white matter

Summary

Summary: The region of CENTRAL NERVOUS SYSTEM that appears lighter in color than the other type, GRAY MATTER. It mainly consists of MYELINATED NERVE FIBERS and contains few neuronal cell bodies or DENDRITES.

Top Publications

  1. Vollmer B, Lundequist A, Mårtensson G, Nagy Z, Lagercrantz H, Smedler A, et al. Correlation between white matter microstructure and executive functions suggests early developmental influence on long fibre tracts in preterm born adolescents. PLoS ONE. 2017;12:e0178893 pubmed publisher
    ..including 3D T1-weighted images for volumetric analyses and Diffusion Tensor Imaging (DTI) for assessment of white matter microstructure...
  2. Bede P, Elamin M, Byrne S, McLaughlin R, Kenna K, Vajda A, et al. Patterns of cerebral and cerebellar white matter degeneration in ALS. J Neurol Neurosurg Psychiatry. 2015;86:468-70 pubmed publisher
  3. Sandhya G, Babu Kande G, Savithri T. Multilevel Thresholding Method Based on Electromagnetism for Accurate Brain MRI Segmentation to Detect White Matter, Gray Matter, and CSF. Biomed Res Int. 2017;2017:6783209 pubmed publisher
    ..MT) method based on the phenomenon of Electromagnetism and it segments the image into three tissues such as White Matter (WM), Gray Matter (GM), and CSF...
  4. Svärd D, Nilsson M, Lampinen B, Lätt J, Sundgren P, Stomrud E, et al. The effect of white matter hyperintensities on statistical analysis of diffusion tensor imaging in cognitively healthy elderly and prodromal Alzheimer's disease. PLoS ONE. 2017;12:e0185239 pubmed publisher
    Diffusion tensor imaging (DTI) has been used to study microstructural white matter alterations in a variety of conditions including normal aging and Alzheimer's disease (AD)...
  5. Ben Assayag E, Eldor R, Korczyn A, Kliper E, Shenhar Tsarfaty S, Tene O, et al. Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline. Stroke. 2017;48:2368-2374 pubmed publisher
    ..The volume and white matter integrity, ischemic lesions, and brain and hippocampal volumes were measured at baseline using 3-T MRI...
  6. Bells S, Lefebvre J, Prescott S, Dockstader C, Bouffet E, Skocic J, et al. Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize. J Neurosci. 2017;37:8227-8238 pubmed publisher
    Cognition is compromised by white matter (WM) injury but the neurophysiological alterations linking them remain unclear. We hypothesized that reduced neural synchronization caused by disruption of neural signal propagation is involved...
  7. Strijbis E, Kooi E, van der Valk P, Geurts J. Cortical Remyelination Is Heterogeneous in Multiple Sclerosis. J Neuropathol Exp Neurol. 2017;76:390-401 pubmed publisher
    ..multiple sclerosis (MS) pathology; they correlate better with physical disability and cognitive impairment than white matter lesions (WMLs)...
  8. Harper L, Bouwman F, Burton E, Barkhof F, Scheltens P, O Brien J, et al. Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis. J Neurol Neurosurg Psychiatry. 2017;88:908-916 pubmed publisher
    ..The results of this study are available for further examination via NeuroVault (http://neurovault.org/collections/ADHMHOPN/). ..
  9. Kulick E, Wellenius G, Kaufman J, DeRosa J, Kinney P, Cheung Y, et al. Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). Stroke. 2017;48:1966-1968 pubmed publisher
    ..We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present...

More Information

Publications62

  1. Acheson A, Wijtenburg S, Rowland L, Winkler A, Mathias C, Hong L, et al. Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol. Brain Behav. 2017;7:e00615 pubmed publisher
    In preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH-), we examined the reproducibility and reliability of global and regional ..
  2. Chen M, Chen P, Lu C, Chen H, Chao Y, Li S, et al. Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson's Disease. Oxid Med Cell Longev. 2017;2017:7371403 pubmed publisher
    ..Owing to the relative low intrinsic antioxidative properties, brain white matter (WM) is vulnerable to the oxidative stress...
