progressive supranuclear palsy

Summary

Summary: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

Top Publications

  1. Golbe L, Ohman Strickland P. A clinical rating scale for progressive supranuclear palsy. Brain. 2007;130:1552-65 pubmed
    We devised a Progressive Supranuclear Palsy (PSP) Rating Scale comprising 28 items in six categories: daily activities (by history), behaviour, bulbar, ocular motor, limb motor and gait/midline...
  2. Gibb G, De Silva R, Revesz T, Lees A, Anderton B, Hanger D. Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy. Brain Res Mol Brain Res. 2004;121:95-101 pubmed
    We found previously that aggregated insoluble tau protein in progressive supranuclear palsy (PSP) brains exhibits a heterogeneous pattern that is not segregated by the type of clinical presentation...
  3. Tuite P, Clark H, Bergeron C, Bower M, St George Hyslop P, Mateva V, et al. Clinical and pathologic evidence of corticobasal degeneration and progressive supranuclear palsy in familial tauopathy. Arch Neurol. 2005;62:1453-7 pubmed
    Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are neurodegenerative tauopathies. Sporadic and familial cases of PSP and CBD have been noted, but both have not been reported in a single family.
  4. Ghosh B, Rowe J, Calder A, Hodges J, Bak T. Emotion recognition in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2009;80:1143-5 pubmed publisher
    b>Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome characterised by akinesis, rigidity, falls, supranuclear gaze palsy and cognitive, particularly executive, dysfunction...
  5. Lorenzl S, Albers D, Chirichigno J, Augood S, Beal M. Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy. J Neurol Sci. 2004;218:39-45 pubmed
    ..as well as their endogenous tissue inhibitors (TIMPs) in postmortem brain tissue from 13 patients with progressive supranuclear palsy (PSP) and 8 age-matched controls...
  6. Pasinetti G, Ksiezak Reding H, Santa Maria I, Wang J, Ho L. Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. J Neurochem. 2010;114:1557-68 pubmed publisher
    A diverse group of neurodegenerative diseases - including progressive supranuclear palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, ..
  7. Kertesz A, Munoz D. Relationship between frontotemporal dementia and corticobasal degeneration/progressive supranuclear palsy. Dement Geriatr Cogn Disord. 2004;17:282-6 pubmed
    b>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were described as separate entities, but prior to that an extrapyramidal variety of Pick's disease was recognized...
  8. Yang W, Woltjer R, Sokal I, Pan C, Wang Y, Brodey M, et al. Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy. Am J Pathol. 2007;171:993-1002 pubmed
    ..We extended our assays to include a limited number of cases of progressive supranuclear palsy (PSP) and dementia with Lewy bodies; we observed increased abnormal tau but not SNCA in PSP, and ..
  9. VanVoorst W, Greenaway M, Boeve B, Ivnik R, Parisi J, Eric Ahlskog J, et al. Neuropsychological findings in clinically atypical autopsy confirmed corticobasal degeneration and progressive supranuclear palsy. Parkinsonism Relat Disord. 2008;14:376-8 pubmed

