superior cervical ganglion


Summary: The largest and uppermost of the paravertebral sympathetic ganglia.

Top Publications

  1. Singh K, Park K, Hong E, Kramer B, Greenberg M, Kaplan D, et al. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008;11:649-58 pubmed publisher
    ..These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration. ..
  2. Liu P, Bean B. Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons. J Neurosci. 2014;34:4991-5002 pubmed publisher
    ..In both rat superior cervical ganglion (SCG) neurons and mouse hippocampal CA1 pyramidal neurons, 100 nm GxTX-1E produced near-saturating block ..
  3. Goellner E, Slavin K. Cervical spinal cord stimulation may prevent cerebral vasospasm by modulating sympathetic activity of the superior cervical ganglion at lower cervical spinal level. Med Hypotheses. 2009;73:410-3 pubmed publisher
  4. Ferreira da Silva F, Barbosa R, Moreira Júnior L, dos Santos Nascimento T, de Oliveira Martins M, Coelho de Souza A, et al. Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion. Clin Exp Pharmacol Physiol. 2009;36:1068-73 pubmed publisher
    ..we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats. 2. 1,8-Cineole (0...
  5. Yang Y, Fukui K, Koike T, Zheng X. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci. 2007;26:2979-88 pubmed
    ..Therefore, our present data suggest the critical role of autophagy in neurite degeneration and may provide a valuable clue in understanding the mechanism of axonal and dendritic degeneration. ..
  6. Furuno T, Ma D, van der Kleij H, Nakanishi M, Bienenstock J. Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors. Neurosci Lett. 2004;372:185-9 pubmed
    ..Our findings show that the expression of NK-1 receptors appears to be important for nerve-mast cell communication. ..
  7. Chung S, Ahn D, Kim Y, Kim Y, Joeng J, Nam T. Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons. Exp Physiol. 2010;95:982-93 pubmed publisher
    ..therefore, investigated the effect of R(i-pre) activation on voltage-dependent Ca(2+) channels in rat superior cervical ganglion (SCG) neurons, using the conventional whole-cell patch-clamp method...
  8. Paggi P, De Stefano M, Petrucci T. Synaptic remodeling induced by axotomy of superior cervical ganglion neurons: Involvement of metalloproteinase-2. J Physiol Paris. 2006;99:119-24 pubmed
    ..the dystrophin-dystroglycan (Dys-DG) complex in the stabilization of intraganglionic synapses in rodent superior cervical ganglion (SCG) by investigating changes in the organization of their post-synaptic apparatus induced either by ..
  9. Xiao Z, Li L, Yu S, Lu Z, Li C, Zheng J. Effects of extracellular Ca(2+) influx and intracellular Ca(2+) release on ethanol-induced cytoplasmic Ca(2+) overload in cultured superior cervical ganglion neurons. Neurosci Lett. 2005;390:98-103 pubmed
    ..was designed to investigate the interference of Ca(2+) homeostasis by ethanol on the primary cultured superior cervical ganglion (SCG) neurons...

More Information


  1. Lu W, Ma H, Sheng Z, Mochida S. Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons. J Biol Chem. 2009;284:1930-7 pubmed publisher
    ..of different modes of synaptic vesicle recycling at a peripheral neuronal synapse formed between superior cervical ganglion neurons in culture, via acute disruption of endocytosis with Dynasore, an inhibitor of dynamin ..
  2. David R, Ciuraszkiewicz A, Simeone X, Orr Urtreger A, Papke R, McIntosh J, et al. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci. 2010;31:978-93 pubmed publisher
    ..Here, we determined the subunit composition of hetero-pentameric nAChRs in the mouse superior cervical ganglion (SCG), the function of distinct receptors (obtained by deletions of nAChR subunit genes) and mechanisms ..
  3. Ikegami K, Kato S, Koike T. N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration. Brain Res. 2004;1030:81-93 pubmed
    ..These results strongly suggest that TLCK intervenes in a common step in the cascade of neuritic degeneration caused by these different experimental paradigms and provides a helpful clue for identifying such a molecular step. ..
