horner syndrome

Summary

Summary: A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)

Top Publications

  1. Mahoney N, Liu G, Menacker S, Wilson M, Hogarty M, Maris J. Pediatric horner syndrome: etiologies and roles of imaging and urine studies to detect neuroblastoma and other responsible mass lesions. Am J Ophthalmol. 2006;142:651-9 pubmed
    To evaluate the frequency of etiologies of Horner syndrome in children and suggest an imaging and laboratory diagnostic protocol to evaluate for neuroblastoma and other lesions in a child presenting with Horner syndrome and no known cause.
  2. Rigamonti A, Iurlaro S, Reganati P, Zilioli A, Agostoni E. Cluster headache and internal carotid artery dissection: two cases and review of the literature. Headache. 2008;48:467-70 pubmed publisher
    ..These cases highlight the need for extensive neuroradiological investigation in cluster headache patients when atypical features are present. We also performed a PubMed search to review the current literature data about this association...
  3. Mirzai H, Baser E. Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis. Indian J Ophthalmol. 2006;54:197-9 pubmed
    ..As in our case, a specific etiology may not always be elicited. Pharmacological testing with apraclonidine may be a practical alternative to cocaine in the diagnosis of HS...
  4. George A, Haydar A, Adams W. Imaging of Horner's syndrome. Clin Radiol. 2008;63:499-505 pubmed publisher
    ..Appropriate imaging requires an anatomical appreciation of the complex and circuitous route the neuronal pathway takes as it passes from the central nervous system to the eye...
  5. Lynch J, Keneally R, Hustead T. Horner's syndrome and trigeminal nerve palsy following epidural analgesia for labor. J Am Board Fam Med. 2006;19:521-3 pubmed
    ..Although reported in few instances in the anesthesia literature, awareness among providers in obstetrics is critical because this could be the first sign of a high sympathetic blockade resulting in potential maternal-fetal morbidity...
  6. Chan C, Paine M, O DAY J. Carotid dissection: a common cause of Horner's syndrome. Clin Exp Ophthalmol. 2001;29:411-5 pubmed
    ..To highlight that internal carotid artery dissection is a common cause of Horner's syndrome and that it is important to diagnose dissection as anticoagulation can prevent carotid thrombosis and embolism...
  7. Freedman K, Brown S. Topical apraclonidine in the diagnosis of suspected Horner syndrome. J Neuroophthalmol. 2005;25:83-5 pubmed
    Topical cocaine is used to confirm the clinical diagnosis of ocular sympathetic denervation, or Horner Syndrome (HS)...
  8. Ross I. The role of Claude Bernard and others in the discovery of Horner's syndrome. J Am Coll Surg. 2004;199:976-80 pubmed
  9. Hirao M, Oku H, Sugasawa J, Utsumi T, Ikeda T. [Three cases of abducens nerve palsy accompanied by Horner syndrome]. Nippon Ganka Gakkai Zasshi. 2006;110:520-4 pubmed
    To report three cases of nasopharyngeal carcinoma, exhibiting abducens nerve palsy and Horner syndrome during the medical treatment of the tumor, whose invasive cavernous sinus lesions could be detected.

More Information

Publications62

  1. Kurihara T. Abducens nerve palsy and ipsilateral incomplete Horner syndrome: a significant sign of locating the lesion in the posterior cavernous sinus. Intern Med. 2006;45:993-4 pubmed
  2. Panciera R, Ritchey J, Baker J, Digregorio M. Trigeminal and polyradiculoneuritis in a dog presenting with masticatory muscle atrophy and Horner's syndrome. Vet Pathol. 2002;39:146-9 pubmed
    ..Histologically, the character and distribution of the inflammation was similar to previously described syndromes of suspected immune-mediated etiology in humans and animals...
