eye burns

Summary

Summary: Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.

Top Publications

  1. Rihawi S, Frentz M, Schrage N. Emergency treatment of eye burns: which rinsing solution should we choose?. Graefes Arch Clin Exp Ophthalmol. 2006;244:845-54 pubmed
    In the treatment of eye burns few data on the comparative application of rinsing solutions exist...
  2. Schrage N, Rihawi R, Frentz M, Reim M. [Acute therapy for eye burns]. Klin Monbl Augenheilkd. 2004;221:253-61 pubmed
    ..Eye rinsing is the major therapeutic measure with a decisive impact on prognosis after chemical or thermal eye irritation. Several different major targets are addressed by this measure...
  3. Ma D, Kuo M, Tsai Y, Chen H, Chen X, Wang S, et al. Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Eye (Lond). 2009;23:1442-50 pubmed publisher
    ..To access the feasibility of using cultivated oral mucosal epithelial cell transplantation (COMET) for the management of severe corneal burn...
  4. Tuft S, Shortt A. Surgical rehabilitation following severe ocular burns. Eye (Lond). 2009;23:1966-71 pubmed publisher
    ..Keratoplasty and cataract surgery may then be necessary to clear the visual axis. Finally, keratoprosthesis is an option for the most severely damaged eyes...
  5. Pastor S, Rodriguez Prats J, Walewska Szafran A, Rodriguez A, Alio J. Conjunctival impression cytology for the diagnosis, follow-up, and treatment in a patient with severe keratoconjunctivitis caused by alkali injury. Cornea. 2009;28:817-20 pubmed publisher
    ..To report a case of severe keratoconjunctivitis after chemical exposure that was treated by a conjunctival-limbal autograft transplantation according to conjunctival impression cytology (CIC) results...
  6. Zhang Z, Ma J, Gao G, Li C, Luo L, Zhang M, et al. Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization. Invest Ophthalmol Vis Sci. 2005;46:4062-71 pubmed
    ..Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor. The purpose of the present study was to evaluate the therapeutic effect of K5 on alkali-burn-induced corneal neovascularization (NV) and to investigate its mechanism of action...
  7. Jang I, Ahn J, Shin J, Kwon Y, Ryu Y, Lee J, et al. Transplantation of reconstructed corneal layer composed of corneal epithelium and fibroblasts on a lyophilized amniotic membrane to severely alkali-burned cornea. Artif Organs. 2006;30:424-31 pubmed
  8. Oh J, Kim M, Shin M, Lee H, Lee J, Wee W. The anti-inflammatory effect of subconjunctival bevacizumab on chemically burned rat corneas. Curr Eye Res. 2009;34:85-91 pubmed publisher
    ..To investigate the effect of bevacizumab in a model of corneal inflammation...
  9. Shahriari H, Tokhmehchi F, Reza M, Hashemi N. Comparison of the effect of amniotic membrane suspension and autologous serum on alkaline corneal epithelial wound healing in the rabbit model. Cornea. 2008;27:1148-50 pubmed publisher
    ..Alkaline corneal epithelial wound closure rates in rabbit eyes were compared after topical applications of amniotic membrane suspension, autologous serum, or preservative-free artificial tears...

More Information

Publications62

  1. Hong J, Qiu T, Wei A, Sun X, Xu J. Clinical characteristics and visual outcome of severe ocular chemical injuries in Shanghai. Ophthalmology. 2010;117:2268-72 pubmed publisher
    ..To study the clinical characteristics of patients with severe ocular chemical injury in Shanghai and to determine their relationship with visual outcome...
  2. Fish R, Davidson R. Management of ocular thermal and chemical injuries, including amniotic membrane therapy. Curr Opin Ophthalmol. 2010;21:317-21 pubmed publisher
    ..To provide a concise review of the literature regarding potential management strategies of ocular thermal and chemical injuries...
  3. Ivekovic R, Tedeschi Reiner E, Novak Laus K, Andrijevic Derk B, Cima I, Mandic Z. Limbal graft and/or amniotic membrane transplantation in the treatment of ocular burns. Ophthalmologica. 2005;219:297-302 pubmed
    ..LSCT is an effective procedure for rehabilitation after severe chemical trauma of the eye with more than 50% limbal involvement...