  4. Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed publisher
    ..Differential distribution of NHERF2 in neurons may therefore determine coupling of mGluR5 receptors and P2Y1 receptors to calcium channels. ..
  5. Lin H, Liu C, Cao D, Chen P, Chen M, Lin S, et al. Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. Proc Natl Acad Sci U S A. 2008;105:19526-31 pubmed publisher
    ..By using a similar technique with rat superior cervical ganglion (SCG) as donor tissue and rabbit endothelium-denuded aortic ring as detector tissue, we report here that ..
  6. Wheeler D, Barrett C, Groth R, Safa P, Tsien R. CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. J Cell Biol. 2008;183:849-63 pubmed publisher
  7. Ma H, Cai Q, Lu W, Sheng Z, Mochida S. KIF5B motor adaptor syntabulin maintains synaptic transmission in sympathetic neurons. J Neurosci. 2009;29:13019-29 pubmed publisher
    ..Here, using cultured superior cervical ganglion neurons combined with manipulation of syntabulin expression or interference with its interaction with ..
  8. Saino T, Satoh Y. Application of real-time confocal laser scanning microscopy to observe living cells in tissue specimens. J Electron Microsc (Tokyo). 2004;53:49-56 pubmed
    ..We conclude that real-time confocal microscopy is a useful tool for investigating structural and functional changes of cells in living tissues, although suitable tissue-preparation is important for these measurements. ..
  9. Zhao R, Liu L, Rittenhouse A. Ca2+ influx through both L- and N-type Ca2+ channels increases c-fos expression by electrical stimulation of sympathetic neurons. Eur J Neurosci. 2007;25:1127-35 pubmed
    ..activity in regulating mRNA levels of c-fos, an activity-dependent transcription factor, in adult rat superior cervical ganglion (SCG) neurons as the majority of Ca2+ channels are N-type, while only a minority are L-type...
  10. Ma H, Mochida S. A cholinergic model synapse to elucidate protein function at presynaptic terminals. Neurosci Res. 2007;57:491-8 pubmed
    ..The cholinergic synapse formed between superior cervical ganglion (SCG) neurons in long-term culture is a useful model for a fast synapse...
  11. Liu L, Zhao R, Bai Y, Stanish L, Evans J, Sanderson M, et al. M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades. J Neurosci. 2006;26:11588-98 pubmed
    ..However, we found previously that M(1)R inhibition of N-current in superior cervical ganglion (SCG) neurons requires loss of PIP(2) and generation of a free fatty acid, probably arachidonic acid (AA)..
  12. Ch ng T, Enquist L. Efficient axonal localization of alphaherpesvirus structural proteins in cultured sympathetic neurons requires viral glycoprotein E. J Virol. 2005;79:8835-46 pubmed
    ..Our results indicate that reduced axonal targeting of viral structural proteins is a compelling explanation for the lack of anterograde spread in neural circuits following infection by a gE-null mutant. ..
  13. Li C, Horn J. Physiological classification of sympathetic neurons in the rat superior cervical ganglion. J Neurophysiol. 2006;95:187-95 pubmed
    A new scheme is presented for identifying three sympathetic phenotypes in the rat superior cervical ganglion using electrophysiology and neuropeptide Y expression...
  14. Si M, Long C, Yang D, Chen M, Lee T. Statins prevent beta-amyloid inhibition of sympathetic alpha7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. J Cereb Blood Flow Metab. 2005;25:1573-85 pubmed
    ..In cultured superior cervical ganglion (SCG) cells, Abeta(1-40), but not Abeta(40-1), blocked choline- and nicotine-induced calcium influx and ..
  15. Heermann S, Schmücker J, Hinz U, Rickmann M, Unterbarnscheidt T, Schwab M, et al. Neuregulin 1 type III/ErbB signaling is crucial for Schwann cell colonization of sympathetic axons. PLoS ONE. 2011;6:e28692 pubmed publisher
    ..Here we use a superior cervical ganglion (SCG) explant assay, in which axons elongate after treatment with nerve growth factor (NGF)...
