uveomeningoencephalitic syndrome

Summary

Summary: A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)

Top Publications

  1. Wu W, Wen F, Huang S, Luo G, Wu D. Choroidal folds in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2007;143:900-901 pubmed
    ..To analyze choroidal folds in Vogt-Koyanagi-Harada (VKH) disease by fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT)...
  2. Yang P, Ren Y, Li B, Fang W, Meng Q, Kijlstra A. Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology. 2007;114:606-14 pubmed
    ..To characterize the clinical features of Vogt-Koyanagi-Harada syndrome (VKH) in Chinese patients...
  3. Yamaki K, Kondo I, Nakamura H, Miyano M, Konno S, Sakuragi S. Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in Lewis rats. Exp Eye Res. 2000;71:361-9 pubmed
    ..Extraocular manifestations such as skin lesions and meningitis were also observed. The clinical course and histological findings in these rats resembled the changes in patients with VKH disease...
  4. Horie Y, Kitaichi N, Takemoto Y, Namba K, Yoshida K, Hirose S, et al. Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. Mol Vis. 2007;13:2334-8 pubmed
    ..Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease...
  5. Read R, Yu F, Accorinti M, Bodaghi B, Chee S, Fardeau C, et al. Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2006;142:119-24 pubmed
    ..To compare the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease...
  6. Sugita S, Takase H, Taguchi C, Imai Y, Kamoi K, Kawaguchi T, et al. Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest Ophthalmol Vis Sci. 2006;47:2547-54 pubmed
    ..To determine whether patients with Vogt-Koyanagi-Harada (VKH) disease have immune responses specific to the melanocyte antigens tyrosinase and gp100...
  7. Maruyama Y, Kishi S. Tomographic features of serous retinal detachment in Vogt-Koyanagi-Harada syndrome. Ophthalmic Surg Lasers Imaging. 2004;35:239-42 pubmed
    ..Intraretinal fluid accumulation appeared as an oval space in the outer retina. On fluorescein angiography, the eyes with intraretinal fluid accumulation showed more severe dye leakage from the retinal pigment epithelium...
  8. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S. Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol. 2000;165:7323-9 pubmed
    ..We conclude that VKH disease is an autoimmune disease against the tyrosinase family proteins...
  9. Bykhovskaya I, Thorne J, Kempen J, Dunn J, Jabs D. Vogt-Koyanagi-Harada disease: clinical outcomes. Am J Ophthalmol. 2005;140:674-8 pubmed
    ..To evaluate the effect of treatment on the incidence of vision impairment and structural ocular complications among patients with Vogt-Koyanagi-Harada (VKH) disease...