More Information

Publications62

  1. Kanazawa M, Shimohata T, Toyoshima Y, Tada M, Kakita A, Morita T, et al. Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study. Mov Disord. 2009;24:1312-8 pubmed publisher
    The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed...
  2. Ros R, Gomez Garre P, Hirano M, Tai Y, Ampuero I, Vidal L, et al. Genetic linkage of autosomal dominant progressive supranuclear palsy to 1q31.1. Ann Neurol. 2005;57:634-41 pubmed
    b>Progressive supranuclear palsy (PSP) is a disorder of unknown pathogenesis. Familial clusters of PSP have been reported related to mutations of protein tau...
  3. Rivaud Pechoux S, Vidailhet M, Brandel J, Gaymard B. Mixing pro- and antisaccades in patients with parkinsonian syndromes. Brain. 2007;130:256-64 pubmed
    ..of patients with parkinsonian syndromes, Parkinson's disease, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), and in a control group. Saccade tasks were performed in single-task blocks (i.e...
  4. Welter M, Do M, Chastan N, Torny F, Bloch F, du Montcel S, et al. Control of vertical components of gait during initiation of walking in normal adults and patients with progressive supranuclear palsy. Gait Posture. 2007;26:393-9 pubmed
    ..This study examined the initiation of gait in patients with progressive supranuclear palsy (PSP, n=10), characterized by the presence of severe postural instability, and controls (n=43)...
  5. Steffen T, Boeve B, Mollinger Riemann L, Petersen C. Long-term locomotor training for gait and balance in a patient with mixed progressive supranuclear palsy and corticobasal degeneration. Phys Ther. 2007;87:1078-87 pubmed
    b>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are slowly progressive tauopathies characterized by impaired balance, disturbances in gait, and frequent falls, among other features...
  6. Murphy K, Karaconji T, Hardman C, Halliday G. Excessive dopamine neuron loss in progressive supranuclear palsy. Mov Disord. 2008;23:607-10 pubmed publisher
    b>Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra...
  7. Papapetropoulos S, Singer C, McCorquodale D, Gonzalez J, Mash D. Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP). Parkinsonism Relat Disord. 2005;11:459-63 pubmed
    ..of this study was to investigate the causes and seasonality of death and co-morbid conditions among progressive supranuclear palsy (PSP) patients...
  8. Suzuki K, Miyamoto T, Miyamoto M, Hirata K. The core body temperature rhythm is altered in progressive supranuclear palsy. Clin Auton Res. 2009;19:65-8 pubmed publisher
    We measured circadian rhythmicity in rectal temperature change and found that the amplitude of body temperature was significantly reduced in patients with progressive supranuclear palsy compared to those with Parkinson disease.
  9. Paviour D, Schott J, Stevens J, Revesz T, Holton J, Rossor M, et al. Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2004;75:1772-5 pubmed
    Most magnetic resonance imaging (MRI) studies of progressive supranuclear palsy (PSP) are cross-sectional and lack post mortem confirmation of the diagnosis...
  10. Lindemann U, Nicolai S, Beische D, Becker C, Srulijes K, Dietzel E, et al. Clinical and dual-tasking aspects in frequent and infrequent fallers with progressive supranuclear palsy. Mov Disord. 2010;25:1040-6 pubmed publisher
    b>Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with no sufficient therapeutic options to date. Falls are the most devastating feature. The causes of these falls are not well understood...
  11. Zampieri C, Di Fabio R. Improvement of gaze control after balance and eye movement training in patients with progressive supranuclear palsy: a quasi-randomized controlled trial. Arch Phys Med Rehabil. 2009;90:263-70 pubmed publisher
    One of the main oculomotor findings in progressive supranuclear palsy (PSP) is the inability to saccade downward. In addition, people with PSP have difficulty suppressing fixation, which may contribute to vertical gaze palsy...
  12. Webb A, Miller B, Bonasera S, Boxer A, Karydas A, Wilhelmsen K. Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders. Arch Neurol. 2008;65:1473-8 pubmed publisher
    ..Due to the inversion, an exact causal locus has been difficult to identify, but the microtubule-associated protein tau gene is a likely candidate gene for its involvement in these diseases with tau inclusion...
  13. Pittman A, Myers A, Abou Sleiman P, Fung H, Kaleem M, Marlowe L, et al. Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet. 2005;42:837-46 pubmed
    The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).
  14. Ito K, Arai K, Yoshiyama Y, Kashiwado K, Sakakibara Y, Hattori T. Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy. Acta Neuropathol. 2008;115:623-8 pubmed publisher
    Tufted astrocytes (TAs) are considered reliable, specific markers for the neuropathologic diagnosis of progressive supranuclear palsy (PSP)...
  15. Slowinski J, Imamura A, Uitti R, Pooley R, Strongosky A, Dickson D, et al. MR imaging of brainstem atrophy in progressive supranuclear palsy. J Neurol. 2008;255:37-44 pubmed
    To enhance the sensitivity and specificity of the clinical diagnosis of progressive supranuclear palsy (PSP), neuroradiological parameters established in pathologically proven cases are needed.
  16. Eckert T, Sailer M, Kaufmann J, Schrader C, Peschel T, Bodammer N, et al. Differentiation of idiopathic Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging. Neuroimage. 2004;21:229-35 pubmed
    The differentiation of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) from idiopathic Parkinson's disease (IPD) is difficult...
