central nervous system

Summary

Summary: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.

Top Publications

  1. Barichello T, Generoso J, Milioli G, Elias S, Teixeira A. Pathophysiology of bacterial infection of the central nervous system and its putative role in the pathogenesis of behavioral changes. Braz J Psychiatry. 2013;35:81-7 pubmed
    Invasion of the central nervous system (CNS) by microorganisms is a severe and frequently fatal event during the course of many infectious diseases...
  2. Yuen T, Johnson K, Miron V, Zhao C, Quandt J, Harrisingh M, et al. Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. Brain. 2013;136:1035-47 pubmed publisher
    ..Our work therefore identifies endothelin 2 and the endothelin receptor type B as a regenerative pathway and suggests that endothelin receptor type B agonists represent a promising therapeutic approach to promote myelin regeneration. ..
  3. Yubero Lahoz S, Robledo P, Farre M, de laTorre R. Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system. Curr Med Chem. 2013;20:1382-96 pubmed
    ..Outside the central nervous system, it is also present in platelets, where it takes up 5-HT from plasma, keeping levels very low (i.e...
  4. Katz D, Liu W, Locke C, Jacobson P, Barnes D, Basu R, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3:e295 pubmed publisher
    ..One milligram of ABT-384 daily fully inhibited hepatic HSD-1. Establishing the dose that fully inhibits central nervous system (CNS) HSD-1 would enable definitive clinical studies in potential CNS indications...
  5. Mukherjee S. Alcoholism and its effects on the central nervous system. Curr Neurovasc Res. 2013;10:256-62 pubmed
    ..of the brain, but, in general, contracts brain tissues, destroys brain cells, as well as depresses the central nervous system. Excessive drinking over a prolonged period of time can cause serious problems with cognition and memory...
  6. Padilla Docal B, Iglesias González I, Bu Coifiu Fanego R, Socarrás Hernández C, Dorta Contreras A. Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. Am J Trop Med Hyg. 2013;88:230-5 pubmed publisher
    ..Variant group B involves C4 in cerebrospinal fluid that comes from blood in the intrathecal activation of the classical pathway. Variant group C includes the alternative pathway. ..
  7. Nakamagoe K, Fujizuka N, Koganezawa T, Shimizu K, Takiguchi S, Horaguchi T, et al. Residual central nervous system damage due to organoarsenic poisoning. Neurotoxicol Teratol. 2013;37:33-8 pubmed publisher
    Drinking well water contaminated with the organoarsenic compound diphenylarsinic acid (DPAA) causes central nervous system (CNS) disorders that improve within several years after last drinking such water...
  8. Crawford A, Chambers C, Franklin R. Remyelination: the true regeneration of the central nervous system. J Comp Pathol. 2013;149:242-54 pubmed publisher
    The myelin sheath, generated by oligodendrocytes in the central nervous system (CNS), is crucial to neuronal function, enabling rapid propagation of nerve impulses and providing trophic support to the axon...
  9. Czyzewski K, Styczynski J, Krenska A, Debski R, Zajac Spychala O, Wachowiak J, et al. Intrathecal therapy with rituximab in central nervous system involvement of post-transplant lymphoproliferative disorder. Leuk Lymphoma. 2013;54:503-6 pubmed publisher
    ..b>Central nervous system (CNS) involvement of PTLD is a very rare event in patients with HSCT...

