chronic brain injury

Summary

Summary: Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.

Top Publications

  1. Christofides J, Bridel M, Egerton M, Mackay G, Forrest C, Stoy N, et al. Blood 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury. J Neurochem. 2006;97:1078-88 pubmed
    ..Interactions between the kynurenine, 5-HT and melatonin pathways should be considered when interpreting changes of tryptophan metabolism...
  2. Golden Z, Golden C, Neubauer R. Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disabil Rehabil. 2006;28:1379-86 pubmed
    One suggested treatment for chronic brain injury (CBI) is the use of hyperbaric oxygen therapy (HBOT). The present study was an evaluation of neuropsychological improvement after HBOT in CBI patients.
  3. Hardy P, Johnston K, De Beaumont L, Montgomery D, Lecomte J, Soucy J, et al. Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury. J Neurol Sci. 2007;253:94-105 pubmed
    ..We studied the therapeutic potential of HBO(2) therapy in a 54-year-old man who had sustained traumatic brain injuries one year before testing that resulted in permanent neurological symptoms...
  4. Hillary F, Biswal B. The influence of neuropathology on the FMRI signal: a measurement of brain or vein?. Clin Neuropsychol. 2007;21:58-72 pubmed
    ..The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal...
  5. Vink R, Cook N, Van Den Heuvel C. Magnesium in acute and chronic brain injury: an update. Magnes Res. 2009;22:158S-162S pubmed
    ..With respect to chronic brain injury, recent results indicate that magnesium deficient mice are susceptible to developing Parkinson's disease, ..
  6. Reinkensmeyer D, Schmit B, Rymer W. Assessment of active and passive restraint during guided reaching after chronic brain injury. Ann Biomed Eng. 1999;27:805-14 pubmed
    We report the use of a mechatronic device for assessing arm movement impairment after chronic brain injury. The device, called the "Assisted Rehabilitation and Measurement Guide," is designed to guide reaching movements across ..
  7. Reinkensmeyer D, Schmit B, Rymer W. Mechatronic assessment of arm impairment after chronic brain injury. Technol Health Care. 1999;7:431-5 pubmed
    ..We report the use of a mechatronic device for evaluation of the arm after chronic brain injury. We performed a series of experiments with the device in order to identify the relative contribution of ..
  8. Kadam S, Mulholland J, Smith D, Johnston M, Comi A. Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokes. Behav Brain Res. 2009;197:77-83 pubmed publisher
    ..Overall, our results demonstrate that ischemia induced by our neonatal stroke model produces behavioral deficits that are consistent with the brain injury...
  9. Reinkensmeyer D, Kahn L, Averbuch M, McKenna Cole A, Schmit B, Rymer W. Understanding and treating arm movement impairment after chronic brain injury: progress with the ARM guide. J Rehabil Res Dev. 2000;37:653-62 pubmed
    ..Directions for future research regarding the efficacy and practicality of rehabilitators are discussed...

More Information

Publications62

  1. Rourke B. Is neuropsychology a psychosocial science?. J Clin Exp Neuropsychol. 2008;30:691-9 pubmed publisher
    ..One clearly evident conclusion of these efforts is that neuropsychology is a psychosocial science. Some implications of our findings for research and clinical practice are outlined...
  2. McCrory P. Boxing and the risk of chronic brain injury. BMJ. 2007;335:781-2 pubmed
  3. Higginson I, Gao W, Jackson D, Murray J, Harding R. Short-form Zarit Caregiver Burden Interviews were valid in advanced conditions. J Clin Epidemiol. 2010;63:535-42 pubmed publisher
    ..To assess six short-form versions of Zarit Burden Interview (ZBI-12, ZBI-8, ZBI-7, ZBI-6, ZBI-4, and ZBI-1) among three caregiving populations...
  4. Widdel L, Winston K. Prognosis for children in cardiac arrest shortly after blunt cranial trauma. J Trauma. 2010;69:783-8 pubmed publisher
    ..The goal of this investigation is to determine the success rate of aggressive cardiorespiratory resuscitation in children who experience blunt cranial trauma of sufficient magnitude to quickly cause cardiac arrest...