  16. Porzionato A, Macchi V, Amagliani A, Castagliuolo I, Parenti A, De Caro R. Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body. Eur J Histochem. 2009;53:135-42 pubmed
    ..Our findings suggest that NT produced by type I cells acts in an autocrine or paracrine way on the same cell type, playing a modulatory role on chemoception. ..
  17. Zaika O, Tolstykh G, Jaffe D, Shapiro M. Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels. J Neurosci. 2007;27:8914-26 pubmed
    ..We group purinergic P2Y and bradykinin B(2) receptors together as having a common mode of action. ..
  18. Chen M, Huang Y, Long C, Yang H, Lee H, Chen P, et al. Bimodal effects of fluoxetine on cerebral nitrergic neurogenic vasodilation in porcine large cerebral arteries. Neuropharmacology. 2012;62:1651-8 pubmed publisher
    ..exclusively blocked nicotine-induced inward currents and calcium influx in cultured neurons of rat superior cervical ganglion and Xenopus oocytes expressing human ?7-, ?3?2-, or ?4?2-nicotinic acetylcholine receptors (nAChRs)...
  19. Goold R, Gordon Weeks P. The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth. Mol Cell Neurosci. 2005;28:524-34 pubmed
    ..Thus, NGF drives increased neurite growth rates partly by coupling the MAPK pathway to the activation of GSK3beta and thereby phosphorylation of MAP1B. ..
  20. Gamper N, Reznikov V, Yamada Y, Yang J, Shapiro M. Phosphatidylinositol [correction] 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci. 2004;24:10980-92 pubmed
    ..We suggest that differential use of PIP2 signals underlies specificity of Gq/11-coupled receptor actions on the channels ..
  21. Hernandez C, Zaika O, Tolstykh G, Shapiro M. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol. 2008;586:1811-21 pubmed publisher
    ..Their activity is regulated by multiple signalling pathways. In superior cervical ganglion sympathetic neurons, muscarinic M(1), angiotensin II AT(1), bradykinin B(2) and purinergic P2Y agonists ..
  22. Deppmann C, Mihalas S, Sharma N, Lonze B, Niebur E, Ginty D. A model for neuronal competition during development. Science. 2008;320:369-73 pubmed publisher
    ..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects. ..
  23. Jia Q, Jia Z, Zhao Z, Liu B, Liang H, Zhang H. Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation. J Neurosci. 2007;27:2503-12 pubmed
    ..We further demonstrate that these two processes are mutually dependent. This study indicates that EGF is a potent modulator of M/KCNQ currents and provides a new dimension to the understanding of the modulation of these channels. ..
  24. Calvert J, Atterbury Thomas A, Leon C, Forsythe I, Gachet C, Evans R. Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia. Br J Pharmacol. 2004;143:525-32 pubmed
    ..In the superior cervical ganglion (SCG), RT-PCR analysis indicated the presence of P2Y(1,2&6) receptors...
  25. Liu L, Heneghan J, Michael G, Stanish L, Egertová M, Rittenhouse A. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. J Cell Physiol. 2008;216:91-100 pubmed publisher
    ..We documented the presence of DAGL in superior cervical ganglion neurons, and then tested the highly selective DAGL inhibitor, RHC-80267, for its capacity to antagonize ..
  26. Porzionato A, Fenu G, Rucinski M, Macchi V, Montella A, Malendowicz L, et al. KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion. Eur J Histochem. 2011;55:e14 pubmed publisher
    ..As a consequence, a possible role of kisspeptins in the regulation of carotid body blood flow and, indirectly, in chemoreceptor discharge may also be hypothesized. ..
  27. Long C, Chen M, Sarwinski S, Chen P, Si M, Hoffer B, et al. Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. Am J Physiol Heart Circ Physiol. 2006;291:H202-9 pubmed
    ..03-0.1 microM) but inhibited at higher concentrations (0.3-10 microM). In cultured superior cervical ganglion (SCG) neurons of the pig and rat, choline (0...
