migraine with aura

Summary

Summary: A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Top Publications

  1. Kumar G, Topper L, Maytal J. Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report. Headache. 2009;49:139-42 pubmed publisher
  2. Lipton R, Dodick D, Silberstein S, Saper J, Aurora S, Pearlman S, et al. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol. 2010;9:373-80 pubmed publisher
    ..We aimed to assess the efficacy and safety of a new portable sTMS device for acute treatment of migraine with aura. We undertook a randomised, double-blind, parallel-group, two-phase, sham-controlled study at 18 centres in ..
  3. Siniatchkin M, Sendacki M, Moeller F, Wolff S, Jansen O, Siebner H, et al. Abnormal changes of synaptic excitability in migraine with aura. Cereb Cortex. 2012;22:2207-16 pubmed publisher
    ..Moreover, altered glutamatergic neurotransmission seems to mediate the relation between abnormal cortical information processing and excitability in migraineurs. ..
  4. Hansen J, Hauge A, Olesen J, Ashina M. Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia. 2010;30:1179-86 pubmed publisher
    ..Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown...
  5. Joshi G, Pradhan S, Mittal B. Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. J Neurol Sci. 2009;277:133-7 pubmed publisher
    ..In contrast, we found synergistic role of ACE (DD)*MTHFR (CT) interaction, showing a positive association in total migraine with aura patients as well as female migraine patients with aura when compared with healthy controls.
  6. Khalil N, Nicotra A, Wilkins A. Asymmetry of visual function in migraine with aura: correlation with lateralisation of headache and aura. Cephalalgia. 2011;31:213-21 pubmed publisher
    Asymmetry of visual phenomena and headache is an important feature of migraine with aura. This asymmetry was explored by assessment of visual illusions, hemifield spatial contrast detection (HCD) and hemifield pattern reversal visual ..
  7. Gelfand A, Fullerton H, Goadsby P. Child neurology: Migraine with aura in children. Neurology. 2010;75:e16-9 pubmed publisher
    ..b>Migraine with aura in children is reviewed, including migraine equivalents such as abdominal migraine and the particular ..
  8. Brighina F, Palermo A, Daniele O, Aloisio A, Fierro B. High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability?. Cephalalgia. 2010;30:46-52 pubmed publisher
    ..facilitation (ICF) to 1 Hz repetitive transcranial magnetic stimulation (rTMS) in patients affected by migraine with aura (MA)...
  9. Kurth T, Schürks M, Logroscino G, Gaziano J, Buring J. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ. 2008;337:a636 pubmed publisher
    To evaluate whether the association between migraine with aura and increased risk of cardiovascular disease is modified by vascular risk groups as measured by the Framingham risk score for coronary heart disease. Prospective cohort study...

More Information

Publications62

  1. Dalkara T, Nozari A, Moskowitz M. Migraine aura pathophysiology: the role of blood vessels and microembolisation. Lancet Neurol. 2010;9:309-17 pubmed publisher
    ..Although migraine with aura has many causes (eg, neuronal network excitability), it seems that migraine and stroke might both be ..
  2. Nair A, Simonetti M, Birsa N, Ferrari M, van den Maagdenberg A, Giniatullin R, et al. Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain. Mol Pain. 2010;6:48 pubmed publisher
  3. Thompson M, Noble Topham S, Percy M, Andrade D, Ebers G. Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus. Neuroreport. 2012;23:45-8 pubmed publisher
    b>Migraine with aura (MA) may share some but not all risk factors with other forms of migraine...
  4. Riant F, Roze E, Barbance C, Méneret A, Guyant Marechal L, Lucas C, et al. PRRT2 mutations cause hemiplegic migraine. Neurology. 2012;79:2122-4 pubmed publisher
    Hemiplegic migraine (HM) is a rare subtype of migraine with aura that occurs as a familial or sporadic condition. The 3 culprit genes identified so far do not account for all familial forms of HM...
