cluster headache

Summary

Summary: A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Top Publications

  1. Morelli N, Pesaresi I, Cafforio G, Maluccio M, Gori S, Di Salle F, et al. Functional magnetic resonance imaging in episodic cluster headache. J Headache Pain. 2009;10:11-4 pubmed publisher
    We have investigated the cerebral activation centre in four patients with episodic cluster headache (CH) with functional magnetic resonance imaging (f-MRI)...
  2. May A. Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. Cephalalgia. 2008;28:799-803 pubmed publisher
    ..This prompted the application of hypothalamic deep-brain stimulation (DBS), with the intention to preventing cluster headache (CH) attacks in selected severe therapy-refractory cases...
  3. Francis G, Becker W, Pringsheim T. Acute and preventive pharmacologic treatment of cluster headache. Neurology. 2010;75:463-73 pubmed publisher
    b>Cluster headache (CH) is a rare and disabling primary headache disorder. CH attacks are unilateral, short, severe headaches associated with ipsilateral autonomic symptoms that occur in a periodic fashion...
  4. Chua N, Vissers K, Wilder Smith O. Quantitative sensory testing may predict response to sphenopalatine ganglion pulsed radiofrequency treatment in cluster headaches: a case series. Pain Pract. 2011;11:439-45 pubmed publisher
    ..From this case series, it might be that cluster headache patients with an impaired CPM response with or without signs of allodynia will respond less favorably to ..
  5. Broner S, Cohen J. Epidemiology of cluster headache. Curr Pain Headache Rep. 2009;13:141-6 pubmed
    b>Cluster headache was first described over 300 years ago, but in the last century our knowledge of the disorder has exploded through both clinical observation and epidemiological data...
  6. Olesen J. The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther. 2008;120:157-71 pubmed publisher
    ..e. independent disorders that are not caused by another disease) are migraine, tension-type headache and cluster headache. All primary headaches are in need of better treatments...
  7. Alonso A, Nixdorf D. Case series of four different headache types presenting as tooth pain. J Endod. 2006;32:1110-3 pubmed
    ..This case series describes four patients, one each with migraine headache, cluster headache, paroxysmal hemicrania, and hemicrania continua, all of which who presented to dentists with the chief ..
  8. Schoenen J, Jensen R, Lanteri Minet M, Láinez M, Gaul C, Goodman A, et al. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia. 2013;33:816-30 pubmed publisher
    The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG)...
  9. Brittain J, Green A, Jenkinson N, Ray N, Holland P, Stein J, et al. Local field potentials reveal a distinctive neural signature of cluster headache in the hypothalamus. Cephalalgia. 2009;29:1165-73 pubmed publisher
    b>Cluster headache (CH) is a debilitating neurovascular condition characterized by severe unilateral periorbital head pain...

More Information

Publications62

  1. Arruda M, Bonamico L, Stella C, Bordini C, Bigal M. Cluster headache in children and adolescents: ten years of follow-up in three pediatric cases. Cephalalgia. 2011;31:1409-14 pubmed publisher
    b>Cluster headache (CH) is a rare cause of headache in children. Onset before 12 years of age is unusual, and long-term follow-up of pediatric cases has been not reported...
  2. DaSilva A, Goadsby P, Borsook D. Cluster headache: a review of neuroimaging findings. Curr Pain Headache Rep. 2007;11:131-6 pubmed
    Classified as a trigeminal autonomic cephalalgia, cluster headache is characterized by recurrent short-lived excruciating pain attacks, which are concurrent with autonomic signs...
  3. Iacovelli E, Coppola G, Tinelli E, Pierelli F, Bianco F. Neuroimaging in cluster headache and other trigeminal autonomic cephalalgias. J Headache Pain. 2012;13:11-20 pubmed publisher
    ..The available functional neuroimaging data in cluster headache and other TACs will thus be summarized...
  4. Tfelt Hansen P, Le H. Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. J Headache Pain. 2009;10:137-43 pubmed publisher
    ..Increase of the neuropeptide CGRP during migraine and cluster headache attacks in the extracerebral circulation as measured in the external jugular vein (EJV) has been regarded as ..
