persistent vegetative state

Summary

Summary: Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.

Top Publications

  1. De Weer A, Da Ros M, Berre J, Melot C, Goldman S, Peigneux P. Environmental influences on activity patterns in altered states of consciousness. Eur J Neurol. 2011;18:1432-4 pubmed publisher
    ..e. presence and actions of other persons...
  2. Cologan V, Schabus M, Ledoux D, Moonen G, Maquet P, Laureys S. Sleep in disorders of consciousness. Sleep Med Rev. 2010;14:97-105 pubmed publisher
    ..At the present time the interactions of sleep and consciousness in brain-injured patients are a little studied subject but, the authors suggest, a potentially very interesting field of research...
  3. Leon Carrion J, Martin Rodriguez J, Damas Lopez J, Barroso y Martin J, Dominguez Morales M. Brain function in the minimally conscious state: a quantitative neurophysiological study. Clin Neurophysiol. 2008;119:1506-14 pubmed publisher
    ..We also try to find EEG cortical sources that differentiate between both conditions using LORETA source analysis...
  4. Hamama Raz Y, Zabari Y, Buchbinder E. From hope to despair, and back: being the wife of a patient in a persistent vegetative state. Qual Health Res. 2013;23:231-40 pubmed publisher
    ..The research was based on semistructured interviews with 12 wives of husbands who were diagnosed with persistent vegetative state between 1 year 2 months and 10 years prior to the interview...
  5. Monti M, Vanhaudenhuyse A, Coleman M, Boly M, Pickard J, Tshibanda L, et al. Willful modulation of brain activity in disorders of consciousness. N Engl J Med. 2010;362:579-89 pubmed publisher
    ..The rate of misdiagnosis is approximately 40%, and new methods are required to complement bedside testing, particularly if the patient's capacity to show behavioral signs of awareness is diminished...
  6. Sara M, Pistoia F. Complexity loss in physiological time series of patients in a vegetative state. Nonlinear Dynamics Psychol Life Sci. 2010;14:1-13 pubmed
    ..Mean ApEn values were lower in patients than in controls (t18 18 = 12.3, p < 0.001). ApEn is able to discriminate patients from controls thus supporting the hypothesis about a decreased neural networks complexity in VS...
  7. Schnakers C, Majerus S, Giacino J, Vanhaudenhuyse A, Bruno M, Boly M, et al. A French validation study of the Coma Recovery Scale-Revised (CRS-R). Brain Inj. 2008;22:786-92 pubmed publisher
  8. Babiloni C, Sara M, Vecchio F, Pistoia F, Sebastiano F, Onorati P, et al. Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. Clin Neurophysiol. 2009;120:719-29 pubmed publisher
    ..Here we tested the hypothesis that these rhythms are abnormal in persistent vegetative state (PVS) patients, who are awake but not aware of self and environment.
  9. Guan J, You C, Liu Y, Zhang R, Wang Z. Characteristics of infradian and circadian rhythms in the persistent vegetative state. J Int Med Res. 2011;39:2281-7 pubmed
    ..characteristics of blood pressure and heart rate in 26 patients with traumatic head injury in a persistent vegetative state (PVS)...

