subcommissural organ

Summary

Summary: Ependymal derivative located at the junction of the THIRD VENTRICLE and the CEREBRAL AQUEDUCT; and the SOMATOSTATIN SECRETING CELLS.

Top Publications

  1. Fernández Llebrez P, Grondona J, Perez J, López Aranda M, Estivill Torrus G, Llebrez Zayas P, et al. Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus. J Neuropathol Exp Neurol. 2004;63:574-86 pubmed
    ..mutants that we observed were the absence or malformation of the posterior commissure (PC) and of the subcommissural organ (SCO), the collapse of the cerebral aqueduct, and the development of hydrocephalus...
  2. Galarza M. Evidence of the subcommissural organ in humans and its association with hydrocephalus. Neurosurg Rev. 2002;25:205-15 pubmed
    ..an attempt is made by extensive review of the literature to give an account of the significance of the subcommissural organ (SCO) in humans and its possible relationship with cerebrospinal fluid (CSF) disorders...
  3. Bouyatas M, Gamrani H. Immunohistochemical evaluation of the effect of lead exposure on subcommissural organ innervation and secretion in Shaw's Jird (Meriones shawi). Acta Histochem. 2007;109:421-7 pubmed
    The secretory activity of subcommissural organ cells is controlled by various extrinsic and intrinsic factors. Lead has been recognised as a neurotoxic heavy metal, since it induces morphological and functional abnormalities in the brain...
  4. Bach A, Lallemand Y, Nicola M, Ramos C, Mathis L, Maufras M, et al. Msx1 is required for dorsal diencephalon patterning. Development. 2003;130:4025-36 pubmed
    ..This indicates that Msx genes may regulate Wnt1 expression at the dorsal midline of the neural tube. Based on these results, we propose a model in which Msx genes are intermediary between Bmp and Wnt at this site. ..
  5. Grondona J, Perez J, Cifuentes M, Lopez Avalos M, Nualart F, Peruzzo B, et al. Analysis of the secretory glycoproteins of the subcommissural organ of the dogfish (Scyliorhinus canicula). Brain Res Mol Brain Res. 1994;26:299-308 pubmed
    ..The lectin binding properties of these compounds point to the 780 kDa compound as a precursor form and the 380 kDa polypeptide as a processed form...
  6. Martinez Pena y Valenzuela I, Carmona Calero E, Perez Gonzalez H, Ormazabal Ramos C, Fernández Rodriguez P, Gonzalez Marrero I, et al. Alterations of the cerebrospinal fluid proteins and subcommissural organ secretion in the arterial hypertension and ventricular dilatation. A study in SHR rats. Histol Histopathol. 2006;21:179-85 pubmed publisher
    ..their possible role in the relationship between hydrocephalus, arterial hypertension and alterations in the subcommissural organ. Brains from control Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) sacrificed with ..
  7. Rodriguez E, Garrido O, Oksche A. Lectin histochemistry of the human fetal subcommissural organ. Cell Tissue Res. 1990;262:105-13 pubmed
    The subcommissural organ (SCO) of 7 human fetuses, 3 to 6...
  8. Barreiro Iglesias A, Villar Cerviño V, Anadón R, Rodicio M. A monoclonal antibody as a tool to study the subcommissural organ and Reissner's fibre of the sea lamprey: an immunofluorescence study before and after a spinal cord transection. Neurosci Lett. 2009;464:34-8 pubmed publisher
    ..brain/spinal cord of both normal and injured animals, anti-GAP-43-like labeling was only observed in the subcommissural organ (SCO) and Reissner's fibre (RF)...
  9. Yulis C, Mota M, Andrades J, Rodriguez S, Peruzzo B, Mancera J, et al. Floor plate and the subcommissural organ are the source of secretory compounds of related nature: comparative immunocytochemical study. J Comp Neurol. 1998;392:19-34 pubmed
    The subcommissural organ of vertebrates secretes glycoproteins into the third ventricle that condense to form Reissner's fiber (RF)...

More Information

Publications62

  1. Tomé M, Jiménez A, Richter H, Vio K, Bermúdez Silva F, Rodriguez E, et al. The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors. Cell Tissue Res. 2004;317:65-77 pubmed
    ..studied the presence of both tyrosine-hydroxylase-immunoreactive nerve fibers and dopamine receptors in the subcommissural organ (SCO), an ependymal brain gland that is located in the roof of the third ventricle and that secretes, into ..
