-23 pubmed publisher
    ..Our results show that the absence of FMRP modifies the diverse effects of BDNF on the FXS phenotype...

More Information

Publications62

  1. King I, Tsai L, Pflanz R, Voigt A, Lee S, Jackle H, et al. Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J Neurosci. 2011;31:1139-48 pubmed publisher
  2. Ohashi K, Vitaliano G, Polcari A, Teicher M. Unraveling the nature of hyperactivity in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2010;67:388-96 pubmed publisher
    ..Seated hyperactivity is a defining feature of the combined and predominantly hyperactive-impulsive subtypes of attention-deficit/hyperactivity disorder (ADHD), but its underlying nature is unknown...
  3. Cerrato M, Carrera O, Vazquez R, Echevarria E, Gutierrez E. Heat makes a difference in activity-based anorexia: a translational approach to treatment development in anorexia nervosa. Int J Eat Disord. 2012;45:26-35 pubmed publisher
    ..To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals...
  4. Li X, Li J, Zhu X, Cui R, Jiao J. Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats. Behav Brain Res. 2010;206:223-8 pubmed publisher
    ..Physostigmine attenuates the expressions but enhances the development of conditioned hyperactivity and sensitization and the possible mechanisms are discussed...
  5. Paine T, Neve R, Carlezon W. Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats. Neuropsychopharmacology. 2009;34:2143-55 pubmed publisher
    ..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders...
  6. Williams J, Sagvolden G, Taylor E, Sagvolden T. Dynamic behavioural changes in the Spontaneously Hyperactive Rat: 1. Control by place, timing, and reinforcement rate. Behav Brain Res. 2009;198:273-82 pubmed publisher
    ..Alterations in learning rate are not a sufficient explanation for either SHR or ADHD difference from controls...
  7. Avale M, Faure P, Pons S, Robledo P, Deltheil T, David D, et al. Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. Proc Natl Acad Sci U S A. 2008;105:15991-6 pubmed publisher
    ..These findings highlight the crucial interplay of nAChRs over the DA control of spontaneous locomotion...
  8. Tomonaga S, Tachibana T, Takahashi H, Sato M, Denbow D, Furuse M. Nitric oxide involves in carnosine-induced hyperactivity in chicks. Eur J Pharmacol. 2005;524:84-8 pubmed
    ..These results suggest that carnosine-induced hyperactivity may be linked to the constitutive NOS (cNOS), rather than iNOS, in the brain. Central carnosine may regulate brain function and/or behaviors by NO generation via cNOS in chicks...
  9. Doly S, Valjent E, Setola V, Callebert J, Herve D, Launay J, et al. Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro. J Neurosci. 2008;28:2933-40 pubmed publisher
    ..e., modulation of 5-HT release. As such, 5-HT(2B) receptor antagonists may serve as promising therapeutic drugs for MDMA abuse...
  10. Ralph Williams R, Paulus M, Zhuang X, Hen R, Geyer M. Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatry. 2003;53:352-9 pubmed
    ..We hypothesized that the DAT KD mice would also display deficits in prepulse inhibition (PPI) and would be perseverative in their locomotor behavior...
  11. Côté S, Tremblay R, Nagin D, Zoccolillo M, Vitaro F. Childhood behavioral profiles leading to adolescent conduct disorder: risk trajectories for boys and girls. J Am Acad Child Adolesc Psychiatry. 2002;41:1086-94 pubmed
    ..To examine the link between childhood behavioral dimensions and adolescent conduct disorder (CD) among a large sample of boys and girls monitored longitudinally...
  12. Schwebel D, Brezausek C, Ramey S, Ramey C. Interactions between child behavior patterns and parenting: implications for children's unintentional injury risk. J Pediatr Psychol. 2004;29:93-104 pubmed
    ..Along with hypotheses to replicate previous univariate effects, it was hypothesized that active, involved parents with sufficient time resources might reduce injury risk among temperamentally at-risk children...
  13. Castellanos F, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002;3:617-28 pubmed
  14. Vanderschuren L, Beemster P, Schoffelmeer A. On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization. Psychopharmacology (Berl). 2003;169:176-85 pubmed
  15. Hillebrand J, de Rijke C, Brakkee J, Kas M, Adan R. Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia. Physiol Behav. 2005;85:151-7 pubmed
    ..These data suggest that ABA rats prefer to prevent hypothermia passively by choosing a warm plate rather than actively regulating body temperature by hyperactivity...
