gait ataxia

Summary

Summary: Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

Top Publications

  1. Ilg W, Timmann D. Gait ataxia--specific cerebellar influences and their rehabilitation. Mov Disord. 2013;28:1566-75 pubmed publisher
    ..As such, one of the most characteristic and sensitive signs of cerebellar damage is gait ataxia. However, characterizing ataxic gait is no easy task, because gait patterns are highly variable...
  2. Oluwole O, Onabolu A, Link H, Rosling H. Persistence of tropical ataxic neuropathy in a Nigerian community. J Neurol Neurosurg Psychiatry. 2000;69:96-101 pubmed
  3. Bultmann U, Pierscianek D, Gizewski E, Schoch B, Fritsche N, Timmann D, et al. Functional recovery and rehabilitation of postural impairment and gait ataxia in patients with acute cerebellar stroke. Gait Posture. 2014;39:563-9 pubmed publisher
    ..assessed motor deficits in the acute phase after isolated cerebellar stroke focusing on postural impairment and gait ataxia and outlines the role of lesion site on motor outcome, the course of recovery and the effect of treadmill ..
  4. Morton S, Bastian A. Mechanisms of cerebellar gait ataxia. Cerebellum. 2007;6:79-86 pubmed
    ..As such, one of the most characteristic and sensitive signs of cerebellar damage is gait ataxia. How the cerebellum normally contributes to locomotor behavior is unknown, though recent work suggests that it ..
  5. Fasano A, Herzog J, Raethjen J, Rose F, Muthuraman M, Volkmann J, et al. Gait ataxia in essential tremor is differentially modulated by thalamic stimulation. Brain. 2010;133:3635-48 pubmed publisher
    Patients with advanced stages of essential tremor frequently exhibit tandem gait ataxia with impaired balance control and imprecise foot placement, resembling patients with a cerebellar deficit...
  6. Morton S, Bastian A. Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia. J Neurophysiol. 2003;89:1844-56 pubmed
    ..We wanted to determine the relative contributions of balance versus leg-coordination deficits to cerebellar gait ataxia in humans...
  7. Tolbert D, Clark B. GDNF and IGF-I trophic factors delay hereditary Purkinje cell degeneration and the progression of gait ataxia. Exp Neurol. 2003;183:205-19 pubmed
    ..b>Gait ataxia and whole body tremor develop concomitant with the degeneration of Purkinje neurons...
  8. De Rosa A, Striano P, Barbieri F, de Falco A, Rinaldi C, Tucci T, et al. Suppression of myoclonus in SCA2 by piracetam. Mov Disord. 2006;21:116-8 pubmed
    ..Piracetam may be considered in the treatment of refractory myoclonus in spinocerebellar degenerations...
  9. Gialanella B, Bertolinelli M, Monguzzi V, Santoro R. Walking and disability after rehabilitation in patients with cerebellar stroke. Minerva Med. 2005;96:373-8 pubmed
    ..Aim of this study is to verify if the presence of extracerebellar stroke lesions negatively affects walking and functional capacities recovery of patients with cerebellar stroke...

More Information

Publications62

  1. Toepfer M, Schroeder M, Unger J, Lochmuller H, Pongratz D, Müller Felber W. Neuromyotonia, myocloni, sensory neuropathy and cerebellar symptoms in a patient with antibodies to neuronal nucleoproteins (anti-Hu-antibodies). Clin Neurol Neurosurg. 1999;101:207-9 pubmed
    A middle-aged patient presented with subacute muscular stiffness, myocloni of both extremity and facial muscles, gait ataxia and symmetrical distal painful paraesthesias. Electrophysiologically, neuromyotonia was confirmed...
  2. Jellema K, Canta L, Tijssen C, van Rooij W, Koudstaal P, van Gijn J. Spinal dural arteriovenous fistulas: clinical features in 80 patients. J Neurol Neurosurg Psychiatry. 2003;74:1438-40 pubmed
  3. Bhidayasiri R, Perlman S. Medical image. "Hot cross bun" sign. N Z Med J. 2007;120:U2563 pubmed
  4. Videt Gibou D, Belliard S, Rivalan J, Menard D, Edan G. [Acquired copper deficiency myelopathy]. Rev Neurol (Paris). 2010;166:639-43 pubmed publisher
    ..Early recognition and treatment may prevent neurological deterioration but improvement seems to be slight and inconstant...