  2. Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, et al. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. Glia. 2000;32:177-91 pubmed
    ..matrix glycoprotein of 4,560 amino acids is expressed and secreted early in development by the subcommissural organ (SCO), an ependymal differentiation located in the roof of the Sylvian aqueduct...
  3. Huh M, Todd M, Picketts D. SCO-ping out the mechanisms underlying the etiology of hydrocephalus. Physiology (Bethesda). 2009;24:117-26 pubmed publisher
    ..and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells...
  4. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, et al. SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. J Cell Sci. 1996;109 ( Pt 5):1053-61 pubmed
    ..SCO-spondin corresponds to glycoproteins secreted by the subcommissural organ (SCO), an ependymal differentiation of the vertebrate brain located at the entrance to the Sylvian aqueduct...
  5. Dietrich P, Shanmugasundaram R, Shuyu E, Dragatsis I. Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum Mol Genet. 2009;18:142-50 pubmed publisher
    ..Our results show that hydrocephalus in mice lacking htt in Wnt1 cell lineages is associated with increase in CSF production by the choroid plexus, and abnormal subcommissural organ.
  6. Nakajima M, Matsuda K, Miyauchi N, Fukunaga Y, Watanabe S, Okuyama S, et al. Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages. Brain Res. 2011;1382:275-81 pubmed publisher
    ..Here we show that conditional inactivation of PS1 in Wnt1 cell lineages results in congenital hydrocephalus and subcommissural organ abnormalities, suggesting a possible role of PS1 in the regulation of cerebrospinal fluid homeostasis.
  7. El Bitar F, Dastugue B, Meiniel A. Neuroblastoma B104 cell line as a model for analysis of neurite outgrowth and neuronal aggregation induced by Reissner's fiber material. Cell Tissue Res. 1999;298:233-42 pubmed
    The subcommissural organ (SCO) is a specialized ependymal structure of the brain that secretes glycoproteins into the cerebrospinal fluid (CSF), which condense to form a thread-like structure - Reissner's fiber (RF)...
  8. Fernández Llebrez P, Perez J, Nadales A, Pérez Fígares J, Rodriguez E. Vascular and leptomeningeal projections of the subcommissural organ in reptiles. Lectin-histochemical, immunocytochemical, and ultrastructural studies. Histochemistry. 1987;87:607-14 pubmed
    ..snake, Natrix maura, and the turtle, Mauremys caspica, the basal processes of the ependymal cells of the subcommissural organ project toward the local blood vessels and the leptomeninges...
  9. Petrov T, Howarth A, Krukoff T, Stevenson B. Distribution of the tight junction-associated protein ZO-1 in circumventricular organs of the CNS. Brain Res Mol Brain Res. 1994;21:235-46 pubmed
    ..The subcommissural organ, known to contain a blood-brain barrier, also displayed continuous ZO-1 staining in blood vessels...
  10. Hoyo Becerra C, Lopez Avalos M, Alcaide Gavilán M, Gómez Roldán M, Perez J, Fernández Llebrez P, et al. Reissner's fiber formation depends on developmentally regulated factors extrinsic to the subcommissural organ. Cell Tissue Res. 2005;321:429-41 pubmed
    ..RF develops by the assembly of glycoproteins released into the cerebrospinal fluid (CSF) by the subcommissural organ (SCO). SCO cells differentiate early during embryonic development...
  11. Heim S, Sill M, Jones D, Vasiljevic A, Jouvet A, Fèvre Montange M, et al. Papillary Tumor of the Pineal Region: A Distinct Molecular Entity. Brain Pathol. 2016;26:199-205 pubmed publisher
    ..overexpressed in PTPR as compared with ependymal tumors included SPDEF, known to be expressed in the rodent subcommissural organ. Notable SPDEF protein expression was encountered in 15/19 PTPRs as compared with only 2/36 ependymal ..