  5. Dresler T, Lürding R, Paelecke Habermann Y, Gaul C, Henkel K, Lindwurm Späth A, et al. Cluster headache and neuropsychological functioning. Cephalalgia. 2012;32:813-21 pubmed publisher
    Despite significant advances in unravelling the pathophysiology of cluster headache (CH), little is known about neuropsychological functioning...
  6. May A, Leone M, Afra J, Linde M, Sandor P, Evers S, et al. EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol. 2006;13:1066-77 pubmed
    b>Cluster headache and the other trigeminal-autonomic cephalalgias [paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome] are rare but very disabling ..
  7. Qiu E, Yu S, Liu R, Wang Y, Ma L, Tian L. Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study. Chin Med J (Engl). 2012;125:705-9 pubmed
    Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH)...
  8. Owen S, Green A, Davies P, Stein J, Aziz T, Behrens T, et al. Connectivity of an effective hypothalamic surgical target for cluster headache. J Clin Neurosci. 2007;14:955-60 pubmed
    ..In a patient with chronic cluster headache we implanted a deep brain stimulating electrode into the ipsilateral postero-medial hypothalamus to ..
  9. Cortelli P, Guaraldi P, Leone M, Pierangeli G, Barletta G, Grimaldi D, et al. Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients. Eur J Neurol. 2007;14:1008-15 pubmed
    ..to determine the cardiovascular effects of chronic stimulation of the posterior hypothalamic area (PHA) in cluster headache (CH) patients...
  10. de Quintana Schmidt C, Casajuana Garreta E, Molet Teixidó J, García Bach M, Roig C, Clavel Laria P, et al. [Stimulation of the occipital nerve in the treatment of drug-resistant cluster headache]. Rev Neurol. 2010;51:19-26 pubmed
    To evaluate the occipital nerve stimulation therapy in as a treatment for drug-resistant cluster headache. Prospective study of four patients, three males and one female. Mean age of 42 years...
  11. Schurks M, Kurth T, Stude P, Rimmbach C, De Jesus J, Jonjic M, et al. G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007;82:396-401 pubmed
    Only about 70% of migraine and cluster headache (CH) patients report significant treatment responses to triptans, which are agonists at 5-HT(1B/D) receptors belonging to the family of G protein-coupled receptors...
  12. Bartsch T, Pinsker M, Rasche D, Kinfe T, Hertel F, Diener H, et al. Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia. 2008;28:285-95 pubmed publisher
    ..DBS) of the posterior hypothalamus was found to be effective in the treatment of drug-resistant chronic cluster headache. We report the results of a multicentre case series of six patients with chronic cluster headache in whom a ..
  13. Fontaine D, Lazorthes Y, Mertens P, Blond S, Geraud G, Fabre N, et al. Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain. 2010;11:23-31 pubmed publisher
    Chronic cluster headache (CCH) is a disabling primary headache, considering the severity and frequency of pain attacks...
  14. Rapoport A, Mathew N, Silberstein S, Dodick D, Tepper S, Sheftell F, et al. Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study. Neurology. 2007;69:821-6 pubmed
    ..and tolerability of zolmitriptan 5 mg and 10 mg nasal spray (ZNS) vs placebo in the acute treatment of cluster headache. Design/ We conducted a multicenter, double-blind, randomized, three-period crossover study using ZNS 5 mg, ..
  15. Seidel S, Lieba Samal D, Vigl M, Wöber C. Clinical features of unilateral headaches beyond migraine and cluster headache and their response to indomethacin. Wien Klin Wochenschr. 2011;123:536-41 pubmed publisher
    The majority of previous studies on unilateral headaches beyond migraine and cluster headache have focussed on certain disorders such as paroxysmal hemicrania, SUNCT and primary stabbing headache...
  16. Balasubramaniam R, Klasser G. Trigeminal autonomic cephalalgias. Part 1: cluster headache. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:345-58 pubmed
    b>Cluster headache is characterized by severe, strictly unilateral pain attacks lasting 15 to 180 minutes localized to orbital, temporal, and midface areas accompanied by ipsilateral autonomic features...