  5. Stuss D, Toth J, Franchi D, Alexander M, Tipper S, Craik F. Dissociation of attentional processes in patients with focal frontal and posterior lesions. Neuropsychologia. 1999;37:1005-27 pubmed
    ..INT, NP, and IOR are mediated by different brain regions and their expression can be modulated by the complexity of the selection task...
  6. Boman I, Lindstedt M, Hemmingsson H, Bartfai A. Cognitive training in home environment. Brain Inj. 2004;18:985-95 pubmed
    ..To examine the efficacy of cognitive rehabilitation in the patient's home or vocational environment...
  7. Fernandez V, Erli H, Kugler J, Paar O. [Cognitive deficits after polytrauma. Studies of quality of life]. Unfallchirurg. 2001;104:938-47 pubmed
    ..The KMS seems to be an easy test to evaluate those cognitive deficits...
  8. Whelan Goodinson R, Ponsford J, Johnston L, Grant F. Psychiatric disorders following traumatic brain injury: their nature and frequency. J Head Trauma Rehabil. 2009;24:324-32 pubmed publisher
    ..To retrospectively establish the nature and frequency of Axis I psychiatric disorders pre- and post-TBI...
  9. Young N, Barden W, Mills W, Burke T, Law M, Boydell K. Transition to adult-oriented health care: perspectives of youth and adults with complex physical disabilities. Phys Occup Ther Pediatr. 2009;29:345-61 pubmed publisher
    ..The transition to adulthood is extremely difficult for individuals with disabilities. We sought to explore the specific issue of transition to adult-oriented health care in a Canadian context...
  10. McCrory P. Cavum septi pellucidi--a reason to ban boxers?. Br J Sports Med. 2002;36:157-61 pubmed
  11. Chen J, Sonsalla P, Pedata F, Melani A, Domenici M, Popoli P, et al. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol. 2007;83:310-31 pubmed
  12. Ioffe M, Ustinova K, Chernikova L, Luk yanova Y, Ivanova Smolenskaya I, Kulikov M. Characteristics of learning voluntary control of posture in lesions of the pyramidal and nigrostriatal systems. Neurosci Behav Physiol. 2004;34:543-9 pubmed
    ..It is suggested that the mechanisms of involvement of the nigrostriatal and corticospinal systems in learning the voluntary control of posture have elements in common as well as unique elements...
  13. Benn K, McColl M. Parental coping following childhood acquired brain injury. Brain Inj. 2004;18:239-55 pubmed
    ..To examine parental coping following an acquired brain injury of their child, the relationship between maternal and paternal coping, and the extent to which social support and family environment affect parental coping...
  14. Pettigrew D, Li Y, Kuntz C, Crutcher K. Global expression of NGF promotes sympathetic axonal growth in CNS white matter but does not alter its parallel orientation. Exp Neurol. 2007;203:95-109 pubmed
  15. Channon S, Crawford S. The effects of anterior lesions on performance on a story comprehension test: left anterior impairment on a theory of mind-type task. Neuropsychologia. 2000;38:1006-17 pubmed
    ..The implications of the findings for our understanding of impairments in story comprehension after brain injury are discussed in terms of models of executive function and theory of mind...
  16. Egeland J, Bosnes O, Johansen H. Factor structure of the Norwegian version of the WAIS-III in a clinical sample: the arithmetic problem. Assessment. 2009;16:292-300 pubmed publisher
    ..Effects of education were particularly high for both the Verbal Comprehension tests and Arithmetic...
  17. Struchen M, Atchison T, Roebuck T, Caroselli J, Sander A. A multidimensional measure of caregiving appraisal: validation of the Caregiver Appraisal Scale in traumatic brain injury. J Head Trauma Rehabil. 2002;17:132-54 pubmed
    ..To investigate the factor structure and concurrent validity of the Caregiver Appraisal Scale (CAS) in a sample of caregivers of adults with traumatic brain injury (TBI)...
  18. Simone L, Schultheis M, Rebimbas J, Millis S. Head-mounted displays for clinical virtual reality applications: pitfalls in understanding user behavior while using technology. Cyberpsychol Behav. 2006;9:591-602 pubmed
    ..The validity and usefulness of the HMD-based virtual environments must be understood to fully reap the benefits of virtual reality (VR) in rehabilitation medicine...
