trigeminal autonomic cephalalgias

Summary

Summary: Primary headache disorders that show symptoms caused by the activation of the AUTONOMIC NERVOUS SYSTEM of the TRIGEMINAL NERVE. These autonomic features include redness and tearing of the EYE, nasal congestion or discharge, facial SWEATING and other symptoms. Most subgroups show unilateral cranial PAIN.

Top Publications

  1. May A, Leone M, Afra J, Linde M, Sandor P, Evers S, et al. EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol. 2006;13:1066-77 pubmed
    ..Intravenous lidocaine may also be helpful as an acute therapy when patients are extremely distressed and disabled by frequent attacks. ..
  2. Matharu M, May A. Functional and structural neuroimaging in trigeminal autonomic cephalalgias. Curr Pain Headache Rep. 2008;12:132-7 pubmed
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterized by unilateral trigeminal distribution pain that occurs in association with ipsilateral cranial autonomic features...
  3. Cittadini E, Matharu M. Symptomatic trigeminal autonomic cephalalgias. Neurologist. 2009;15:305-12 pubmed publisher
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterized by strictly unilateral head pain that occurs in association with ipsilateral cranial autonomic features...
  4. Leone M, Bussone G. Pathophysiology of trigeminal autonomic cephalalgias. Lancet Neurol. 2009;8:755-64 pubmed publisher
    ..conjunctival injection and tearing (SUNCT) are primary headaches recently classified together as trigeminal autonomic cephalalgias (TACs)...
  5. Iacovelli E, Coppola G, Tinelli E, Pierelli F, Bianco F. Neuroimaging in cluster headache and other trigeminal autonomic cephalalgias. J Headache Pain. 2012;13:11-20 pubmed publisher
    The central nervous system mechanisms involved in trigeminal autonomic cephalalgias, a group of primary headaches characterized by strictly unilateral head pain that occurs in association with ipsilateral craniofacial autonomic features, ..
  6. May A. Update on the diagnosis and management of trigemino-autonomic headaches. J Neurol. 2006;253:1525-32 pubmed
    ..Although TACs are, in comparison with migraine, quite rare, it is nevertheless very important to consider the clinical factor that they are easy to diagnose and the treatment is very effective in most patients. ..
  7. Goadsby P, Cittadini E, Burns B, Cohen A. Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments. Curr Opin Neurol. 2008;21:323-30 pubmed publisher
    The review was designed to summarize recent research relevant to the trigeminal autonomic cephalalgias, which include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival ..
  8. Irimia P, Cittadini E, Paemeleire K, Cohen A, Goadsby P. Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias. Cephalalgia. 2008;28:626-30 pubmed publisher
    ..unilateral photophobia or phonophobia, or both, during headache attacks comparing patients with trigeminal autonomic cephalalgias (TACs)--including cluster headache, short-lasting unilateral neuralgiform headache attacks with ..
  9. Marmura M. Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias. Curr Pain Headache Rep. 2010;14:145-50 pubmed publisher
    ..This article describes the role of intravenous lidocaine and mexiletine in the management of headache and trigeminal autonomic cephalalgias based on the published literature to date and provides practical guidelines for their use.

More Information

Publications62

  1. Camarda C, Camarda R, Monastero R. Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: two case reports. Clin Neurol Neurosurg. 2008;110:88-91 pubmed
    ..We report one subject with CPH and another with HC intolerant to indomethacin, who responded remarkably well to topiramate. ..
  2. Balasubramaniam R, Klasser G, Delcanho R. Trigeminal autonomic cephalalgias: a review and implications for dentistry. J Am Dent Assoc. 2008;139:1616-24 pubmed
    ..features, pathophysiology, diagnosis, treatment, orofacial presentations and dental implications of trigeminal autonomic cephalalgias (TACs): cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral neuralgiform ..
  3. Goadsby P, Cittadini E, Cohen A. Trigeminal autonomic cephalalgias: paroxysmal hemicrania, SUNCT/SUNA, and hemicrania continua. Semin Neurol. 2010;30:186-91 pubmed publisher
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders that include cluster headache (CH), paroxysmal hemicrania (PH), and short-lasting unilateral neuralgiform headache attacks with conjunctival injection ..