  5. Prometti P, Olivares A, Gaia G, Bonometti G, Comini L, Scalvini S. Biodex Fall Risk Assessment in the Elderly With Ataxia: A New Age-Dependent Derived Index in Rehabilitation: An Observational Study. Medicine (Baltimore). 2016;95:e2977 pubmed publisher
    ..The normalized FRI could be a standardized measure for identifying frailer patients becoming a further criterium of discharge home and marker of fall risk at home. ..
  6. Lin J, Lachmann E, Nagler W. Paraneoplastic cerebellar degeneration as the first manifestation of cancer. J Womens Health Gend Based Med. 2001;10:495-502 pubmed
    ..Patients typically experience pancerebellar symptoms, including gait ataxia, dysarthria, nystagmus, and truncal and appendicular ataxia...
  7. Raison M, Aubin C, Detrembleur C, Fisette P, Samin J. Quantification of intervertebral efforts during walking: comparison between a healthy and a scoliotic subject. Stud Health Technol Inform. 2008;140:61-4 pubmed
    ..5 to max 1.9 Nm/kg) than the healthy subject (from -1.5 to 1.5 Nm/kg). This disequilibrium in the left-right balance of the scoliotic patient is a bit rectified after surgery (from -1.3 to 1.1 Nm/kg)...
  8. Launay M, Delmont E, Benaim C, Sacconi S, Butori C, Desnuelle C. [Anti-MAG paraproteinemic demyelinating polyneuropathy: a clinical, biological, electrophysiological and anatomopathological descriptive study of a 13-patients' cohort]. Rev Neurol (Paris). 2009;165:1071-9 pubmed publisher
    ..Polyneuropathies associated with IgM paraproteinemia and anti-myelin associated glycoprotein (MAG) antibodies (MAG-PN) have to be differentiated from chronic inflammatory demyelinating polyneuropathies...
  9. Pipatpajong H, Phanthumchinda K. Neurofibromatosis type I associated multiple sclerosis. J Med Assoc Thai. 2011;94:505-10 pubmed
    ..Only thirteen cases with NF1 and multiple sclerosis have been described in the literature. The association has been hypothesized to be related to mutations in the neurofibromin protein or oligodendrocyte-myelin glycoprotein (OMgp) gene...
  10. Liu J, Cole C, Sherr G, Kestle J, Walker M. Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a child. J Neurosurg. 2005;103:266-9 pubmed
    ..11-year-old girl presented with urinary urgency, progressive lower-extremity weakness, myelopathy, and severe gait ataxia. Magnetic resonance imaging of the spine demonstrated a large extradural arachnoid cyst extending from T-8 to T-..
  11. Li X, Deng S, Xie Z. [Acute effects of low and moderate doses of alcohol on coordinate motor and autonomic nervous function in a group of healthy Hans]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23:635-9 pubmed
    ..These suggested that the increase of alcohol intake is adverse to human body's adaptation to the sharp change of circumstance...
  12. Fujikawa A, Tsuchiya K, Takeuchi S, Hachiya J. Diffusion-weighted MR imaging in acute spinal cord ischemia. Eur Radiol. 2004;14:2076-8 pubmed
    ..DW imaging of the spinal cord can contribute to the early detection of spinal cord vascular compromise...
  13. Carrillo F, Schneider S, Taylor A, Srinivasan V, Kapoor R, Bhatia K. Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia. Cerebellum. 2009;8:22-7 pubmed publisher
    ..Dystonia was generalized and with prominent oromandibular involvement. Unusually, a leash of telangiectasia was present on the posterior pharyngeal wall, while other features frequently associated with A-T were absent...
  14. Kerbrat A, Ferre J, Fillatre P, Ronziere T, Vannier S, Carsin Nicol B, et al. Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase. N Engl J Med. 2016;375:1717-1725 pubmed
    ..In a phase 1 study, BIA 10-2474, an orally administered reversible FAAH inhibitor, was given to healthy volunteers to assess safety...