  12. Meiniel A. SCO-spondin, a glycoprotein of the subcommissural organ/Reissner's fiber complex: evidence of a potent activity on neuronal development in primary cell cultures. Microsc Res Tech. 2001;52:484-95 pubmed
    In the cattle, SCO-spondin was shown to be a brain-secreted glycoprotein specifically expressed in the subcommissural organ (SCO), an ependymal differentiation located in the roof of the Sylvian aqueduct...
  13. Ortega E, Muñoz R, Luza N, Guerra F, Guerra M, Vio K, et al. The value of early and comprehensive diagnoses in a human fetus with hydrocephalus and progressive obliteration of the aqueduct of Sylvius: Case Report. BMC Neurol. 2016;16:45 pubmed publisher
    Mutant rodent models have highlighted the importance of the ventricular ependymal cells and the subcommissural organ (a brain gland secreting glycoproteins into the cerebrospinal fluid) in the development of fetal onset hydrocephalus...
  14. Lu K, Peracchia C. Freeze-fracture studies on the subcommissural organ tight junction in gerbils and mice. Proc Natl Sci Counc Repub China B. 1987;11:289-96 pubmed
    Freeze-fracture studies on the tight junction of ependymal cells in the gerbil and mouse subcommissural organ (SCO) show an obvious species-specific variation...
  15. Cifuentes M, Perez J, Grondona J, Fernández Llebrez P. Seasonal variation in the secretory activity of the subcommissural organ (SCO) of reptiles. Neurosci Lett. 1996;219:9-12 pubmed
    Seasonal variations in the secretory activity of the subcommissural organ (SCO) of snakes and turtles was studied by immunocytochemistry, lectins, and electron microscopy...
  16. Perez J, Garrido O, Cifuentes M, Alonso F, Estivill Torrus G, Eller G, et al. Bovine Reissner's fiber (RF) and the central canal of the spinal cord: an immunocytochemical study using a set of monoclonal antibodies against the RF-glycoproteins. Cell Tissue Res. 1996;286:33-42 pubmed
    The subcommissural organ secretes N-linked complex-type glycoproteins into the cerebrospinal fluid. These glycoproteins condense to form Reissner's fiber (RF), which extends along the fourth ventricle and central canal of the spinal cord...
  17. Lehmann C, Naumann W. Axon pathfinding and the floor plate factor Reissner's substance in wildtype, cyclops and one-eyed pinhead mutants of Danio rerio. Brain Res Dev Brain Res. 2005;154:1-14 pubmed
    ..This glycoprotein is also produced by the dorsal median subcommissural organ (SCO)...
  18. Lu K, Chiang H, Lin H. Fine structural and cytochemical studies on the hamster subcommissural organ. Proc Natl Sci Counc Repub China B. 1987;11:297-306 pubmed
    The subcommissural organ (SCO) of the golden hamster (Mesocricetus auratus) was studied by conventional electron microscopy, freeze-fracture technique, zinc-iodide-osmium (ZIO) and acid phosphatase cytochemical reactions...
  19. Rodriguez E, Rodriguez S, Schoebitz K, Yulis C, Hoffmann P, Manns V, et al. Light- and electron-microscopic investigation of the rat subcommissural organ grafted under the kidney capsule, with particular reference to immunocytochemistry and lectin histochemistry. Cell Tissue Res. 1989;258:499-514 pubmed
    ..rat, a serotonin-mediated neural input may have an inhibitory influence on the secretory activity of the subcommissural organ (SCO)...
  20. Caprile T, Osorio G, Henriquez J, Montecinos H. Polarized expression of integrin beta1 in diencephalic roof plate during chick development, a possible receptor for SCO-spondin. Dev Dyn. 2009;238:2494-504 pubmed publisher
    ..caudal diencephalon is formed by the posterior commissure (PC) and the underlying secretory ependyma, the subcommissural organ (SCO)...
  21. Schöniger S, Maronde E, Kopp M, Korf H, Nurnberger F. Transcription factor CREB and its stimulus-dependent phosphorylation in cell and explant cultures of the bovine subcommissural organ. Cell Tissue Res. 2002;308:131-42 pubmed
    The subcommissural organ (SCO) is an ependymal brain gland that synthesizes and secretes glycoproteins. Very little is known about the signal transduction cascades operating in this organ and their impact on gene expression...
