nodose ganglion

Summary

Summary: The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.

Top Publications

  1. Wei I, Huang C, Chang H, Tseng C, Tu H, Wen C, et al. Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning. J Chem Neuroanat. 2005;29:149-56 pubmed
    ..hypoxic preconditioning (MHPC)-induced NOS expression would attenuate the neuropathological changes in the nodose ganglion (NG) of severe hypoxic exposure (SHE) rats...
  2. Qiao G, Cheng Z, Huo R, Sui X, Lu Y, Li B. GM1 ganglioside contributes to retain the neuronal conduction and neuronal excitability in visceral and baroreceptor afferents. J Neurochem. 2008;106:1637-45 pubmed publisher
    ..At soma of myelinated A and unmyelinated C-type nodose ganglion neurons (NGNs), the action potential spike frequency reduced by CTX-B is also prevented by GM1...
  3. Wacker M, Tyburski J, Ammar C, Adams M, Orr J. Detection of thromboxane A(2) receptor mRNA in rabbit nodose ganglion neurons. Neurosci Lett. 2005;386:121-6 pubmed publisher
    ..Therefore, we conclude that the presence of TP mRNA in a subset of cultured nodose ganglion neurons allows for the possibility that TXA(2) may directly stimulate or modulate vagal afferent neurons.
  4. Kinch D, Peters J, Simasko S. Comparative pharmacology of cholecystokinin induced activation of cultured vagal afferent neurons from rats and mice. PLoS ONE. 2012;7:e34755 pubmed publisher
    ..The pure antagonistic action of JMV-180 in this in vitro preparation suggests that prior reported differential effects of JMV-180 on satiation in rats versus mouse must be mediated by a site other than vagal afferent activation. ..
  5. Paulino G, Barbier de la Serre C, Knotts T, Oort P, Newman J, Adams S, et al. Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. Am J Physiol Endocrinol Metab. 2009;296:E898-903 pubmed publisher
    ..Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets. ..
  6. Doan T, Stephans K, Ramirez A, Glazebrook P, Andresen M, Kunze D. Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers. J Neurosci. 2004;24:3335-43 pubmed
    ..At the sensory receptor terminal, CsCl decreased the threshold pressure for initiation of mechanoreceptor discharge. Therefore, elimination of the I(H) increases excitability of both the soma and the peripheral sensory terminals. ..
  7. Jelsing J, Larsen P, Vrang N. The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion. Neurosci Lett. 2009;463:125-9 pubmed publisher
    ..paraventricular (PVN) and ventromedial hypothalamic (VMH) nucleus, in the brainstem dorsal vagal complex or nodose ganglion of lean Zucker rats, CB(1)R mRNA levels were consistently elevated in obese Zucker rats pointing to a direct ..
  8. Li B, Schild J. Comparisons of somatic action potentials from dispersed and intact rat nodose ganglia using patch-clamp technique. Acta Pharmacol Sin. 2002;23:481-9 pubmed
    ..It is most important that the nodose slice enables us to study the AP and ion channel characteristics on identified NSN by afferent fiber CV with adult animals. ..
  9. Glazebrook P, Ramirez A, Schild J, Shieh C, Doan T, Wible B, et al. Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons. J Physiol. 2002;541:467-82 pubmed

More Information

Publications62

  1. Peiser C, Springer J, Groneberg D, McGregor G, Fischer A, Lang R. Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus. Neurosci Lett. 2002;320:41-4 pubmed
    ..leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing...
  2. Zhang G, Lin R, Wiggers M, Snow D, Lee L. Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol. 2008;586:5771-86 pubmed publisher
    ..In conclusion, allergen-induced airway inflammation clearly elevated capsaicin sensitivity in myelinated pulmonary afferents, which probably resulted from an increased expression of TRPV1 in these sensory nerves. ..
  3. Vermehren Schmaedick A, Jenkins V, Hsieh H, Brown A, Page M, Brooks V, et al. Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats. J Neurosci Res. 2013;91:220-9 pubmed publisher
    ..Our previous studies show that brain-derived neurotrophic factor (BDNF) is abundantly expressed by rat nodose ganglion (NG) neurons, including baroreceptor afferents and their central terminals in the medial NTS...