  17. Cittadini E, May A, Straube A, Evers S, Bussone G, Goadsby P. Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. Arch Neurol. 2006;63:1537-42 pubmed
    b>Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection...
  18. Imai N, Yagi N, Kuroda R, Konishi T, Serizawa M, Kobari M. Clinical profile of cluster headaches in Japan: low prevalence of chronic cluster headache, and uncoupling of sense and behaviour of restlessness. Cephalalgia. 2011;31:628-33 pubmed publisher
    ..Subjects comprised 86 consecutive new cluster headache patients (68 males, 18 females; mean age, 38.4?±?12.2 years; range, 17-73 years). Mean age at onset was 31...
  19. Benemei S, Appendino G, Geppetti P. Pleasant natural scent with unpleasant effects: cluster headache-like attacks triggered by Umbellularia californica. Cephalalgia. 2010;30:744-6 pubmed publisher
    ..Here, we report the case of a 69-year-old Italian gardener, affected during his young adult age by cluster headache, who, 10 years from his last cluster episode, developed shorter-lasting cluster-like headache attacks after ..
  20. Bartsch T, Paemeleire K, Goadsby P. Neurostimulation approaches to primary headache disorders. Curr Opin Neurol. 2009;22:262-8 pubmed
    ..management options in medically intractable chronic-headache syndromes, such as chronic migraine, chronic cluster headache and hemicrania continua, are often limited...
  21. Rozen T, Fishman R. Female cluster headache in the United States of America: what are the gender differences? Results from the United States Cluster Headache Survey. J Neurol Sci. 2012;317:17-28 pubmed publisher
    To present results from the United States Cluster Headache Survey regarding gender differences in cluster headache demographics, clinical characteristics, diagnostic delay, triggers, treatment response and personal burden...
  22. Ladda J, Straube A, Förderreuther S, Krause P, Eggert T. Quantitative sensory testing in cluster headache: increased sensory thresholds. Cephalalgia. 2006;26:1043-50 pubmed
    To determine if recently reported changes in sensory thresholds during migraine attacks can also be seen in cluster headache (CH), we performed quantitative sensory testing (QST) in 10 healthy subjects and in 16 patients with CH...
  23. Burns B, Watkins L, Goadsby P. Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology. 2009;72:341-5 pubmed publisher
    b>Cluster headache is a primary headache involving repeated attacks of excruciatingly severe headache usually occurring several times a day...
  24. Starr P, Barbaro N, Raskin N, Ostrem J. Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg. 2007;106:999-1005 pubmed
    b>Cluster headache (CH) is the most severe of the primary headache disorders...
  25. Torelli P, Castellini P, Cucurachi L, Devetak M, Lambru G, Manzoni G. Cluster headache prevalence: methodological considerations. A review of the literature. Acta Biomed. 2006;77:4-9 pubmed
    b>Cluster headache (CH), also known as "suicide headache", is characterized by a distinctive periodic temporal pattern and by accompanying autonomic symptoms during the attacks...
  26. Steinberg A, Axelsson R, Ideström L, Muller S, Nilsson Remahl A. White blood cell SPECT during active period of cluster headache and in remission. Eur J Neurol. 2012;19:220-5 pubmed publisher
    b>Cluster headache (CH) is an episodic headache disorder characterized by recurrent, unilateral attacks of excruciating pain in the temporal/orbital region...
  27. Schurks M, Kurth T, Geissler I, Tessmann G, Diener H, Rosskopf D. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Cephalalgia. 2007;27:363-7 pubmed
    The risk of cluster headache (CH) is associated with the G-allele of the G1246A polymorphism in the hypocretin receptor 2 (HCRTR2) gene. First-line medication is effective in only about 70-80% of CH patients...
  28. Absinta M, Rocca M, Colombo B, Falini A, Comi G, Filippi M. Selective decreased grey matter volume of the pain-matrix network in cluster headache. Cephalalgia. 2012;32:109-15 pubmed publisher
    We assessed the pattern of regional white matter and grey matter abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM). Using a 3...