  3. Chappell F, Del Carmen Valdés Hernández M, Makin S, Shuler K, Sakka E, Dennis M, et al. Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study. Trials. 2017;18:78 pubmed publisher
    b>White matter hyperintensities (WMHs) are commonly seen on in brain imaging and are associated with stroke and cognitive decline. Therefore, they may provide a relevant intermediate outcome in clinical trials...
  4. Spiegelhalder K, Regen W, Prem M, Baglioni C, Nissen C, Feige B, et al. Reduced anterior internal capsule white matter integrity in primary insomnia. Hum Brain Mapp. 2014;35:3431-8 pubmed
    ..Up to now, nothing is known about the integrity of white matter tracts in insomnia patients...
  5. Almeida R, Lyons D. On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function. J Neurosci. 2017;37:10023-10034 pubmed publisher
    ..However, MRI-based imaging studies have shown that white matter, primarily composed of myelinated axons, can also be dynamically regulated by activity of the healthy brain...
  6. Taib T, Leconte C, Van Steenwinckel J, Cho A, Palmier B, Torsello E, et al. Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice. PLoS ONE. 2017;12:e0184811 pubmed publisher
    Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with neurological deficits. Neuroinflammation originating from microglial activation may participate in WMI and associated disorders...
  7. Aoki Y, Yoncheva Y, Chen B, Nath T, Sharp D, Lazar M, et al. Association of White Matter Structure With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. JAMA Psychiatry. 2017;74:1120-1128 pubmed publisher
    ..Clinical overlap between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is increasingly appreciated, but the underlying brain mechanisms remain unknown to date...
  8. Puthenparampil M, Federle L, Poggiali D, Miante S, Signori A, Pilotto E, et al. Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis. PLoS ONE. 2017;12:e0183957 pubmed publisher
    ..Global cortical thickness (gCTh), pericalcarin CTh (pCTh) and white matter volume (WMV) were analysed by means of Freesurfer on 3D-T1 scans...
  9. Vandermosten M, Cuynen L, Vanderauwera J, Wouters J, Ghesquière P. White matter pathways mediate parental effects on children's reading precursors. Brain Lang. 2017;173:10-19 pubmed publisher
    ..fathers' reading skills predicted reading of the child by operating through a child's left ventral white matter pathway. For mothers no clear mediating role of the neural system was observed...
  10. Kochunov P, Coyle T, Rowland L, Jahanshad N, Thompson P, Kelly S, et al. Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia. JAMA Psychiatry. 2017;74:958-966 pubmed publisher
    Efforts to remediate the multiple cognitive function impairments in schizophrenia should consider white matter as one of the underlying neural mechanisms.
  11. Feng Y, Qiu S, Xia X, Ji S, Lee C. A computational study of invariant I5 in a nearly incompressible transversely isotropic model for white matter. J Biomech. 2017;57:146-151 pubmed publisher
    The aligned axonal fiber bundles in white matter make it suitable to be modeled as a transversely isotropic material...
  12. Yew B, Nation D. Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia. Brain. 2017;140:1987-2001 pubmed publisher
  13. Wada T, Hayashi N, Motegi S, Nagase H, Ujita K, Ogura A, et al. Relationship between Blurring and Refocus Flip Angle in 3D-double Inversion Recovery MRI. Nihon Hoshasen Gijutsu Gakkai Zasshi. 2017;73:389-394 pubmed publisher
    ..b>White matter attenuated inversion recovery (WAIR) images as a test sample were obtained by 1...
  14. van Nierop G, van Luijn M, Michels S, Melief M, Janssen M, Langerak A, et al. Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients. Acta Neuropathol. 2017;134:383-401 pubmed publisher
    ..a comprehensive analysis on T cells recovered from paired blood, cerebrospinal fluid (CSF), normal-appearing white matter (NAWM) and white matter lesions (WML) from 27 MS patients with advanced disease shortly after death...
  15. Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner H, Lassmann H. Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis. Brain. 2017;140:1900-1913 pubmed publisher
    ..We found microglia activation in normal white matter of controls and that the degree of activation increased with age...
  16. Judson M, Burette A, Thaxton C, Pribisko A, Shen M, Rumple A, et al. Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice. J Neurosci. 2017;37:7347-7361 pubmed publisher
    ..mice reveals that microcephaly in the AS mouse model is primarily driven by deficits in the growth of white matter tracts, which by adulthood are characterized by densely packed axons of disproportionately small caliber...