More Information

Publications62

  1. Heiss W. PET in coma and in vegetative state. Eur J Neurol. 2012;19:207-11 pubmed publisher
  2. Candelieri A, Cortese M, Dolce G, Riganello F, Sannita W. Visual pursuit: within-day variability in the severe disorder of consciousness. J Neurotrauma. 2011;28:2013-7 pubmed publisher
    ..These percentages are congruent with the reported misdiagnosis rate between the two conditions, and document spontaneous variability possibly related to circadian rhythms...
  3. Fernandez Espejo D, Junque C, Bernabeu M, Roig Rovira T, Vendrell P, Mercader J. Reductions of thalamic volume and regional shape changes in the vegetative and the minimally conscious states. J Neurotrauma. 2010;27:1187-93 pubmed publisher
    ..Our findings suggest that MCS and VS patients present different patterns of regional thalamic abnormalities, and that these differences partially explain their clinical profile...
  4. Boly M, Garrido M, Gosseries O, Bruno M, Boveroux P, Schnakers C, et al. Preserved feedforward but impaired top-down processes in the vegetative state. Science. 2011;332:858-62 pubmed publisher
    ..This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception. ..
  5. Phillips C, Bruno M, Maquet P, Boly M, Noirhomme Q, Schnakers C, et al. "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. Neuroimage. 2011;56:797-808 pubmed publisher
    ..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
  6. Racine E, Rodrigue C, Bernat J, Riopelle R, Shemie S. Observations on the ethical and social aspects of disorders of consciousness. Can J Neurol Sci. 2010;37:758-68 pubmed
    ..We conclude by highlighting areas needing further research and collaboration...
  7. Vanhaudenhuyse A, Noirhomme Q, Tshibanda L, Bruno M, Boveroux P, Schnakers C, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain. 2010;133:161-71 pubmed publisher
    ..Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology...
  8. Sara M, Pistoia F, Pasqualetti P, Sebastiano F, Onorati P, Rossini P. Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomes. Neurorehabil Neural Repair. 2011;25:35-42 pubmed publisher
    Establishing prognosis in patients in a persistent vegetative state (VS) is still challenging...
  9. Panksepp J, Fuchs T, Garcia V, Lesiak A. Does any aspect of mind survive brain damage that typically leads to a persistent vegetative state? Ethical considerations. Philos Ethics Humanit Med. 2007;2:32 pubmed
    ..the conclusion that all aspects of consciousness are gone in patients who have descended into a persistent vegetative state (PVS)...
  10. Owen A, Coleman M. Detecting awareness in the vegetative state. Ann N Y Acad Sci. 2008;1129:130-8 pubmed publisher
  11. Fins J, Illes J, Bernat J, Hirsch J, Laureys S, Murphy E. Neuroimaging and disorders of consciousness: envisioning an ethical research agenda. Am J Bioeth. 2008;8:3-12 pubmed publisher
    ..It represents an interdisciplinary approach to the challenges posed by the emerging use of neuroimaging technologies to describe and characterize disorders of consciousness...
  12. Landsness E, Bruno M, Noirhomme Q, Riedner B, Gosseries O, Schnakers C, et al. Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state. Brain. 2011;134:2222-32 pubmed publisher
    ..We suggest that the study of sleep and homoeostatic regulation of slow wave activity may provide a complementary tool for the assessment of brain function in minimally conscious state and vegetative state patients...
  13. Luaute J, Maucort Boulch D, Tell L, Quelard F, Sarraf T, Iwaz J, et al. Long-term outcomes of chronic minimally conscious and vegetative states. Neurology. 2010;75:246-52 pubmed publisher
  14. Gray K, Knickman T, Wegner D. More dead than dead: perceptions of persons in the persistent vegetative state. Cognition. 2011;121:275-80 pubmed publisher
    Patients in persistent vegetative state (PVS) may be biologically alive, but these experiments indicate that people see PVS as a state curiously more dead than dead...
  15. Faugeras F, Rohaut B, Weiss N, Bekinschtein T, Galanaud D, Puybasset L, et al. Probing consciousness with event-related potentials in the vegetative state. Neurology. 2011;77:264-8 pubmed publisher
    ..We recently designed an original rule extraction ERP test that is positive only in subjects who are conscious of the long-term regularity of auditory stimuli...
  16. Jackson E. The minimally conscious state and treatment withdrawal: W v M. J Med Ethics. 2013;39:559-61 pubmed publisher
    ..This short comment on the Court of Protection decision in W v M draws attention to the primacy the judge gave to the preservation of life and discusses the relative lack of weight accorded to M's previously expressed views. ..
  17. Boly M, Tshibanda L, Vanhaudenhuyse A, Noirhomme Q, Schnakers C, Ledoux D, et al. Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum Brain Mapp. 2009;30:2393-400 pubmed publisher
    ..Future studies are needed to give a full characterization of default network connectivity in the VS patients population...
  18. Laureys S, Boly M. What is it like to be vegetative or minimally conscious?. Curr Opin Neurol. 2007;20:609-13 pubmed
    ..Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness...