More Information

Publications62

  1. Iqniebi A, Gaafar A, Sheereen A, Al Suliman A, Mohamed G, Al Hussein K, et al. HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia. Mol Vis. 2009;15:1876-80 pubmed
    ..So, the purpose of this study was to investigate the association of human leukocyte antigen (HLA)-DRB1 alleles to VKH patients and to clarify the molecular genetic mechanism underlying the susceptibility or resistance to VKH disease...
  2. Zhao C, Zhang M, Wen X, Dong F, Han B, Du H. Choroidal folds in acute Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm. 2009;17:282-8 pubmed publisher
    ..To shed light on the clinical significance of choroidal folds (CFs) in acute Vogt-Koyanagi-Harada disease (VKH)...
  3. Meng Q, Liu X, Yang P, Hou S, Du L, Zhou H, et al. PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome. Mol Vis. 2009;15:386-92 pubmed
    ..To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population...
  4. Sheu S. Update on uveomeningoencephalitides. Curr Opin Neurol. 2005;18:323-9 pubmed
    ..Also, the treatment of choice differs in different parts of the world. This review addresses the literature on the possible pathogenesis, diagnosis and treatment of this disorder...
  5. Bacsal K, Wen D, Chee S. Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2008;145:480-486 pubmed publisher
    ..To determine whether clinically isolated anterior segment recurrence is associated with concomitant subclinical choroidal inflammation in Vogt-Koyanagi-Harada (VKH) disease...
  6. Kamondi A, Szegedi A, Papp A, Seres A, Szirmai I. Vogt-Koyanagi-Harada disease presenting initially as aseptic meningoencephalitis. Eur J Neurol. 2000;7:719-22 pubmed
    ..However, VKH syndrome has a much higher incidence in Asia; cases in other races, including white people in Europe, also occur...
  7. Tsujikawa A, Yamashiro K, Yamamoto K, Nonaka A, Fujihara M, Kurimoto Y. Retinal cystoid spaces in acute Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2005;139:670-7 pubmed
    ..Exudative retinal detachment in acute Vogt-Koyanagi-Harada syndrome often is associated with subfoveal yellowish round structures. This report describes the incidence and clinical characteristics of these structures...
  8. Gupta A, Kamal S, Gupta V, Bambery P, Kaura B. HLA typing in Vogt-Koyanagi-Harada syndrome in North Indian patients. Ocul Immunol Inflamm. 2007;15:89-97 pubmed
    ..To report the HLA profile of VKH patients from India...
  9. Kasahara A, Hiraide A, Tomita N, Iwahashi H, Imagawa A, Ohguro N, et al. Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C. J Gastroenterol. 2004;39:1106-9 pubmed
  10. da Silva F, Damico F, Marin M, Goldberg A, Hirata C, Takiuti P, et al. Revised diagnostic criteria for vogt-koyanagi-harada disease: considerations on the different disease categories. Am J Ophthalmol. 2009;147:339-345.e5 pubmed publisher
  11. Hou S, Yang P, Du L, Zhou H, Lin X, Liu X, et al. Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population. Mol Vis. 2008;14:2597-603 pubmed
    ..To examine whether small ubiquitin-like modifier 4 (SUMO4) polymorphisms were associated with Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population...
  12. Hu K, Yang P, Jiang Z, Hou S, Du L, Li F. STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behçet's disease. Hum Immunol. 2010;71:723-6 pubmed publisher
    ..Our results suggest that TT genotype of rs7574865 may be a susceptible factor for VKH syndrome in a Chinese Han population, and that GG genotype of this SNP may confer susceptibility in male BD patients...
  13. Yang P, Ji L, Zhou H, Huang X, Xie C, Jin H, et al. Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. Ocul Immunol Inflamm. 2001;9:185-91 pubmed
    ..To evaluate the expression of Fas/FasL antigen on peripheral blood T lymphocytes in patients with Behcet's disease, Vogt-Koyanagi-Harada (VKH) syndrome, and idiopathic anterior uveitis...
  14. Du L, Yang P, Hou S, Lin X, Zhou H, Huang X, et al. Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome. Clin Immunol. 2008;127:43-8 pubmed publisher
    ..1% versus 60.0%, P= 0.0013, n= 16, Pc = 0.021). These results suggest that CTLA-4 genetic polymorphisms are associated with the susceptibility to VKH syndrome...
  15. Read R, Rao N, Cunningham E. Vogt-Koyanagi-Harada disease. Curr Opin Ophthalmol. 2000;11:437-42 pubmed
    ..Complications are the main cause of reversible and irreversible vision loss, with subretinal fibrosis and choroidal neovascular membranes having particularly poor prognoses...
  16. Bouchenaki N, Herbort C. The contribution of indocyanine green angiography to the appraisal and management of Vogt-Koyanagi-Harada disease. Ophthalmology. 2001;108:54-64 pubmed
  17. Heussen F, Vasconcelos Santos D, Pappuru R, Walsh A, Rao N, Sadda S. Ultra-wide-field green-light (532-nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease. Ophthalmic Surg Lasers Imaging. 2011;42:272-7 pubmed publisher
    ..To assess the prevalence of peripheral fundus autofluorescence (FAF) abnormalities in chronic Vogt-Koyanagi-Harada disease (VKH)...
  18. Yamaki K, Gocho K, Sakuragi S. Pathogenesis of Vogt-Koyanagi-Harada disease. Int Ophthalmol Clin. 2002;42:13-23 pubmed
  19. Damico F, Cunha Neto E, Goldberg A, Iwai L, Marin M, Hammer J, et al. T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis. Invest Ophthalmol Vis Sci. 2005;46:2465-71 pubmed