  4. Strecker T, Koulchitsky S, Dieterle A, Neuhuber W, Weyand M, Messlinger K. Release of calcitonin gene-related peptide from the jugular-nodose ganglion complex in rats--a new model to examine the role of cardiac peptidergic and nitrergic innervation. Neuropeptides. 2008;42:543-50 pubmed publisher
    ..lung is conveyed to the brainstem by primary afferent fibers originating from vagal sensory neurons (jugular-nodose ganglion complex, JNC)...
  5. Li B, Schild J. Persistent tetrodotoxin-resistant Na+ currents are activated by prostaglandin E2 via cyclic AMP-dependent pathway in C-type nodose neurons of adult rats. Biochem Biophys Res Commun. 2007;355:1064-8 pubmed
  6. Yu S, Ru F, Ouyang A, Kollarik M. 5-Hydroxytryptamine selectively activates the vagal nodose C-fibre subtype in the guinea-pig oesophagus. Neurogastroenterol Motil. 2008;20:1042-50 pubmed publisher
    ..The response to 5-HT in nodose C-fibres is mediated by the 5-HT(3) receptor in their neuronal membrane. ..
  7. Li Y, Tran T, Muelleman R, Schultz H. Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel. Cardiovasc Res. 2008;79:715-21 pubmed publisher
    ..The nodose ganglion (NG) contains the cell bodies of the aortic baroreceptor (AB) neurons...
  8. Qiao G, Yang B, Li W, Li B. Effects of artemisinin on action potentials from C-type nodose ganglion neurons. Acta Pharmacol Sin. 2003;24:937-42 pubmed
    ..Neonatal and adult rats were selected for the preparation of isolated nodose ganglia neurons (NGN) and nodose ganglion-vagus slice preparation...
  9. Li B, Schild J. Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia. J Neurosci Methods. 2007;164:75-85 pubmed
    ..An intact rat nodose ganglion preparation was used to randomly sample neurons (n=76) using the patch clamp technique...
  10. Vahl T, Tauchi M, Durler T, Elfers E, Fernandes T, Bitner R, et al. Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology. 2007;148:4965-73 pubmed
    ..These data are consistent with an important component of neural mediation of GLP-1 action. ..
  11. Grabauskas G, Song I, Zhou S, Owyang C. Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia. J Physiol. 2010;588:617-32 pubmed publisher
    ..The results also show that PIP(2) can determine the excitability of glucose-excited neurons...
  12. Nakagawa A, Satake H, Nakabayashi H, Nishizawa M, Furuya K, Nakano S, et al. Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Auton Neurosci. 2004;110:36-43 pubmed
    ..derived from those electrophysiological observations, receptor gene expressions of GLP-1 and GIP in the rat nodose ganglion were examined by means of reverse transcriptase-mediated polymerase chain reaction (RT-PCR) and Northern blot ..
  13. Kosta V, Guić M, Aljinovic J, Caric A, Grkovic I. The influence of exercise on morphological and neurochemical properties of neurons in rat nodose ganglia. Neurosci Lett. 2011;490:36-40 pubmed publisher
    ..These data indicate that exercise leads to plastic changes in nodose ganglia neurons that may initiate changes of vagal activity caused by prolonged exercise. ..
  14. Schild J, Kunze D. Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents. Auton Neurosci. 2012;172:4-12 pubmed publisher
    ..But the complement of VGC in C-type neurons provides far greater capacity for neuromodulation of cell excitability than can be obtained from A-type baroreceptors. ..
  15. Tu H, Zhang L, Tran T, Muelleman R, Li Y. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Neuroscience. 2010;165:39-52 pubmed publisher
    ..the protein expression and the electrophysiological characteristics of HCN channels were investigated in nodose ganglion (NG) afferent neurons (A-fiber and C-fiber neurons) from sham and streptozotocin (STZ)-induced diabetic rats...
  16. Matsumoto S, Yoshida S, Ikeda M, Tanimoto T, Saiki C, Takeda M, et al. Effect of 8-bromo-cAMP on the tetrodotoxin-resistant sodium (Nav 1.8) current in small-diameter nodose ganglion neurons. Neuropharmacology. 2007;52:904-24 pubmed
    ..8-Br-cAMP)-induced modification of tetrodotoxin-resistant (TTX-R) sodium current in neonatal rat nodose ganglion neurons is mediated by the activation of protein kinase A (PKA) and/or protein kinase C (PKC)...