  3. Ozveren M, Uchida K, Erol F, Tiftikci M, Cobanoglu B, Kawase T. Isolated abducens nerve paresis associated with incomplete Horner's syndrome caused by petrous apex fracture--case report and anatomical study. Neurol Med Chir (Tokyo). 2001;41:494-8 pubmed
    ..Concurrent functional loss of the abducens nerve and the periarterial sympathetic plexus clinically manifested as incomplete Horner's syndrome in our patient...
  4. Fons C, Vasconcelos M, Vidal M, Puy R, Capdevila A, Sanchez L, et al. Agenesis of internal carotid artery in a child with ipsilateral Horner's syndrome. J Child Neurol. 2009;24:101-4 pubmed publisher
    ..The final diagnosis was right, congenital Horner's syndrome due to ipsilateral internal carotid agenesis. We describe in detail the radiological findings and pathophysiological mechanisms of this unusual association...
  5. van der Wiel H. Johann Friedrich Horner (1831-1886). J Neurol. 2002;249:636-7 pubmed
  6. Chandrasekhar S, Peterfreund R. Horner's syndrome following very low concentration bupivacaine infusion for labor epidural analgesia. J Clin Anesth. 2003;15:217-9 pubmed
    ..04%) in an epidural infusion. We discuss the possible factors that could have contributed to this occurrence despite the extremely dilute concentration of local anesthetic used for analgesia...
  7. Cozzaglio L, Coladonato M, Doci R, Travaglini P, Vizzotto L, Osio M, et al. Horner's syndrome as a complication of thyroidectomy: report of a case. Surg Today. 2008;38:1114-6 pubmed publisher
    ..The prompt and complete recovery of this patient suggests that the cervical sympathetic chain was damaged by retractor stretching...
  8. Tubbs R, Oakes W. Horner's syndrome resulting from agenesis of the internal carotid artery: report of a third case. Childs Nerv Syst. 2005;21:81-2 pubmed
    ..Only two previous reports of agenesis of the internal carotid artery with a coexistent Horner's syndrome are to be found in the medical literature...
  9. McCorry D, Bamford J. Painful Horner's syndrome caused by carotid dissection. Postgrad Med J. 2004;80:164 pubmed
  10. Nautiyal A, Singh S, DiSalle M, O SULLIVAN J. Painful Horner syndrome as a harbinger of silent carotid dissection. PLoS Med. 2005;2:e19 pubmed
  11. Dinc H, Alioglu Z, Erdol H, Ahmetoglu A. Agenesis of the internal carotid artery associated with aortic arch anomaly in a patient with congenital Horner's syndrome. AJNR Am J Neuroradiol. 2002;23:929-31 pubmed
    ..High resolution CT of the skull base revealed the absence of the left carotid channel, consistent with congenital agenesis of the ICA...
  12. Dziewas R, Konrad C, Dräger B, Evers S, Besselmann M, Ludemann P, et al. Cervical artery dissection--clinical features, risk factors, therapy and outcome in 126 patients. J Neurol. 2003;250:1179-84 pubmed
    ..Patients with dissection-related cervical artery occlusion had a significantly increased risk of suffering a disabling stroke...
  13. Tsuda H, Ishikawa H, Kishiro M, Koga N, Kashima Y. Abducens nerve palsy and postganglionic Horner syndrome with or without severe headache. Intern Med. 2006;45:851-5 pubmed
    To report the clinical features of 9 patients with both abducens nerve palsy and postganglionic Horner syndrome.
  14. Tsuda H, Yorinaga Y, Tamada Y, Kutsuki S, Nakanoma T, Tai K, et al. Combination of abducens nerve palsy and ipsilateral postganglionic Horner syndrome as an initial manifestation of uterine cervical cancer. Intern Med. 2009;48:1457-60 pubmed
    A 74-year-old woman presented with abducens nerve palsy, postganglionic Horner syndrome and sensory disturbance in the territory of the ophthalmic nerve on the left side...
  15. Tsuda H, Ishikawa H, Asayama K, Saito T, Endo S, Mizutani T. Abducens nerve palsy and Horner syndrome due to metastatic tumor in the cavernous sinus. Intern Med. 2005;44:644-6 pubmed
    ..Two years later, right abducens nerve palsy and Horner syndrome appeared...