  4. Hoffart L, Matonti F, Conrath J, Daniel L, Ridings B, Masson G, et al. Inhibition of corneal neovascularization after alkali burn: comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. Clin Exp Ophthalmol. 2010;38:346-52 pubmed
    ..To compare the effects of different doses of bevacizumab with both saline and dexamethasone on inflammatory angiogenesis in the rat cornea induced by small chemical lesions...
  5. Tejwani S, Kolari R, Sangwan V, Rao G. Role of amniotic membrane graft for ocular chemical and thermal injuries. Cornea. 2007;26:21-6 pubmed
    ..To evaluate the results of amniotic membrane transplantation (AMT) for ocular surface reconstruction in chemical and thermal injuries...
  6. Gakhramanov F. Effect of natural antioxidants on antioxidant activity and lipid peroxidation in eye tissue of rabbits with chemical burns. Bull Exp Biol Med. 2005;140:289-91 pubmed
    Chemical eye burns were accompanied by free radical oxidation of lipids and dysfunction of the antioxidant protection system. The decrease in antioxidant activity of blood plasma reflected a generalized type of these processes...
  7. Ma Y, Xu Y, Xiao Z, Yang W, Zhang C, Song E, et al. Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells. 2006;24:315-21 pubmed
    ..This study provides the first line of evidence that MSCs can be used for reconstruction of damaged corneas, presenting a new source for autotransplantation in the treatment of corneal disorders...
  8. Saika S, Yamanaka O, Okada Y, Miyamoto T, Kitano A, Flanders K, et al. Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Am J Physiol Cell Physiol. 2007;293:C75-86 pubmed
    ..Together, these data suggest that overexpression of PPARgamma may represent an effective new strategy for treatment of ocular surface burns...
  9. Márquez de Aracena R, Montero de Espinosa I, Munoz M, Pereira G. [Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results]. Arch Soc Esp Oftalmol. 2007;82:475-81 pubmed
    ..The efficiency of the subconjunctival application of autologous platelet concentrate in patients with ocular burns was assessed...
  10. Spöler F, Först M, Kurz H, Frentz M, Schrage N. Dynamic analysis of chemical eye burns using high-resolution optical coherence tomography. J Biomed Opt. 2007;12:041203 pubmed
    ..optical coherence tomography (OCT) to visualize penetration kinetics during the initial phase of chemical eye burns is evaluated...
  11. Le Q, Wang W, Hong J, Sun X, Zheng T, Zhu W, et al. An in vivo confocal microscopy and impression cytology analysis of goblet cells in patients with chemical burns. Invest Ophthalmol Vis Sci. 2010;51:1397-400 pubmed publisher
    ..To evaluate goblet cell density (GCD) on conjunctiva and cornea in patients with ocular chemical burns by in vivo laser scanning confocal microscopy (LSCM) and impression cytology (IC) and to explore the correlation between two methods...
  12. Shi W, Gao H, Wang T, Xie L. Combined penetrating keratoplasty and keratolimbal allograft transplantation in comparison with corneoscleral transplantation in the treatment of severe eye burns. Clin Exp Ophthalmol. 2008;36:501-7 pubmed publisher
    ..The aim of this study is to compare the therapeutic outcomes between penetrating keratoplasty (PK) combined with keratolimbal allograft (KLAL) transplantation and corneoscleral transplantation in patients with severe corneal burns...
  13. López García J, Rivas L, García Lozano I, Murube J. Analysis of corneal surface evolution after moderate alkaline burns by using impression cytology. Cornea. 2006;25:908-13 pubmed
    ..To compare corneal surface evolution after moderate alkaline burns by impression cytology in patients treated with medical therapy or with amniotic membrane transplantation (AMT)...
  14. Hosseini H, Nejabat M, Mehryar M, Yazdchi T, Sedaghat A, Noori F. Bevacizumab inhibits corneal neovascularization in an alkali burn induced model of corneal angiogenesis. Clin Exp Ophthalmol. 2007;35:745-8 pubmed
    ..This study aimed to evaluate the effect of subconjunctival bevacizumab (Avastin) on experimental corneal neovascularization in rabbits...