  28. Vanterpool C, Vanterpool E, Pearce W, Buchholz J. Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia. J Appl Physiol (1985). 2006;101:392-400 pubmed
    Sympathetic nerves arising from the superior cervical ganglion (SCG) protect the cerebrovasculature during periods of acute hypertension and may play a role in homeostasis of target organs...
  29. Vanterpool C, Pearce W, Buchholz J. Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells. J Appl Physiol (1985). 2005;99:963-71 pubmed
    ..We measured [Ca2+]i transients in isolated fura 2-loaded superior cervical ganglion cells from 6-, 12-, 20-, and 24-mo-old Fischer 344 rats...
  30. Zaika O, Lara L, Gamper N, Hilgemann D, Jaffe D, Shapiro M. Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels. J Physiol. 2006;575:49-67 pubmed
    ..the role of modulation by angiotensin II (angioII) of M current in controlling discharge properties of superior cervical ganglion (SCG) sympathetic neurons and the mechanism of action of angioII on cloned Kv7 channels in a ..
  31. Thompson J, Dolcet X, Hilton M, Tolcos M, Davies A. HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms. Mol Cell Neurosci. 2004;27:441-52 pubmed
    ..Here, we show that HGF promotes the survival of mature sympathetic neurons of the superior cervical ganglion (SCG) grown at low density in defined medium lacking other neurotrophic factors...
  32. Lee R, Liu Y, Chen P, Liu C, Chen M, Lin H, et al. Sympathetic ????-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine. Am J Physiol Heart Circ Physiol. 2011;301:H344-54 pubmed publisher
    ..on nAChR-expressing oocytes by two-electrode voltage recording, and mRNA and protein expression in the superior cervical ganglion (SCG) and middle cervical ganglion (MCG) by reverse transcription PCR and Western blotting...
  33. Kameda Y, Saitoh T, Nemoto N, Katoh T, Iseki S. Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body. Dev Dyn. 2012;241:1289-300 pubmed publisher
    ..e., the neural crest origin. The deficiency of Hes1 caused severe hypoplasia of the superior cervical ganglion (SCG). At embryonic day (E) 17.5-E18.5, the volume of the SCG in Hes1 null mutants was reduced to 26...
  34. Gutierrez H, Kisiswa L, O Keeffe G, Smithen M, Wyatt S, Davies A. Regulation of neurite growth by tumour necrosis superfamily member RANKL. Open Biol. 2013;3:120150 pubmed publisher
    ..These findings reveal that RANKL is a novel negative regulator of neurite growth from developing PNS neurons and that it exerts its effects by IKK?-dependent activation of NF-?B. ..
  35. Walker R, Foster A, Randolph C, Isaacson L. Changes in NGF and NT-3 protein species in the superior cervical ganglion following axotomy of postganglionic axons. Brain Res. 2009;1255:1-8 pubmed publisher
    Mature sympathetic neurons in the superior cervical ganglion (SCG) are regulated by target-derived neurotrophins such as nerve growth factor (NGF) and neurotrophin-3 (NT-3)...
  36. Kubista H, Kosenburger K, Mahlknecht P, Drobny H, Boehm S. Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors. Br J Pharmacol. 2009;156:1342-52 pubmed publisher
    ..Here, we searched for inhibitory presynaptic M(1) receptors. In primary cultures of rat superior cervical ganglion neurons, Ca(2+) currents were recorded via the perforated patch-clamp technique, and the release of [(3)..
  37. Mao D, Yasuda R, Fan H, Wolfe B, Kellar K. Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose Ganglia. Mol Pharmacol. 2006;70:1693-9 pubmed
    ..These findings indicate that the nAChRs in SCG and nodose ganglia are heterogeneous, which suggests that different receptor subtypes may play different roles in these ganglia or may be activated under different conditions. ..