  17. Ross L, Del Bene V, Molholm S, Jae Woo Y, Andrade G, Abrahams B, et al. Common variation in the autism risk gene CNTNAP2, brain structural connectivity and multisensory speech integration. Brain Lang. 2017;174:50-60 pubmed publisher
    ..2) CNTNAP2 variations are associated with differences in white matter (WM) tracts comprising the speech-language circuitry...
  18. Verhaaren B, Debette S, Bis J, Smith J, Ikram M, Adams H, et al. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet. 2015;8:398-409 pubmed publisher
    The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized...
  19. Sarabdjitsingh R, Loi M, Joels M, Dijkhuizen R, van der Toorn A. Early life stress-induced alterations in rat brain structures measured with high resolution MRI. PLoS ONE. 2017;12:e0185061 pubmed publisher
    ..However, changes were relatively modest and-unlike behavior- not mitigated by blockade of glucocorticoid receptors during a critical developmental period. ..
  20. Datta G, Colasanti A, Rabiner E, Gunn R, Malik O, Ciccarelli O, et al. Neuroinflammation and its relationship to changes in brain volume and white matter lesions in multiple sclerosis. Brain. 2017;140:2927-2938 pubmed publisher
    ..from the T1- and T2-weighted magnetic resonance imaging and relative 11C-PBR28 uptake in the normal-appearing white matter was estimated as a distribution volume ratio with respect to a caudate pseudo-reference region...
  21. Mollison D, Sellar R, Bastin M, Mollison D, Chandran S, Wardlaw J, et al. The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0177727 pubmed publisher
    Moderate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS)...
  22. Wald C. Social networks: Better together. Nature. 2016;531:S14-5 pubmed publisher
  23. Zheng W, Chen Q, Chen X, Wan L, Qin W, Qi Z, et al. Brain White Matter Impairment in Patients with Spinal Cord Injury. Neural Plast. 2017;2017:4671607 pubmed publisher
    It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance...
  24. Wardlaw J, Valdés Hernández M, Muñoz Maniega S. What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc. 2015;4:001140 pubmed publisher
  25. Chaves M, Bettini M, Fernandez M, Basalo M, Rojas J, Besada C, et al. Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile. Arq Neuropsiquiatr. 2017;75:272-276 pubmed publisher
    ..An MRI with DTI was performed in all patients and fractional anisotropy (FA) was analyzed in the white matter using the tract based spatial statistics program. Twenty-four patients with ALS (15 females, mean age 66.9 + -2...
  26. Nemoto K. [Understanding Voxel-Based Morphometry]. Brain Nerve. 2017;69:505-511 pubmed publisher
    ..The core process of VBM is segmenting the brain into grey matter, white matter, and cerebrospinal fluid, warping the segmented images to a template space and smoothing...
  27. Maggipinto T, Bellotti R, Amoroso N, Diacono D, Donvito G, Lella E, et al. DTI measurements for Alzheimer's classification. Phys Med Biol. 2017;62:2361-2375 pubmed publisher
    Diffusion tensor imaging (DTI) is a promising imaging technique that provides insight into white matter microstructure integrity and it has greatly helped identifying white matter regions affected by Alzheimer's disease (AD) in its early ..
  28. Petribu N, Aragão M, van der Linden V, Parizel P, Jungmann P, Araújo L, et al. Follow-up brain imaging of 37 children with congenital Zika syndrome: case series study. BMJ. 2017;359:j4188 pubmed publisher
    ..All presented cerebral calcifications on the initial scan, predominantly at cortical-white matter junction...
  29. Gawłowska Sawosz M, Pawełczyk A, Gębski P, Pawełczyk T, Strzelecki D, Rabe Jabłońska J. Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. Psychiatr Pol. 2017;51:735-750 pubmed publisher
    The aim of the project was to assess the differences in the white matter (WM) fiber structure between patients with early onset schizophrenia (EOS), their first degree relatives and controls using Fractional Anisotropy (FA), and an ..
  30. Freedman B, Sink K, Hugenschmidt C, Hughes T, Williamson J, Whitlow C, et al. Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus. Am J Kidney Dis. 2017;70:627-637 pubmed publisher
    ..eGFR (CKD-EPI creatinine equation), spot UACR. MRI-based cerebral white matter volume (WMV), gray matter volume (GMV), and white matter lesion volume; cognitive performance (Mini-Mental ..