  15. Synofzik M, Schicks J, Lindig T, Biskup S, Schmidt T, Hansel J, et al. Acetazolamide-responsive exercise-induced episodic ataxia associated with a novel homozygous DARS2 mutation. J Med Genet. 2011;48:713-5 pubmed publisher
    ..So far, affected individuals were invariably compound heterozygous for two mutations in DARS2, and drug treatments have remained elusive...
  16. Arbogast S, Khanna S, Koontz D, Tomsak R, Katirji B, Leigh R. Chronic ataxic neuropathy mimicking dorsal midbrain syndrome. J Neurol Neurosurg Psychiatry. 2007;78:1276-7 pubmed
    ..Thus, in common with Miller Fisher syndrome, CANOMAD may present with clinical findings implicating involvement of the central nervous system, which contains ganglioside antigens to anti-GD1b antibodies...
  17. Takado Y, Hara K, Shimohata T, Tokiguchi S, Onodera O, Nishizawa M. New mutation in the non-gigantic exon of SACS in Japanese siblings. Mov Disord. 2007;22:748-9 pubmed
  18. Whittle I, Knight R, Will R. Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease. Acta Neurochir (Wien). 2006;148:677-9; discussion 679 pubmed
    ..The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced...
  19. Mulholland P. Susceptibility of the cerebellum to thiamine deficiency. Cerebellum. 2006;5:55-63 pubmed
  20. Hackett P, Roach R. High altitude cerebral edema. High Alt Med Biol. 2004;5:136-46 pubmed
    ..We conclude the review with several case histories to illustrate key clinical features of the disorder...
  21. Inoue N, Ichimura H, Goto S, Hashimoto Y, Ushio Y. MR imaging findings of spinal posterior column involvement in a case of Miller Fisher syndrome. AJNR Am J Neuroradiol. 2004;25:645-8 pubmed
  22. Butterfield R, Roper R, Rhein D, Melvold R, Haynes L, Ma R, et al. Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination. Genetics. 2003;163:1041-6 pubmed
    ..Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice...
  23. Bhupali C, Cummings B, Parker L, Young R, Noviski N. Positive lidocaine toxicology screen after J-Tip for venipuncture. Pediatr Emerg Care. 2013;29:1278-9 pubmed publisher
    ..This report serves to remind clinicians that topical anesthetics may interfere with toxicology assays, leading to unreliable toxicology results. ..
  24. Misra S, Ramesh R, Ramu C, Srirangalaxmi G, Radhakrishn H, Vajresware -. Adrenomyeloneuropathy. J Assoc Physicians India. 2012;60:58-61 pubmed
    A 29-year-old male patient presented with progressive spastic paraparesis of three years duration. He also had gait ataxia which led to recurrent falls. In addition, there was pigmentation of the skin creases, tongue and buccal mucosa...
  25. Ogi S, Fukumitsu N, Tsuchida D, Uchiyama M, Mori Y, Matsui K. Imaging of bilateral striopallidodentate calcinosis. Clin Nucl Med. 2002;27:721-4 pubmed
    ..The moderate reduction of cerebral blood flow in bilateral thalami was also identified using brain SPECT...
  26. Furst A, Kaegi B, Haas C. [Rupture of the extensor carpi radialis tendon in two horses]. Schweiz Arch Tierheilkd. 2010;152:183-7 pubmed publisher
    ..Prognosis in these cases was good, as both horses returned within 6 months back to their previous work...
  27. Lee S, Cha S, Lee S, Song C. Reversible inferior colliculus lesion in metronidazole-induced encephalopathy: magnetic resonance findings on diffusion-weighted and fluid attenuated inversion recovery imaging. J Comput Assist Tomogr. 2009;33:305-8 pubmed publisher
    ..This is to present reversible inferior colliculus lesions in metronidazole-induced encephalopathy, to focus on the diffusion-weighted imaging (DWI) and fluid attenuated inversion recovery (FLAIR) imaging...
  28. Ranasuriya D, Feld R, Nairn S. A case of acute disseminated encephalomyelitis in a 12-year-old boy. Pediatr Emerg Care. 2008;24:697-9 pubmed publisher
    ..We describe a case of a male adolescent who presented to the emergency department with vomiting and lethargy. A review of the pathophysiology and clinical presentation for acute disseminated encephalomyelitis is presented here...