  15. Dan L, Shi long Y, Miao li L, Yong ping L, Hong jie M, Ying Z, et al. Inhibitory effect of oral doxycycline on neovascularization in a rat corneal alkali burn model of angiogenesis. Curr Eye Res. 2008;33:653-60 pubmed publisher
    ..To examine the efficacy of oral doxycycline treatment (as compared to oral and topical dexamethasone) for inhibiting corneal neovascularization (CNV)...
  16. Marquez De Aracena Del Cid R, Montero De Espinosa Escoriaza I. Subconjunctival application of regenerative factor-rich plasma for the treatment of ocular alkali burns. Eur J Ophthalmol. 2009;19:909-15 pubmed
    ..To study the efficiency of the subconjunctival application of autologous regenerative factor-rich plasma (RFRP) in patients with different degrees of ocular alkali burns...
  17. Ghasemi H, Ghazanfari T, Ghassemi Broumand M, Javadi M, Babaei M, Soroush M, et al. Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans. Cutan Ocul Toxicol. 2009;28:71-7 pubmed publisher
    ..Although many descriptive studies about SM-induced ocular injuries are present in the medical literature, few of them have been conducted over a large group with serious ocular involvement...
  18. Tandon R, Gupta N, Kalaivani M, Sharma N, Titiyal J, Vajpayee R. Amniotic membrane transplantation as an adjunct to medical therapy in acute ocular burns. Br J Ophthalmol. 2011;95:199-204 pubmed publisher
    ..To evaluate the role of amniotic membrane transplantation in patients with acute ocular burns...
  19. Feng Y, Feng Y, Zhu X, Dang Y, Ma Q. Alkali burn causes aldehyde dehydrogenase 3A1 (ALDH3A1) decrease in mouse cornea. Mol Vis. 2004;10:845-50 pubmed
    ..Our study was intended to detect changes in ALDH3A1 expression after corneal alkaline burn...
  20. Sangwan V, Basu S, Vemuganti G, Sejpal K, Subramaniam S, Bandyopadhyay S, et al. Clinical outcomes of xeno-free autologous cultivated limbal epithelial transplantation: a 10-year study. Br J Ophthalmol. 2011;95:1525-9 pubmed publisher
    ..Ocular burns can damage the corneal epithelial stem cells located at the limbus. This study evaluated the efficacy of xeno-free autologous cell-based treatment of limbal stem cell deficiency...
  21. Choi J, Choi J, Joo C. Effects of amniotic membrane suspension in the rat alkali burn model. Mol Vis. 2011;17:404-12 pubmed
    ..The main objective of this study is to determine the anti-inflammatory effect of topical amniotic membrane (AM) suspension on corneal alkali burn compared to topical serum eyedrops...
  22. Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, et al. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol. 2005;166:1405-18 pubmed
    ..Together these data suggest that overexpression of Smad7 may have effects beyond those of simply blocking Smad3/TGF-beta signaling and may represent an effective new strategy for treatment of ocular burns...
  23. Iwanami H, Ishizaki M, Fukuda Y, Takahashi H. Expression of matrix metalloproteinases (MMP)-12 by myofibroblasts during alkali-burned corneal wound healing. Curr Eye Res. 2009;34:207-14 pubmed publisher
    ..The purpose of this study was to determine the expression of MMP-12 by myofibroblasts during the healing of alkali-burned rabbit corneas (ARC), thus implicating its role in ECM remodeling...
  24. Lee S, Leem H, Jeong S, Lee K. Bevacizumab accelerates corneal wound healing by inhibiting TGF-beta2 expression in alkali-burned mouse cornea. BMB Rep. 2009;42:800-5 pubmed
    ..These results indicate that bevacizumab may be useful in reducing neovascularization and improving corneal transparency following corneal alkali burn injury by accelerating regeneration of the basement membrane...
  25. Du L, Wu X, Li M, Wang S, Pang K. Effect of different biomedical membranes on alkali-burned cornea. Ophthalmic Res. 2008;40:282-90 pubmed publisher
    ..To evaluate the effects of different biomedical membranes on alkali-burned cornea in vivo...
  26. Choi S, Chun K, Lee S, Rah S. A case of photic retinal injury associated with exposure to plasma arc welding. Korean J Ophthalmol. 2006;20:250-3 pubmed
    ..To report of photic retinopathy induced by plasma arc welding, and the OCT (optical coherence tomography) results of damaged retinal lesions...