  38. Yin X, Cui W, Hu G, Wang H. Desensitization of alpha7 nicotinic receptors potentiated the inhibitory effect on M-current induced by stimulation of muscarinic receptors in rat superior cervical ganglion neurons. J Neural Transm (Vienna). 2005;112:1133-48 pubmed
    Whole-cell patch-clamp recording from rat superior cervical ganglion neurons in culture was used to investigate the modulatory effect of desensitized alpha7-nAChRs on mAChRs...
  39. MacInnis B, Campenot R. Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway. Mol Cell Neurosci. 2005;28:430-9 pubmed
    ..Identification of the pathways that regulate axonal survival and degeneration will provide possible target sites for pharmacological treatments of neurodegenerative diseases and traumatic injury. ..
  40. Winks J, Hughes S, Filippov A, Tatulian L, Abogadie F, Brown D, et al. Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci. 2005;25:3400-13 pubmed
  41. Osterloh J, Yang J, Rooney T, Fox A, Adalbert R, Powell E, et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012;337:481-4 pubmed publisher
    ..Our results provide direct evidence that axons actively promote their own destruction after injury and identify dSarm/Sarm1 as a member of an ancient axon death signaling pathway. ..
  42. Ito T, Hioki H, Nakamura K, Tanaka Y, Nakade H, Kaneko T, et al. Gamma-aminobutyric acid-containing sympathetic preganglionic neurons in rat thoracic spinal cord send their axons to the superior cervical ganglion. J Comp Neurol. 2007;502:113-25 pubmed
    Gamma-aminobutyric acid (GABA)-containing fibers have been observed in the rat superior cervical ganglion (SCG) and, to a lesser extent, in the stellate ganglion (STG). The aim of present study is to clarify the source of these fibers...
  43. Towers E, Gilley J, Randall R, Hughes R, Kristiansen M, Ham J. The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons. Nucleic Acids Res. 2009;37:3044-60 pubmed publisher
    ..These results suggest that part of the mechanism by which the MLK-JNK-c-Jun pathway promotes neuronal apoptosis is by activating the transcription of the dp5 gene. ..
  44. Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty D, Halegoua S. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci. 2005;25:5236-47 pubmed
    ..Pincher is the first distinguishing molecular component of a novel mechanistic pathway for endosomal signaling in neurons. ..
  45. Wheeler D, Barrett C, Tsien R. L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors. Neuropharmacology. 2006;51:27-36 pubmed
    ..We investigated the effects of LTCC ligands on nAChR currents and downstream signaling in rat superior cervical ganglion (SCG) neurons...
  46. Gutierrez H, O Keeffe G, Gavalda N, Gallagher D, Davies A. Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA. J Neurosci. 2008;28:8246-56 pubmed publisher
    ..In neonatal superior cervical ganglion sympathetic neurons, enhancing NF-kappaB transcriptional activity by overexpressing either the p65 NF-..
  47. Girard B, Keller E, Schutz K, May V, Braas K. Pituitary adenylate cyclase activating polypeptide and PAC1 receptor signaling increase Homer 1a expression in central and peripheral neurons. Regul Pept. 2004;123:107-16 pubmed
    ..and immediate early gene product isoform of Homer, was identified to be strongly upregulated in superior cervical ganglion (SCG) sympathetic neurons...
  48. Waithe D, Ferron L, Dolphin A. Stargazin-related protein ?? is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth. J Cell Sci. 2011;124:2049-57 pubmed publisher
    ..These findings open the possibility that ?? has an essential trafficking role in relation to neurite outgrowth as a component of endosomes involved in neurite extension and growth cone remodelling. ..
  49. Mozayan M, Chen M, Si M, Chen P, Premkumar L, Lee T. Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. J Cereb Blood Flow Metab. 2006;26:1562-76 pubmed
    ..confocal microscopy, significant calcium influx induced by choline and nicotine in cultured porcine superior cervical ganglion (SCG) cells was attenuated by ChEIs...