    ..This study was undertaken to analyze T-cell recognition and the cytokine expression profile induced by melanocyte epitopes in HLA-DRB1*0405-positive and -negative patients with VKH uveitis...
  20. Kitamura M, Takami K, Kitaichi N, Kitachi N, Namba K, Kitamei H, et al. Comparative study of two sets of criteria for the diagnosis of Vogt-Koyanagi-Harada's disease. Am J Ophthalmol. 2005;139:1080-5 pubmed
    ..The purpose of the present study was to assess the concordance between these criteria and the traditional Sugiura's diagnosis system...
  21. Li B, Yang P, Zhou H, Huang X, Jin H, Chu L, et al. Upregulation of T-bet expression in peripheral blood mononuclear cells during Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2005;89:1410-2 pubmed
    ..To test the hypothesis that T-bet expression is altered in patients with Vogt-Koyanagi-Harada (VKH) disease...
  22. Gocho K, Kondo I, Yamaki K. Identification of autoreactive T cells in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 2001;42:2004-9 pubmed
    ..To determine the finer specificity and immunologic features of autoreactive T cells in Vogt-Koyanagi-Harada (VKH) disease...
  23. Vasconcelos Santos D, Sohn E, Sadda S, Rao N. Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: fundus autofluorescence and spectral domain-optical coherence tomography findings. Retina. 2010;30:33-41 pubmed publisher
  24. Okamoto Y, Miyake Y, Horio N, Takakuwa H, Yamamoto E, Terasaki H. Delayed regeneration of foveal cone photopigments in Vogt-Koyanagi-Harada disease at the convalescent stage. Invest Ophthalmol Vis Sci. 2004;45:318-22 pubmed
    ..To evaluate the physiological characteristics of the macula in patients with Vogt-Koyanagi-Harada disease during the convalescent stage with specific reference to the kinetics of foveal cone photopigment regeneration...
  25. Goldberg A, Yamamoto J, Chiarella J, Marin M, Sibinelli M, Neufeld R, et al. HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. Hum Immunol. 1998;59:183-8 pubmed
  26. Yamaguchi Y, Otani T, Kishi S. Tomographic features of serous retinal detachment with multilobular dye pooling in acute Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2007;144:260-5 pubmed
    ..To clarify the morphologic background of serous retinal detachment with multilobular dye pooling on fluorescein angiography (FA) in acute Vogt-Koyanagi-Harada (VKH) disease...
  27. Chi W, Yang P, Li B, Wu C, Jin H, Zhu X, et al. IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immunol. 2007;119:1218-24 pubmed
    ..Vogt-Koyanagi-Harada (VKH) disease is a systemic refractory autoimmune disease. IL-23 has been thought to play a critical role in autoimmune disease through inducing the development of IL-17-producing CD4(+) T cells...
  28. Read R. Vogt-Koyanagi-Harada disease. Ophthalmol Clin North Am. 2002;15:333-41, vii pubmed
    ..Complications, including cataract, glaucoma, choroidal neovascular membrane formation, and subretinal fibrosis, may limit final visual acuity...
  29. Chee S, Jap A, Bacsal K. Spectrum of Vogt-Koyanagi-Harada disease in Singapore. Int Ophthalmol. 2007;27:137-42 pubmed
    ..Review of all cases of Vogt-Koyanagi-Harada disease (VKH) handled in the Uveitis Clinic of the Singapore National Eye Centre, with the aim of determining the clinical spectrum of this disease in these patients and the outcomes of treatment...
  30. Levinson R, See R, Rajalingam R, Reed E, Park M, Rao N, et al. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Hum Immunol. 2004;65:1477-82 pubmed
    ..No HLA-DQB1 allele was significantly increased compared to controls. This study is the first to identify a possible association between HLA-DRB1*0404 and VKH disease, as well as to find DRB1*0102 and DRB1*0410 in Mestizo patients...
  31. Read R, Holland G, Rao N, Tabbara K, Ohno S, Arellanes Garcia L, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol. 2001;131:647-52 pubmed
    ..To present revised criteria for the diagnosis of Vogt-Koyanagi-Harada disease, a chronic, bilateral, granulomatous ocular and multisystem inflammatory condition of unknown cause...
  32. Andreoli C, Foster C. Vogt-Koyanagi-Harada disease. Int Ophthalmol Clin. 2006;46:111-22 pubmed
  33. Liu X, Yang P, Lin X, Ren X, Zhou H, Huang X, et al. Inhibitory effect of Cyclosporin A and corticosteroids on the production of IFN-gamma and IL-17 by T cells in Vogt-Koyanagi-Harada syndrome. Clin Immunol. 2009;131:333-42 pubmed publisher
    ..These data suggest that an upregulated Th1 and Th17 response is associated with active VKH syndrome. CsA and corticosteroids may exert their immunosuppressive role by downregulating Th1 and Th17 cells...
  34. Kawaguchi T, Horie S, Bouchenaki N, Ohno Matsui K, Mochizuki M, Herbort C. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2010;30:41-50 pubmed publisher
    ..To evaluate clinical and angiographic differences in patients with Vogt-Koyanagi-Harada (VKH) disease during the early 4-month treatment phase with high- or medium-dose systemic corticosteroid therapy...
  35. de Smet M, Rao N. Retinal cystoid spaces in acute Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2005;140:962; author reply 962-3 pubmed