  29. McClelland S, Barnett G, Neyman G, Suh J. Repeat trigeminal nerve radiosurgery for refractory cluster headache fails to provide long-term pain relief. Headache. 2007;47:298-300 pubmed
    Medically refractory cluster headache (MRCH) is a debilitating condition that has proven resistant to many modalities...
  30. Leone M, Cecchini A, Mea E, Tullo V, Bussone G. Epidemiology of fixed unilateral headaches. Cephalalgia. 2008;28 Suppl 1:8-11 pubmed publisher
    ..Among 63 consecutive chronic cluster headache patients seen by us from 1999 to 2007, 32 (51%) had side shift...
  31. Sostak P, Krause P, Förderreuther S, Reinisch V, Straube A. Botulinum toxin type-A therapy in cluster headache: an open study. J Headache Pain. 2007;8:236-41 pubmed
    ..the efficacy and tolerability of botulinum toxin type-A (BTX-A) as add-on in the prophylactic treatment of cluster headache (CH)...
  32. Rozen T, Fishman R. Inhaled oxygen and cluster headache sufferers in the United States: use, efficacy and economics: results from the United States Cluster Headache Survey. Headache. 2011;51:191-200 pubmed publisher
    To present results from the United States Cluster Headache Survey concerning the use of inhaled oxygen as acute treatment for cluster headache (CH)...
  33. Magis D, Schoenen J. Neurostimulation in chronic cluster headache. Curr Pain Headache Rep. 2008;12:145-53 pubmed
    About 1% of all chronic cluster headache patients become intractable (iCCH; ie, they are refractory to adequate regimens of all established preventive drugs)...
  34. Magis D, Schoenen J. Occipital nerve stimulation for intractable chronic cluster headache: new hope for a dreadful disease?. Acta Neurol Belg. 2011;111:18-21 pubmed
    Chronic cluster headache (CCH) is one of the most painful primary headaches. A small percentage of CCH become intractable (iCCH) and is refractory to the majority of preventing drugs...
  35. Donnet A, Tamura M, Valade D, Regis J. Trigeminal nerve radiosurgical treatment in intractable chronic cluster headache: unexpected high toxicity. Neurosurgery. 2006;59:1252-7; discussion 1257 pubmed
    ..a prospective open trial designed to evaluate trigeminal nerve radiosurgical treatment in intractable chronic cluster headache (CCH). Medium- and long-term results have not yet been reported...
  36. Ansarinia M, Rezai A, Tepper S, Steiner C, Stump J, Stanton Hicks M, et al. Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches. Headache. 2010;50:1164-74 pubmed publisher
    ..Chronic long-term outcome studies are needed to determine the utility of SPG stimulation for management and prevention of CH. ..
  37. Pipolo C, Bussone G, Leone M, Lozza P, Felisati G. Sphenopalatine endoscopic ganglion block in cluster headache: a reevaluation of the procedure after 5 years. Neurol Sci. 2010;31 Suppl 1:S197-9 pubmed publisher
    b>Cluster headache (CH) is considered the most painful form of primary headaches. It is characterized by severe unilateral pain, typically associated with autonomic manifestations and may be divided into an episodic and a chronic form...
  38. Busch V, Jakob W, Juergens T, Schulte Mattler W, Kaube H, May A. Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Cephalalgia. 2007;27:1206-14 pubmed
    ..Although reports regarding effective occipital nerve blockades in cluster headache exist, the reason for the improvement of the clinical symptoms is not known...
  39. Leone M, Franzini A, Cecchini A, Broggi G, Bussone G. Stimulation of occipital nerve for drug-resistant chronic cluster headache. Lancet Neurol. 2007;6:289-91 pubmed
  40. Gaul C, Christmann N, Schroder D, Weber R, Shanib H, Diener H, et al. Differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache. Cephalalgia. 2012;32:571-7 pubmed publisher
    Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.
  41. Rainero I, Gallone S, Rubino E, Ponzo P, Valfrè W, Binello E, et al. Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache. Headache. 2008;48:1108-14 pubmed publisher
    Several studies suggested that genetic factors play a role in cluster headache (CH) susceptibility. We found a significant association between the 1246 G>A polymorphism of the hypocretin receptor-2 (HCRTR2) gene and the disease...