  16. Trantham Davidson H, Vazdarjanova A, Dai R, Terry A, Bergson C. Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav Brain Res. 2008;189:244-9 pubmed publisher
  17. van Elburg A, Kas M, Hillebrand J, Eijkemans R, van Engeland H. The impact of hyperactivity and leptin on recovery from anorexia nervosa. J Neural Transm (Vienna). 2007;114:1233-7 pubmed
    ..No major relationship of activity with the course of recovery was detected, suggesting that in contrast to the acute stage of the disease, leptin and activity levels during the recovery process are dissociated...
  18. Prickaerts J, Moechars D, Cryns K, Lenaerts I, Van Craenendonck H, Goris I, et al. Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J Neurosci. 2006;26:9022-9 pubmed
    ..The behavioral observations led to the suggestion that the model at hand recapitulates hyperactivity as observed in the manic phase of bipolar disorder...
  19. Unger E, Eve D, Perez X, Reichenbach D, Xu Y, Lee M, et al. Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiol Dis. 2006;21:431-43 pubmed
    ..Thus, expression of A53T mutant human alpha-synuclein in mice results in adult-onset hyperactivity associated with D1 receptor and dopamine transporter-mediated alterations in dopamine neurotransmission...
  20. Geyer M, Ellenbroek B. Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:1071-9 pubmed
    ..Moreover, there is an urgent need for animal models focusing more on the negative and the cognitive symptoms. Hence, improved animal models are crucial for developing better treatments for schizophrenia...
  21. Sagvolden T, Russell V, Aase H, Johansen E, Farshbaf M. Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1239-47 pubmed
  22. Mattsson A, Lindqvist E, Ogren S, Olson L. Increased phencyclidine-induced hyperactivity following cortical cholinergic denervation. Neuroreport. 2005;16:1815-9 pubmed
    ..These results suggest that aberrations in cholinergic function might lead to glutamatergic dysfunctions, which might be of relevance for the pathophysiology for schizophrenia...
  23. Griggs R, Weir C, Wayman W, Koeltzow T. Intermittent methylphenidate during adolescent development produces locomotor hyperactivity and an enhanced response to cocaine compared to continuous treatment in rats. Pharmacol Biochem Behav. 2010;96:166-74 pubmed publisher
  24. Delavarian M, Towhidkhah F, Gharibzadeh S, Dibajnia P. Automatic classification of hyperactive children: comparing multiple artificial intelligence approaches. Neurosci Lett. 2011;498:190-3 pubmed publisher
    ..With examining 16 different available classifiers, by using "Prtools", we have proposed nearest mean classifier as the most accurate classifier with 96.92% accuracy in this research...
  25. Zhao C, Sun T, Li M. Neural basis of the potentiated inhibition of repeated haloperidol and clozapine treatment on the phencyclidine-induced hyperlocomotion. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38:175-82 pubmed publisher
    ..These findings suggest that repeated HAL achieves its potentiated inhibition of the PCP-induced hyperlocomotion by acting on the NAs, CeA and VTA, while CLZ does so by acting on the mPFC, LSv and VTA...
  26. Kadota Y, Cooper G, Burton A, Lemon J, Schall U, Lloyd A, et al. Autonomic hyper-vigilance in post-infective fatigue syndrome. Biol Psychol. 2010;85:97-103 pubmed publisher
    ..Together with the distinct pattern in cardiac responsivity these findings present a picture of physiological hyper-vigilance and response inflexibility...
  27. Seibt K, Oliveira R, Zimmermann F, Capiotti K, Bogo M, Ghisleni G, et al. Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio). Behav Brain Res. 2010;214:417-22 pubmed publisher
    ..In this work we demonstrated the value of the zebrafish, a simple to use animal model, in developing some behavioral features observed in schizophrenia, which may indicate a new approach for drug screening...
  28. Dawe G, Nagarajah R, Albert R, Casey D, Gross K, Ratty A. Antipsychotic drugs dose-dependently suppress the spontaneous hyperactivity of the chakragati mouse. Neuroscience. 2010;171:162-72 pubmed publisher
    ..These data suggest that the spontaneous circling and hyperactivity of the ckr mouse may allow screening of candidate antipsychotic compounds, distinguishing compounds with aripriprazole-like profiles...