  50. O Keeffe G, Gutierrez H, Pandolfi P, Riccardi C, Davies A. NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nat Neurosci. 2008;11:135-42 pubmed publisher
    ..Our results reveal a previously unknown signaling loop in developing sympathetic neurons that is crucial for NGF-dependent axon growth and target innervation. ..
  51. Luther J, Birren S. Nerve growth factor decreases potassium currents and alters repetitive firing in rat sympathetic neurons. J Neurophysiol. 2006;96:946-58 pubmed
    ..of NGF causes a change in the repetitive firing pattern of cultured sympathetic neurons of the rat superior cervical ganglion. Neurons fire fewer action potentials in NGF, but with increased frequency, demonstrating an NGF-..
  52. Ascano M, Richmond A, Borden P, Kuruvilla R. Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses. J Neurosci. 2009;29:11674-85 pubmed publisher
  53. Ma C, Palmer A, Taylor J. Synergistic effects of osteonectin and NGF in promoting survival and neurite outgrowth of superior cervical ganglion neurons. Brain Res. 2009;1289:1-13 pubmed publisher
    ..the effects of osteonectin (ON), a major factor secreted by SCs, on survival and neuritogenesis of mouse superior cervical ganglion (SCG) neurons...
  54. Putz G, Kristufek D, Orr Urtreger A, Changeux J, Huck S, Scholze P. Nicotinic acetylcholine receptor-subunit mRNAs in the mouse superior cervical ganglion are regulated by development but not by deletion of distinct subunit genes. J Neurosci Res. 2008;86:972-81 pubmed
    ..We could previously show in the mouse superior cervical ganglion (SCG) that the absence of distinct subunits affects the functional properties of receptors...
  55. Liu L, Roberts M, Rittenhouse A. Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons. Eur Biophys J. 2004;33:255-64 pubmed
    ..A2 (PLA2), and arachidonic acid (AA) as additional molecules involved in N-current inhibition in superior cervical ganglion (SCG) neurons by the slow pathway...
  56. Neame S, Rubin L, Philpott K. Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol. 1998;142:1583-93 pubmed
    ..During NGF withdrawal-induced apoptosis of intact rat superior cervical ganglion (SCG) neurons, we observe the redistribution of cytochrome c from the mitochondria to the cytoplasm...
  57. Delmas P, Brown D, Dayrell M, Abogadie F, Caulfield M, Buckley N. On the role of endogenous G-protein beta gamma subunits in N-type Ca2+ current inhibition by neurotransmitters in rat sympathetic neurones. J Physiol. 1998;506 ( Pt 2):319-29 pubmed
    ..PTX-insensitive inhibition by angiotensin II. They also support the view that voltage-dependent inhibition results from a direct G beta gamma-Ca2+ channel interaction. ..
  58. Gamper N, Shapiro M. Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol. 2003;122:17-31 pubmed
    ..Ca2+]i modulation of M current in superior cervical ganglion (SCG) neurons followed the same pattern as in CHO cells expressed with KCNQ2/3 and wt CaM, suggesting ..
  59. Scholze T, Moskvina E, Mayer M, Just H, Kubista H, Boehm S. Sympathoexcitation by bradykinin involves Ca2+-independent protein kinase C. J Neurosci. 2002;22:5823-32 pubmed
    ..In primary cultures of rat superior cervical ganglion neurons, bradykinin caused an accumulation of inositol trisphosphate, an inhibition of M-currents, and a ..
  60. Si M, Lee T. Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation. Circ Res. 2002;91:62-9 pubmed
    ..Endogenous choline may play an important role in regulating cerebral sympathetic activity and vascular tone. ..
  61. Spanswick D, Renaud L, Logan S. Bilaterally evoked monosynaptic EPSPs, NMDA receptors and potentiation in rat sympathetic preganglionic neurones in vitro. J Physiol. 1998;509 ( Pt 1):195-209 pubmed
    ..Fifty-two of these SPNs were identified histologically as innervating the superior cervical ganglion (SCG) by the presence of Lucifer Yellow introduced from the patch pipette and the appearance of ..