More Information

Publications32

  1. Ashton J. The atypical cannabinoid O-1602: targets, actions, and the central nervous system. Cent Nerv Syst Agents Med Chem. 2012;12:233-9 pubmed
    ..However, there is evidence that O-1602 has significant effects in the central nervous system as well as other parts of the body...
  2. Williams J, Patel J, Daniels B, Klein R. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med. 2014;211:791-9 pubmed publisher
    ..have been identified, there has yet to be an approved therapy that promotes remyelination in the damaged central nervous system (CNS)...
  3. Kichev A, Rousset C, Baburamani A, Levison S, Wood T, Gressens P, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem. 2014;289:9430-9 pubmed publisher
    ..The toxicity of TRAIL in primary neurons suggests that TRAIL signaling participates in neonatal brain injury after inflammation and HI. ..
  4. Lee K, Seo J, Shin J, Ji E, Roh J, Kim J, et al. Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. Proc Natl Acad Sci U S A. 2014;111:2794-9 pubmed publisher
  5. Amamoto R, Arlotta P. Development-inspired reprogramming of the mammalian central nervous system. Science. 2014;343:1239882 pubmed publisher
    ..Here, we focus on the central nervous system to consider whether and how reprogramming of cell identity may affect regeneration and modeling of a ..
  6. Puccini J, Ruller C, Robinson S, Knopp K, Buchmeier M, Doran K, et al. Distinct neural stem cell tropism, early immune activation, and choroid plexus pathology following coxsackievirus infection in the neonatal central nervous system. Lab Invest. 2014;94:161-81 pubmed publisher
    ..neonatal mouse model of infection, we evaluated the consequences of early viral infection upon the host central nervous system (CNS) by comparing CVB3 and LCMV infection...
  7. Carty M, Reinert L, Paludan S, Bowie A. Innate antiviral signalling in the central nervous system. Trends Immunol. 2014;35:79-87 pubmed publisher
    The innate immune system mediates protection against neurotropic viruses capable of infecting the central nervous system (CNS)...
  8. Shi M, Colarusso P, Calaruso P, Mody C. Real-time in vivo imaging of fungal migration to the central nervous system. Cell Microbiol. 2012;14:1819-27 pubmed publisher
    ..technical advances have afforded valuable new insights into the pathogenesis of fungal infections in the central nervous system (CNS), which continue to cause devastating complications, particularly in immunocompromised individuals...
  9. Zhao Y, Jordan I, Lunyak V. Epigenetics components of aging in the central nervous system. Neurotherapeutics. 2013;10:647-63 pubmed publisher
    ..recent discoveries that have shaped the emerging viewpoints in the field of epigenetic influences in the central nervous system (CNS), focusing on the following questions: (i) How is the CNS shaped during development when precursor ..
  10. Liu J, Sisk J, Gama L, Clements J, Witwer K. Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Mol Brain. 2013;6:40 pubmed publisher
  11. Lin S, Huang Y, Zhang L, Heng M, Ptacek L, Fu Y. MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A. 2013;110:17468-73 pubmed publisher
    ..Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in ..
  12. Wager T, Chandrasekaran R, Hou X, Troutman M, Verhoest P, Villalobos A, et al. Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes. ACS Chem Neurosci. 2010;1:420-34 pubmed publisher
    ..Neuroscience therapeutic area, we embarked on a detailed study of the property space for a collection of central nervous system (CNS) molecules...
  13. Bakhti M, Snaidero N, Schneider D, Aggarwal S, Mobius W, Janshoff A, et al. Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system. Proc Natl Acad Sci U S A. 2013;110:3143-8 pubmed publisher
    During the development of the central nervous system (CNS), oligodendrocytes wrap their plasma membrane around axons to form a multilayered stack of tightly attached membranes...
  14. Wilkinson I, Selvarajah D, Greig M, Shillo P, Boland E, Gandhi R, et al. Magnetic resonance imaging of the central nervous system in diabetic neuropathy. Curr Diab Rep. 2013;13:509-16 pubmed publisher
    ..and nerve function are well documented and, in addition, evidence is emerging regarding changes within the central nervous system (CNS) that are concomitant with the presence of DPN...
  15. Tseng H, Liu C, Price M, Jong A, Chang J, Toffaletti D, et al. Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. PLoS ONE. 2012;7:e45083 pubmed publisher
    A mouse brain transmigration assessment (MBTA) was created to investigate the central nervous system (CNS) pathogenesis of cryptococcal meningoencephalitis...
  16. Lampron A, Pimentel Coelho P, Rivest S. Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol. 2013;521:3863-76 pubmed publisher
    Microglia are the brain-resident macrophages tasked with the defense and maintenance of the central nervous system (CNS)...
  17. Li J, Fang L, Killer H, Flammer J, Meyer P, Neutzner A. Meningothelial cells as part of the central nervous system host defence. Biol Cell. 2013;105:304-15 pubmed publisher
    ..components of the meninges protecting the brain and as such provide important barrier function for the central nervous system building the interface between neuronal tissue and the cerebrospinal fluid (CSF)...
  18. Borrell V, Cárdenas A, Ciceri G, Galcerán J, Flames N, Pla R, et al. Slit/Robo signaling modulates the proliferation of central nervous system progenitors. Neuron. 2012;76:338-52 pubmed publisher
    ..Here we report that central nervous system progenitors express Robo1 and Robo2, receptors for Slit proteins that regulate axon guidance, and that ..
  19. Hacohen Y, Wright S, Waters P, Agrawal S, Carr L, Cross H, et al. Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens. J Neurol Neurosurg Psychiatry. 2013;84:748-55 pubmed publisher
    ..with a clinical diagnosis of probable autoimmune encephalopathy, both with and without antibodies to central nervous system antigens...
  20. Porsolt R. The usefulness of non-human primates in central nervous system safety pharmacology. J Pharmacol Toxicol Methods. 2013;68:23-9 pubmed publisher
    The present paper will suggest, on the basis of experimental evidence, that several non-human primate (NHP) procedures can be uniquely useful and relevant for central nervous system (CNS) safety pharmacology purposes.
  21. Chanson J, Echaniz Laguna A, Blanc F, Lacour A, Ballonzoli L, Kremer S, et al. Central nervous system abnormalities in patients with PMP22 gene mutations: a prospective study. J Neurol Neurosurg Psychiatry. 2013;84:392-7 pubmed publisher
    ..Although mainly expressed in the PNS, PMP22 mRNA and protein are also present in the central nervous system (CNS). To investigate whether patients with PMP22 mutations present with CNS abnormalities...
  22. Haanstra K, Hofman S, Lopes Estêvão D, Blezer E, Bauer J, Yang L, et al. Antagonizing the ?4?1 integrin, but not ?4?7, inhibits leukocytic infiltration of the central nervous system in rhesus monkey experimental autoimmune encephalomyelitis. J Immunol. 2013;190:1961-73 pubmed publisher
    ..These results demonstrate that blocking ?(4)?(7) exclusively does not inhibit immune surveillance of the CNS in primates...
  23. Mattner F, Staykova M, Berghofer P, Wong H, Fordham S, Callaghan P, et al. Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis. J Nucl Med. 2013;54:291-8 pubmed publisher
    ..The biodistribution of (18)F-PBR111 was measured in 13 areas of the central nervous system and compared with PET imaging results during different phases of RR EAE...