dorsal raphe nucleus


Summary: The dorsal region of the raphe nucleus which is a source of the SEROTONERGIC NEURONS innervating the TELENCEPHALON; DIENCEPHALON; MESENCEPHALON; and RHOMBENCEPHALON.

Top Publications

  1. Felger J, Haroon E, Miller A. Risk and Resilience: Animal Models Shed Light on the Pivotal Role of Inflammation in Individual Differences in Stress-Induced Depression. Biol Psychiatry. 2015;78:7-9 pubmed publisher
  2. Matias S, Lottem E, Dugué G, Mainen Z. Activity patterns of serotonin neurons underlying cognitive flexibility. elife. 2017;6: pubmed publisher
    ..Our findings show how the activity patterns of serotonin neurons support a role in cognitive flexibility, and suggest a revised model of dopamine-serotonin opponency with potential clinical implications. ..
  3. Yang H, Sternson S. Raphe Circuits on the Menu. Cell. 2017;170:409-410 pubmed publisher
    The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN.
  4. Nectow A, Schneeberger M, Zhang H, Field B, Renier N, Azevedo E, et al. Identification of a Brainstem Circuit Controlling Feeding. Cell. 2017;170:429-442.e11 pubmed publisher
    ..Here, we show that neurons in the dorsal raphe nucleus, expressing vesicular transporters for GABA or glutamate (hereafter, DRNVgat and DRNVGLUT3
  5. Brisch R, Steiner J, Mawrin C, Krzyżanowska M, Jankowski Z, Gos T. Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders. Eur Arch Psychiatry Clin Neurosci. 2017;267:403-415 pubmed publisher
    ..The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal ..
  6. Zhou L, Liu M, Li Q, Deng J, Mu D, Sun Y. Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus. Cell Rep. 2017;18:3018-3032 pubmed publisher
    ..the organization of long-range synaptic inputs to serotonergic neurons and GABAergic neurons in the dorsal raphe nucleus (DRN) of mice with a combination of viral tracing, slice electrophysiological, and optogenetic techniques...
  7. Natarajan R, Forrester L, Chiaia N, Yamamoto B. Chronic-Stress-Induced Behavioral Changes Associated with Subregion-Selective Serotonin Cell Death in the Dorsal Raphe. J Neurosci. 2017;37:6214-6223 pubmed publisher
    ..These findings identify a mechanism of subregion-selective death of 5HT neurons in the dorsal raphe, a defined neuroanatomical pathway, and a behavioral phenotype that mirror stress-associated diseases such as major depressive disorder. ..
  8. Zhong W, Li Y, Feng Q, Luo M. Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons. J Neurosci. 2017;37:8863-8875 pubmed publisher
    ..Both dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nucleus (DRN) participate in reward processing...
  9. Xiao J, Song M, Li F, Liu X, Anwar A, Zhao H. Effects of GABA microinjection into dorsal raphe nucleus on behavior and activity of lateral habenular neurons in mice. Exp Neurol. 2017;298:23-30 pubmed publisher
    The dorsal raphe nucleus (DRN) is a key site for 5-hydroxytryptamine (5-HT) synthesis and release. DRN dysfunction has been implicated in several stress-related disorders, including depression and anxiety...

More Information


  1. Yang T, Jang E, Ryu Y, Lee G, Lee E, Chang S, et al. Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus. BMC Complement Altern Med. 2017;17:528 pubmed publisher
    ..Our results suggest that acupuncture can ameliorate anxiety-like behaviors, possibly through regulation of SERT in the DRN. ..
  2. Correia P, Lottem E, Banerjee D, Machado A, Carey M, Mainen Z. Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons. elife. 2017;6: pubmed publisher
    ..We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with ..
  3. Cho J, Treweek J, Robinson J, Xiao C, Bremner L, Greenbaum A, et al. Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli. Neuron. 2017;94:1205-1219.e8 pubmed publisher
    ..Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning...
  4. Bethea C, Mueller K, Reddy A, Kohama S, Urbanski H. Effects of obesogenic diet and estradiol on dorsal raphe gene expression in old female macaques. PLoS ONE. 2017;12:e0178788 pubmed publisher
    ..These results suggest that with regard to function and viability in the dorsal raphe, HT may not be as beneficial for obese women as normal weight women. ..