  5. Sacco S, Rasura M, Cao M, Bozzao A, Carolei A. CADASIL presenting as status migrainosus and persisting aura without infarction. J Headache Pain. 2009;10:51-3 pubmed publisher
    ..We describe a novel migrainous manifestation of CADASIL consisting in status migrainosus and persistent aura without infarction. The symptoms resolved after i.v. treatment with lorazepam and mannitol. ..
  6. Gudmundsson L, Scher A, Aspelund T, Eliasson J, Johannsson M, Thorgeirsson G, et al. Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ. 2010;341:c3966 pubmed publisher
    ..Headache was classified as migraine without aura, migraine with aura, or non-migraine headache. Median follow-up was 25.9 years (0.1-40...
  7. Brighina F, Cosentino G, Vigneri S, Talamanca S, Palermo A, Giglia G, et al. Abnormal facilitatory mechanisms in motor cortex of migraine with aura. Eur J Pain. 2011;15:928-35 pubmed publisher
    ..stimulation (hf-rTMS) on the activity of facilitatory circuits of motor cortex in 18 patients affected by migraine with aura and 18 healthy subjects...
  8. Menon S, Lea R, Roy B, Hanna M, Wee S, Haupt L, et al. The human ?-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients. J Headache Pain. 2012;13:513-9 pubmed publisher
    ..A total of 153 chronic migraine with aura sufferers were assessed for migraine head pain using the Migraine Disability Assessment Score instrument and ..
  9. Lev R, Granovsky Y, Yarnitsky D. Orbitofrontal disinhibition of pain in migraine with aura: an interictal EEG-mapping study. Cephalalgia. 2010;30:910-8 pubmed publisher
    ..underlying the processes of interictal dishabituation to experimental pain in subjects suffering from migraine with aura (MWA)...
  10. Griebe M, Flux F, Wolf M, Hennerici M, Szabo K. Multimodal assessment of optokinetic visual stimulation response in migraine with aura. Headache. 2014;54:131-41 pubmed publisher
    This study aimed to assess activation patterns and the hemodynamic response to optokinetic stimulation in migraine with aura patients compared with controls...
  11. Todt U, Netzer C, Toliat M, Heinze A, Goebel I, Nurnberg P, et al. New genetic evidence for involvement of the dopamine system in migraine with aura. Hum Genet. 2009;125:265-79 pubmed publisher
    ..test the hypothesis that genetic variation in the dopamine system contributes to the susceptibility to migraine with aura (MA), we performed a comprehensive genetic association study of altogether ten genes from the dopaminergic ..
  12. Schurks M, Zee R, Buring J, Kurth T. MTHFR 677C->T and ACE D/I polymorphisms and migraine attack frequency in women. Cephalalgia. 2010;30:447-56 pubmed publisher
    ..Among the 3186 migraineurs with complete genotype and attack frequency data, 1270 reported migraine with aura (MA) (attack frequency 76 ? weekly; 219 monthly; 123 every other month; 852 fewer than six times/year) and ..
  13. Rigatelli G, Cardaioli P, Dell avvocata F, Giordan M, Braggion G, Chinaglia M, et al. Transcatheter patent foramen ovale closure is effective in reducing migraine independently from specific interatrial septum anatomy and closure devices design. Cardiovasc Revasc Med. 2010;11:29-33 pubmed publisher
    ..We sought to assess effectiveness of transcatheter PFO closure in reducing or curing migraine with aura in patients with previous paradoxical embolism in relation with specific interatrial septum anatomy and ..
  14. Esserlind A, Kirchmann M, Hauge A, Le H, Olesen J. A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura. Eur J Neurol. 2012;19:603-9 pubmed publisher
    ..The aim of this study is to evaluate the association of clinical characteristics in migraine with aura (MA) with the newly discovered minor allele A of rs1835740 at 8q22.1...
  15. Artto V, Metso T, Metso A, Putaala J, Haapaniemi E, Wessman M, et al. Migraine with aura is a risk factor for cervical artery dissection: a case-control study. Cerebrovasc Dis. 2010;30:36-40 pubmed publisher
    ..This connection may represent a common pathophysiological or genetic background, or both. Migraine activity appears to be alleviated by CAD. ..