  42. Rozen T. Cluster headache with aura. Curr Pain Headache Rep. 2011;15:98-100 pubmed publisher
    Aura was not recognized as a clinical symptom of cluster headache until fairly recently, but studies now have indicated that upwards of 20% of patients with cluster headache may have aura, the same percentage of migraine sufferers who ..
  43. Magis D, Bruno M, Fumal A, Gérardy P, Hustinx R, Laureys S, et al. Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. BMC Neurol. 2011;11:25 pubmed publisher
    Occipital nerve stimulation (ONS) has raised new hope for drug-resistant chronic cluster headache (drCCH), a devastating condition. However its mode of action remains elusive...
  44. Huber G, Lampl C. Oxygen therapy influences episodic cluster headache and related cutaneous brush and cold allodynia. Headache. 2009;49:134-6 pubmed publisher
    b>Cluster headache (CH) is characterized by a series of sudden attacks of short-lasting severe headache pain with ipsilateral autonomic features, including lacrimation, rhinorrhea, localized sweating, eyelid edema, and partial or complete ..
  45. Fontaine D, Christophe Sol J, Raoul S, Fabre N, Geraud G, Magne C, et al. Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation. Cephalalgia. 2011;31:1101-5 pubmed publisher
    Greater occipital nerve stimulation (ONS) has been recently proposed to treat severe chronic cluster headache patients (CCH) refractory to medical treatment. We report the results of a French multidisciplinary cohort study...
  46. Schürks M, Neumann F, Kessler C, Diener H, Kroemer H, Kurth T, et al. MTHFR 677C>T polymorphism and cluster headache. Headache. 2011;51:201-7 pubmed publisher
    ..between the 677C>T polymorphism (rs1801133) in the methylenetetrahydrofolate reductase gene (MTHFR) and cluster headache is plausible, but has not been investigated. To investigate this association among Caucasians...
  47. Rozen T. Cluster headache as the result of secondhand cigarette smoke exposure during childhood. Headache. 2010;50:130-2 pubmed publisher
    Unique to cluster headache (CH) compared with all other primary headache conditions is its association with a personal history of cigarette smoking...
  48. Donnet A, Lanteri Minet M, Guegan Massardier E, Mick G, Fabre N, Geraud G, et al. Chronic cluster headache: a French clinical descriptive study. J Neurol Neurosurg Psychiatry. 2007;78:1354-8 pubmed
    b>Cluster headache (CH) is a relatively rare disease and episodic CH is more frequent than chronic CH. Few studies have described the characteristics of patients with chronic CH...
  49. Katsarava Z, Obermann M, Yoon M, Dommes P, Kuznetsova J, Weimar C, et al. Prevalence of cluster headache in a population-based sample in Germany. Cephalalgia. 2007;27:1014-9 pubmed
    ..of 6,000 inhabitants of the city of Essen in Germany was screened using a standard questionnaire for possible cluster headache (CH). Fifty-six percent responded (N = 3336, 50.5% of them women, mean age 44.7 +/- 12.7 years)...
  50. Rainero I, Rubino E, Gallone S, Fenoglio P, Negro E, De Martino P, et al. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. Headache. 2010;50:92-8 pubmed publisher
    Alcohol is a well-known trigger factor for cluster headache attacks during the active phases of the disease...
  51. Verslegers W, Pickut B, De Deyn P. Paroxysmal neuralgic upper cervical pain attacks: the lower syndrome of cluster headache. Clin Neurol Neurosurg. 2006;108:737-43 pubmed
    We present a group of seven patients with a lower syndrome (LS) of cluster headache (CH)...
  52. Sprenger T, Ruether K, Boecker H, Valet M, Berthele A, Pfaffenrath V, et al. Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia. 2007;27:1033-42 pubmed
    Neuroimaging studies have explored cerebral activation patterns in patients with cluster headache (CH) during attacks and have revealed activation of multiple brain areas known to belong to the general pain-processing network...
  53. Ekbom K, Svensson D, Pedersen N, Waldenlind E. Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population. Neurology. 2006;67:798-803 pubmed
    To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population...