  17. Daly D, Park S, Valinsky W, Beyak M. Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse. J Physiol. 2011;589:2857-70 pubmed publisher
    ..We performed whole cell patch clamp recordings on nodose ganglion neurons, both unlabelled, and those labelled by fast blue injection into the wall of the jejunum...
  18. Chang H, Liao W, Lue J, Wen C, Shieh J. Upregulation of NMDA receptor and neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats. J Chem Neuroanat. 2003;25:137-47 pubmed
    ..the present study aimed to examine if the expression of nNOS and NMDA receptor subunit 1 (NMDAR1) in the nodose ganglion (NG) would alter under different extents of hypoxia treatment...
  19. Kwong K, Carr M, Gibbard A, Savage T, Singh K, Jing J, et al. Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs. J Physiol. 2008;586:1321-36 pubmed publisher
    ..we obtained data supporting the hypothesis that the TTX-R sodium currents are similarly distributed between nodose ganglion A-fibres and C-fibres innervating the lung...
  20. Wan F, Li G, Liu S, Zhu G, Xu C, Lin J, et al. P2X2/3 receptor activity of rat nodose ganglion neurons contributing to myocardial ischemic nociceptive signaling. Auton Neurosci. 2010;158:58-64 pubmed publisher
    ..The present results have shown that the sensitivity of P2X(2/3) receptor in nodose ganglion neurons was increased after myocardial ischemic injury under electrophysiological observation...
  21. Kosta V, Guić M, Aljinovic J, Sapunar D, Grkovic I. Immunohistochemical characteristics of neurons in nodose ganglia projecting to the different chambers of the rat heart. Auton Neurosci. 2010;155:33-8 pubmed publisher
    ..11%). These findings reveal that chambers of the rat heart are innervated with immunohistochemically different subpopulations of neurons from the nodose ganglia. ..
  22. Matsumoto S, Ikeda M, Yoshida S, Tanimoto T, Takeda M, Nasu M. Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones. Br J Pharmacol. 2005;145:503-13 pubmed
    ..on the modification of the tetrodotoxin-resistant Na+ current (I(NaR)) in acutely isolated neonatal rat nodose ganglion (NG) neurones. 2 Of the four EP receptor agonists ranging from 0...
  23. Sun H, Li D, Chen S, Hittelman W, Pan H. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther. 2009;331:851-9 pubmed publisher
    ..was present on nerve fibers and terminals in the adventitia of the ascending aorta and aortic arch, the nodose ganglion neurons, and afferent fibers in the solitary tract of the brainstem...
  24. Ikeda M, Yoshida S, Kadoi J, Nakano Y, Mastumoto S. The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons. Life Sci. 2005;78:47-53 pubmed
    ..activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, ..
  25. Burdyga G, Spiller D, Morris R, Lal S, Thompson D, Saeed S, et al. Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience. 2002;109:339-47 pubmed
    ..Moreover, RT-PCR revealed the long form of the leptin receptor in a human nodose ganglion. The identities of RT-PCR products were confirmed by sequencing...
  26. Davies A, Lee K, Jaenisch R. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron. 1993;11:565-74 pubmed
    ..These findings indicate that p75 enhances the sensitivity of NGF-dependent cutaneous sensory neurons to NGF and may explain, at least in part, the cutaneous sensory abnormalities of mice homozygous for the p75 mutation. ..
  27. Yu S, Gao G, Peterson B, Ouyang A. TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2009;297:G34-42 pubmed publisher
    ..Collectively, our data provide new evidence that sensitizing TRPA1 via a PAR2-dependent mechanism plays an important role in mast cell activation-induced mechanical hypersensitivity of vagal nodose C-fibers in guinea pig esophagus. ..
  28. Li B, Schild J. Patch clamp electrophysiology in nodose ganglia of adult rat. J Neurosci Methods. 2002;115:157-67 pubmed
    ..Here, we present a methodology for preparing nodose ganglion from adult rat (250-400 g) for study using the patch clamp technique...