  16. Post M, van Gent M, Plokker H, Westermann C, Kelder J, Mager J, et al. Pulmonary arteriovenous malformations associated with migraine with aura. Eur Respir J. 2009;34:882-7 pubmed publisher
    b>Migraine with aura (MA) is associated with cardiac right-to-left shunt. We prospectively studied the association between pulmonary arteriovenous malformations (PAVMs) and MA in hereditary haemorrhagic telangiectasia (HHT)...
  17. Caputi L, Usai S, Carriero M, Grazzi L, D Amico D, Falcone C, et al. Microembolic air load during contrast-transcranial Doppler: a trigger for migraine with aura?. Headache. 2010;50:1320-7 pubmed publisher
    There is a well-known association between migraine with aura (MA) and right-to-left shunt (RILES) because of patent foramen ovale (PFO)...
  18. Hougaard A, Amin F, Amin F, Hauge A, Ashina M, Olesen J. Provocation of migraine with aura using natural trigger factors. Neurology. 2013;80:428-31 pubmed publisher
    It is well-known that migraine attacks can be precipitated by various stimuli. More than 50% of patients with migraine with aura (MA) know of at least one stimulus that always or often triggers their MA attacks...
  19. Pietrobon D. Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. J Physiol. 2010;588:1871-8 pubmed publisher
    Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1 (P/Q-type) Ca2+ channels...
  20. Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, et al. Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011;7:e1002129 pubmed publisher
    Familial hemiplegic migraine type 2 (FHM2) is an autosomal dominant form of migraine with aura that is caused by mutations of the ?2-subunit of the Na,K-ATPase, an isoform almost exclusively expressed in astrocytes in the adult brain...
  21. Russell M, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10:457-70 pubmed publisher
    Hemiplegic migraine is a rare form of migraine with aura that involves motor aura (weakness). This type of migraine can occur as a sporadic or a familial disorder. Familial forms of hemiplegic migraine are dominantly inherited...
  22. Adams P, Rungta R, Garcia E, van den Maagdenberg A, MacVicar B, Snutch T. Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel. Proc Natl Acad Sci U S A. 2010;107:18694-9 pubmed publisher
    ..The findings also suggest that P/Q-type channel CDF is an important mechanism required for normal synaptic plasticity at a fast synapse in the mammalian CNS. ..
  23. Hansen J, Thomsen L, Olesen J, Ashina M. Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype. Neurology. 2008;71:841-7 pubmed publisher
    ..Familial hemiplegic migraine (FHM) is a dominantly inherited subtype of migraine with aura associated with several gene mutations...
  24. Roecklein K, Scher A, Smith A, Harris T, Eiriksdottir G, Garcia M, et al. Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura. Cephalalgia. 2013;33:469-82 pubmed publisher
    ..5.1.20) enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura. Other genes encoding molecular components of this pathway include methionine synthase ( MTR ; EC 2.1.1...
  25. Barros J, Damasio J, Tuna A, Alves I, Silveira I, Pereira Monteiro J, et al. Cerebellar ataxia, hemiplegic migraine, and related phenotypes due to a CACNA1A missense mutation: 12-year follow-up of a large Portuguese family. JAMA Neurol. 2013;70:235-40 pubmed publisher
    ..The clinical spectrum of missense mutation CACNA1A -related disorders is much broader than strictly familial hemiplegic migraine. ..
  26. Theriot J, Toga A, Prakash N, Ju Y, Brennan K. Cortical sensory plasticity in a model of migraine with aura. J Neurosci. 2012;32:15252-61 pubmed publisher
    ..These mechanisms provide a novel neurobiological substrate to explain the sensory alterations of the migraine attack. ..
  27. Chabriat H, Joutel A, Dichgans M, Tournier Lasserve E, Bousser M. Cadasil. Lancet Neurol. 2009;8:643-53 pubmed publisher
    ..although patients with CADASIL have an earlier age at onset of stroke events, an increased frequency of migraine with aura, and a slightly variable pattern of ischaemic white-matter lesions on brain MRI...