  27. Cole N, Hume E, Jalbert I, Vijay A, Krishnan R, Willcox M. Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis. Angiogenesis. 2007;10:47-54 pubmed
    ..Our studies indicate that 12-MTA may provide clinically significant advantages over conventional steroids for the treatment of vessel growth in the cornea...
  28. Tamhane A, Vajpayee R, Biswas N, Pandey R, Sharma N, Titiyal J, et al. Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. Ophthalmology. 2005;112:1963-9 pubmed
    ..To evaluate the role of amniotic membrane transplantation (AMT) in acute ocular burns...
  29. Kobayashi A, Shirao Y, Yoshita T, Yagami K, Segawa Y, Kawasaki K, et al. Temporary amniotic membrane patching for acute chemical burns. Eye (Lond). 2003;17:149-58 pubmed
    ..To describe the surgical technique, and its usefulness, of temporary amniotic membrane patching (AMP) in the acute phase of ocular chemical injury...
  30. Kuckelkorn R, Schrage N, Keller G, Redbrake C. Emergency treatment of chemical and thermal eye burns. Acta Ophthalmol Scand. 2002;80:4-10 pubmed
    Chemical and thermal eye burns account for a small but significant fraction of ocular trauma. The speed at which initial irrigation of the eye begins, has the greatest influence on the prognosis and outcome of eye burns...
  31. Sridhar M, Bansal A, Sangwan V, Rao G. Amniotic membrane transplantation in acute chemical and thermal injury. Am J Ophthalmol. 2000;130:134-7 pubmed
    ..To present a case of chemical injury and a case of thermal injury treated by amniotic membrane transplantation in acute phase...
  32. Tsai R, Li L, Chen J. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med. 2000;343:86-93 pubmed
    ..However, this procedure requires a large limbal graft from the healthy eye and is not possible in patients who have bilateral lesions...
  33. Khaw P, Shah P, Elkington A. Injury to the eye. BMJ. 2004;328:36-8 pubmed
  34. Yamada J, Dana M, Sotozono C, Kinoshita S. Local suppression of IL-1 by receptor antagonist in the rat model of corneal alkali injury. Exp Eye Res. 2003;76:161-7 pubmed
    ..We conclude that local antagonism of IL-1 after alkali injury can significantly decrease corneal inflammation and lead to enhanced corneal transparency...
  35. Rama P, Bonini S, Lambiase A, Golisano O, Paterna P, De Luca M, et al. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation. 2001;72:1478-85 pubmed
    ..We sought to establish a culture system that allows preservation of limbal stem cells and preparation of manageable epithelial sheets and to investigate whether such cultures can permanently restore total limbal stem cell deficiency...
  36. Joseph A, Dua H, King A. Failure of amniotic membrane transplantation in the treatment of acute ocular burns. Br J Ophthalmol. 2001;85:1065-9 pubmed
    ..To report the failure of amniotic membrane transplantation (AMT) for ocular surface reconstruction in patients with severe acute chemical and thermal burns...
  37. Schrage N, Langefeld S, Zschocke J, Kuckelkorn R, Redbrake C, Reim M. Eye burns: an emergency and continuing problem. Burns. 2000;26:689-99 pubmed
    Adequate treatment of eye burns is an essential task of rescue teams. Clinical and occupational medicine studies have shown that efficient emergency treatment can prevent severe eye damage, but therapy is frequently delayed or inadequate...
  38. Ralph R. Tetracyclines and the treatment of corneal stromal ulceration: a review. Cornea. 2000;19:274-7 pubmed
    ..To demonstrate the potential value of tetracyclines in the treatment of corneal ulceration after moderate to severe ocular chemical injuries...
  39. Cejkova J. Histochemical study of leukocyte elastase activity in alkali-burned rabbit cornea. Ophthalmic Res. 1997;29:154-60 pubmed
    ..These results show that leukocyte elastase is associated with corneal destruction after a severe alkali burn...
  40. Ozturk F, Kurt E, Cerci M, Emiroglu L, Inan U, Turker M, et al. The effect of propolis extract in experimental chemical corneal injury. Ophthalmic Res. 2000;32:13-8 pubmed
    ..To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes...