  36. da Silva F, Hirata C, Olivalves E, Oyamada M, Yamamoto J. Fundus-based and electroretinographic strategies for stratification of late-stage Vogt-Koyanagi-Harada disease patients. Am J Ophthalmol. 2009;148:939-45.e3 pubmed publisher
  37. Herbort C, Mantovani A, Bouchenaki N. Indocyanine green angiography in Vogt-Koyanagi-Harada disease: angiographic signs and utility in patient follow-up. Int Ophthalmol. 2007;27:173-82 pubmed
  38. Andrade R, Muccioli C, Farah M, Nussenblatt R, Belfort R. Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2004;137:572-4 pubmed
    ..To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease...
  39. Ohta K, Yoshimura N. Bcl-2 expression by CD4 T lymphocytes in Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm. 2002;10:93-103 pubmed
  40. Wu L, Evans T, Saravia M, Schlaen A, Couto C. Intravitreal bevacizumab for choroidal neovascularization secondary to Vogt-Koyanagi-Harada syndrome. Jpn J Ophthalmol. 2009;53:57-60 pubmed publisher
    ..The second had a subfoveal CNV that responded to a single intravitreal injection of bevacizumab. Intravitreal bevacizumab may be a useful drug to treat CNV in eyes with VKH syndrome. ..
  41. Fardeau C, Tran T, Gharbi B, Cassoux N, Bodaghi B, Lehoang P. Retinal fluorescein and indocyanine green angiography and optical coherence tomography in successive stages of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27:163-72 pubmed
    ..To report features of retinal fluorescein (FA) and indocyanine green (ICGA) angiography and optical coherence tomography (OCT) at successive stages of Vogt-Koyanagi-Harada (VKH) disease...
  42. Shu Q, Yang P, Hou S, Li F, Chen Y, Du L, et al. Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behçet's disease in a Chinese Han population. Hum Immunol. 2010;71:988-91 pubmed publisher
    ..The C allele and TT genotype of rs763780 in the IL-17F gene appear to be associated with protection and susceptibility to VKH syndrome. The tested two IL-17 SNPs are not found to be associated with Behçet's disease...
  43. Yang P, Chen L, Zhou H, Zhong H, Wang H, Huang X, et al. Resistance of lymphocytes to Fas-mediated apoptosis in Behçet's disease and Vogt-Koyangi-Harada syndrome. Ocul Immunol Inflamm. 2002;10:47-52 pubmed
    ..To investigate this hypothesis, a study was carried out to evaluate the resistance of lymphocytes to apoptosis in these two uveitis entities...
  44. Otani S, Sakurai T, Yamamoto K, Fujita T, Matsuzaki Y, Goto Y, et al. Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2006;90:773-7 pubmed
    ..To isolate autoantigens possibly involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease...
  45. Wakabayashi T, Morimura Y, Miyamoto Y, Okada A. Changing patterns of intraocular inflammatory disease in Japan. Ocul Immunol Inflamm. 2003;11:277-86 pubmed
    ..We investigated the frequencies and clinical characteristics of Japanese patients with uveitis...
  46. Fang W, Yang P. Vogt-koyanagi-harada syndrome. Curr Eye Res. 2008;33:517-23 pubmed publisher
    ..It is also one of the most common forms of uveitis among pigmented races including Chinese patients...
  47. Rao N. Pathology of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27:81-5 pubmed
    ..In chronic VKH the peripheral fundus scars are not Dalén-Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium...
  48. Horie Y, Takemoto Y, Miyazaki A, Namba K, Kase S, Yoshida K, et al. Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. Mol Vis. 2006;12:1601-5 pubmed
    ..The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT))...
  49. Levinson R, Du Z, Luo L, Holland G, Rao N, Reed E, et al. KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. Hum Immunol. 2008;69:349-53 pubmed publisher
    ..The trends observed in this study are consistent with those reported for other autoimmune diseases...
  50. Yamaki K, Takiyama N, Itho N, Mizuki N, Seiya M, Sinsuke W, et al. Experimentally induced Vogt-Koyanagi-Harada disease in two Akita dogs. Exp Eye Res. 2005;80:273-80 pubmed
    ..We concluded that a VKH-like disease had been induced in these dogs, and this supports the tentative conclusion that the spontaneously occurring chorioretinal disease in Akita dogs is VKH disease...
  51. Prasad P, Levinson R. In silico prediction of binding of putative antigenic peptides to HLA-DRB1 alleles in Vogt-Koyanagi-Harada disease. Clin Immunol. 2005;116:143-8 pubmed
    ..In silico methods hold promise for high-throughput evaluation of putative auto-antigens, for testing and generating hypotheses, and suggest a correlation between HLA binding and immunogenicity...
  52. Yang P, Zhang Z, Zhou H, Li B, Huang X, Gao Y, et al. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res. 2005;30:943-8 pubmed
    ..To address the clinical pattern and characteristics of uveitis in a tertiary center for uveitis in China and compare the similarity and difference in the distribution of uveitis entities between China and other countries...
  53. Parc C, Guenoun J, Dhote R, Brezin A. Optical coherence tomography in the acute and chronic phases of Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm. 2005;13:225-7 pubmed
    ..To assess the potential of optical coherence tomography (OCT) in the diagnosis and monitoring of serous retinal detachment in Vogt-Koyanagi-Harada (VKH) disease and to describe OCT characteristics of subretinal sequelae of the disease...