  17. Cotter C, Armytage T, Crimmins D. The use of zolpidem in the treatment of progressive supranuclear palsy. J Clin Neurosci. 2010;17:385-6 pubmed publisher
    b>Progressive supranuclear palsy (PSP) is a debilitating progressive neurodegenerative disorder for which there is no proven pharmacological treatment...
  18. Quattrone A, Nicoletti G, Messina D, Fera F, Condino F, Pugliese P, et al. MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 2008;246:214-21 pubmed
    ..pons, middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) for differentiating progressive supranuclear palsy (PSP) from Parkinson disease (PD) and Parkinson variant of multiple system atrophy (MSA-P), with ..
  19. Gama R, Távora D, Bomfim R, Silva C, de Bruin V, de Bruin P. Sleep disturbances and brain MRI morphometry in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy - a comparative study. Parkinsonism Relat Disord. 2010;16:275-9 pubmed publisher
    ..study evaluated and compared sleep disturbances in patients with PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and analyzed associations with brain magnetic resonance imaging (MRI) morphometry...
  20. Warnecke T, Oelenberg S, Teismann I, Hamacher C, Lohmann H, Ringelstein E, et al. Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy. Mov Disord. 2010;25:1239-45 pubmed publisher
    Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia...
  21. Kertesz A, Blair M, McMonagle P, Munoz D. The diagnosis and course of frontotemporal dementia. Alzheimer Dis Assoc Disord. 2007;21:155-63 pubmed
    ..6%, Primary Progressive Aphasia (PPA) 31.6%, possible PPA 10.6%, Corticobasal Syndrome (CBDS) and Progressive Supranuclear Palsy (PSP) 8.1%, Semantic Dementia (SD) 6.6%, and possible FTD 5.3%...
  22. Paviour D, Lees A, Josephs K, Ozawa T, Ganguly M, Strand C, et al. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Brain. 2004;127:2441-51 pubmed
    ..A diagnosis of progressive supranuclear palsy (PSP) had been considered in all three cases at initial presentation...
  23. Lang A. Treatment of progressive supranuclear palsy and corticobasal degeneration. Mov Disord. 2005;20 Suppl 12:S83-91 pubmed
    Success in treating patients with progressive supranuclear palsy and corticobasal degeneration remains exceedingly low...
  24. Garbutt S, Riley D, Kumar A, Han Y, Harwood M, Leigh R. Abnormalities of optokinetic nystagmus in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2004;75:1386-94 pubmed
    To measure vertical and horizontal responses to optokinetic (OK) stimulation and investigate directional abnormalities of quick phases in progressive supranuclear palsy (PSP).
  25. Halliday G, Macdonald V, Henderson J. A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease. Brain. 2005;128:2272-80 pubmed
    ..cortical activation are associated with the major symptoms observed in both Parkinson's disease and progressive supranuclear palsy (PSP)...
  26. Zampieri C, Di Fabio R. Progressive supranuclear palsy: disease profile and rehabilitation strategies. Phys Ther. 2006;86:870-80 pubmed
  27. Borroni B, Gardoni F, Parnetti L, Magno L, Malinverno M, Saggese E, et al. Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiol Aging. 2009;30:34-40 pubmed
    ..No CSF marker for progressive supranuclear palsy (PSP) is currently available...
  28. Rohrer J, Paviour D, Bronstein A, O Sullivan S, Lees A, Warren J. Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis. Mov Disord. 2010;25:179-188 pubmed publisher
    ..currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities...
  29. Josephs K, Petersen R, Knopman D, Boeve B, Whitwell J, Duffy J, et al. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology. 2006;66:41-8 pubmed
    To examine the relationship between early clinical features, pathologies, and biochemistry of the frontotemporal lobar degenerations (FTLDs), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD).
  30. Weiner W. A differential diagnosis of Parkinsonism. Rev Neurol Dis. 2005;2:124-31 pubmed
    ..review discusses the key clinical features of these various syndromes, including Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, corticobasal ganglionic degeneration, Lewy body disease, vascular ..
  31. Murphy M, Friedman J, Tetrud J, Factor S. Neurodegenerative disorders mimicking progressive supranuclear palsy: a report of three cases. J Clin Neurosci. 2005;12:941-5 pubmed
    b>Progressive supranuclear palsy (PSP) is rarely confused with other parkinsonian disorders once the vertical gaze palsy appears. Corticobasal degeneration is the most common differential diagnostic entity...
  32. Stamelou M, Pilatus U, Reuss A, Magerkurth J, Eggert K, Knake S, et al. In vivo evidence for cerebral depletion in high-energy phosphates in progressive supranuclear palsy. J Cereb Blood Flow Metab. 2009;29:861-70 pubmed publisher
    Indirect evidence from laboratory studies suggests that mitochondrial energy metabolism is impaired in progressive supranuclear palsy (PSP), but brain energy metabolism has not yet been studied directly in vivo in a comprehensive manner ..
  33. Arnulf I, Merino Andreu M, Bloch F, Konofal E, Vidailhet M, Cochen V, et al. REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep. 2005;28:349-54 pubmed
    ..rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects.
  34. Bartolo M, Serrao M, Perrotta A, Tassorelli C, Sandrini G, Pierelli F. Lack of trigemino-cervical reflexes in progressive supranuclear palsy. Mov Disord. 2008;23:1475-9 pubmed publisher
    ..Because extensive neuronal degeneration at brainstem level has been demonstrated in progressive supranuclear palsy (PSP), in this pilot study we evaluated the TCR responses in 12 subjects with PSP, and in 16 healthy ..