  31. Chandesris M, Gray F, Bruneval P, Azarine A, Boddaert N, Oppenheim C, et al. A neuropathological study of cerebrovascular abnormalities in a signal transducer and activator of transcription 3-deficient patient. J Allergy Clin Immunol. 2015;136:1418-21.e1-5 pubmed publisher
  32. Akashi T, Takahashi S, Mugikura S, Sato S, Murata T, Umetsu A, et al. Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions. AJR Am J Roentgenol. 2017;209:W160-W168 pubmed publisher
    ..in the pathogenesis of cerebral vascular disease and to present a classification of MRI findings of ischemic white matter lesions for use in elucidating pathogenesis...
  33. Zhou Y, Liu J, Driesen N, Womer F, Chen K, Wang Y, et al. White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations. Biomed Res Int. 2017;2017:3107845 pubmed publisher
    b>White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ). Understanding these variations may elucidate distinct markers of genetic vulnerability and conversion to psychosis...
  34. Schmidt R, Seiler S, Loitfelder M. Longitudinal change of small-vessel disease-related brain abnormalities. J Cereb Blood Flow Metab. 2016;36:26-39 pubmed
    ..Confluent white matter lesions show fast progression and correlations with cognitive decline...
  35. Pagnozzi A, Dowson N, Doecke J, Fiori S, Bradley A, Boyd R, et al. Identifying relevant biomarkers of brain injury from structural MRI: Validation using automated approaches in children with unilateral cerebral palsy. PLoS ONE. 2017;12:e0181605 pubmed publisher
    ..Furthermore, the strong and significant association between quantifications of injury observed on structural MRI and multiple clinical scores accord with empirically established structure-function relationships. ..
  36. Reijmer Y, van Veluw S, Greenberg S. Ischemic brain injury in cerebral amyloid angiopathy. J Cereb Blood Flow Metab. 2016;36:40-54 pubmed
    ..A better understanding of the underlying mechanisms of ischemic brain injury in CAA will be a key step toward new interventions to improve long-term cognitive outcomes for patients with CAA. ..
  37. Martinez Cerdeno V, Lechpammer M, Lott A, Schneider A, Hagerman R. Fragile X-Associated Tremor/Ataxia Syndrome in a Man in His 30s. JAMA Neurol. 2015;72:1070-3 pubmed publisher
  38. Cho H, Baek M, Choi J, Lee S, Kim J, Ryu Y, et al. 18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome. Neurology. 2017;89:1170-1178 pubmed publisher
    ..showed asymmetrically increased 18F-AV-1451 binding in the focal regions of the precentral gray and white matter and in the midbrain, predominantly in the contralateral side...
  39. He Z, Han D, Efimova O, Guijarro P, Yu Q, Oleksiak A, et al. Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques. Nat Neurosci. 2017;20:886-895 pubmed publisher
    ..Here we characterized the transcriptome of the cortical layers and adjacent white matter in the prefrontal cortexes of humans, chimpanzees and rhesus macaques using unsupervised sectioning followed by ..
  40. Samra K, Boon I, Packer G, Jacob S. Lethal high: acute disseminated encephalomyelitis (ADEM) triggered by toxic effect of synthetic cannabinoid black mamba. BMJ Case Rep. 2017;2017: pubmed publisher
    ..The patient made a slow but significant recovery after a course of intravenous methylprednisolone, intravenous immunoglobulins and oral steroids, and was later transferred to a rehabilitation bed. ..
  41. Wang M, Owen J, Mukherjee P, Raj A. Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease. PLoS Comput Biol. 2017;13:e1005550 pubmed publisher
    ..embedding of the edges of the cerebral graph have been postulated to elucidate the relative importance of white matter tracts to the overall network connectivity, explaining the varying effects of localized white matter pathology ..
  42. Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, et al. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. PLoS ONE. 2017;12:e0181392 pubmed publisher
    ..No association of UCP2 polymorphisms with the occurrence of neurodegenerative disorders or grey and white matter structure or resting-state functional connectivity was observed...