  29. Halberstadt A, Lehmann Masten V, Geyer M, Powell S. Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology (Berl). 2011;215:81-92 pubmed publisher
  30. Feng J, Xu Y, Wang M, Ruan Y, So K, Tissir F, et al. A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. J Neurosci. 2012;32:13729-43 pubmed publisher
    ..Postnatal neurogenesis was preserved and mutant interneurons were able to migrate to the hippocampus. Thus, like in neocortex, Celsr3 is required for hippocampal development, connectivity and function, and for pyramidal cell maturation...
  31. Oliver C, Sloneem J, Hall S, Arron K. Self-injurious behaviour in Cornelia de Lange syndrome: 1. Prevalence and phenomenology. J Intellect Disabil Res. 2009;53:575-89 pubmed publisher
    ..Self-injurious behaviour is frequently identified as part of the behavioural phenotype of Cornelia de Lange syndrome (CdLS). We conducted a case-control study of the prevalence and phenomenology of self-injurious behaviour (SIB) in CdLS...
  32. Kaundal R, Iyer S, Kumar A, Sharma S. Protective effects of pioglitazone against global cerebral ischemic-reperfusion injury in gerbils. J Pharmacol Sci. 2009;109:361-7 pubmed
    ..This study demonstrates the neuroprotective activity of pioglitazone in global cerebral IR injury and its neuroprotective effects may be attributed to reduction in oxidative stress and DNA fragmentation...
  33. Zalot A, Jones D, Kincaid C, Smith T. Hyperactivity, impulsivity, inattention (HIA) and conduct problems among African American youth: the roles of neighborhood and gender. J Abnorm Child Psychol. 2009;37:535-49 pubmed publisher
    ..Future research directions and implications of the findings are discussed...
  34. Young J, Kooistra K, Geyer M. Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil. Neuropsychopharmacology. 2011;36:1385-96 pubmed publisher
    ..The modafinil-induced alterations in exploratory behavior may reflect increased synaptic dopamine and secondary actions mediated by dopamine drd1 and drd4 receptors...
  35. Suchy Y, Lee J, Marchand W. Aberrant cortico-subcortical functional connectivity among women with poor motor control: toward uncovering the substrate of hyperkinetic perseveration. Neuropsychologia. 2013;51:2130-41 pubmed publisher
    ..e., in the absence of known neuropathology). The purpose of the present study was to examine anomalies in brain functioning associated with HKP tendencies in a non-injured brain...
  36. Mann N, Bitsios P. Modafinil treatment of amphetamine abuse in adult ADHD. J Psychopharmacol. 2009;23:468-71 pubmed publisher
    ..The drug resolved both the inattention/hyperactivity symptoms as well as the amphetamine abuse. Modafinil may be a suitable candidate treatment for adults with ADHD and stimulant abuse...
  37. Vidal P, Pérez Padilla A, Pellón R. Rapid development of semistarvation-induced hyperactivity in Dark Agouti rats. Excessive wheel running and effect of 3,4-methylenedioxymethamphetamine (MDMA). Appetite. 2013;61:30-5 pubmed publisher
    ..These results, by showing a general high level of wheel running in Dark Agouti rats, once again emphasise the close relationship between activity and weight loss in the development of SIH and related phenomena such as ABA...
  38. Maskey D, Pradhan J, Oh C, Kim M. Changes in the distribution of calbindin D28-k, parvalbumin, and calretinin in the hippocampus of the circling mouse. Brain Res. 2012;1437:58-68 pubmed publisher
    ..A decrease in CaBPs and the probable resultant glutamate-mediated excitability could contribute to the functional changes that lead to the characteristic behavioral features of cir mice...
  39. Gao J, Li M. Time-dependence of risperidone and asenapine sensitization and associated D2 receptor mechanism. Behav Brain Res. 2013;257:286-94 pubmed publisher
    ..These findings suggest that risperidone and asenapine sensitization is long-lasting, follows the TDS principle, and is likely mediated by D2 receptor supersensitivity. ..