  35. Antonini A, Benti R, De Notaris R, Tesei S, Zecchinelli A, Sacilotto G, et al. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Neurol Sci. 2003;24:149-50 pubmed
    ..70 patients with Parkinson's disease (PD), 10 with multiple system atrophy (MSA-P type), and 10 with progressive supranuclear palsy (PSP). Data were compared with 12 age-matched control subjects...
  36. Ozsancak C, Auzou P, Dujardin K, Quinn N, Destee A. Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy and Parkinson's disease. J Neurol. 2004;251:1317-23 pubmed
  37. O Sullivan S, Massey L, Williams D, Silveira Moriyama L, Kempster P, Holton J, et al. Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain. 2008;131:1362-72 pubmed publisher
    Prognostic predictors have not been defined for progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). Subtypes of both disorders have been proposed on the basis of early clinical features...
  38. Price S, Paviour D, Scahill R, Stevens J, Rossor M, Lees A, et al. Voxel-based morphometry detects patterns of atrophy that help differentiate progressive supranuclear palsy and Parkinson's disease. Neuroimage. 2004;23:663-9 pubmed
    b>Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) are neurodegenerative diseases with distinctive pathological appearances. Early clinical diagnosis can be difficult...
  39. Paviour D, Thornton J, Lees A, Jager H. Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy. Mov Disord. 2007;22:68-74 pubmed
    b>Progressive supranuclear palsy (PSP) and the parkinsonian variant of multiple-system atrophy (MSA-P) may present with a similar phenotype...
  40. Williams D, Lees A, Wherrett J, Steele J. J. Clifford Richardson and 50 years of progressive supranuclear palsy. Neurology. 2008;70:566-73 pubmed publisher
    To trace the historical events leading to Richardson's clinical description of progressive supranuclear palsy (PSP) in the context of subsequent observations of its clinical heterogeneity and pathologic overlap with other tauopathies.
  41. Boxer A, Geschwind M, Belfor N, GORNO TEMPINI M, Schauer G, Miller B, et al. Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy. Arch Neurol. 2006;63:81-6 pubmed
    Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease.
  42. Ingelsson M, Ramasamy K, Russ C, Freeman S, Orne J, Raju S, et al. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathol. 2007;114:471-9 pubmed
    ..alter the ratio between four (4R tau) and three (3R tau) repeat tau isoforms whereas cases with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) mainly have 4R tau brain pathology...
  43. Nicoletti G, Tonon C, Lodi R, Condino F, Manners D, Malucelli E, et al. Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease. Mov Disord. 2008;23:2370-6 pubmed publisher
    The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system ..
  44. Brown R, Lacomblez L, Landwehrmeyer B, Bak T, Uttner I, Dubois B, et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain. 2010;133:2382-93 pubmed publisher
    ..a prevalent cohort of patients with a clinical diagnosis of either multiple system atrophy (n=372) or progressive supranuclear palsy (n=311) from the Neuroprotection and Natural History in Parkinson Plus Syndromes cohort...
  45. Kertesz A. Pick Complex: an integrative approach to frontotemporal dementia: primary progressive aphasia, corticobasal degeneration, and progressive supranuclear palsy. Neurologist. 2003;9:311-7 pubmed
    ..Recently, chromosome 17 localization and tau mutations were discovered in familial forms of the disease...
  46. Puig B, Rey M, Ferrer I. Individual and regional variations of phospho-tau species in progressive supranuclear palsy. Acta Neuropathol. 2005;110:261-8 pubmed
  47. Ito S, Makino T, Shirai W, Hattori T. Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy. Neuroradiology. 2008;50:981-5 pubmed publisher
    b>Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction...
  48. Seppi K, Scherfler C, Donnemiller E, Virgolini I, Schocke M, Goebel G, et al. Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis. Arch Neurol. 2006;63:1154-60 pubmed
    ..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent...
  49. Keith Rokosh J, Ang L. Progressive supranuclear palsy: a review of co-existing neurodegeneration. Can J Neurol Sci. 2008;35:602-8 pubmed
    The neuropathological findings of 32 progressive supranuclear palsy (PSP) cases over a period of 17 years were reviewed.
  50. Silveira Moriyama L, Hughes G, Church A, Ayling H, Williams D, Petrie A, et al. Hyposmia in progressive supranuclear palsy. Mov Disord. 2010;25:570-7 pubmed publisher
    Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP)...
  51. Chiu W, Kaat L, Seelaar H, Rosso S, Boon A, Kamphorst W, et al. Survival in progressive supranuclear palsy and frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2010;81:441-5 pubmed publisher
    To compare survival and to identify prognostic predictors for progressive supranuclear palsy and frontotemporal dementia.
  52. Soliveri P, Piacentini S, Girotti F. Limb apraxia in corticobasal degeneration and progressive supranuclear palsy. Neurology. 2005;64:448-53 pubmed
    Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) share pathologic features, and cortical and subcortical signs...
  53. Pittman A, Myers A, Duckworth J, Bryden L, Hanson M, Abou Sleiman P, et al. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Hum Mol Genet. 2004;13:1267-74 pubmed
    ..The more common haplotype H1 is over-represented in patients with progressive supranuclear palsy (PSP) and corticobasal degeneration...