  22. Didier R, Dastugue B, Meiniel A. The secretory material of the subcommissural organ of the chick embryo. Characterization of a specific polypeptide by two-dimensional electrophoresis. Int J Dev Biol. 1995;39:493-9 pubmed
    The subcommissural organ (SCO) is a cerebral gland that releases into the cerebrospinal fluid a carbohydrate-rich glycoprotein which condenses to form Reissner's fiber (RF)...
  23. Szathmari A, Champier J, Ghersi Egea J, Jouvet A, Watrin C, Wierinckx A, et al. Molecular characterization of circumventricular organs and third ventricle ependyma in the rat: potential markers for periventricular tumors. Neuropathology. 2013;33:17-29 pubmed publisher
    ..Some of these organs, such as the pineal gland (PG), subcommissural organ (SCO), and organum vasculosum of the lamina terminalis, might be the sites of origin of periventricular ..
  24. Takeuchi I, Kimura R, Shoji R. Dysplasia of subcommissural organ in congenital hydrocephalus spontaneously occurring in CWS/Idr rats. Experientia. 1988;44:338-40 pubmed
    The subcommissural organ (SCO) of the congenital hydrocephalus spontaneously occurring in CWS/Idr rats was severely reduced in size and displaced at some distance from the anterior end of the cerebral aqueduct...
  25. Balaban C, Schuerger R, Severs W. Evidence for a noradrenergic projection to the subcommissural organ. Neurosci Lett. 1994;180:209-13 pubmed
    Several physiological studies have shown that the subcommissural organ (SCO) is influenced by catecholamines. This study provides immunohistochemical evidence for a noradrenergic input to the SCO of rats...
  26. Hoyo Becerra C, López Ávalos M, Cifuentes M, Visser R, Fernández Llebrez P, Grondona J. The subcommissural organ and the development of the posterior commissure in chick embryos. Cell Tissue Res. 2010;339:383-95 pubmed publisher
    The subcommissural organ (SCO) is an ependymal differentiation located in the diencephalon under the posterior commissure (PC)...
  27. Biosca A, Azcoitia I. Evidence for apical secretion in the subcommissural organ of the chicken (Gallus gallus). J Hirnforsch. 1989;30:265-71 pubmed
    The apical surface and apical cytoplasm of the ependymal cells of the subcommissural organ (SCO) of the chicken, Gallus gallus were investigated by scanning and transmission electron microscopy...
  28. Redecker P. Immunohistochemical localization of glial fibrillary acidic protein (GFAP) and vimentin in the subcommissural organ of the Mongolian gerbil (Meriones unguiculatus). Cell Tissue Res. 1989;255:595-600 pubmed
    The chemical composition of intermediate filaments (IF's) in the ependyma of the subcommissural organ (SCO) of the Mongolian gerbil (Meriones unguiculatus) was investigated immunohistochemically in paraffin-embedded tissue...
  29. Rodriguez E, Rodriguez S, Hein S. The subcommissural organ. Microsc Res Tech. 1998;41:98-123 pubmed
    The subcommissural organ (SCO) is a phylogenetically ancient and conserved structure. During ontogeny, it is one of the first brain structures to differentiate...
  30. Gonzalez C, Garces G, Saez J, Schöbitz K, Rodriguez E. The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions. Neurosci Lett. 1999;262:175-8 pubmed
    The subcommissural organ (SCO) is a circunventricular organ secreting glycoproteins into the ventricle...
  31. Kundurovic Z, Dilberovic F, Kulenovic A. [Characteristics of the ependyma in various parts of the subcommissural organs in rats]. Med Arh. 1998;52:185-7 pubmed
    In this work the authors have researched ependyma of some parts of subcommissural organ of rats by optic microscopy. 4% formaldehyde was injected in vivo in carotid arteries...
  32. Schöniger S, Wehming S, Gonzalez C, Schöbitz K, Rodriguez E, Oksche A, et al. The dispersed cell culture as model for functional studies of the subcommissural organ: preparation and characterization of the culture system. J Neurosci Methods. 2001;107:47-61 pubmed
    The subcommissural organ (SCO) is an enigmatic secretory gland of the brain, which is believed to be derived from ependymal (glial) precursor cells...