  16. Hered R, Cummings R, Helffrich R. Persistent Horner's syndrome after spinal fusion and epidural analgesia. A case report. Spine (Phila Pa 1976). 1998;23:387-90 pubmed
    ..A case report of a clinical observation...
  17. Biousse V, Touboul P, D Anglejan Chatillon J, Levy C, Schaison M, Bousser M. Ophthalmologic manifestations of internal carotid artery dissection. Am J Ophthalmol. 1998;126:565-77 pubmed
    ..To report the ophthalmologic symptoms and signs associated with extracranial internal carotid artery dissection...
  18. Wilhelm H, Ochsner H, Kopycziok E, Trauzettel Klosinski S, Schiefer U, Zrenner E. Horner's syndrome: a retrospective analysis of 90 cases and recommendations for clinical handling. Ger J Ophthalmol. 1992;1:96-102 pubmed
    ..Additional ocular motor palsies or other local signs were present in these 6 cases. Goiter was frequently associated with preganglionic Horner's syndrome...
  19. Mahdy T, Youssef T, Elmonem H, Omar W, Elateef A. T4 sympathectomy for palmar hyperhidrosis: looking for the right operation. Surgery. 2008;143:784-9 pubmed publisher
    ..All patients of the ETS4 group were satisfied with the outcome. In conclusion, ETS4 sympathectomy is an effective method for treating PH and it decreases the rate of compensatory hydrosis (CH)...
  20. Yang C, Lee J, Wu C, Tsai J, Chou S, Huang M. Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. Chest. 2012;142:246-251 pubmed publisher
  21. de Seze J, Vukusic S, Viallet Marcel M, Tilikete C, Zephir H, Delalande S, et al. Unusual ocular motor findings in multiple sclerosis. J Neurol Sci. 2006;243:91-5 pubmed
    ..In the other four cases they occurred 3 months (Horner syndrome), 6 years and 12 years (bilateral third nerve palsy) and 2 years (one-and-a-half syndrome) after the disease ..
  22. Holland C. Bilateral Horner's syndrome in a dog with diabetes mellitus. Vet Rec. 2007;160:662-4 pubmed
  23. Balaggan K, Hugkulstone C, Bremner F. Episodic segmental iris dilator muscle spasm: the tadpole-shaped pupil. Arch Ophthalmol. 2003;121:744-5 pubmed
  24. Jennett R, Tarby T. Disuse osteoporosis as evidence of brachial plexus palsy due to intrauterine fetal maladaptation. Am J Obstet Gynecol. 2001;185:236-7 pubmed
    ..The presence of clear-cut evidence of disuse osteoporosis during the early neonatal period is compelling evidence of an intrauterine onset of brachial plexus palsy...
  25. Saylam C, Ozgiray E, Orhan M, Cagli S, Zileli M. Neuroanatomy of cervical sympathetic trunk: a cadaveric study. Clin Anat. 2009;22:324-30 pubmed publisher
    ..Anterior surgical approach to the cervical spine is a commonly used procedure. Although Horner syndrome due to sympathetic injury is not a common sequence of cervical operations, our findings support the current ..
  26. Pérez Iñigo M, Gonzalez I, Fernandez F, Diaz S, Ferrer C, Alias E, et al. [Usefulness of apraclonidine in the diagnosis of Horner syndrome]. Arch Soc Esp Oftalmol. 2009;84:105-8 pubmed
    We present four cases: two males with Horner Syndrome, who were diagnosed by means of apraclonidine 0.5% and cocaine 4% tests respectively...
  27. Friedman L, Godovik G, Eidelman L. [Horner's syndrome during epidural analgesia in labor: an alarming sign or a benign phenomenon?]. Harefuah. 2002;141:507-9, 580 pubmed
    ..Epidural analgesia can be carefully continued albeit appearance of the syndrome...