  19. Demertzi A, Ledoux D, Bruno M, Vanhaudenhuyse A, Gosseries O, Soddu A, et al. Attitudes towards end-of-life issues in disorders of consciousness: a European survey. J Neurol. 2011;258:1058-65 pubmed publisher
    ..Given the observed individual variability, we stress the importance of advance directives and identification of proxies when discussing end-of-life issues in patients with disorders of consciousness...
  20. Fernandez Espejo D, Junque C, Vendrell P, Bernabeu M, Roig T, Bargallo N, et al. Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury. Brain Inj. 2008;22:882-90 pubmed publisher
    ..To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury...
  21. Schnakers C, Vanhaudenhuyse A, Giacino J, Ventura M, Boly M, Majerus S, et al. Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol. 2009;9:35 pubmed publisher
    ..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
  22. Rosanova M, Gosseries O, Casarotto S, Boly M, Casali A, Bruno M, et al. Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain. 2012;135:1308-20 pubmed publisher
  23. Bagnato S, Boccagni C, Prestandrea C, Sant Angelo A, Castiglione A, Galardi G. Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma. Clin Neurophysiol. 2010;121:274-80 pubmed publisher
  24. Racine E, Amaram R, Seidler M, Karczewska M, Illes J. Media coverage of the persistent vegetative state and end-of-life decision-making. Neurology. 2008;71:1027-32 pubmed publisher
    Conflicting perspectives about the diagnosis and prognosis of the persistent vegetative state (PVS) as well as end-of-life (EOL) decision-making were disseminated in the Terri Schiavo case...
  25. Cruse D, Chennu S, Chatelle C, Fernandez Espejo D, Bekinschtein T, Pickard J, et al. Relationship between etiology and covert cognition in the minimally conscious state. Neurology. 2012;78:816-22 pubmed publisher
    ..We investigated the relationships between etiology and both overt and covert cognitive abilities in a group of patients in the minimally conscious state (MCS)...
  26. Luchetti M. Eluana Englaro, chronicle of a death foretold: ethical considerations on the recent right-to-die case in Italy. J Med Ethics. 2010;36:333-5 pubmed publisher
  27. Dolce G, Quintieri M, Serra S, Lagani V, Pignolo L. Clinical signs and early prognosis in vegetative state: a decisional tree, data-mining study. Brain Inj. 2008;22:617-23 pubmed publisher
    ..The purpose of this study was to identify by artificial intelligence procedures (classification and regression trees, data-mining) the significant neurological signs correlated to and predictive of outcome...
  28. Sancisi E, Battistini A, Di Stefano C, Simoncini L, Simoncini L, Montagna P, et al. Late recovery from post-traumatic vegetative state. Brain Inj. 2009;23:163-6 pubmed publisher
    ..The aim of this study was to report that late recovery with moderate disability is possible, even after several months in vegetative state...
  29. Kahane G, Savulescu J. Brain damage and the moral significance of consciousness. J Med Philos. 2009;34:6-26 pubmed publisher
    ..We argue that enjoyment of consciousness might actually give stronger moral reasons not to preserve a patient's life and, indeed, that these might be stronger when patients retain significant cognitive function...
  30. Sheather J. Should we respect precedent autonomy in life-sustaining treatment decisions?. J Med Ethics. 2013;39:547-50 pubmed publisher
    ..These decisions raise difficult questions about personal identity and about the threshold of evidence that is required of an earlier decision in order for it to be respected. ..
  31. Yu T, Lang S, Vogel D, Markl A, Müller F, Kotchoubey B. Patients with unresponsive wakefulness syndrome respond to the pain cries of other people. Neurology. 2013;80:345-52 pubmed publisher
    ..The aim of this study was to assess residual affective consciousness in a specific network of brain structures, the so-called pain matrix (PM) of the brain...
  32. Wu D, Cai G, Yuan Y, Liu L, Li G, Song W, et al. Application of nonlinear dynamics analysis in assessing unconsciousness: a preliminary study. Clin Neurophysiol. 2011;122:490-498 pubmed publisher
    ..Twenty-one subjects in persistent vegetative state (PVS), 16 in minimally conscious state (MCS) and 30 normal conscious subjects (control group) with ..
  33. Vanhaudenhuyse A, Schnakers C, Bredart S, Laureys S. Assessment of visual pursuit in post-comatose states: use a mirror. J Neurol Neurosurg Psychiatry. 2008;79:223 pubmed publisher
  34. Fisher C, Appelbaum P. Diagnosing consciousness: neuroimaging, law, and the vegetative state. J Law Med Ethics. 2010;38:374-85 pubmed publisher
    ..Finally, we discuss broader scientific, ethical, and legal issues associated with the advent of neuroimaging for disorders of consciousness and conclude with policy recommendations that could help to mitigate confusion in this realm...
  35. Wilkinson D, Kahane G, Horne M, Savulescu J. Functional neuroimaging and withdrawal of life-sustaining treatment from vegetative patients. J Med Ethics. 2009;35:508-11 pubmed publisher
    ..Although functional neuroimaging is likely to play an increasing role in the assessment of patients in a vegetative state, caution is needed in the interpretation of neuroimaging findings. ..