  29. Plowright W. What's in a name? Symmetrical spinal poliomalacia or spinal muscular atrophy of sheep in Kenya. Vet Rec. 2004;154:342-4 pubmed
  30. Mihara M, Miyai I, Hatakenaka M, Kubota K, Sakoda S. Sustained prefrontal activation during ataxic gait: a compensatory mechanism for ataxic stroke?. Neuroimage. 2007;37:1338-45 pubmed
    ..These results suggest that sustained prefrontal activation during ataxic gait might be relevant to compensatory mechanisms for ataxic gait after infratentorial stroke...
  31. McConnell J, Garosi L, Dennis R, Smith K. Imaging of a spinal nephroblastoma in a dog. Vet Radiol Ultrasound. 2003;44:537-41 pubmed
    ..A diagnosis of nephroblastoma was made on histological examination. The imaging features of this rare tumor and the differentiation of intradural-extramedullary and intramedullary masses are discussed...
  32. Crosse K, Worth A. Computer-assisted surgical correction of an antebrachial deformity in a dog. Vet Comp Orthop Traumatol. 2010;23:354-61 pubmed publisher
    ..To report the use of three dimensional (3D) computed tomographic (CT) imaging, computer simulation and rapid prototype modelling to aid surgical correction of a complex antebrachial deformity in a dog...
  33. Stierstorfer B, Eichhorn W, Schmahl W, Brandmuller C, Kaaden O, Neubauer A. Equine herpesvirus type 1 (EHV-1) myeloencephalopathy: a case report. J Vet Med B Infect Dis Vet Public Health. 2002;49:37-41 pubmed
    ..Virological findings confirmed an acute equine herpesvirus type 1 infection and virus was isolated from the spinal cord of a 26-year-old mare...
  34. Fretwurst T, Wanner L, Nahles S, Raguse J, Stricker A, Metzger M, et al. A prospective study of factors influencing morbidity after iliac crest harvesting for oral onlay grafting. J Craniomaxillofac Surg. 2015;43:705-9 pubmed publisher
    ..Patients undergoing bone harvest from the anterior superior iliac crest with oral grafting show a low minor complication rate and a high overall satisfaction of 95%. ..
  35. Kim K, Ha J, Chung S, Kim C, Kim S, Hyun B, et al. Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice. J Vet Sci. 2003;4:209-12 pubmed
    ..However, GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse...
  36. Keegan K, Arafat S, Skubic M, Wilson D, Kramer J, Messer N, et al. Detection of spinal ataxia in horses using fuzzy clustering of body position uncertainty. Equine Vet J. 2004;36:712-7 pubmed
    ..Subjective neurological evaluation in horses is prone to bias. An objective method of spinal ataxia detection is not subject to these limitations and could be of use in equine practice and research...
  37. Geyer H, Schaumburg H, Herskovitz S. Methyl bromide intoxication causes reversible symmetric brainstem and cerebellar MRI lesions. Neurology. 2005;64:1279-81 pubmed
    ..MRI showed strikingly symmetric brainstem and cerebellar lesions. The patient's clinical course and the topography and resolution of his MRI abnormalities suggest that this condition is an energy deprivation syndrome...
  38. Haim A, Lahav A, Pritsch T, Drexler M, Yizhar Z. [Locomotion and posture disabilities in Down syndrome]. Harefuah. 2009;148:543-7, 570 pubmed
    ..The abnormal gait develops from early childhood and continues into adulthood. This review focuses on the characteristics of this syndrome as concerning the damage to the lower extremities and trunk and the typical gait patterns...
  39. Listernick R. A 2-year-old girl with an abnormal gait. Pediatr Ann. 2005;34:850-3 pubmed
  40. Alpert J. GALOP syndrome: case report with 7-year follow-up. South Med J. 2004;97:410-2 pubmed
    An elderly woman complaining of a gait disorder was found to have the GALOP syndrome (gait ataxia, late-onset polyneuropathy). She exhibited mild distal weakness and sensory loss in the legs, a positive Romberg, and an unsteady gait...