  40. Gravius A, Laszy J, Pietraszek M, Sághy K, Nagel J, Chambon C, et al. Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behav Pharmacol. 2011;22:122-35 pubmed publisher
    ..These data show moderate efficacy in some models for AD but do not support the therapeutic potential of 5-HT6 antagonists for schizophrenia...
  41. Downing C, Balderrama Durbin C, Hayes J, Johnson T, Gilliam D. No effect of prenatal alcohol exposure on activity in three inbred strains of mice. Alcohol Alcohol. 2009;44:25-33 pubmed publisher
    ..The present study investigated the effects of prenatal ethanol exposure on activity in mice from three inbred strains: C57BL/6 (B6), Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS)...
  42. Rasmussen B, Unterwald E, Rawls S. Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats. Drug Alcohol Depend. 2011;118:484-8 pubmed publisher
  43. van Gaalen M, Relo A, Mueller B, Gross G, Mezler M. NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance. Neurosci Lett. 2012;510:58-61 pubmed publisher
    ..Deletion of NgR1 did not affect amphetamine- or phencyclidine (PCP)-induced hyperactivity, two models of positive symptoms of schizophrenia. Taken together, ngr(-/-) animals show slower acquisition of a spatial learning and memory task...
  44. Fabricius K, Helboe L, Fink Jensen A, Wortwein G, Steiniger Brach B. Pharmacological characterization of social isolation-induced hyperactivity. Psychopharmacology (Berl). 2011;215:257-66 pubmed publisher
    ..The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia...
  45. Caraballo R, Soraru A, Cersosimo R. Electroclinical overlap of two types of epileptic encephalopathy occurring in the same children in a certain age period?. Epilepsy Res. 2012;101:185-90 pubmed publisher
    ..5 years. All three patients could be considered to have two EE: CSWSS syndrome and LGS or to have had overlapping features of these epileptic syndromes...
  46. Han S, Tai C, Westenbroek R, Yu F, Cheah C, Potter G, et al. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature. 2012;489:385-90 pubmed publisher
    ..These results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome...
  47. Ma J, Leung L. Kindled seizure in the prefrontal cortex activated behavioral hyperactivity and increase in accumbens gamma oscillations through the hippocampus. Behav Brain Res. 2010;206:68-77 pubmed publisher
    ..Postictal gamma and hyperactivity required an intact hippocampus, perhaps through the hippocampal-NAC pathway. PFC kindling, similar to hippocampal CA1 kindling, resulted in a prolonged deficit in PPI...
  48. Karlsson R, Tanaka K, Heilig M, Holmes A. Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist. Biol Psychiatry. 2008;64:810-4 pubmed publisher
  49. Sadleir L, Mountier E, Gill D, Davis S, Joshi C, Devile C, et al. Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype. Neurology. 2017;89:1035-1042 pubmed publisher
    ..Remarkably, 8 of 9 children had the recurrent missense mutation p.Thr226Met. ..
  50. Bankstahl M, Bankstahl J, Loscher W. Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy. Exp Neurol. 2012;234:70-84 pubmed publisher
    ..These findings demonstrate that in the pilocarpine model, similar to epilepsy patients, epileptic rats differ in their response to an AED, which is most likely due to as yet unknown genetic factors...
  51. Perez S, Shah A, Asher A, Lodge D. Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia. Int J Neuropsychopharmacol. 2013;16:1331-9 pubmed publisher
    ..Therefore, we have provided initial preclinical evidence demonstrating the feasibility of hippocampal DBS as a potential novel approach for the treatment of schizophrenia...
  52. Oshikoya K, Senbanjo I, Njokanma O, Soipe A. Use of complementary and alternative medicines for children with chronic health conditions in Lagos, Nigeria. BMC Complement Altern Med. 2008;8:66 pubmed publisher
  53. Chen L, Yang X, Liu Y, Zeng D, Tang Y, Yan B, et al. Quantitative and trajectory analysis of movement trajectories in supplementary motor area seizures of frontal lobe epilepsy. Epilepsy Behav. 2009;14:344-53 pubmed publisher
    ..This study proved the feasibility of quantitative analysis of SMA seizures and suggests it should be further evaluated for its capability to distinguish different seizure semiologies for the diagnosis of epilepsy...