  19. Ragnarsson K. Traumatic brain injury research since the 1998 NIH Consensus Conference: accomplishments and unmet goals. J Head Trauma Rehabil. 2006;21:379-87 pubmed
    ..However, there is need to replicate many of these studies using more scientifically rigorous methodologies, while other areas of important TBI research remain largely unexplored...
  20. Rugg Gunn F, Boulby P, Symms M, Barker G, Duncan J. Imaging the neocortex in epilepsy with double inversion recovery imaging. Neuroimage. 2006;31:39-50 pubmed
    ..DIR is, therefore, a useful quantitative MRI technique for characterising epileptic foci and may contribute to presurgical evaluation...
  21. Hoffmann Richter U. [Perspectives]. Psychiatr Prax. 2006;33:361-3 pubmed
  22. Greiffenstein F, Baker J. Comparison of premorbid and postinjury mmpi-2 profiles in late postconcussion claimants. Clin Neuropsychol. 2001;15:162-70 pubmed
    ..The findings did not support an 'eggshell plaintiff' theory of chronic postconcussive complaints. The view that chronic postconcussive complaints require a wider focus on non-neuropsychological factors is enhanced...
  23. Ferrari R, Obelieniene D, Russell A, Darlington P, Gervais R, Green P. Symptom expectation after minor head injury. A comparative study between Canada and Lithuania. Clin Neurol Neurosurg. 2001;103:184-90 pubmed
    ..The purpose of the present study is to compare the frequency and nature of expected symptoms in Lithuania (a country where the chronic post-concussive syndrome is largely unknown) with that in Canada...
  24. Kashluba S, Paniak C, Blake T, Reynolds S, Toller Lobe G, Nagy J. A longitudinal, controlled study of patient complaints following treated mild traumatic brain injury. Arch Clin Neuropsychol. 2004;19:805-16 pubmed
    ..Overall, the treated MTBI group's symptom complaints diminished from baseline to 3 months post-injury, with relatively few differences remaining between the two groups...
  25. Young N, Steele C, Fehlings D, Jutai J, Olmsted N, Williams J. Use of health care among adults with chronic and complex physical disabilities of childhood. Disabil Rehabil. 2005;27:1455-60 pubmed
    ..Their admission rate is 9.0 times that of the general population, and few have a primary care physician. A new model of service may be necessary for this high-needs group...
  26. Tasky K, Rudrud E, Schulze K, Rapp J. Using choice to increase on-task behavior in individuals with traumatic brain injury. J Appl Behav Anal. 2008;41:261-5 pubmed
    ..The results for all 3 participants indicated that permitting individuals to choose from a list of tasks increased on-task behavior...
  27. Barreca S, Velikonja D, Brown L, Williams L, Davis L, Sigouin C. Evaluation of the effectiveness of two clinical training procedures to elicit yes/no responses from patients with a severe acquired brain injury: a randomized single-subject design. Brain Inj. 2003;17:1065-75 pubmed
  28. Hoofien D, Gilboa A, Vakil E, Donovick P. Traumatic brain injury (TBI) 10-20 years later: a comprehensive outcome study of psychiatric symptomatology, cognitive abilities and psychosocial functioning. Brain Inj. 2001;15:189-209 pubmed
    ..In addition to their epidemiological importance, the results indicate that persons with TBI and their families may need professional assistance to maintain a reasonable psychosocial quality of life, even more than a decade post-injury...
  29. Najdowski A, Wallace M, Ellsworth C, MacAleese A, Cleveland J. Functional analyses and treatment of precursor behavior. J Appl Behav Anal. 2008;41:97-105 pubmed
    ..These results suggest that functional analysis of precursor behavior may offer an alternative, indirect method to assess the operant function of severe problem behavior...
  30. Piguet O, King A, Harrison D. Assessment of minimally responsive patients: clinical difficulties of single-case design. Brain Inj. 1999;13:829-37 pubmed
    ..Beyond the results (which were equivocal), the clinical difficulties in conducting single case study designs in rehabilitation are discussed. Ways to minimize these difficulties are proposed...