  36. Shah S, Schiff N. Central thalamic deep brain stimulation for cognitive neuromodulation - a review of proposed mechanisms and investigational studies. Eur J Neurosci. 2010;32:1135-44 pubmed publisher
    ..Although available data provide evidence for proof-of-concept, very significant challenges for study design and development of CT/DBS for clinical use are identified...
  37. Vanhaudenhuyse A, Laureys S, Perrin F. Cognitive event-related potentials in comatose and post-comatose states. Neurocrit Care. 2008;8:262-70 pubmed
    ..In coma-survivors, cognitive potentials are more frequently obtained when using stimuli that are more ecologic or have an emotional content (such as the patient's own name) than when using classical sine tones...
  38. Schnakers C, Ledoux D, Majerus S, Damas P, Damas F, Lambermont B, et al. Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders. Brain Inj. 2008;22:926-31 pubmed publisher
  39. Cruse D, Chennu S, Chatelle C, Bekinschtein T, Fernández Espejo D, Pickard J, et al. Bedside detection of awareness in the vegetative state: a cohort study. Lancet. 2011;378:2088-94 pubmed publisher
  40. Bekinschtein T, Golombek D, Simonetta S, Coleman M, Manes F. Circadian rhythms in the vegetative state. Brain Inj. 2009;23:915-9 pubmed publisher
    ..To evaluate whether vegetative state patients maintain circadian rhythms...
  41. Höller Y, Bergmann J, Kronbichler M, Crone J, Schmid E, Golaszewski S, et al. Preserved oscillatory response but lack of mismatch negativity in patients with disorders of consciousness. Clin Neurophysiol. 2011;122:1744-54 pubmed publisher
    ..The diagnostic validity of non-phase-locked oscillations (NPLOs) and mismatch negativity (MMN) in an oddball task for assessing attentional reactivity in patients with disordered consciousness was examined...
  42. Laureys S, Celesia G, Cohadon F, Lavrijsen J, Leon Carrion J, Sannita W, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 2010;8:68 pubmed publisher
    ..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS)...
  43. Coleman M, Davis M, Rodd J, Robson T, Ali A, Owen A, et al. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain. 2009;132:2541-52 pubmed publisher
  44. Estraneo A, Moretta P, Loreto V, Lanzillo B, Santoro L, Trojano L. Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. Neurology. 2010;75:239-45 pubmed publisher
  45. Sara M, Pistoia F, Mura E, Onorati P, Govoni S. Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. Arch Phys Med Rehabil. 2009;90:1245-9 pubmed publisher
    Sporadic cases of recovery from persistent vegetative state (PVS) after administration of intrathecal baclofen (ITB) have been reported without giving any possible explanation for its paradoxical effect...
  46. Fellinger R, Klimesch W, Schnakers C, Perrin F, Freunberger R, Gruber W, et al. Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses. Clin Neurophysiol. 2011;122:2177-84 pubmed publisher
    ..Although behavioral evaluation of awareness in disorders of consciousness is difficult it remains the clinical standard. We believe that the refinement of EEG and analyses techniques would improve our characterization of those patients...
  47. Schnakers C, Perrin F, Schabus M, Majerus S, Ledoux D, Damas P, et al. Voluntary brain processing in disorders of consciousness. Neurology. 2008;71:1614-20 pubmed publisher
    ..In this study, we explored a new active evoked-related potentials paradigm as an alternative method for the detection of voluntary brain activity...
  48. Boly M, Faymonville M, Schnakers C, Peigneux P, Lambermont B, Phillips C, et al. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol. 2008;7:1013-20 pubmed publisher
    ..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
  49. Rossetti A, Oddo M, Logroscino G, Kaplan P. Prognostication after cardiac arrest and hypothermia: a prospective study. Ann Neurol. 2010;67:301-7 pubmed publisher
    ..We undertook this study to verify the prognostic value of clinical and electrophysiological variables in the TH setting...
  50. Monti M, Coleman M, Owen A. Executive functions in the absence of behavior: functional imaging of the minimally conscious state. Prog Brain Res. 2009;177:249-60 pubmed publisher
    ..This paradigm thus exemplifies the potential for fMRI to explore high-level cognitive functions, and awareness, in the absence of any behavioral response...
  51. Striano P, Bifulco F, Servillo G. The saga of Eluana Englaro: another tragedy feeding the media. Intensive Care Med. 2009;35:1129-31 pubmed publisher
  52. Di H, Boly M, Weng X, Ledoux D, Laureys S. Neuroimaging activation studies in the vegetative state: predictors of recovery?. Clin Med (Lond). 2008;8:502-7 pubmed
    ..The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness...
  53. Racine E, Karczewska M, Seidler M, Amaram R, Illes J. How the public responded to the Schiavo controversy: evidence from letters to editors. J Med Ethics. 2010;36:571-3 pubmed publisher
    ..Distinct public discourses can be encountered in different stakeholders suggesting complex and extensive pluralism even within the media...