  4. Pareja J, Alvarez M. The usual treatment of trigeminal autonomic cephalalgias. Headache. 2013;53:1401-14 pubmed publisher
    b>Trigeminal autonomic cephalalgias include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, and rhinorrhea (SUNCT)...
  5. Holle D, Katsarava Z, Obermann M. The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?. Curr Pain Headache Rep. 2011;15:101-7 pubmed publisher
    The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the ..
  6. Goadsby P, Cohen A, Matharu M. Trigeminal autonomic cephalalgias: diagnosis and treatment. Curr Neurol Neurosci Rep. 2007;7:117-25 pubmed
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterized by unilateral head pain that occurs in association with ipsilateral cranial autonomic features...
  7. Cosentino G, Fierro B, Puma A, Talamanca S, Brighina F. Different forms of trigeminal autonomic cephalalgias in the same patient: description of a case. J Headache Pain. 2010;11:281-4 pubmed publisher
    The trigeminal autonomic cephalalgias (TACs), including cluster headache, paroxysmal hemicrania and SUNCT, are characterized by the cardinal combination of short-lasting unilateral pain and autonomic phenomena affecting the head...
  8. Leone M, Franzini A, Proietti Cecchini A, Mea E, Broggi G, Bussone G. Deep brain stimulation in trigeminal autonomic cephalalgias. Neurotherapeutics. 2010;7:220-8 pubmed publisher
    ..with conjunctival injection and tearing (SUNCT syndrome) are primary headaches grouped together as trigeminal autonomic cephalalgias (TACs)...
  9. Goadsby P. Trigeminal autonomic cephalalgias. Continuum (Minneap Minn). 2012;18:883-95 pubmed publisher
    This article covers the clinical manifestations and differential diagnosis of the trigeminal autonomic cephalalgias (TACs)...
  10. Viana M, Tassorelli C, Allena M, Nappi G, Sjaastad O, Antonaci F. Diagnostic and therapeutic errors in trigeminal autonomic cephalalgias and hemicrania continua: a systematic review. J Headache Pain. 2013;14:14 pubmed publisher
    b>Trigeminal autonomic cephalalgias (TACs) and hemicrania continua (HC) are relatively rare but clinically rather well-defined primary headaches...
  11. Robbins M, Lipton R. The epidemiology of primary headache disorders. Semin Neurol. 2010;30:107-19 pubmed publisher
    ..The incidence, prevalence, burden, and comorbidities of these disorders are discussed, and the risk factors for progression from episodic to chronic daily headache are also reviewed. ..
  12. Guerrero A, Rojo E, Herrero S, Neri M, Bautista L, Peñas M, et al. Characteristics of the first 1000 headaches in an outpatient headache clinic registry. Headache. 2011;51:226-31 pubmed publisher
    ..4%; group 2 (Tension-type headache), 16%; group 3 (Trigeminal autonomic cephalalgias), 2.6%; group 4 (Other primary headaches) and group 13 (Cranial neuralgias), 3.4%...
  13. Shareef A, Dafer R, Jay W. Neuro-ophthalmologic manifestations of primary headache disorders. Semin Ophthalmol. 2008;23:169-77 pubmed publisher
    ..This article reviews two major primary headache disorders, migraine and trigeminal autonomic cephalgias, and discusses their neuro-ophthalmic complications, clinical presentation, and treatment. ..
  14. Spierings E. Hemicrania continua should not be classified as a trigeminal autonomic cephalalgia. Headache. 2013;53:869-70 pubmed publisher
    ..presentation trumps experimental testing: Not only is there no basis to classify hemicrania continua in the category of the so-called trigeminal autonomic cephalalgias, also the very existence of this category lacks solid foundation.
  15. Salawu F, Olokoba A, Danburam A. A review of trigeminal autonomic cephalalgias: diagnosis and treatment. Niger J Med. 2009;18:17-24 pubmed
    The trigeminal autonomic cephalalgias (TACs) include cluster headache, paroxysmal hemicrania and short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing and its close relative short-lasting ..
  16. Jensen R. [Headache]. Ugeskr Laeger. 2006;168:1950-3 pubmed
    ..The most frequent primary headache disorders, their differential diagnosis and the current treatment strategy are briefly reviewed. ..