  31. Guan J, Mathai S, Harris P, Wen J, Zhang R, Brimble M, et al. Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats. Neuropharmacology. 2007;53:749-62 pubmed
    ..The pharmacokinetic profile and potent long-term protective effects of NNZ 2591 suggests its utility for the treatment of ischemic brain injury and other neurological conditions requiring chronic intervention...
  32. Morris D, Shaw S, Mark V, Uswatte G, Barman J, Taub E. The influence of neuropsychological characteristics on the use of CI therapy with persons with traumatic brain injury. NeuroRehabilitation. 2006;21:131-7 pubmed
    ..We discuss the implications of these neuropsychological factors for CI therapy used for chronic TBI and propose further research to more thoroughly investigate these issues...
  33. Margulies S. The postconcussion syndrome after mild head trauma part II: is migraine underdiagnosed?. J Clin Neurosci. 2000;7:495-9 pubmed
    ..The evidence for post-traumatic migraine as the cause of the postconcussion syndrome in a proportion of patients is reviewed...
  34. Brandi G, Bechir M, Sailer S, Haberthür C, Stocker R, Stover J. Transcranial color-coded duplex sonography allows to assess cerebral perfusion pressure noninvasively following severe traumatic brain injury. Acta Neurochir (Wien). 2010;152:965-72 pubmed publisher
    ..Assess optimal equation to noninvasively estimate intracranial pressure (eICP) and cerebral perfusion pressure (eCPP) following severe traumatic brain injury (TBI) using transcranial color-coded duplex sonography (TCCDS)...
  35. Nybo T, Koskiniemi M. Cognitive indicators of vocational outcome after severe traumatic brain injury (TBI) in childhood. Brain Inj. 1999;13:759-66 pubmed
    ..The results support the recent reports on the vulnerability of a young child's brain to early trauma. The study also strongly suggests that the final assessment of outcome after childhood TBI should be done in adulthood...
  36. Whitnall L, McMillan T, Murray G, Teasdale G. Disability in young people and adults after head injury: 5-7 year follow up of a prospective cohort study. J Neurol Neurosurg Psychiatry. 2006;77:640-5 pubmed
    ..Past studies have not examined representative head injury populations and typically report findings in terms of functioning across social, psychological, neurobehavioural, or cognitive domains rather than global outcome...
  37. de Oliveira Souza R, Moll J, Moll F, de Oliveira D. Executive amnesia in a patient with pre-frontal damage due to a gunshot wound. Neurocase. 2001;7:383-9 pubmed
    ..As such, it is probably closely related to procedural learning and may depend on the same fronto-subcortical loops that mediate the actual execution of behaviour...
  38. de Kruijk J, Leffers P, Meerhoff S, Rutten J, Twijnstra A. Effectiveness of bed rest after mild traumatic brain injury: a randomised trial of no versus six days of bed rest. J Neurol Neurosurg Psychiatry. 2002;73:167-72 pubmed
    ..The prevalence of PTC after six months is estimated to be between 20 and 80%. Bed rest has been advocated to prevent PTC but its effectiveness has never been established...
  39. Gerhart K, Mellick D, Weintraub A. Violence-related traumatic brain injury: a population-based study. J Trauma. 2003;55:1045-53 pubmed
  40. Shiller A, Burke D, Kim H, Calvanio R, Dechman K, Santini C. Treatment with amantadine potentiated motor learning in a patient with traumatic brain injury of 15 years' duration. Brain Inj. 1999;13:715-21 pubmed
    ..The results suggest that amantadine facilitates some measures of motor recovery in chronic brain injury. Further trials are warranted to investigate this issue.
  41. Schonberger M, Humle F, Teasdale T. Subjective outcome of brain injury rehabilitation in relation to the therapeutic working alliance, client compliance and awareness. Brain Inj. 2006;20:1271-82 pubmed
    ..They had suffered a traumatic brain injury (n = 27), a cerebrovascular accident (n = 49) or some other neurological insult (n = 10)...
