basal forebrain


Summary: The region of the telencephalon located rostral and ventral to the STRIATUM comprising AMYGDALA; SEPTAL NUCLEI; SUBSTANTIA INNOMINATA and ventral pallidum.

Top Publications

  1. Balasubramanian S, Mintzer J, Wahlquist A. Induction of salivary nerve growth factor by Yogic breathing: a randomized controlled trial. Int Psychogeriatr. 2015;27:168-70 pubmed publisher
  2. López Hernández G, Ananth M, Jiang L, Ballinger E, Talmage D, Role L. Electrophysiological properties of basal forebrain cholinergic neurons identified by genetic and optogenetic tagging. J Neurochem. 2017;142 Suppl 2:103-110 pubmed publisher
    ..This allowed us to visualize basal forebrain cholinergic neurons in acute slice preparations...
  3. Suárez R, Paolino A, Kozulin P, Fenlon L, Morcom L, Englebright R, et al. Development of body, head and brain features in the Australian fat-tailed dunnart (Sminthopsis crassicaudata; Marsupialia: Dasyuridae); A postnatal model of forebrain formation. PLoS ONE. 2017;12:e0184450 pubmed publisher
  4. Dickson D, Murray M. Intraneuronal amyloid-? accumulation in basal forebrain cholinergic neurons: a marker of vulnerability, yet inversely related to neurodegeneration. Brain. 2015;138:1444-5 pubmed publisher
  5. Wang Y, Wang Y, Chen Z. [The role of central cholinergic system in epilepsy]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:15-21 pubmed
    ..with other neurons may regulate the development of epilepsy, especially the cholinergic circuit from basal forebrain to hippocampus, while cholinergic local interneurons have not been reported to be associated with epilepsy...
  6. Sharma R, Sahota P, Thakkar M. Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption. J Neurochem. 2017;142:710-720 pubmed publisher
    ..However, neuronal substrates mediating sleep-promoting effects of alcohol are unknown. Since the basal forebrain (BF) cholinergic neurons are implicated in the homeostatic regulation of sleep, we hypothesized that the BF ..
  7. Knowland D, Lilascharoen V, Pacia C, Shin S, Wang E, Lim B. Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression. Cell. 2017;170:284-297.e18 pubmed publisher
    ..We propose that distinct components of the VP PV circuit can subserve related, yet separate depressive-like phenotypes in mice, which could ultimately provide a platform for symptom-specific treatments of depression. ..
  8. Alam M, McGinty D. Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for 'Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption' on page. J Neurochem. 2017;142:620-623 pubmed publisher
    ..This editorial highlights the study entitled, "Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption" by Sharma and colleagues...
  9. Le T, Zhou Q, Cobos I, Zhang S, Zagozewski J, Japoni S, et al. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017;37:8816-8829 pubmed publisher
    ..2005) or contribute to the pathogenesis of some autism spectrum disorders. GABAergic dysfunction in the basal ganglia could disrupt the learning and development of complex motor and cognitive behaviors (Rubenstein and Merzenich, 2003). ..

More Information


  1. Liu A, Goldfinger M, Questari H, Pearce R, Gentleman S. ARTAG in the basal forebrain: widening the constellation of astrocytic tau pathology. Acta Neuropathol Commun. 2016;4:59 pubmed publisher
  2. Chang S, Smedley E, Stansfield K, Stott J, Smith K. Optogenetic Inhibition of Ventral Pallidum Neurons Impairs Context-Driven Salt Seeking. J Neurosci. 2017;37:5670-5680 pubmed publisher
    ..These results highlight the importance of the VP in context-driven reward-seeking behavior. ..
  3. Zhai Q, Lai D, Cui P, Zhou R, Chen Q, Hou J, et al. Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway. Crit Care Med. 2017;45:e1075-e1082 pubmed publisher
    b>Basal forebrain cholinergic neurons are proposed as a major neuromodulatory system in inflammatory modulation...