  17. Kozminski M. Resident and fellow section. Expert opinion: trigeminal autonomic cephalgia post transsphenoidal surgery. Headache. 2008;48:658-9; discussion 659-60 pubmed publisher
  18. Favier I, Ferrari M, Haan J. [Trigeminal autonomic cephalalgias: three forms of unilateral, short-lasting headache with facial autonomic symptoms]. Ned Tijdschr Geneeskd. 2008;152:139-42 pubmed
    b>Trigeminal autonomic cephalalgias (TACs) include cluster headache, paroxysmal hemicranias and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCTs)...
  19. Broggi G, Franzini A, Leone M, Bussone G. Update on neurosurgical treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain with deep brain stimulation of posterior hypothalamus: results and comments. Neurol Sci. 2007;28 Suppl 2:S138-45 pubmed
    ..brain stimulation (DBS) of the posterior hypothalamus over seven years, for treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain...
  20. Mathew P, Garza I. Headache. Semin Neurol. 2011;31:5-17 pubmed publisher
    ..of Headache Disorders, 2nd Edition (ICHD-2), and treatment strategies of the more common primary headache disorders with a focus on migraine, trigeminal autonomic cephalalgias, tension-type headache, and chronic daily headache.
  21. Bussone G, Franzini A, Proietti Cecchini A, Mea E, Curone M, Tullo V, et al. Deep brain stimulation in craniofacial pain: seven years' experience. Neurol Sci. 2007;28 Suppl 2:S146-9 pubmed
    ..Hypothalamic stimulation is an effective, safe and well tolerated treatment for chronic drug-refractory CH. It appears as a valid alternative to destructive surgical modalities, and has the additional advantage of being reversible. ..
  22. Favoni V, Grimaldi D, Pierangeli G, Cortelli P, Cevoli S. SUNCT/SUNA and neurovascular compression: new cases and critical literature review. Cephalalgia. 2013;33:1337-48 pubmed publisher
    ..Brain MRI should always be performed with a dedicated view to exclude neurovascular compression. The high percentage of remission after MVD supports the pathogenetic role of neurovascular compression. ..
  23. Akerman S, Holland P, Summ O, Lasalandra M, Goadsby P. A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization. Brain. 2012;135:3664-75 pubmed publisher
    b>Trigeminal autonomic cephalalgias are highly disabling primary headache disorders, characterized by severe unilateral head pain and associated ipsilateral cranial autonomic features...
  24. Dafer R, Jay W. Headache and the eye. Curr Opin Ophthalmol. 2009;20:520-4 pubmed publisher
    ..and ocular symptoms are common manifestations of two primary headache disorders, migraine and trigeminal autonomic cephalalgias, and many secondary headache disorders...
  25. Williams M, Broadley S. SUNCT and SUNA: clinical features and medical treatment. J Clin Neurosci. 2008;15:526-34 pubmed publisher
    ..Lamotrigine is effective in the majority of cases and subcutaneous lignocaine is useful as acute treatment for severe recalcitrant attacks. ..
  26. Leone M. Deep brain stimulation in headache. Lancet Neurol. 2006;5:873-7 pubmed
    ..Future studies might determine whether other areas of the pain matrix are suitable targets for neuromodulation in patients with cluster headache who do not respond to hypothalamic modulation. ..
  27. Mathew T, Nadimpally U, Sarma G, Nadig R. Trigeminal autonomic cephalalgia as a presenting feature of Neuromyelitis Optica: "A rare combination of two uncommon disorders". Mult Scler Relat Disord. 2016;6:73-4 pubmed publisher
    ..TACs are a rare group of headache disorders characterized by severe unilateral headache in the V1 distribution of the trigeminal nerve and autonomic symptoms. This presentation in NMO is hitherto unreported in literature. ..
  28. Seijo Martinez M, García Bargo M. Trigeminal autonomic cephalgias: is neuroimaging always indicated?. Arch Neurol. 2007;64:917 pubmed
  29. Pedraza M, Ruiz M, Rodriguez C, Muñoz I, Barón J, Mulero P, et al. [Occipital neuralgia: clinical and therapeutic characteristics of a series of 14 patients]. Rev Neurol. 2013;57:193-8 pubmed
    ..Ha de tenerse en cuenta, dada su respuesta escasa a preventivos, y completa y prolongada a bloqueos anestesicos. ..