  28. Almog Y, Gepstein R, Kesler A. Diagnostic value of imaging in horner syndrome in adults. J Neuroophthalmol. 2010;30:7-11 pubmed publisher
    The yield of imaging in Horner syndrome has been explored only in children. This study evaluates the yield of imaging in adults.
  29. Patel R, Adam R, Maldjian C, Lincoln C, Yuen A, Arneja A. Cervical carotid artery dissection: current review of diagnosis and treatment. Cardiol Rev. 2012;20:145-52 pubmed publisher
    ..diagnosis of carotid artery dissection can be challenging, with common presentations including pain, partial Horner syndrome, cranial nerve palsies, or cerebral ischemia...
  30. Tsivgoulis G, Mantatzis M, Vadikolias K, Heliopoulos I, Charalampopoulos K, Mitsoglou A, et al. Internal carotid artery dissection presenting as new-onset cluster headache. Neurol Sci. 2013;34:1251-2 pubmed publisher
  31. Jarvis J, Watson A, Robertson G. Horner's syndrome after central venous catheterisation. N Z Med J. 2005;118:U1470 pubmed
  32. Escriva E, Martínez Costa L. [Incomplete Horner's syndrome as a presenting sign of fourth ventricle ependymoma]. Arch Soc Esp Oftalmol. 2013;88:359-61 pubmed publisher
    ..After surgical treatment, the patient developed a residual paresis of the sixth cranial nerve...
  33. Wiegand S, Kureck I, Chapot R, Sesterhenn A, Bien S, Werner J. Early side effects after embolization of a carotid body tumor using Onyx. J Vasc Surg. 2010;52:742-5 pubmed publisher
    ..mL Onyx (ethylene-vinyl alcohol copolymer; Micro Therapeutics, Irvine, Calif), the patient showed symptoms of Horner syndrome and deficits of the hypoglossal and glossopharyngeal nerves...
  34. Peterson J, Bilyk J, Sergott R. But it's not all there. Surv Ophthalmol. 2013;58:492-9 pubmed publisher
    ..Dilation lag was noted in the smaller pupil and Horner syndrome was suspected despite the lack of eyelid ptosis...
  35. Bucci T, Califano L. Bernard-Horner's syndrome: unusual complication after neck dissection. J Oral Maxillofac Surg. 2008;66:833 pubmed publisher
  36. Gesundheit B, Greenberg M. Medical mystery: brown eye and blue eye--the answer. N Engl J Med. 2005;353:2409-10 pubmed
  37. Talkad A, Kattah J, Xu M, Orth E, Chang J. Prolactinoma presenting as painful postganglionic Horner syndrome. Neurology. 2004;62:1440-1 pubmed
  38. Buttinelli C, Spalloni A, Fieschi C, Rasura M. Migraine and arterial dissection in a young woman. Neurol Sci. 2001;22:275-8 pubmed
    ..Our aim in the future is, therefore, to study a larger sample of migraine patients in order to find those patients who are most at risk of arterial dissection and who should, consequently, be carefully studied...
  39. Guilloton L, Demarquay G, Quesnel L, de Charry F, Drouet A, Zagnoli F. [Dysautonomic syndrome of the face with Harlequin sign and syndrome: Three new cases and a review of the literature]. Rev Neurol (Paris). 2013;169:884-91 pubmed publisher
    ..This syndrome can occur alone or associated to other dysautonomic phenomena such as Horner syndrome, Adie syndrome or Ross syndrome.
  40. de la Calle A, Marin F, Marenco M. [Horner's syndrome following epidural analgesia for labor]. Rev Esp Anestesiol Reanim. 2004;51:461-4 pubmed
    ..Nevertheless, the diagnosis should be kept in mind so that unnecessary treatment is avoided, given that the clinical course is favorable with spontaneous resolution...
  41. Lipková B, Kacerik M, Krauseová O, Popluhár J. [Ocular signs and symptoms after scoliosis surgery (a case report)]. Cesk Slov Oftalmol. 2011;67:67-70 pubmed
    ..The inconvenience disappeared spontaneously and gradually 3 months after the reoperation, mobility is in good order and x- ray documents firm fixation of supermounting...