  41. Arora R, Mehta D, Jain V. Amniotic membrane transplantation in acute chemical burns. Eye (Lond). 2005;19:273-8 pubmed
    ..To evaluate the outcome of fresh amniotic membrane transplantation (AMT) for ocular surface reconstruction in acute chemical burns...
  42. Gomes J, dos Santos M, Cunha M, Mascaro V, Barros J, de Sousa L. Amniotic membrane transplantation for partial and total limbal stem cell deficiency secondary to chemical burn. Ophthalmology. 2003;110:466-73 pubmed
    ..To evaluate the surgical outcome of preserved amniotic membrane transplantation (AMT) for ocular surface reconstruction in chemical burn with limbal stem cell deficiency...
  43. Burgalassi S, Raimondi L, Pirisino R, Banchelli G, Boldrini E, Saettone M. Effect of xyloglucan (tamarind seed polysaccharide) on conjunctival cell adhesion to laminin and on corneal epithelium wound healing. Eur J Ophthalmol. 2000;10:71-6 pubmed
    ..To explore the role of a natural polysaccharide extracted from tamarind seed (xyloglucan, or tamarind seed polysaccharide, TSP) on the integrin-substrate recognition system and on repair of corneal wounds...
  44. Merle H, Gerard M, Schrage N. [Ocular burns]. J Fr Ophtalmol. 2008;31:723-34 pubmed
    ..Surgical techniques aimed at restoring the destroyed limbal stem cells have altered the prognosis of severe corneal burns. In order to decrease the incidence of burns, prevention, particularly in industry, is essential...
  45. Rao K, Rao L, Kamath A, Jain V. Bilateral macular hole secondary to remote lightning strike. Indian J Ophthalmol. 2009;57:470-2 pubmed publisher
    ..This is the first case report of such nature in India to the best of our knowledge...
  46. Belokopytov M, Ben Shlomo G, Rosner M, Belkin M, Dubinski G, Epstein Y, et al. Functional efficacy of glatiramer acetate treatment for laser-induced retinal damage in rats. Lasers Surg Med. 2008;40:196-201 pubmed publisher
    ..To functionally evaluate the efficacy of glatiramer acetate (Cop-1) as a neuroprotective treatment for laser-induced retinal injuries in rats...
  47. Bodunde O, Onadipe J. Ocular emergency--a case report. Niger J Med. 2005;14:327-8 pubmed
    ..Irrigation is the major emergency therapeutic measure of such burns and this also has an impact on the prognosis. We hereby present a case report of chemical burns...
  48. Burillon C. [Other surgical therapies for cornea burns]. J Fr Ophtalmol. 2004;27:1191-6 pubmed
    ..Lamellar keratoplasty is preferred because it provides tectonic support. After several graft failures, a keratoprosthesis is the last solution for these bilaterally affected patients, but evisceration cannot be always avoided...
  49. Liu K, Gu B, Chiang C, Zhang D, Li Q. Rescue of vision in burn patients with total eyelid loss. Burns. 2012;38:269-73 pubmed publisher
    ..In this article, we present a simple technique to partially solve this problem...
  50. Arikan S, Karaca T, Ertekin Y, Comez A, Ersan I, Demirtaş S, et al. Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn. Cornea. 2016;35:543-9 pubmed publisher
    ..To investigate the antiapoptotic effect of topically administered azithromycin (AZM) on corneal epithelial and endothelial cells in a rat model of corneal alkali burn...
  51. Siatiri H, Moghimi S, Malihi M, Khodabande A. Use of sealant (HFG) in corneal perforations. Cornea. 2008;27:988-91 pubmed publisher
    ..To repair corneal perforation using human fibrin glue and determine its efficacy...
  52. Kim J, Chun Y, Song K, Song G, Kim J. The effect of in vivo grown corneal epithelium transplantation on persistent epithelial defects with limbal stem cell deficiency. J Korean Med Sci. 2008;23:502-8 pubmed publisher
    ..A corneal epithelial sheet, grown in vivo, can be transplanted to treat eye with a severe ocular surface disease, such as total limbal deficiency...
  53. Ueno M, Lyons B, Burzenski L, Gott B, Shaffer D, Roopenian D, et al. Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature. Invest Ophthalmol Vis Sci. 2005;46:4097-106 pubmed
    ..The present study was conducted to investigate healing of alkali-burned corneas in MRL/MpJ (MRL) mice...