  30. Lambru G, Matharu M. SUNCT and SUNA: medical and surgical treatments. Neurol Sci. 2013;34 Suppl 1:S75-81 pubmed publisher
    ..This review provides an overview of the current pharmacological and surgical options for SUNCT and SUNA syndromes. ..
  31. Lambru G, Nesbitt A, Shanahan P, Matharu M. Coexistence of hemiplegic migraine with SUNCT or SUNA: a case series. Cephalalgia. 2012;32:258-62 pubmed publisher
    ..attacks with cranial autonomic symptoms (SUNA) are also very rare conditions that are classified as trigeminal autonomic cephalalgias. This report provides the first description of an association between HM and SUNCT/SUNA...
  32. May A, Jurgens T. Trigeminal-autonomic headaches in daily clinical practice. Expert Rev Neurother. 2006;6:1531-43 pubmed
    ..This review gives a brief clinical description of the headache disorders and recent pathophysiological findings, as well as an overview of the treatment of cluster headache, paroxysmal hemicranias and SUNCT syndrome. ..
  33. Franzini A, Messina G, Cordella R, Marras C, Broggi G. Deep brain stimulation of the posteromedial hypothalamus: indications, long-term results, and neurophysiological considerations. Neurosurg Focus. 2010;29:E13 pubmed publisher
    ..patients, DBS of the pHyp can be considered an effective procedure for the treatment of refractory trigeminal autonomic cephalalgias, aggressive behavior, and MS-related TN in the first trigeminal branch...
  34. Strahlendorf J, Schiffer R, Strahlendorf H. Unilateral or "side-locked" migrainous headache with autonomic symptoms linked to night guard use. Headache. 2008;48:1537-9 pubmed publisher
    ..We believe the headaches were initiated by night guard-initiated irritation of the trigeminal nerve and a trigeminal autonomic reflex resulting in unilateral migrainous headache with autonomic signs. ..
  35. Rozen T. Trigeminal autonomic cephalalgias. Neurol Clin. 2009;27:537-56 pubmed publisher
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes all marked by headache and associated autonomic features...
  36. Monti A, Rapela F, Bacile Bacile E, Uberti D. [Primary cephaleas. A revision of their diagnosis and therapeutic approach]. Rev Fac Cien Med Univ Nac Cordoba. 2006;63:53-64 pubmed
    ..Other primary headaches: variability of trigger factors and role of desensitization process. we remark the complexity of headache and the of physicians' role: to relief patients suffering, throughout a precise diagnosis and treatment. ..
  37. Hegarty A, Zakrzewska J. Differential diagnosis for orofacial pain, including sinusitis, TMD, trigeminal neuralgia. Dent Update. 2011;38:396-400, 402-3, 405-6 passim pubmed
    ..Although primary care clinicians would not be expected to diagnose rare pain conditions, such as trigeminal autonomic cephalalgias, they should be able to assess the presenting pain complaint to such an extent that, if required, an ..
  38. Leone M, Cecchini A, Tullo V, Curone M, Di Fiore P, Bussone G. Cluster headache: what has changed since 1999?. Neurol Sci. 2013;34 Suppl 1:S71-3 pubmed publisher
    ..Taken together, there is now sufficient body of evidence indicating that CH and TACs can be regarded as a unique headache spectrum-syndrome, due to involvement of specific brain areas. ..
  39. Rozen T. A history of cigarette smoking is associated with the development of cranial autonomic symptoms with migraine headaches. Headache. 2011;51:85-91 pubmed publisher
    ..Each subtype of cranial autonomic symptoms was all more frequent in smokers. A history of cigarette smoking appears to be associated with the development of cranial autonomic symptoms with migraine headaches. ..
  40. Allena M, Tassorelli C, Sances G, Guaschino E, Sandrini G, Nappi G, et al. Is hemicrania continua a single entity or the association of two headache forms? Considerations from a case report. Headache. 2010;50:877-81 pubmed publisher
    ..The analysis of this case raises interesting issues regarding the proper place of HC among the primary headache forms. ..