  29. Tu H, Liu J, Zhu Z, Zhang L, Pipinos I, Li Y. Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats. J Neurophysiol. 2012;107:591-602 pubmed publisher
  30. Fang X, Cui Z. The anti-botulism triterpenoid toosendanin elicits calcium increase and exocytosis in rat sensory neurons. Cell Mol Neurobiol. 2011;31:1151-62 pubmed publisher
    ..These data together indicate that toosendanin modulates sensory neurons, but had opposite effects on membrane potential depending on the presence or absence of capsaicin receptor/TRPV 1 channel. ..
  31. Rytel L, Całka J. Neuropeptide profile changes in sensory neurones after partial prepyloric resection in pigs. Ann Anat. 2016;206:48-56 pubmed publisher
  32. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology. 2002;123:1120-8 pubmed
    ..Ghrelin suppressed firing of the vagal afferent, whereas CCK stimulated it. This study indicated that the gastric vagal afferent is the major pathway conveying ghrelin's signals for starvation and GH secretion to the brain. ..
  33. Neuhuber W, Kressel M, Stark A, Berthoud H. Vagal efferent and afferent innervation of the rat esophagus as demonstrated by anterograde DiI and DiA tracing: focus on myenteric ganglia. J Auton Nerv Syst. 1998;70:92-102 pubmed
    ..derivative DiA was used to selectively label fibers from the nucleus ambiguus, dorsal motor nucleus and nodose ganglion, respectively, terminating in the rat esophagus, and to compare them with the innervation of the gastric ..
  34. Gillespie B, Burns G, Ritter R. NMDA channels control meal size via central vagal afferent terminals. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1504-11 pubmed
    ..we examined 15% sucrose intake after 50-nl MK-801 injections ipsilateral or contralateral to unilateral nodose ganglion removal (ganglionectomy)...
  35. Page A, Young R, Martin C, Umaerus M, O Donnell T, Cooper N, et al. Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology. 2005;128:402-10 pubmed
    ..Group II (mGluR2 and 3) and group III mGluR (mGluR4, 6, 7, 8) are novel targets for inhibition of vagal signaling with therapeutic potential in, for example, GERD. ..
  36. Hondoh A, Ishida Y, Ugawa S, Ueda T, Shibata Y, Yamada T, et al. Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex. Brain Res. 2010;1319:60-9 pubmed publisher
  37. Baker C, Bronner Fraser M. Establishing neuronal identity in vertebrate neurogenic placodes. Development. 2000;127:3045-56 pubmed
    ..in the grafted ectoderm are induced to express the epibranchial placode marker Pax2 and form neurons in the nodose ganglion that express the epibranchial neuron marker Phox2a on the same schedule as host nodose neurons...
  38. Dunn P, Liu M, Zhong Y, King B, Burnstock G. Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones. Br J Pharmacol. 2000;130:1378-84 pubmed
    ..However, Ip(5)I at concentrations up to 30 microM was without effect. 3. Nodose ganglion neurones responded to alpha,beta-meATP with slowly-desensitizing inward currents...
  39. Savtchenko L, Gogan P, Korogod S, Tyc Dumont S. Imaging stochastic spatial variability of active channel clusters during excitation of single neurons. Neurosci Res. 2001;39:431-46 pubmed
    ..Such spatial flicker modifies the direction of lateral current along the neuronal membrane and may have important consequences on the intrinsic processing capabilities of the neuron. ..
  40. Chang H, Tseng C, Wei I, Lue J, Wen C, Shieh J. Melatonin restores the cytochrome oxidase reactivity in the nodose ganglia of acute hypoxic rats. J Pineal Res. 2005;39:206-14 pubmed
    ..This study aimed to elucidate whether melatonin would exert beneficial effects on the neuronal functions of the nodose ganglion (NG) following acute hypoxic insult...
  41. Uno T, Koike S, Bamba H, Hirota R, Hisa Y. Capsaicin receptor expression in rat laryngeal innervation. Ann Otol Rhinol Laryngol. 2004;113:356-8 pubmed
    ..We investigated the expression of VR1 and VRL-1 in the rat larynx and nodose ganglion using VR1 and VRL-1 immunohistochemical analysis with visualization by diaminobenzidine reaction...