  43. Wendelken C, Ferrer E, Ghetti S, Bailey S, Cutting L, Bunge S. Frontoparietal Structural Connectivity in Childhood Predicts Development of Functional Connectivity and Reasoning Ability: A Large-Scale Longitudinal Investigation. J Neurosci. 2017;37:8549-8558 pubmed publisher
    ..Our results demonstrate the importance of strong white matter connectivity between RLPFC and IPL during middle childhood for the subsequent development of both robust FC and ..
  44. Lee W, Jung K, Ryu Y, Lee K, Kim J, Lee S, et al. Progression of Cerebral White Matter Hyperintensities and the Associated Sonographic Index. Radiology. 2017;284:824-833 pubmed publisher
    Purpose To evaluate the relationship between penetrating arterial pulsation and the progression of white matter hyperintensities (WMHs) by using the sonographic resistance index (RI) along the M1 segment of the middle cerebral artery (MCA)..
  45. Takemura H, Pestilli F, Weiner K, Keliris G, Landi S, Sliwa J, et al. Occipital White Matter Tracts in Human and Macaque. Cereb Cortex. 2017;27:3346-3359 pubmed publisher
    ..These similarities and differences between the occipital lobe tracts will be useful in establishing which circuitry in the macaque can serve as an accurate model for human visual cortex...
  46. Abe A, Nishiyama Y, Harada Abe M, Okubo S, Ueda M, Mishina M, et al. Relative risk values of age, acrolein, IL-6 and CRP as markers of periventricular hyperintensities: a cross-sectional study. BMJ Open. 2014;4:e005598 pubmed
    Brain white matter hyperintensities can be divided into periventricular hyperintensity (PVH) and deep-and-subcortical white matter hyperintensity (DSWMH); the former contributes more to cognitive dysfunction and infarction risk...
  47. Pasi M, van Uden I, Tuladhar A, de Leeuw F, Pantoni L. White Matter Microstructural Damage on Diffusion Tensor Imaging in Cerebral Small Vessel Disease: Clinical Consequences. Stroke. 2016;47:1679-84 pubmed publisher
  48. van Dalen J, Moll van Charante E, Caan M, Scheltens P, Majoie C, Nederveen A, et al. Effect of Long-Term Vascular Care on Progression of Cerebrovascular Lesions: Magnetic Resonance Imaging Substudy of the PreDIVA Trial (Prevention of Dementia by Intensive Vascular Care). Stroke. 2017;48:1842-1848 pubmed publisher
    This study aimed to evaluate the effect of a nurse-led multidomain cardiovascular intervention on white matter hyperintensity (WMH) progression and incident lacunar infarcts in community-dwelling elderly with hypertension...
  49. Cannon T. Deciphering the Genetic Complexity of Schizophrenia. JAMA Psychiatry. 2016;73:5-6 pubmed publisher
  50. Vilar Bergua A, Riba Llena I, Nafría C, Bustamante A, Llombart V, Delgado P, et al. Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability. J Cereb Blood Flow Metab. 2016;36:55-71 pubmed
    ..vascular disease refers to a form of vascular cognitive impairment characterized by the presence of diffuse white matter hyperintensities (WMHs) and multiple lacunar infarcts...
  51. Olivito G, Dayan M, Battistoni V, Clausi S, Cercignani M, Molinari M, et al. Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging. PLoS ONE. 2017;12:e0180439 pubmed publisher
    ..study we used dMRI-based tractography to determine the degree and pattern of pathological changes of cerebellar white matter microstructure in patients with focal cerebellar lesions...
  52. Zamboni G, Griffanti L, Jenkinson M, Mazzucco S, Li L, Küker W, et al. White Matter Imaging Correlates of Early Cognitive Impairment Detected by the Montreal Cognitive Assessment After Transient Ischemic Attack and Minor Stroke. Stroke. 2017;48:1539-1547 pubmed publisher
    ..impairment is pathologically significant, then it should be specifically associated with the presence of white matter hyperintensities (WMHs) and reduced fractional anisotropy (FA) on magnetic resonance imaging...
  53. Schiller R, Ijsselstijn H, Madderom M, Rietman A, Smits M, van Heijst A, et al. Neurobiologic Correlates of Attention and Memory Deficits Following Critical Illness in Early Life. Crit Care Med. 2017;45:1742-1750 pubmed publisher
    ..b>White matter microstructure and hippocampal volume were assessed using diffusion tensor imaging and structural MRI, ..