  41. Wang S, Hung C, Fuh J, Lirng J, Hwu C. Cranial autonomic symptoms in patients with pituitary adenoma presenting with headaches. Acta Neurol Taiwan. 2009;18:104-12 pubmed
    Different types of symptomatic trigeminal autonomic cephalalgias (TACs) have been reported in patients with pituitary adenoma...
  42. May A. Diagnosis and clinical features of trigemino-autonomic headaches. Headache. 2013;53:1470-8 pubmed publisher
    ..Although TACS are, in comparison to migraine, quite rare, they are nevertheless clinically very important for the neurologist to consider as they are easy to diagnose and the treatment is very effective in most patients. ..
  43. Müller K, Alstadhaug K, Bekkelund S. A randomized trial of telemedicine efficacy and safety for nonacute headaches. Neurology. 2017;89:153-162 pubmed publisher
    ..NCT02270177. This study provides Class III evidence that a one-time telemedicine consultation for nonacute headache is noninferior to a one-time traditional consultation regarding long-term treatment outcome and safety. ..
  44. Silberstein S, Vodovskaia N. Trigeminal autonomic cephalalgias other than cluster headache. Med Clin North Am. 2013;97:321-8 pubmed publisher
    b>Trigeminal autonomic cephalalgias are short-lasting primary headache disorders associated with autonomic symptoms. Paroxysmal hemicrania is a rare headache disorder similar to cluster headache...
  45. Tarantino S, Vollono C, Capuano A, Vigevano F, Valeriani M. Chronic paroxysmal hemicrania in paediatric age: report of two cases. J Headache Pain. 2011;12:263-7 pubmed publisher
    ..Therefore, our children can be included amongst the very few cases of this trigeminal autonomic cephalgia described in the paediatric age. ..
  46. Robbins M, Grosberg B, Lipton R. Coexisting trigeminal autonomic cephalalgias and hemicrania continua. Headache. 2010;50:489-96 pubmed publisher
    The trigeminal autonomic cephalalgias (TACs) and hemicrania continua (HC) share many clinical characteristics including unilateral pain and ipsilateral autonomic features...
  47. Stankewitz A, Voit H, Bingel U, Peschke C, May A. A new trigemino-nociceptive stimulation model for event-related fMRI. Cephalalgia. 2010;30:475-85 pubmed publisher
    ..This method will provide an ideal opportunity to study the trigeminal pain system in both health and pathological conditions such as idiopathic headache disorders. ..
  48. Valade D. [Cluster headache and other trigeminal-autonomic headaches]. Ann Otolaryngol Chir Cervicofac. 2007;124 Suppl 1:S50-5 pubmed
  49. Constantoyannis C, Kagadis G, Chroni E. Percutaneous balloon compression for trigeminal neuralgias and autonomic cephalalgia. Headache. 2008;48:130-4 pubmed
    ..However, further studies are deemed necessary to establish it as the first-line treatment in medically resistant trigeminal pain. ..
  50. Haane D, Koehler P, te Lintelo M, Peatfield R. Trigeminal autonomic cephalalgia sine headache. J Neurol. 2011;258:586-9 pubmed publisher
    ..symptoms with an attack duration and distribution and/or response to therapy suggesting one of the trigeminal autonomic cephalalgias, but without accompanying headache...
  51. Liu F, Fuh J, Wang S. Symptomatic trigeminal autonomic cephalalgia associated with allodynia in a patient with multiple sclerosis. J Chin Med Assoc. 2008;71:583-6 pubmed publisher
    ..We suggest that the spinal trigeminal nucleus lesion was responsible for the symptomatology of TAC and cutaneous allodynia in our patient. ..
  52. Goadsby P. Neuromodulatory approaches to the treatment of trigeminal autonomic cephalalgias. Acta Neurochir Suppl. 2007;97:99-110 pubmed
    The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by intense pain and associated activation of cranial parasympathetic autonomic outflow pathways out of proportion to the pain...
  53. Havanka H, Forssel H. [Only headache and facial pain?]. Duodecim. 2005;121:649-50 pubmed