  42. Liebeskind D. Wallerian degeneration of the corticospinal tracts. Neurology. 2004;62:828 pubmed
  43. Zahn P, Van Aken H, Marcus A. Horner's syndrome following epidural anesthesia with ropivacaine for cesarean delivery. Reg Anesth Pain Med. 2002;27:445-6 pubmed
  44. Weinreb I, Goldstein D, Perez Ordonez B. Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol. 2008;32:1742-8 pubmed publisher
    ..A 29-year-old man presented with a right-sided Horner syndrome suggesting a sympathetic chain related lesion. No radiologic evidence of a mass was appreciated initially...
  45. Harrahill M. Suspected blunt carotid injury in a 54-year-old woman after a motor vehicle crash: a brief review. J Emerg Nurs. 2003;29:582-3 pubmed
  46. Murchison A, Rosen M, Bilyk J. Horner syndrome as a presenting sign of nasopharyngeal carcinoma. Ophthalmic Plast Reconstr Surg. 2009;25:401-2 pubmed publisher
    ..The authors present a case of a 57-year-old healthy man with sudden-onset unilateral ptosis. MRI showed an ulcerating soft-tissue mass in the nasopharynx with skull base invasion. Biopsy confirmed nasopharyngeal carcinoma. ..
  47. Ramos R, Ureña A, Rivas F, Macia I, Rosado G, Pequeño S, et al. Impact of T3 thoracoscopic sympathectomy on pupillary function: a cause of partial Horner's syndrome?. Surg Endosc. 2012;26:1146-52 pubmed publisher
    ..The objective of our study is to evaluate the repercussion of T3 sympathetic denervation on pupillary tone in patients with primary hyperhidrosis...
  48. Ding P, Tufano R, Campbell Malone R, Feng W, Kim S, German R. Horner syndrome after carotid sheath surgery in a pig: anatomic study of cervical sympathetic chain. Comp Med. 2011;61:453-6 pubmed
    In an experimental model, iatrogenic Horner syndrome developed after a right carotid sheath surgery in an infant pig (Sus scrofa)...
  49. Bhaskar G, Lodha R, Kabra S. Unusual complications of empyema thoracis: diaphragmatic palsy and Horner's syndrome. Indian J Pediatr. 2006;73:941-3 pubmed
    ..These complications of empyema thoracis have not been reported earlier. We discuss the possible mechanisms for these complications...
  50. Burlacu C, Buggy D. Coexisting harlequin and Horner syndromes after high thoracic paravertebral anaesthesia. Br J Anaesth. 2005;95:822-4 pubmed
    ..developed transient, well-demarcated, right-sided hemifacial erythema and sweating, and left-sided Horner syndrome postoperatively...
  51. Williamson J, Leopold G, Prabhu V, Ingrams D. Successful treatment of a rare metastatic malignant carotid body tumour in a young adult, with conservative surgery and local radiotherapy. J Laryngol Otol. 2012;126:428-31 pubmed publisher
    ..We report a patient with a malignant carotid body paraganglioma treated with surgery and adjuvant radiotherapy. We discuss her treatment and outcome in the light of the published literature...
  52. Murphy C, Bangash I, Varma A. Dry beriberi mimicking the Guillain-Barre syndrome. Pract Neurol. 2009;9:221-4 pubmed publisher
    ..CSF was normal. He improved with high dose vitamin replacement and physiotherapy but remains dependent on a Zimmer frame for mobility and a splint for wrist drop...
  53. Vucic S, Palmer W, Cros D. Radiculoplexopathy with conduction block caused by acute Epstein-Barr virus infection. Neurology. 2005;64:530-2 pubmed
    ..Neurophysiologic studies demonstrated CB in the proximal left median and ulnar nerve segments. The authors conclude that this syndrome resulted from a postinfectious process following acute EBV infection...