  42. Wladyka C, Kunze D. KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons. J Physiol. 2006;575:175-89 pubmed
    ..These data indicate that the M-current is present in nodose neurons, is activated at resting membrane potential and that it is physiologically important in regulating excitability by maintaining cells at negative voltages. ..
  43. Fox E, Phillips R, Byerly M, Baronowsky E, Chi M, Powley T. Selective loss of vagal intramuscular mechanoreceptors in mice mutant for steel factor, the c-Kit receptor ligand. Anat Embryol (Berl). 2002;205:325-42 pubmed
    ..Injections of wheat germ agglutinin-horseradish peroxidase and of dextran into the nodose ganglion were employed to label intramuscular arrays and intraganglionic laminar endings, the other vagal ..
  44. Szereda Przestaszewska M, Kaczynska K. Peripheral 5-HT1A receptors are not essential for increased ventilation evoked by systemic 8-OH-DPAT challenge in anaesthetized rats. Exp Physiol. 2007;92:953-61 pubmed
  45. Nozdrachev A, Akkuratov E, Fateev M. [Populations of afferent neurons in the sensory ganglia detected using lectin from Laburnum anagyroides]. Morfologiia. 2003;124:38-40 pubmed
  46. Keating C, Beyak M, Foley S, Singh G, Marsden C, Spiller R, et al. Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism. J Physiol. 2008;586:4517-30 pubmed publisher
    ..by extracellular recordings from jejunal mesenteric afferent bundles and patch clamp recordings of isolated nodose ganglion neurons (NGNs)...
  47. Kollarik M, Carr M, Ru F, Ring C, Hart V, Murdock P, et al. Transgene expression and effective gene silencing in vagal afferent neurons in vivo using recombinant adeno-associated virus vectors. J Physiol. 2010;588:4303-15 pubmed publisher
    ..Finally, the AAV2/8 vectors are efficiently taken up by the vagal nerve terminals in the visceral tissue and retrogradely transported to the cell body, allowing for tissue-specific transduction. ..
  48. Ai J, Gozal D, Li L, Wead W, Chapleau M, Wurster R, et al. Degeneration of vagal efferent axons and terminals in cardiac ganglia of aged rats. J Comp Neurol. 2007;504:74-88 pubmed
  49. Wank M, Neuhuber W. Local differences in vagal afferent innervation of the rat esophagus are reflected by neurochemical differences at the level of the sensory ganglia and by different brainstem projections. J Comp Neurol. 2001;435:41-59 pubmed
    ..The present study provides a possible morphological basis for bronchopulmonary and aversive reflexes elicited upon stimulation of the esophagus. ..
  50. Jia Y, Wang X, Aponte S, Rivelli M, Yang R, Rizzo C, et al. Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel. Br J Pharmacol. 2002;135:764-70 pubmed
    ..These results indicate that N/OFQ-induced hyperpolarization of tachykinin containing airway sensory nerves, through an inward-rectifier K(+) channel activation, accounts for the inhibition of capsaicin-evoked broncoconstriction. ..
  51. Lieu T, Undem B. Neuroplasticity in vagal afferent neurons involved in cough. Pulm Pharmacol Ther. 2011;24:276-9 pubmed publisher
    ..These results strengthen the conclusion that the phenotypic characteristics of afferent nerves involved in cough may vary, depending on the context in which they are studied...
  52. Ohtori S, Takahashi K, Chiba T, Yamagata M, Sameda H, Moriya H. Sensory innervation of the cervical facet joints in rats. Spine (Phila Pa 1976). 2001;26:147-50 pubmed
    ..The present findings regarding the multisegmental innervation to the facet joint may be of importance in the treatment of facet joint syndrome. ..
  53. Ishibashi H, Eto K, Arimura Y, Yamada J, Hatano Y, Nishikawa M, et al. Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons. Brain Res. 2006;1097:65-70 pubmed
    ..the effect of dextromethorphan on 5-hydroxytryptamine (5-HT)-induced currents in acutely dissociated rat nodose ganglion neurons using nystatin-perforated patch-clamp recording configuration...