  28. Scher A, Gudmundsson L, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, et al. Migraine headache in middle age and late-life brain infarcts. JAMA. 2009;301:2563-70 pubmed publisher
    ..These individuals with headache were classified as having migraine without aura, migraine with aura, or nonmigraine headache. A comprehensive cardiovascular risk assessment was performed at both examinations...
  29. D Onofrio F, Cologno D, Petretta V, Finocchi C, Autunno M, Marsala G, et al. Restless legs syndrome is not associated with migraine with aura: a clinical study. Neurol Sci. 2011;32 Suppl 1:S153-6 pubmed publisher
    ..we performed an observational study on the occurrence of RLS in patients affected by "pure" migraine with aura (pMA)...
  30. Tikka Kleemola P, Kaunisto M, Hämäläinen E, Todt U, Göbel H, Kaprio J, et al. Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura. Cephalalgia. 2009;29:1224-31 pubmed publisher
    The effect of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura (MA) susceptibility is not established yet...
  31. Eikermann Haerter K, Dilekoz E, Kudo C, Savitz S, Waeber C, Baum M, et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. 2009;119:99-109 pubmed publisher
    Familial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of migraine with aura that is associated with hemiparesis. As with other types of migraine, it affects women more frequently than men...
  32. Hauge A, Asghar M, Schytz H, Christensen K, Olesen J. Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. Lancet Neurol. 2009;8:718-23 pubmed publisher
    b>Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and we therefore investigated whether tonabersat has a preventive effect in migraine with aura...
  33. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann Haerter K, Liu C, et al. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol. 2010;67:221-9 pubmed publisher
    ..arteriovenous shunts are associated with serious complications such as cerebral emboli, stroke, and migraine with aura. The pathophysiological mechanisms that link these conditions are unknown...
  34. Wahl A, Praz F, Tai T, Findling O, Walpoth N, Nedeltchev K, et al. Improvement of migraine headaches after percutaneous closure of patent foramen ovale for secondary prevention of paradoxical embolism. Heart. 2010;96:967-73 pubmed publisher
    ..150 patients (25%; aged 51+/-11 years) suffered from migraine, including 96 patients with migraine with aura. All implantation procedures were successful, without procedural complications...
  35. Nappi R, Sances G, Allais G, Terreno E, Benedetto C, Vaccaro V, et al. Effects of an estrogen-free, desogestrel-containing oral contraceptive in women with migraine with aura: a prospective diary-based pilot study. Contraception. 2011;83:223-8 pubmed publisher
    b>Migraine with aura (MA) is a contraindication to the use of combined oral contraceptives (COCs) because of the increased risk of ischemic stroke...
  36. de Vries B, Frants R, Ferrari M, van den Maagdenberg A. Molecular genetics of migraine. Hum Genet. 2009;126:115-32 pubmed publisher
    ..into two main subtypes that are based on the absence or presence of an aura: migraine without aura (MO) and migraine with aura (MA)...
  37. Cavestro C, Richetta L, L episcopo M, Pedemonte E, Duca S, Di Pietrantonj C. Anatomical variants of the circle of willis and brain lesions in migraineurs. Can J Neurol Sci. 2011;38:494-9 pubmed
    ..We examined anomalies of the whole circle of Willis and their relationship with vascular brain lesions in migraineurs, to identify any possible vascular mechanism in migraine...
  38. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010;30:8807-14 pubmed publisher
    Attacks of migraine with aura represent a phenomenon in which abnormal neuronal activity in the cortex produces sensory disturbances (aura) some 20-40 min before the onset of headache...
  39. Cucchiara B, Wolf R, Nagae L, Zhang Q, Kasner S, Datta R, et al. Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PLoS ONE. 2013;8:e71007 pubmed publisher
    To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion.
  40. Hauge A, Kirchmann M, Olesen J. Characterization of consistent triggers of migraine with aura. Cephalalgia. 2011;31:416-38 pubmed publisher
    The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA)...