  33. Saha S, Jain M, Subhedar N. Subcommissural organ-Reissner's fiber complex of the teleost Clarias batrachus responds to GABA treatment. Brain Res. 2000;852:335-43 pubmed
    b>Subcommissural organ (SCO) is a highly specialized ependymal gland located in the roof of the third ventricle...
  34. Caprile T, Hein S, Rodriguez S, Montecinos H, Rodriguez E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. Brain Res Mol Brain Res. 2003;110:177-92 pubmed
    The subcommissural organ (SCO) is a brain gland that secretes glycoproteins into the cerebrospinal fluid (CSF), where they subsequently aggregate to form Reissner fiber (RF)...
  35. Schafer H, Blum V. Studies on the subcommissural organ of Salmo gairdneri. J Morphol. 1988;196:345-51 pubmed
    The light microscopic analysis of serial sections of the subcommissural organ (SCO) of the rainbow trout (Salmo gairdneri) shows that the form of the groove-like (in cross section) organ varies over its total length...
  36. Laalaoui A, Ahboucha S, Didier Bazes M, Fevre Montange M, Meiniel A, Gamrani H. Postnatal secretion of the subcommissural organ of the Meriones shawi: control of serotonin innervation. Brain Res Dev Brain Res. 2001;126:75-80 pubmed
    The postnatal development of the subcommissural organ (SCO) glycoprotein secretion in form of Reissner's fiber and the putative control of the serotonin innervation upon the SCO activity were examined by immunohistochemistry in the semi-..
  37. Kecman M, Somer L, Matavulj M. [Histological picture of the subcommissural organ in chronic alcoholism in rats]. Med Pregl. 1990;43:290-2 pubmed
    ..The changes obtained corroborate the idea of an active engagement of the SCO in the course of chronic alcohol consumption by experimental rats. ..
  38. Meiniel R, Molat J, Duchier Liris N, Meiniel A. Ontogenesis of the secretory epithelium of the bovine subcommissural organ. A histofluorescence study using lectins and monoclonal antibodies. Brain Res Dev Brain Res. 1990;55:171-80 pubmed
    ..analysis of the differentiation of a group of specialized (secretory) ependymal cells in the subcommissural organ (SCO) of the brain was undertaken in the bovine using a monoclonal antibody (C1B8A8) which is specific of ..
  39. El Emam Dief A, Caldwell J, Jirikowski G. Colocalization of p450 aromatase and oxytocin immunostaining in the rat hypothalamus. Horm Metab Res. 2013;45:273-6 pubmed publisher
    ..Our findings suggest that systemic androgens may be aromatized to estrogens in male oxytocinergic neurons linked to the limbic system. ..
  40. Saha S, Subhedar N. Calcitonin-like immunoreactivity in the subcommissural organ-Reissner's fiber complex of some freshwater and marine teleosts. J Chem Neuroanat. 2011;41:122-8 pubmed publisher
    The subcommissural organ (SCO) is a highly specialised circumventricular ependymal organ covering and penetrating the posterior commissure. The secretory products of the SCO condense to form Reissner's fiber (RF)...
  41. Meiniel A, Molat J, Meiniel R. Complex-type glycoproteins synthesized in the subcommissural organ of mammals. Light- and electron-microscopic investigations by use of lectins. Cell Tissue Res. 1988;253:383-95 pubmed
    The secretory activity in the subcommissural organ (SCO) of the sheep and cow was examined by means of lectin histochemistry and cytochemistry. Among the various lectins tested...
  42. Hung Tsai M, Hsiang Wu C, Pin Chen W, Yung Shieh J, Yuan Wen C. Novel distribution of calcitonin gene-related peptide in rodent subcommissural organs. Neuroreport. 2003;14:1851-6 pubmed
    ..A species difference in the CGRP distributions of rodents SCOs may therefore imply its different synthesis rates or release pathways. ..
  43. Pérez Fígares J, Jimenez A, Perez Martin M, Fernández Llebrez P, Cifuentes M, Riera P, et al. Spontaneous congenital hydrocephalus in the mutant mouse hyh. Changes in the ventricular system and the subcommissural organ. J Neuropathol Exp Neurol. 1998;57:188-202 pubmed
    The subcommissural organ is an ependymal gland located at the entrance of the cerebral aqueduct. It secretes glycoproteins into the cerebrospinal fluid, where they aggregate to form Reissner's fiber...