  41. Dogulu F, Onk A, Kaymaz M, Kardes O, Baykaner M. Acute cerebellitis with hydrocephalus. Neurology. 2003;60:1717 pubmed
  42. Tesio L, Rota V. Gait analysis on split-belt force treadmills: validation of an instrument. Am J Phys Med Rehabil. 2008;87:515-26 pubmed publisher
  43. Ozawa E, Fujimoto T, Motomura M, Shirabe S, Yoshimura T, Tanaka K. [A case of CIDP with horizontal gaze-evoked nystagmus and ataxia]. Rinsho Shinkeigaku. 2002;42:221-6 pubmed
    ..We diagnosed this case was CIDP with cerebellar ataxia. After administration of high dose steroid therapy, intravenous methylprednisolone 1000 mg/day, his symptoms including ataxia and polyneuropathy were apparently improved...
  44. Yutzy B, Holznagel E, Coulibaly C, Stuke A, Hahmann U, Deslys J, et al. Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent. J Gen Virol. 2007;88:3469-78 pubmed
    ..However, there are differences in the clinical course between orally and intracerebrally infected animals that may influence the detection of other biomarkers...
  45. Maehara T, Shimada A, Morita T, Sawashima Y, Sawashima K. Distribution of the inflammatory lesions in the central nervous system of dogs affected with disseminated and ocular form of granulomatous meningoencephalomyelitis. J Vet Med Sci. 2009;71:509-12 pubmed
    An aged Maltese dog (dog 1) showed gait ataxia for a month and suddenly died after convulsion...
  46. Cary J, Hellyer P. Anesthesia case of the month. Evaluation and treatment of suspected squamous cell carcinoma of the third eyelid. J Am Vet Med Assoc. 2002;221:790-2 pubmed
  47. Jain V, Prabhakar S, Bagga R, Kalra J, Gopalan S. Paraneoplastic cerebellar degeneration with ovarian endometroid carcinoma. Acta Obstet Gynecol Scand. 2003;82:672-3 pubmed
  48. de Crecchio G, Cennamo G, de Leeuw N, Ventruto M, Lonardo M, Friso P, et al. Severe myopia with unusual retinal anomalies and Dandy-Walker sequence in two sibs. A distinct new neuro-ocular disorder. Ophthalmic Genet. 2013;34:254-7 pubmed publisher
    ..The peculiarity of the retinopathy consists of pathological myopia with anomalous vitreal fenestrated membranes in the retinal periphery. We suppose that these associations may configure a new genetic syndrome...
  49. Oluwole O, Oludiran A. Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars. Int J Health Geogr. 2013;12:41 pubmed publisher
    ..This study was done to determine if cyanogenicity of cassava cultivars is higher in lowland than highland areas, and if areas of endemicity of ataxic polyneuropathy colocalize with areas of highest cyanogenicity of cassava...
  50. Stolze H, Klebe S, Petersen G, Raethjen J, Wenzelburger R, Witt K, et al. Typical features of cerebellar ataxic gait. J Neurol Neurosurg Psychiatry. 2002;73:310-2 pubmed
    ..Although gait disturbance is one of the most pronounced and disabling symptoms in cerebellar disease (CD), quantitative studies on this topic are rare...
  51. Schrag A, Ben Shlomo Y, Quinn N. How common are complications of Parkinson's disease?. J Neurol. 2002;249:419-23 pubmed
    ..Parkinson's disease (PD) can be associated with a wide range of complications of advancing disease and treatment. However, it is unclear how often these occur in the overall population of patients with PD...
  52. Rizzo G, Pizza F, Scaglione C, Tonon C, Lodi R, Barbiroli B, et al. A case of fragile X premutation tremor/ataxia syndrome with evidence of mitochondrial dysfunction. Mov Disord. 2006;21:1541-2 pubmed
  53. Madhusudanan M, Menon M, Ummer K, Radhakrishnanan K. Clinical and etiological profile of tropical ataxic neuropathy in Kerala, South India. Eur Neurol. 2008;60:21-6 pubmed publisher
    ..Very little is known about the occurrence of tropical ataxic neuropathy (TAN) from southern India. This study describes the clinical spectrum of TAN from Kerala, southern India, and explores its etiology...