  41. Brighina F, Palermo A, Panetta M, Daniele O, Aloisio A, Cosentino G, et al. Reduced cerebellar inhibition in migraine with aura: a TMS study. Cerebellum. 2009;8:260-6 pubmed publisher
    ..Cerebellar inhibition is reduced in migraineurs. This could account, at least in part, for the reduced inhibitory efficiency previously showed in cerebral cortex of these patients. ..
  42. Liman T, Neeb L, Rosinski J, Wellwood I, Reuter U, Doehner W, et al. Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study. Cephalalgia. 2012;32:459-66 pubmed publisher
    ..and contribute to the increased risk of ischemic stroke in migraine, particularly in women with migraine with aura (MA). However, data on endothelial function in MA are controversial...
  43. Bigal M, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease: a population-based study. Neurology. 2010;74:628-35 pubmed publisher
    ..98-3.23). Both migraine with and without aura are associated with cardiovascular disease (CVD) and with risk factors for CVD. However, since our sample size is large, the clinical relevance of the differences is yet to be established. ..
  44. Gonçalves F, Martins Oliveira A, Lacchini R, Belo V, Speciali J, Dach F, et al. Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura. Gene. 2013;512:35-40 pubmed publisher
  45. Gudmundsson L, Aspelund T, Scher A, Thorgeirsson G, Johannsson M, Launer L, et al. C-reactive protein in migraine sufferers similar to that of non-migraineurs: the Reykjavik Study. Cephalalgia. 2009;29:1301-10 pubmed publisher
    ..Migraineurs with visual or sensory symptoms were further defined as having migraine with aura (MA) or without aura (MO)...
  46. Hauge A, Hougaard A, Olesen J. On the methodology of drug trials in migraine with aura. Cephalalgia. 2010;30:1041-8 pubmed publisher
    Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura...
  47. Hauge A, Kirchmann M, Olesen J. Trigger factors in migraine with aura. Cephalalgia. 2010;30:346-53 pubmed publisher
    The aim of the present study was to identify trigger factors in migraine with aura (MA)...
  48. Tfelt Hansen P. History of migraine with aura and cortical spreading depression from 1941 and onwards. Cephalalgia. 2010;30:780-92 pubmed publisher
    Several personal descriptions of migraine with aura from 1870 onwards reported a slow, gradual progression of symptoms...
  49. Vernieri F, Moro L, Altamura C, Palazzo P, Antonelli Incalzi R, Rossini P, et al. Patients with migraine with aura have increased flow mediated dilation. BMC Neurol. 2010;10:18 pubmed publisher
    ..This phenomenon observed peripherally might reflect similar characteristics in the cerebral circulation. ..
  50. Tullo V, Allais G, Curone M, Ferrari M, Omboni S, Benedetto C, et al. Frovatriptan versus zolmitriptan for the acute treatment of migraine with aura: a subgroup analysis of a double-blind, randomized, multicenter, Italian study. Neurol Sci. 2012;33 Suppl 1:S61-4 pubmed publisher
    b>Migraine with aura affects ~20-30 % of migraineurs and it is much less common than migraine without aura. The aim of this study was to compare the efficacy of frovatriptan 2.5 mg and zolmitriptan 2...
  51. Schurks M, Zee R, Buring J, Kurth T. ACE D/I polymorphism, migraine, and cardiovascular disease in women. Neurology. 2009;72:650-6 pubmed publisher
    ..b>Migraine with aura doubled the risk for CVD, but only for carriers of the DD (multivariable-adjusted relative risk [RR] = 2...
  52. Holzer K, Esposito L, Stimmer H, Hemmer B, Poppert H. Cerebral vasculitis mimicking migraine with aura in a patient with Crohn's disease. Acta Neurol Belg. 2009;109:44-8 pubmed
    ..We present a case of Crohn's disease-associated vasculitis mimicking migraine with aura. A 28-year-old woman with Crohn's disease and known migraine with aura had suffered from daily migraine ..
  53. D Andrea G, Bussone G, Allais G, Aguggia M, D Onofrio F, Maggio M, et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol Sci. 2009;30 Suppl 1:S121-4 pubmed publisher
    ..ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, in the prophylactic treatment of migraine with aura (MA)...