  44. Viehweg J, Naumann W. Radial secretory glia conserved in the postnatal vertebrate brain: a study in the rat. Anat Embryol (Berl). 1996;194:355-63 pubmed
    ..glial cells in the roof of the last diencephalic prosomer, ependymocytes and hypendymocytes, form the subcommissural organ. The cells of this complex were labelled immunocytochemically, using an antiserum against their specific ..
  45. Bermudez Silva F, Perez J, Cifuentes M, Perez Martin M, Grondona J, Lopez Avalos M, et al. A sensitive method to analyse the effect of putative regulatory ligands on the release of glycoprotein from primary cultures of dispersed bovine subcommissural organ cells. J Neurosci Methods. 2010;191:239-43 pubmed publisher
    The subcommissural organ (SCO) releases into the cerebrospinal fluid (CSF) large glycoproteins that polymerize forming the Reissner's fibre (RF), which is involved in CSF circulation and homeostasis...
  46. Rodriguez S, Caprile T. Functional aspects of the subcommissural organ-Reissner's fiber complex with emphasis in the clearance of brain monoamines. Microsc Res Tech. 2001;52:564-72 pubmed
    ..It grows continuously in the caudal direction by addition of newly released glycoproteins by the subcommissural organ (SCO) to its proximal end. Several hypotheses about RF function have been advanced...
  47. Bermúdez Silva F, Leon Quinto T, Martin F, Soria B, Nadal A, Perez J, et al. Bovine subcommissural organ displays spontaneous and synchronous intracellular calcium oscillations. Brain Res. 2003;977:90-6 pubmed
    The subcommissural organ (SCO) is an ependymal brain gland that secretes into the cerebrospinal fluid glycoproteins that polymerize, forming Reissner's fiber (RF)...
  48. Schöbitz K, Gonzalez C, Peruzzo B, Yulis C, Rodriguez E. Organ culture of the bovine subcommissural organ: evidence for synthesis and release of the secretory material. Microsc Res Tech. 2001;52:496-509 pubmed
    The subcommissural organ (SCO) is a brain circumventricular organ formed by ependymal and hypendymal secretory cells...
  49. Meiniel A. The secretory ependymal cells of the subcommissural organ: which role in hydrocephalus?. Int J Biochem Cell Biol. 2007;39:463-8 pubmed
    ..system gives rise to several specialized cell types, including the secretory ependymal cells located in the subcommissural organ. These elongated cells show large cisternae in their cytoplasm, which are filled with material secreted ..
  50. Laalaoui A, Chouaf L, Didier Bazes M, Geffard M, Belin M, Gamrani H. GABA uptake and phenotypic characteristics of the subcommissural ependymocytes of the semi-desertic rodent, Meriones shawi: correlation with serotoninergic innervation. Cell Tissue Res. 1996;285:435-43 pubmed
    ..have emphasized species differences in the serotoninergic innervation and phenotypic characteristics of the subcommissural organ in mammals...
  51. El Hiba O, Gamrani H, Ahboucha S. Increased Reissner's fiber material in the subcommissural organ and ventricular area in bile duct ligated rats. Acta Histochem. 2012;114:673-81 pubmed publisher
    ..Among the circumventricular organs, the subcommissural organ secretes a glycoprotein known as Reissner's fiber, which condenses and forms an ever-growing thread-like ..
  52. Meiniel R, Creveaux I, Dastugue B, Meiniel A. Specific transcripts analysed by in situ hybridization in the subcommissural organ of bovine embryos. Cell Tissue Res. 1995;279:101-7 pubmed
    The subcommissural organ (SCO) secretes specific glycoproteins into the cerebrospinal fluid that aggregate to constitute Reissner's fiber (RF), a thread-like structure running along the central canal of the spinal cord...
  53. Benammi H, El Hiba O, Gamrani H. Evidence of a subcommissural organ involvement in the brain response to lead exposure and a modulatory potential of curcumin. Neuroreport. 2016;27:264-71 pubmed publisher
    ..In the present study, we aimed to assess: (i) The subcommissural organ (SCO) responsiveness as a secretory circumventricular organ to chronic and acute Pb intoxication together ..