  42. Hibbard M, Bogdany J, Uysal S, Kepler K, Silver J, Gordon W, et al. Axis II psychopathology in individuals with traumatic brain injury. Brain Inj. 2000;14:45-61 pubmed
    ..To determine the frequency and nature of post-TBI personality disorders (PDs) in a community-based sample of individuals with TBI...
  43. Anderson V, Catroppa C, Rosenfeld J, Haritou F, Morse S. Recovery of memory function following traumatic brain injury in pre-school children. Brain Inj. 2000;14:679-92 pubmed
    ..Children with mild TBI exhibited few memory problems. Findings are discussed in the context of theories of plasticity and recovery of function...
  44. Esselman P, Dillman Long J. Morbidity and management conference: an approach to quality improvement in brain injury rehabilitation. J Head Trauma Rehabil. 2002;17:257-62 pubmed
    ..Rehabilitation Medicine has a long history of working as a coordinated multidisciplinary team caring for complex patients with chronic conditions and is in a position to be a leader in QI activities...
  45. Tanriverdi F, Unluhizarci K, Kocyigit I, Tuna I, Karaca Z, Durak A, et al. Brief communication: pituitary volume and function in competing and retired male boxers. Ann Intern Med. 2008;148:827-31 pubmed
    ..Pituitary consequences of chronic head trauma in boxing have not been investigated in detail...
  46. Ergun A, Koch C, Oder W. Do somatosensory evoked potentials in traumatic brain injury patients indicate brainstem generators for frontally recorded N18, P20 and cervical N13?. Brain Inj. 2004;18:289-98 pubmed
    ..To examine the generator of frontal somatosensory evoked potentials by studying patients with traumatic brain injury in the chronic phase...
  47. Hove L, Bock J, Christoffersen J, Hedegaard M. Analysis of 127 peripartum hypoxic brain injuries from closed claims registered by the Danish Patient Insurance Association. Acta Obstet Gynecol Scand. 2008;87:72-5 pubmed
    ..The authors investigated the circumstances of registered peripartum hypoxic brain injuries in order to identify potential opportunities to improve patient safety and prevent injuries...
  48. Sidaros A, Engberg A, Sidaros K, Liptrot M, Herning M, Petersen P, et al. Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain. 2008;131:559-72 pubmed
    ..These findings support that DTI is a clinically relevant biomarker in TBI, which may have prognostic value and also might serve as a tool for revealing changes in the neural tissue during recovery...
  49. Omalu B, DeKosky S, Minster R, Kamboh M, Hamilton R, Wecht C. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery. 2005;57:128-34; discussion 128-34 pubmed
    ..This case draws attention to the need for further studies in the cohort of retired National Football League players to elucidate the neuropathological sequelae of repeated mild traumatic brain injury in professional football...
  50. Ergh T, Rapport L, Coleman R, Hanks R. Predictors of caregiver and family functioning following traumatic brain injury: social support moderates caregiver distress. J Head Trauma Rehabil. 2002;17:155-74 pubmed
    ..This study examined predictors of family dysfunction and caregiver distress among 60 pairs of persons who sustained a traumatic brain injury and their caregivers...
  51. Hibbard M, Cantor J, Charatz H, Rosenthal R, Ashman T, Gundersen N, et al. Peer support in the community: initial findings of a mentoring program for individuals with traumatic brain injury and their families. J Head Trauma Rehabil. 2002;17:112-31 pubmed
    ..To evaluate the impact of a community-based peer support program for individuals and their family members following traumatic brain injury (TBI)...
  52. Brown T, Mount J, Rouland B, Kautz K, Barnes R, Kim J. Body weight-supported treadmill training versus conventional gait training for people with chronic traumatic brain injury. J Head Trauma Rehabil. 2005;20:402-15 pubmed
    ..To compare body weight support treadmill training (BWSTT) to conventional overground gait training (COGT)...
  53. Obonsawin M, Jefferis S, Lowe R, Crawford J, Fernandes J, Holland L, et al. A model of personality change after traumatic brain injury and the development of the Brain Injury Personality Scales. J Neurol Neurosurg Psychiatry. 2007;78:1239-47 pubmed